To evaluate the effects of treatment with FSH on seminal parameters and spontaneous pregnancy in male infertility. Design: Prospective, controlled, randomized clinical study. Setting: Infertility center at a universit...To evaluate the effects of treatment with FSH on seminal parameters and spontaneous pregnancy in male infertility. Design: Prospective, controlled, randomized clinical study. Setting: Infertility center at a university hospital. Patient(s): One hundred twelve men affected by idiopathic oligozoospermia. Intervention(s): Patients were randomized into two groups: 62 subjects were treated with 100 IU of recombinant human FSH on alternate days for 3 months, and 50 patients did not receive any treatment. Semen analysis was performed in all subjects at the end of this period of treatment and after the following 3 months. Subjects who had not reached spontaneous pregnancy underwent assisted reproductive techniques. Main Outcome Measure(s): Seminal parameters, testicular cytologic analysis, FSH, LH, T, and inhibin B concentrations. Result(s): The treatment group considered as a whole did not show modifications in sperm parameters. However, a subgroup of these (30, 48.4% ) had a significant increase of sperm count (responder group). In the period including 3 months after the withdrawal of FSH therapy, we observed a significantly higher spontaneous pregnancy rate in the responder group (5 of 30 [16.7% ]) with respect to nonresponder and nontreated groups (1 of 32 [3.1% ] and 2 of 50 [4.0% ], respectively). Furthermore, the improvement of seminal parameters in the responder group allowed these patients to undergo less frequent IVF- ET/intracytoplasmic sperm injection. Conclusion(s): Results from this controlled, randomized clinical trial show that FSH therapy does not improve sperm concentration or pregnancy rate when infertile male patients are chosen solely by the clinical criteria of idiopathic oligospermia and normal FSH concentration. Subgroup analysis, however, does indicate that patients without maturation arrest in addition to the clinical scenario do benefit from medical therapy.展开更多
目的研究祛风止动方联合利培酮治疗抽动障碍的临床疗效及安全性。方法采用随机对照设计方法,将300例中、重度抽动障碍患儿分为中药组(祛风止动方)、中西医结合组(祛风止动方+利培酮)和西药组(利培酮),治疗24周。分别于治疗后2、4、8、12...目的研究祛风止动方联合利培酮治疗抽动障碍的临床疗效及安全性。方法采用随机对照设计方法,将300例中、重度抽动障碍患儿分为中药组(祛风止动方)、中西医结合组(祛风止动方+利培酮)和西药组(利培酮),治疗24周。分别于治疗后2、4、8、12、24周时进行随访,采用耶鲁综合抽动严重程度量表(Yale global tic severity scale,YGTSS)和中医证候量表评估治疗效果,记录不良反应的发生情况。结果治疗后24周随访时:依据YGTSS减分率计算总有效率,中药组、中西医结合组和西药组分别为91.0%、94.2%和84.4%,西药组与中西医结合组比较差异有统计学意义(P<0.05);不良反应发生率,中药组为4.50%、中西医结合组为0,西药组为7.78%,组间比较差异有统计学意义(P<0.05)。结论祛风止动方联合利培酮治疗抽动障碍的临床疗效良好,且无明显不良反应。展开更多
文摘To evaluate the effects of treatment with FSH on seminal parameters and spontaneous pregnancy in male infertility. Design: Prospective, controlled, randomized clinical study. Setting: Infertility center at a university hospital. Patient(s): One hundred twelve men affected by idiopathic oligozoospermia. Intervention(s): Patients were randomized into two groups: 62 subjects were treated with 100 IU of recombinant human FSH on alternate days for 3 months, and 50 patients did not receive any treatment. Semen analysis was performed in all subjects at the end of this period of treatment and after the following 3 months. Subjects who had not reached spontaneous pregnancy underwent assisted reproductive techniques. Main Outcome Measure(s): Seminal parameters, testicular cytologic analysis, FSH, LH, T, and inhibin B concentrations. Result(s): The treatment group considered as a whole did not show modifications in sperm parameters. However, a subgroup of these (30, 48.4% ) had a significant increase of sperm count (responder group). In the period including 3 months after the withdrawal of FSH therapy, we observed a significantly higher spontaneous pregnancy rate in the responder group (5 of 30 [16.7% ]) with respect to nonresponder and nontreated groups (1 of 32 [3.1% ] and 2 of 50 [4.0% ], respectively). Furthermore, the improvement of seminal parameters in the responder group allowed these patients to undergo less frequent IVF- ET/intracytoplasmic sperm injection. Conclusion(s): Results from this controlled, randomized clinical trial show that FSH therapy does not improve sperm concentration or pregnancy rate when infertile male patients are chosen solely by the clinical criteria of idiopathic oligospermia and normal FSH concentration. Subgroup analysis, however, does indicate that patients without maturation arrest in addition to the clinical scenario do benefit from medical therapy.
文摘目的研究祛风止动方联合利培酮治疗抽动障碍的临床疗效及安全性。方法采用随机对照设计方法,将300例中、重度抽动障碍患儿分为中药组(祛风止动方)、中西医结合组(祛风止动方+利培酮)和西药组(利培酮),治疗24周。分别于治疗后2、4、8、12、24周时进行随访,采用耶鲁综合抽动严重程度量表(Yale global tic severity scale,YGTSS)和中医证候量表评估治疗效果,记录不良反应的发生情况。结果治疗后24周随访时:依据YGTSS减分率计算总有效率,中药组、中西医结合组和西药组分别为91.0%、94.2%和84.4%,西药组与中西医结合组比较差异有统计学意义(P<0.05);不良反应发生率,中药组为4.50%、中西医结合组为0,西药组为7.78%,组间比较差异有统计学意义(P<0.05)。结论祛风止动方联合利培酮治疗抽动障碍的临床疗效良好,且无明显不良反应。
