目的分析常规MRI平扫、DWI联合动态增强扫描(DCE-MRI)在前列腺癌(Prostatic Cancer PC)诊断中的价值。方法方便选取2015年1月—2016年6月该院接收的60例疑似前列腺癌(PC)患者为研究对象,行常规MRI平扫、DWI联合动态增强扫描(DCE-MRI)。...目的分析常规MRI平扫、DWI联合动态增强扫描(DCE-MRI)在前列腺癌(Prostatic Cancer PC)诊断中的价值。方法方便选取2015年1月—2016年6月该院接收的60例疑似前列腺癌(PC)患者为研究对象,行常规MRI平扫、DWI联合动态增强扫描(DCE-MRI)。并对比病理诊断结果 ,评价诊断准确率。结果经病理证实42例前列腺癌,其中11例B期,占26.2%;19例C期,占45.2%;7例D1期,占16.7%;5例D2期,占11.9%。所有确诊患者合并前列腺增生。其余为良性前列腺增生(BPH),合并前列腺炎10例;确诊38例,准确率为90.5%。结论 MRI平扫、DWI联合动态增强扫描可明显提升前列腺癌确诊率,减少误诊风险,为临床治疗提供有效保障,建议临床采纳并推广。展开更多
Objective: To select a target molecule associated with invasive potential in PC-3M cell. Methods: Cell subclones were isolated from PC-3M cell line with the method of limited dilution and their invasive ability charac...Objective: To select a target molecule associated with invasive potential in PC-3M cell. Methods: Cell subclones were isolated from PC-3M cell line with the method of limited dilution and their invasive ability characterized by monolayer invasion assay. The expression of u-PAR in the cell subclones at mRNA and protein levels was assayed respectively by non-competitive quantitative RT-PCR and immunohistochemical assay. Results: The expression level of u-PAR in highly invasive cell subclones was higher than that of lower invasive subclones. Conclusion: The higher expression level of u-PAR is associated with the relative strong invasive ability of PC-3M subclones. It is indicated that the u-PAR might be a promising target molecule for inhibiting invasion of highly invasive PC-3M cell subclones.展开更多
文摘目的分析常规MRI平扫、DWI联合动态增强扫描(DCE-MRI)在前列腺癌(Prostatic Cancer PC)诊断中的价值。方法方便选取2015年1月—2016年6月该院接收的60例疑似前列腺癌(PC)患者为研究对象,行常规MRI平扫、DWI联合动态增强扫描(DCE-MRI)。并对比病理诊断结果 ,评价诊断准确率。结果经病理证实42例前列腺癌,其中11例B期,占26.2%;19例C期,占45.2%;7例D1期,占16.7%;5例D2期,占11.9%。所有确诊患者合并前列腺增生。其余为良性前列腺增生(BPH),合并前列腺炎10例;确诊38例,准确率为90.5%。结论 MRI平扫、DWI联合动态增强扫描可明显提升前列腺癌确诊率,减少误诊风险,为临床治疗提供有效保障,建议临床采纳并推广。
文摘Objective: To select a target molecule associated with invasive potential in PC-3M cell. Methods: Cell subclones were isolated from PC-3M cell line with the method of limited dilution and their invasive ability characterized by monolayer invasion assay. The expression of u-PAR in the cell subclones at mRNA and protein levels was assayed respectively by non-competitive quantitative RT-PCR and immunohistochemical assay. Results: The expression level of u-PAR in highly invasive cell subclones was higher than that of lower invasive subclones. Conclusion: The higher expression level of u-PAR is associated with the relative strong invasive ability of PC-3M subclones. It is indicated that the u-PAR might be a promising target molecule for inhibiting invasion of highly invasive PC-3M cell subclones.
