目的:对比Monaco计划系统Per Calculation(PC)和Per Control Point(PCP)两种统计噪声设置方式的剂量计算精度和计算效率。方法:选取30例IMRT/VMAT治疗计划,其中胸部和鼻咽部肿瘤各15例,两种噪声统计方式按照剂量计算精度递减的方式分别...目的:对比Monaco计划系统Per Calculation(PC)和Per Control Point(PCP)两种统计噪声设置方式的剂量计算精度和计算效率。方法:选取30例IMRT/VMAT治疗计划,其中胸部和鼻咽部肿瘤各15例,两种噪声统计方式按照剂量计算精度递减的方式分别设置为5组和6组,评估其对计算时间和各剂量学评价指标的影响。结果:两种噪声统计方式计算时间(s)分别为131.78±26.91、6.76±3.57、1.75±0.57、0.84±0.24、0.84±0.24(PC)和259.20±80.15、73.53±26.00、9.18±3.26、3.60±1.67、1.59±0.75、1.13±0.49(PCP),均与计算精度呈负相关,且差异具有统计学意义(P<0.05);两组计划各剂量学评价指标箱图分析显示,均值和特定剂量的体积等指标四分位距较小,最大值和全局最大值等评价指标四分位距较大;两组计划各剂量学评价指标单因素ANOVA分析结果无统计学差异(P>0.05)。结论:两种统计噪声设置方式均可用于临床治疗计划计算精度设置;治疗计划全局最大值与统计噪声正相关,计算时间与统计噪声负相关;不同PC/PCP参数设置对均值和特定剂量的体积等评价影响较小,对全局和串行器官最大值影响较大。展开更多
目的评估人工智能技术在左侧乳腺癌患者危及器官自动勾画中的几何和剂量学精度,为自动勾画技术的临床应用提供参考。方法选取2021年4月~2022年6月于哈尔滨医科大学附属第一医院行左侧乳腺癌放射治疗患者13例的资料作为研究对象。应用人...目的评估人工智能技术在左侧乳腺癌患者危及器官自动勾画中的几何和剂量学精度,为自动勾画技术的临床应用提供参考。方法选取2021年4月~2022年6月于哈尔滨医科大学附属第一医院行左侧乳腺癌放射治疗患者13例的资料作为研究对象。应用人工智能勾画软件对危及器官(organ at risk,OAR)进行手动和自动勾画,其中OAR包括:左右肺、心脏、气管、食道和脊髓,比较两组勾画间的Dice相似系数(dice similarity coefficient,DSC)、Jaccard系数(Jaccard coefficient,JC)、Hausdorf距离(Hausdorff distance,HD)、质心距离(center of mass deviation,CMD)、包容性系数(inclusive index,IncI)、敏感性指数(sensitivity index,SI)和勾画时间。在剂量学精度方面,提取两组勾画方式的左肺V_(5)、V_(10)、V_(20)、V_(30)、D_(mean)、右肺D_(mean)、心脏V_(20)、V_(25)、V_(30)、V_(40)、D_(mean)、脊髓D_(max)、食道D_(max)和气管D_(max)剂量学数据,比较剂量学数据间的统计学差异情况。结果几何精度方面,所有OAR的DSC≥0.83,JC≥0.70,HD≤17.06 mm,CMD≤3.03 mm,IncI≥0.74,SI≥0.89。剂量学数据方面,手动勾画和自动勾画的主要剂量学指标,左肺V_(20)分别为(21.39±5.19)%和(21.24±4.93)%,心脏V_(25)分别为(9.57±4.36)%和(9.28±4.15)%,脊髓D_(max)分别为(19.98±12.59)Gy和(19.92±12.65)Gy,均满足临床对乳腺癌放疗OAR的保护要求,且两组勾画间的剂量学数据差异无统计学意义(P>0.05)。自动勾画和手动勾画的时间分别为(65.23±7.01)s vs.(1808.92±104.03)s(P<0.05)。结论自动勾画软件能以较高的几何和剂量学精度完成左侧乳腺癌放疗患者的OAR勾画工作,同时节省了大量勾画时间,提高了勾画效率。展开更多
BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantificat...BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future.展开更多
Objective The treatment planning system currently represents one of the basics of radiation therapy,because it is the only method to estimate patient dose delivery fast forward and accurately represent estimated tumor...Objective The treatment planning system currently represents one of the basics of radiation therapy,because it is the only method to estimate patient dose delivery fast forward and accurately represent estimated tumor location of the tumor with the possibility of estimating densities in the tissue surrounding the tumor to overcome dose calculation defects but radial estimated the patient.Despite the flaws associated with the systems and calculates the dose of your programs in all programs currently existing in the world.Than necessary,to the existence of a review of the accuracy of accounts and how to confirm the radiation dose to the patient programs.Methods A total of 35 cancer patients were considered for this study,with 245 field measurements made with low-and high-energy diode detectors for brain and prostate cases.The treatments for all patients were planned using Eclipse Treatment Planning System version 13.6.Results Of the 105 field measurements made for the prostate cancer patients,16 included discrepancies outside the ±5% action level.Of the 145 measurements taken of the brain cases,there were four outside the ±5% action level.The results indicated a higher degree of accuracy.The study revealed that,for the prostate measurements,the higher discrepancy in the doses for the particular fields(exceeding the action level) may have been due to the isocenter being very close to the jaws and multi-leaf collimator of the linear accelerator machine.As a result,scatter from the jaws and the multi-leaf collimator could have contributed to the high dose delivered to the diode;hence,a probable higher discrepancy of the dose in more brain cases due highest quality of VMAT technique and fixation system.Conclusion A greater percentage of the observed discrepancies were well within the set tolerance level.However,it is recommended that the positioning of the diode on the patient's skin and the angular sensitivity of the diodes be reconsidered.It is also recommended that a more accurate calculation of expected diode values be performed,especially for fields that pass through the table.These efforts would achieve action levels of ±5%.展开更多
文摘目的:对比Monaco计划系统Per Calculation(PC)和Per Control Point(PCP)两种统计噪声设置方式的剂量计算精度和计算效率。方法:选取30例IMRT/VMAT治疗计划,其中胸部和鼻咽部肿瘤各15例,两种噪声统计方式按照剂量计算精度递减的方式分别设置为5组和6组,评估其对计算时间和各剂量学评价指标的影响。结果:两种噪声统计方式计算时间(s)分别为131.78±26.91、6.76±3.57、1.75±0.57、0.84±0.24、0.84±0.24(PC)和259.20±80.15、73.53±26.00、9.18±3.26、3.60±1.67、1.59±0.75、1.13±0.49(PCP),均与计算精度呈负相关,且差异具有统计学意义(P<0.05);两组计划各剂量学评价指标箱图分析显示,均值和特定剂量的体积等指标四分位距较小,最大值和全局最大值等评价指标四分位距较大;两组计划各剂量学评价指标单因素ANOVA分析结果无统计学差异(P>0.05)。结论:两种统计噪声设置方式均可用于临床治疗计划计算精度设置;治疗计划全局最大值与统计噪声正相关,计算时间与统计噪声负相关;不同PC/PCP参数设置对均值和特定剂量的体积等评价影响较小,对全局和串行器官最大值影响较大。
文摘目的评估人工智能技术在左侧乳腺癌患者危及器官自动勾画中的几何和剂量学精度,为自动勾画技术的临床应用提供参考。方法选取2021年4月~2022年6月于哈尔滨医科大学附属第一医院行左侧乳腺癌放射治疗患者13例的资料作为研究对象。应用人工智能勾画软件对危及器官(organ at risk,OAR)进行手动和自动勾画,其中OAR包括:左右肺、心脏、气管、食道和脊髓,比较两组勾画间的Dice相似系数(dice similarity coefficient,DSC)、Jaccard系数(Jaccard coefficient,JC)、Hausdorf距离(Hausdorff distance,HD)、质心距离(center of mass deviation,CMD)、包容性系数(inclusive index,IncI)、敏感性指数(sensitivity index,SI)和勾画时间。在剂量学精度方面,提取两组勾画方式的左肺V_(5)、V_(10)、V_(20)、V_(30)、D_(mean)、右肺D_(mean)、心脏V_(20)、V_(25)、V_(30)、V_(40)、D_(mean)、脊髓D_(max)、食道D_(max)和气管D_(max)剂量学数据,比较剂量学数据间的统计学差异情况。结果几何精度方面,所有OAR的DSC≥0.83,JC≥0.70,HD≤17.06 mm,CMD≤3.03 mm,IncI≥0.74,SI≥0.89。剂量学数据方面,手动勾画和自动勾画的主要剂量学指标,左肺V_(20)分别为(21.39±5.19)%和(21.24±4.93)%,心脏V_(25)分别为(9.57±4.36)%和(9.28±4.15)%,脊髓D_(max)分别为(19.98±12.59)Gy和(19.92±12.65)Gy,均满足临床对乳腺癌放疗OAR的保护要求,且两组勾画间的剂量学数据差异无统计学意义(P>0.05)。自动勾画和手动勾画的时间分别为(65.23±7.01)s vs.(1808.92±104.03)s(P<0.05)。结论自动勾画软件能以较高的几何和剂量学精度完成左侧乳腺癌放疗患者的OAR勾画工作,同时节省了大量勾画时间,提高了勾画效率。
文摘BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future.
文摘Objective The treatment planning system currently represents one of the basics of radiation therapy,because it is the only method to estimate patient dose delivery fast forward and accurately represent estimated tumor location of the tumor with the possibility of estimating densities in the tissue surrounding the tumor to overcome dose calculation defects but radial estimated the patient.Despite the flaws associated with the systems and calculates the dose of your programs in all programs currently existing in the world.Than necessary,to the existence of a review of the accuracy of accounts and how to confirm the radiation dose to the patient programs.Methods A total of 35 cancer patients were considered for this study,with 245 field measurements made with low-and high-energy diode detectors for brain and prostate cases.The treatments for all patients were planned using Eclipse Treatment Planning System version 13.6.Results Of the 105 field measurements made for the prostate cancer patients,16 included discrepancies outside the ±5% action level.Of the 145 measurements taken of the brain cases,there were four outside the ±5% action level.The results indicated a higher degree of accuracy.The study revealed that,for the prostate measurements,the higher discrepancy in the doses for the particular fields(exceeding the action level) may have been due to the isocenter being very close to the jaws and multi-leaf collimator of the linear accelerator machine.As a result,scatter from the jaws and the multi-leaf collimator could have contributed to the high dose delivered to the diode;hence,a probable higher discrepancy of the dose in more brain cases due highest quality of VMAT technique and fixation system.Conclusion A greater percentage of the observed discrepancies were well within the set tolerance level.However,it is recommended that the positioning of the diode on the patient's skin and the angular sensitivity of the diodes be reconsidered.It is also recommended that a more accurate calculation of expected diode values be performed,especially for fields that pass through the table.These efforts would achieve action levels of ±5%.
