Bimatoprost is a novel ocular hypotensive agent and a synthetic prostamide analog. Pharmacological evaluation, involving functional and radioligand binding studies on recombinant and natural receptors, showed that bim...Bimatoprost is a novel ocular hypotensive agent and a synthetic prostamide analog. Pharmacological evaluation, involving functional and radioligand binding studies on recombinant and natural receptors, showed that bimatoprost acts through novel, prostamide sensitive receptors. The drug lacks meaningful interaction with known human receptors, including ocular drug tar-展开更多
The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and F2alpha and their synthetic analog Bimatoprost have been described, bu...The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and F2alpha and their synthetic analog Bimatoprost have been described, but little has been reported on their metabolism and pharmacology, except that they do not appear to activate prostanoid or cannabinoid receptors. These studies were performed to determine if prostamides exhibit simi-展开更多
文摘Bimatoprost is a novel ocular hypotensive agent and a synthetic prostamide analog. Pharmacological evaluation, involving functional and radioligand binding studies on recombinant and natural receptors, showed that bimatoprost acts through novel, prostamide sensitive receptors. The drug lacks meaningful interaction with known human receptors, including ocular drug tar-
文摘The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and F2alpha and their synthetic analog Bimatoprost have been described, but little has been reported on their metabolism and pharmacology, except that they do not appear to activate prostanoid or cannabinoid receptors. These studies were performed to determine if prostamides exhibit simi-
