伴IgG-κ型副球蛋白血症的渐进性坏死性黄色肉芽肿一例

渐进性坏死性黄色肉芽肿临床易误诊为类脂质渐进性坏死、睑黄瘤、环状肉芽肿等。本例患者眼睑及眶周、颈后及腰部皮肤散布黄红色斑块,组织病理符合渐进性坏死性黄色肉芽肿,血清免疫固定电泳示单克隆IgG,Kappa轻链。目前尚无标准治疗,国内外报道的治疗方法包括系统使用糖皮质激素、大剂量注射免疫球蛋白、甲氨蝶呤、沙利度胺、利妥昔单抗、干扰素α以及TNF-α抑制剂和抗疟药物等,本例患者应用甲泼尼龙、沙利度胺、白芍总苷治疗7个月,皮损明显改善,目前仍在继续随访中。

无渐进坏死性黄色肉芽肿伴IgG κ型副球蛋白血症1例

患者女,58岁。面颈部橘红色斑块5年。皮肤科情况:面部。尤其右眼眶周围和颈部融合性橘红色斑块、结节。皮损边界清楚,部分皮疹边缘可见红晕。血清免疫电泳示单克隆IgG k轻链。组织病理:表面萎缩变薄,真皮全层弥漫性组织细胞,泡沫细胞及多核巨细胞浸润,部分区域可见散在淋巴细胞浸润,未见明显渐进性坏死。诊断为无渐进坏死性黄色肉芽肿伴IgG κ型副球蛋白血症。

副球蛋白血症的渐进性坏死性黄色肉芽肿1例

患者女，69岁，朝鲜族，主诉周身起黄褐色斑块，痛、痒4个月。患者4个月前无明显诱因于前胸、背部，起黄褐色斑块，时有痒、痛，未予治疗。皮损渐增多，于颈、胸、背部出现黄褐色斑块、结节、丘疹，曾在当地医院用过抗生素，口服中药汤剂，外用自制药物（具体不祥），皮损未缓解。既往有荨麻疹史，家族中无同样病史患者。

伴副球蛋白血症的渐进坏死性黄色肉芽肿

Necrobiotic xanthogranuloma is a rare cutaneous condition that can be mistaken for atypical necrobiosis lipoidica. It has a strong association with a paraproteinaemia, which may progress to frank haematological malignancy. We describe four patients with variable cutaneous features, and their treatment response.

伴IgA-κ型副球蛋白血症的渐进性坏死性黄色肉芽肿1例

患者男,57岁,全身多发皮下结节伴体重减轻4个月。皮肤科情况:头面部、躯干、四肢泛发大小不等黄红色、紫红色结节。血清免疫固定电泳:单克隆Ig A,Kappa轻链。组织病理:真皮内大量组织细胞、泡沫细胞及Touton巨细胞浸润,未见明显胶原渐进性坏死。诊断:伴IgA-κ型副球蛋白血症的渐进性坏死性黄色肉芽肿。

β_2微球蛋白在几种恶性血液病中的临床意义

近年来,β2微球蛋白（β2-m）在临床医学中的广泛应用日益受到国内外学者的关注。本文将着重对β2-m在常见恶性血液病中的诊断和预后评价作一综述. 一、多发性骨髓瘤（MM） 1974年,Kither等首次测定了167例各种晚期肿瘤患者的β2-m,发现以MM患者增高最为显著.1978年,Kin发现恶性肿瘤患者血清和腹水中β2-m明显升高,尤其是MM患者,占66.6％,且认为升高的机制系肿瘤细胞合成β2

cDNA Cloning and Genomic Structure of PM/mPM Gene from B.mori

[ Objective] The experiment aimed to clone Paramyosin/mini-Paramyosin （PM/mPM） gene to analyze the relations between it and moving behaviors. [Method] PCR method and RACE technology were used to obtain whole cDNA of PM and some cDNA of mPM of Bombyx moil. By comparing wgs of Bombyx mori, the genomic sequence of PM/mPM of Bombyx mori was obtained, and, their genome structure was determined. [ Result] PM/mPM genes consisted of 17 exons and 16 intrens. By the use of selective promoters, The gene sequence encoded PM and mPM, while PM and mPM shared the last 6 exons. The cluster analysis between PM of Bombyx mori and PM of other invertebrate animals demonstrated that the relation between Bombyx mori and Bombyx mandarina was closest and the relation between Bombyx mori and Drosophila melanogaster was farthest in Insecta. [ Conclusion] There was no point mutation which could influence flight in amino acid sequence of PM of Bombyx mori and Bombyx mandarina, so the difference of flight capacity of Bombyx mori and Bombyx mandarina might be regulated by other mechanism.

硬化性黏液水肿1例

患者女,43岁,全身泛发性丘疹、硬化伴瘙痒1年半。皮损组织病理示:真皮内黏蛋白沉积,阿辛兰染色阳性;免疫固定电泳:IgG(+),轻链λ(+);骨髓细胞学检查未见明显异常。诊断:硬化性黏液水肿。