应用混合多维MR成像无创评估前列腺组织成分诊断前列腺癌的可行性

目的:对应用混合多维MR成像无创评估前列腺组织成分诊断前列腺癌的可行性进行分析。方法:选取2017年1月-2018年11月的50例前列腺癌患者和50例健康体检者进行混合多维MR成像。通过拟合即可得到三区信号模型,从而计算各分区的T2值,通过成像时间、强度以及峰值对比前列腺癌患者应用混合多维MR成像参数;利用Functool软件对图像进行处理后计算患者各区带组织间质、上皮和腺泡腔的体积,同时通过Gleason评分与Spearman评分相关系数与T2值比较,进行分析。结果:前列腺癌患者与健康人群的前列腺在进行混合多维MR成像时参数、各区带组织间质、上皮和腺泡腔的体积之间比较,差异均有统计学意义(P<0.05)。其中成像时间和峰值强度之间比较,差异有统计学意义(P<0.05),前列腺癌患者上皮组织的体积分数较健康人群大,而腺泡腔与基质则健康人群大于前列腺癌患者。通过评分之间的比较可知,Gleason评分与Spearman评分相关系数与T2值比较存在显著差异(P<0.05)。结论:应用混合多维MR成像无创评估前列腺组织成分诊断前列腺癌具有可行性。

核磁共振成像对良性前列腺增生组织成分的预测研究

目的:研究核磁共振成像(MRI)与良性前列腺增生(BPH)组织学成分的关系。方法:选取43例前列腺穿刺患者(均确认为BPH),穿刺前行核磁共振检查。穿刺标本进行腺体百分比测算,并记录各穿刺点的影像学信号强度,进行差异性分析。利用IMAGE J软件对MRI图像进行分析,判断腺体成分比,并与前列腺体积(TPV)、前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)、残余尿量(RUV)等临床数据进行相关性分析。结果:腺瘤组、混合组、间质组在穿刺点/外周带信号比上存在显著性差异,提示腺体成分表现出较高的信号比而间质成分信号比较低。影像学图片中腺体成分比与PSA、TPV存在正相关性,与IPSS评分和RUV无明显相关性。结论:通过MRI检查,可以在临床上通过无创的方法,来判断增生部分的腺体比例,为治疗用药和决策提供帮助。

Quantitative analysis of diffusion-weighted magnetic resonance images:differentiation between prostate cancer and normal tissue based on a computer-aided diagnosis system

Diffusion-weighted imaging(DWI) is considered to be one of the dominant modalities used in prostate cancer(PCa) detection and the assessment of lesion aggressiveness,especially for peripheral zone(PZ) PCa.Computer-aided diagnosis(CAD),which is capable of automatically extracting and evaluating image features,can integrate multiple parameters and improve the detection of PCa.In this study,13 quantitative image features were extracted from DWI by CAD,and diagnostic efficacy was analyzed in both the PZ and transition zone(TZ).The results demonstrated that there was a significant difference(P<0.05) between PCa and non-PCa for nine of the 13 features in the PZ and five of the 13 features in the TZ.Besides,the prediction outcome of CAD had a strong correlation with the DWI scores that were graded by experienced radiologists according to the Prostate Imaging-Reporting and Data System Version 2(PI-RADS v2).