越来越多的证据表明,可溶性Aβ42低聚物对长时程增强（long term potentiation,m）的抑制作用,是阿尔茨海默病特征的学习及记忆损害的主要原因。这些作用应该是由于Aβ42与诱导LTP的某些细胞效应因子之间的相互作用所致。但是与Aβ42相...越来越多的证据表明,可溶性Aβ42低聚物对长时程增强（long term potentiation,m）的抑制作用,是阿尔茨海默病特征的学习及记忆损害的主要原因。这些作用应该是由于Aβ42与诱导LTP的某些细胞效应因子之间的相互作用所致。但是与Aβ42相互作用的分子信号具体途径目前尚不明确。其困难在于不同刺激条件下诱导的LTP,其表达通过不同的信号途径。实验的目的旨在比较高频刺激（high frequency stimulation,HFS）和配对θ短阵快速脉冲刺激（theta burst stimulation,TBS）诱导下,Aβ42领事水平的效应因子对LTP的抑制作用。实验数据表明：无论HFS或者TBS,展开更多
Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/ (on +off times)] is poorly understood. The authors performed a multice...Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/ (on +off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.展开更多
文摘越来越多的证据表明,可溶性Aβ42低聚物对长时程增强（long term potentiation,m）的抑制作用,是阿尔茨海默病特征的学习及记忆损害的主要原因。这些作用应该是由于Aβ42与诱导LTP的某些细胞效应因子之间的相互作用所致。但是与Aβ42相互作用的分子信号具体途径目前尚不明确。其困难在于不同刺激条件下诱导的LTP,其表达通过不同的信号途径。实验的目的旨在比较高频刺激（high frequency stimulation,HFS）和配对θ短阵快速脉冲刺激（theta burst stimulation,TBS）诱导下,Aβ42领事水平的效应因子对LTP的抑制作用。实验数据表明：无论HFS或者TBS,
文摘Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/ (on +off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.
