目的:对医院新引进的射波刀按照国际原子能机构(IAEA)TRS-398号报告进行模体绝对剂量测量,进而探索水模体位置的重复性对治疗计划绝对剂量验证通过率的影响,确保输出剂量更加精准地投照到患者肿瘤。方法:选取60、40和25 mm 3种准直器按...目的:对医院新引进的射波刀按照国际原子能机构(IAEA)TRS-398号报告进行模体绝对剂量测量,进而探索水模体位置的重复性对治疗计划绝对剂量验证通过率的影响,确保输出剂量更加精准地投照到患者肿瘤。方法:选取60、40和25 mm 3种准直器按照正面入射、侧面入射和混合入射方式分别设计3个计划,采用德国PTW公司的UNIDOSEwebline型静电计和TW310100.125cc指形电离室测量绝对剂量。结果:每一组实验3种不同准直器测量对治疗计划绝对剂量的TPS计算值与实际测量值之间的偏差基本一致(小于0.7%)。当射束全部从模体的正面入射时,无论是单射束还是多个射束,验证偏差均在2%左右;随着侧向射束的引入,其值由3%左右逐渐增大到4%左右;甚至当射束全部从侧向入射时,偏差达5%以上;但将模体固定之后再重复测量,即使在侧向射束也存在的条件下,偏差下降为2%左右。结论:模体空间相对位置的重复性是引起计划系统计算结果和实际测量结果之间偏差增大的主要原因。展开更多
目的探讨定位像的扫描参数对智能管电压辅助(Scout on Tube Voltage Assist,kV assist)技术联合自动管电流调制技术的影响。方法利用GE Revolution CT机和CT剂量体模,改变定位像的管电压、管电流、球管的投射角度以及床相对于机架等中...目的探讨定位像的扫描参数对智能管电压辅助(Scout on Tube Voltage Assist,kV assist)技术联合自动管电流调制技术的影响。方法利用GE Revolution CT机和CT剂量体模,改变定位像的管电压、管电流、球管的投射角度以及床相对于机架等中心点的距离,研究使用kV assist技术联合自动管电流调制技术时的断层图像管电流曲线和图像质量。利用ImageJ软件获取断层图像的管电流、容积CT剂量指数和剂量长度乘积,分别计算定位像和断层的信噪比并进行比较。结果当定位像的管电压发生变化时,定位像管电压为120 kV,图像质量较好,且辐射剂量较低。当定位像的管电流发生变化时,但曝光量无明显变化,定位像的管电流对图像质量和辐射剂量基本没有影响。当定位像的投射角度发生变化时,90°和180°结合时图像质量较好,且辐射剂量较低。当CT床相对于机架等中心点的距离发生变化时,扫描部位的中心置于机架机架等中心点时,图像质量较好,且辐射剂量较低。结论通过研究定位像的参数对断层的管电流曲线的影响,发现在使用kV assist技术联合自动管电流调制技术时,选择合适参数可以在获得较好的图像质量,同时能降低CT检查的辐射剂量。展开更多
Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body. Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results: The pharmacokinetics o...Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body. Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results: The pharmacokinetics of Ginsenoside Rg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg.g-1 Ginsenoside Rg3 in 8 male volunteers, the plasma concentration-time course fitted in well with a two-compartment open model, with the following pharmacokinetic parameters: Tmax 0.660.10 h, Cmax 166 ngmL-1, T1/2a 0.460.12 h, T1/2b 4.91.1 h, T1/2(Ka) 0.280.04 h, AUC0-∞ 7726 ngmL-1h, respectively. No kinetic analysis was made after an oral dose of 0.8 mg.g-1 Rg3 in other 6 volunteers because of the low concentration, but there was a good correlation between Cmax and dosage of the two groups. Conclusion: The absorption of Rg3 was rapid in the human body, and its elimination was rapid too after oral administration of Ginsenoside Rg3. The pharmacokinetic results shows that it exhibited the first-order kinetic characteristics.展开更多
The dosimetric inter-comparison studies carry pertinent significance to ensure uniform radiation dose delivery for clinical trials. This paper investigates the comparative performance analysis of an X-ray high power l...The dosimetric inter-comparison studies carry pertinent significance to ensure uniform radiation dose delivery for clinical trials. This paper investigates the comparative performance analysis of an X-ray high power linear accelerator per- formed by the International Dosimetry Survey Mission and Institute of Nuclear Medicine ＆ Oncology （INMOL）, Lahore. The measurements were made using cylindrical ionization chambers based on the International Atomic Energy Agency （IAEA） TRS-398 protocol for absorbed dose-to-water dosimetric standards, and the percentage deviation was found to be between 0.5 % - 1%. The dosimetric analysis concerning linear X-ray accelerator output performed by INMOL, Lahore was found to be in good agreement with the results of IAEA Dosimtery Survey Mission.展开更多
文摘目的:对医院新引进的射波刀按照国际原子能机构(IAEA)TRS-398号报告进行模体绝对剂量测量,进而探索水模体位置的重复性对治疗计划绝对剂量验证通过率的影响,确保输出剂量更加精准地投照到患者肿瘤。方法:选取60、40和25 mm 3种准直器按照正面入射、侧面入射和混合入射方式分别设计3个计划,采用德国PTW公司的UNIDOSEwebline型静电计和TW310100.125cc指形电离室测量绝对剂量。结果:每一组实验3种不同准直器测量对治疗计划绝对剂量的TPS计算值与实际测量值之间的偏差基本一致(小于0.7%)。当射束全部从模体的正面入射时,无论是单射束还是多个射束,验证偏差均在2%左右;随着侧向射束的引入,其值由3%左右逐渐增大到4%左右;甚至当射束全部从侧向入射时,偏差达5%以上;但将模体固定之后再重复测量,即使在侧向射束也存在的条件下,偏差下降为2%左右。结论:模体空间相对位置的重复性是引起计划系统计算结果和实际测量结果之间偏差增大的主要原因。
文摘Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body. Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results: The pharmacokinetics of Ginsenoside Rg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg.g-1 Ginsenoside Rg3 in 8 male volunteers, the plasma concentration-time course fitted in well with a two-compartment open model, with the following pharmacokinetic parameters: Tmax 0.660.10 h, Cmax 166 ngmL-1, T1/2a 0.460.12 h, T1/2b 4.91.1 h, T1/2(Ka) 0.280.04 h, AUC0-∞ 7726 ngmL-1h, respectively. No kinetic analysis was made after an oral dose of 0.8 mg.g-1 Rg3 in other 6 volunteers because of the low concentration, but there was a good correlation between Cmax and dosage of the two groups. Conclusion: The absorption of Rg3 was rapid in the human body, and its elimination was rapid too after oral administration of Ginsenoside Rg3. The pharmacokinetic results shows that it exhibited the first-order kinetic characteristics.
文摘The dosimetric inter-comparison studies carry pertinent significance to ensure uniform radiation dose delivery for clinical trials. This paper investigates the comparative performance analysis of an X-ray high power linear accelerator per- formed by the International Dosimetry Survey Mission and Institute of Nuclear Medicine ＆ Oncology （INMOL）, Lahore. The measurements were made using cylindrical ionization chambers based on the International Atomic Energy Agency （IAEA） TRS-398 protocol for absorbed dose-to-water dosimetric standards, and the percentage deviation was found to be between 0.5 % - 1%. The dosimetric analysis concerning linear X-ray accelerator output performed by INMOL, Lahore was found to be in good agreement with the results of IAEA Dosimtery Survey Mission.
