Objective: To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate(MTX)-in medical management of unruptured ectopic pregnancies. Design: Prospective randomized clinica...Objective: To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate(MTX)-in medical management of unruptured ectopic pregnancies. Design: Prospective randomized clinical trial. Setting: Tertiary university hospital. Patient(s): The study population included 108 patients presenting with unruptured ectopic pregnancies who fulfilled the criteria for medical management. Intervention(s): A single dose(study group) or multiple doses(control group) of MTX were administered IM. Main Outcome Measure(s): Success rate of medical management in each group. Result(s): Of the 54 patients on the single-dose protocol, treatment was considered successful in 48 patients(88.9%). Of the 54 patients on the multiple-dose protocol, 50 participants responded to the treatment(92.6%). The diffe- rence between success rates in the two groups was not statistically significant(P=.7; odds ratio 0.64; 95%confidence interval 0.17-2.4). In the single-dose and multiple-dose groups, 15(27.8%) and 20(37%) patients, respectively, had complications(P=.3). Conclusion(s): The results of our study showed that single-dose treatment with MTX could be as successful as multiple doses. The incidence of complications did not differ between the two groups. It appears that single-dose treatment could be the first line of treatment in selected patients.展开更多
目的揭示川乌煎煮时间、给药剂量与毒性的相关性。方法采用均匀设计的方法,将川乌分别煎煮15 m in,30m in,1,2,3,4,6 h,生药含量依次为临床用量的6,12,24,48,72,96,120倍。模型对照组和各给药组于复制痹证动物模型后,按组给药30 d。观...目的揭示川乌煎煮时间、给药剂量与毒性的相关性。方法采用均匀设计的方法,将川乌分别煎煮15 m in,30m in,1,2,3,4,6 h,生药含量依次为临床用量的6,12,24,48,72,96,120倍。模型对照组和各给药组于复制痹证动物模型后,按组给药30 d。观测动物生长发育、血液学、血液生化学、脏器系数、病理组织学变化及停药15 d后上述指标的变化。将结果进行多元回归分析,得出川乌煎煮时间、剂量与毒性的相关性。结果川乌水煎液能抑制痹证动物的足跖肿胀;对模型动物的生长发育无明显影响;对其造血系统无明显毒性;对其肝脏、肾脏、心脏有一定毒性。川乌水煎液毒性最大的煎煮时间和给药剂量是30 m in,120倍。结论煎煮30 m in,给药剂量为临床用量120倍时,川乌水煎液对痹证动物产生的毒性最大,但药效最佳。展开更多
文摘Objective: To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate(MTX)-in medical management of unruptured ectopic pregnancies. Design: Prospective randomized clinical trial. Setting: Tertiary university hospital. Patient(s): The study population included 108 patients presenting with unruptured ectopic pregnancies who fulfilled the criteria for medical management. Intervention(s): A single dose(study group) or multiple doses(control group) of MTX were administered IM. Main Outcome Measure(s): Success rate of medical management in each group. Result(s): Of the 54 patients on the single-dose protocol, treatment was considered successful in 48 patients(88.9%). Of the 54 patients on the multiple-dose protocol, 50 participants responded to the treatment(92.6%). The diffe- rence between success rates in the two groups was not statistically significant(P=.7; odds ratio 0.64; 95%confidence interval 0.17-2.4). In the single-dose and multiple-dose groups, 15(27.8%) and 20(37%) patients, respectively, had complications(P=.3). Conclusion(s): The results of our study showed that single-dose treatment with MTX could be as successful as multiple doses. The incidence of complications did not differ between the two groups. It appears that single-dose treatment could be the first line of treatment in selected patients.
文摘目的揭示川乌煎煮时间、给药剂量与毒性的相关性。方法采用均匀设计的方法,将川乌分别煎煮15 m in,30m in,1,2,3,4,6 h,生药含量依次为临床用量的6,12,24,48,72,96,120倍。模型对照组和各给药组于复制痹证动物模型后,按组给药30 d。观测动物生长发育、血液学、血液生化学、脏器系数、病理组织学变化及停药15 d后上述指标的变化。将结果进行多元回归分析,得出川乌煎煮时间、剂量与毒性的相关性。结果川乌水煎液能抑制痹证动物的足跖肿胀;对模型动物的生长发育无明显影响;对其造血系统无明显毒性;对其肝脏、肾脏、心脏有一定毒性。川乌水煎液毒性最大的煎煮时间和给药剂量是30 m in,120倍。结论煎煮30 m in,给药剂量为临床用量120倍时,川乌水煎液对痹证动物产生的毒性最大,但药效最佳。
