Radioimmunoassay,enzyme linked immunospot assay and enzyme immunoassay were used for the determinations of plasma steroid hormone's level,antibody producing cell's counting and IgM level in this study.The de...Radioimmunoassay,enzyme linked immunospot assay and enzyme immunoassay were used for the determinations of plasma steroid hormone's level,antibody producing cell's counting and IgM level in this study.The decreased number of antibody producing cells and low IgM levels were observed in sexual immature rainbow trout during the spawning season.These fish were reared under almost constant water temperature and natural photoperiod.Moreover,low IgM level was also observed in immature rainbow trout,which were reared under short photoperiod,and IgM level was not changed by treatment of testosterone.The results suggest that photoperoid may cause the changes in immune competence.It is possible that circadian rhythm accompanied with photoperiod may influence physiological function of fish,so that immune competence is changed.展开更多
I discuss the modification of Einstein's Theory of General Relativity based on a periodic functional approach. In this new approach, a corrected periodic gravitational coupling constant arises and plays the role of p...I discuss the modification of Einstein's Theory of General Relativity based on a periodic functional approach. In this new approach, a corrected periodic gravitational coupling constant arises and plays the role of periodic damping term acting on the theory. It is found that it is achievable to have an oscillating universe dominated by dark energy and expanding aceeleratedly in time.展开更多
IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating ce...IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger domain.We found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the factthat IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination byIAPs on signal transduction, cell cycle, and apoptosis.展开更多
This paper is concerned with the number and distributions of limit cycles of a cubic Z2-symmetry Hamiltonian system under quintic perturbation.By using qualitative analysis of differential equation,bifurcation theory ...This paper is concerned with the number and distributions of limit cycles of a cubic Z2-symmetry Hamiltonian system under quintic perturbation.By using qualitative analysis of differential equation,bifurcation theory of dynamical systems and the method of detection function,we obtain that this system exists at least 14 limit cycles with the distribution C91 [C11 + 2(C32 2C12)].展开更多
The relationship between second-order cyclostationary method and time-frequency distribution is studied, and cyclic autocorrelation(CA) function is indicated to be one sort of special time-frequency distribution met...The relationship between second-order cyclostationary method and time-frequency distribution is studied, and cyclic autocorrelation(CA) function is indicated to be one sort of special time-frequency distribution method. Furthermore, a fault diagnosis method for reciprocating compressors based on empirical mode decomposition (EMD) and CA function is proposed, and then it is applied to the fault diagnosis of reciprocating compressor valve. Firstly, the vibration signal of reciprocating compressor valve is decomposed by using ENID method, and several intrinsic mode functions (IMFs) are obtained. Secondly, the IMFs are evaluated by some denoising criterions to remove the noise and interfering ones. Finally, the CA functions of the remained IMFs are calculated, which will be used to reconstruct the CA function of the original vibration signal. Engineering application indicates that this method can sufficiently inhibit the cross-interference items of CA function. Therefore, more explicit working conditions of reciprocating compressor components can be achieved.展开更多
Background: Exercise-associated menstrual dysfunction (EAMD) is a common health problem in female athletes as a part of female athlete triad (FAT), a condition related to low energy availability. In this study, w...Background: Exercise-associated menstrual dysfunction (EAMD) is a common health problem in female athletes as a part of female athlete triad (FAT), a condition related to low energy availability. In this study, we explored the possibility that carbohydrate supplements can improve the status of EAMD and prevent exercise-induced ovarian injury in a FAT rat model. This research aimed to provide experimental evidence with regard to the relationship of energy intervention and EAMD. Methods: Forty-five female Sprague-Dawley rats (2 months old) were randomly divided into five experimental groups: control group (C), 9-week exercise as model for EAMD (E), post-EAMD recovery group (R), oligosaccharide intervention group (O), and glucose intervention group (G). All rats were sacrificed at the end of 9 weeks. Serum samples were collected for measuring gonadotropin releasing hormone, follicle stimulating hormone, luteinizing hormone, 1713-estradiol and progesterone levels. The ovaries were taken for investigation of exercise- and carbohydrate-induced follicular subcellular structure changes. Results: Exercise induced irregular menstrual cycles and ovary subcellular structural damages, such as swollenness of mitochondria in rats from groups E and R. Both glucose and oligosaccharide supplements restored well-differentiated mitochondria in the ovarian follicular cells, and a significant improvement of endoplasmic reticulum and Golgi in swollenness in theca cells in groups O and G compared to groups C, E, and R. There was no difference in mitochondria subcellular structural changes between groups O and G. Group E showed attenuation of serum levels of 17β-estradiol and progesterone compared to C. There were no differences of 17β-estradiol serum levels among groups O, G, and R, while group G showed a lower level of progesterone than C. Conclusion: Female adult rats with 9-week continuous exercise can cause menstrual dysregulation as a model for EAMD. Post-EAMD intervention with glucose and oligosaccharide intake can normalize the menstrual cycle, restore the follicular subcellular structure, and reverse the exercise-induced reduction of ovary sex hormones. It suggests a positive feedback of hypothalamus-pituitary-ovary axis might be involved in the molecular mechanisms of energy intake in treating EAMD.展开更多
The physical-mechanical,chemical,and durability characteristics of alkali-activated materials(AAMs)have been widely investigated.However,a critical gap in the literature is the lack of a comprehensive overview of rece...The physical-mechanical,chemical,and durability characteristics of alkali-activated materials(AAMs)have been widely investigated.However,a critical gap in the literature is the lack of a comprehensive overview of recently published literature regarding the life cycle assessment(LCA)of these binders.This study aims to fill that gap by conducting a systematic literature review of globally published literature on the topic.This paper consolidates knowledge by searching different databases,focusing on LCA studies that used AAMs as pastes,mortars,concretes,bricks,and rammed earth/soil blocks.The selected articles were reviewed and categorized based on precursors,alkaline activators,functional units,system boundaries,life cycle inventory databases,allocation,impact methodologies,and software used.Additionally,this paper also critically analyzes the key challenges of LCA for AAMs.The major challenges were identified as selecting a functional unit,subjectivity in boundary systems,and data interpretation.This work concludes that AAMs show substantial advantages in global warming potential compared to ordinary Portland cement-based materials;however,the average of other categories such as marine ecotoxicity and ozone layer depletion has been reported to be higher than for the reference samples.展开更多
Objective To observe the clinical efficacy of acupuncture and moxibustion in treatment of functional amenorrhea by establishing artificial cycle.Method One hundred and twelve eligible patients with functional amenorrh...Objective To observe the clinical efficacy of acupuncture and moxibustion in treatment of functional amenorrhea by establishing artificial cycle.Method One hundred and twelve eligible patients with functional amenorrhea were divided into an acupuncture-moxibustion group(64 cases) and a western medication group(48 cases) by adopting random method.According to the pattern differentiation of amenorrhea of traditional Chinese medicine,the patients in the acupuncture-moxibustion group were classified into two types:amenorrhea due to blood depletion and amenorrhea due to stagnation of blood.For patients with amenorrhea due to blood depletion,Guanyuan(关元 CV4),Zhongji(中极CV 3),GuiTlai(归来ST 29),Geshu(膈俞 BL 17),Ganshu(肝俞BL 18),Pishu(脾俞 BL 20) and Shenshu(肾俞 BL 23) were selected.At first,BL 17,BL 18,BL 20 and BL 23 were needled;after deqi,reinforcing method was applied,and the needles were not retained.Then,warmingneedle moxibustion was applied at CV 4,CV 3 and ST 29,and the needles were retained for 30 min.For patients with amenorrhea due to stagnation of blood,CV 3,Qihai(气海CV 6),Xuehai(血海 SP 10),Sanyinjiao(三阴交 SP 6)and Xingjian(行间 LR 2) were selected,reducing method was applied,and the needles were retained for 30 min.The treatment was performed once a day,and treatment for 15 consecutive days were the 1st cycle.The 2nd and3 rd cycles started from the 5th day of menstruation(for the patients still not menstruating,the 2nd and 3rd cycles started from the 29 th and 57 th days since the 1st day of treatment),and the treatment lasted for 15 days.Three cycles were needed.In the western medicine group,estrogen-progestogen was taken orally for 21 days(one cycle) to establish a artificial cycle.The levels of FSH and LH were tested and compared on the 3rd day of menstruation before treatment and after the 3rd cycle of treatment,and the adverse effects were analyzed statistically.Follow-up visit was conducted for the patients after treatment for three cycles,and the recurrence rate was calculated.Result The levels of FSH and LH of patients with functional amenorrhea were enhanced significantly through establishing artificial cycle by acupuncture and moxibustion.There was no significant difference between the acupuncture-moxibustion group and the western medication group in effective rate(P〉0.05);but the adverse effect rate(1.49%) and recurrence rate(25.0%) of the acupuncture-moxibustion group were lower than that of the western medication group(with the adverse effect rate of 4.14%,and recurrence rate of 69.8%)(both P〈0.05).Conclusion The levels of FSH and LH of patients with functional amenorrhea can be enhanced significantly through establishing artificial cycle by acupuncture and moxibustion.The efficacy of acupuncture and moxibustion in treatment of functional amenorrhea by establishing artificial cycle is equivalent to that of oral administration of estrogen-progestogen in treatment of functional amenorrhea by establishing artificial cycle,but the adverse effect rate and recurrence rate of acupuncture and moxibustion group are lower.展开更多
Holographic polymer/liquid-crystal composites,which are periodically ordered materials with alternative polymer-rich and liquid-crystal-rich phases, have drawn increasing interest due to their unique capabilities of r...Holographic polymer/liquid-crystal composites,which are periodically ordered materials with alternative polymer-rich and liquid-crystal-rich phases, have drawn increasing interest due to their unique capabilities of reconstructing colored three-dimensional(3 D) images and enabling the electro-optic response. They are formed via photopolymerization induced phase separation upon exposure to laser interference patterns, where a fast photopolymerization is required to facilitate the holographic patterning. Yet, the fast photopolymerization generally leads to depressed phase separation and it remains challenging to boost the holographic performance via kinetics control.Herein, we disclose that the ketyl radical inhibition is able to significantly boost the phase separation and holographic performance by preventing the proliferated diffusion of initiating radicals from the constructive to the destructive regions. Dramatically depressed phase separation is caused when converting the inhibiting ketyl radical to a new initiating radical, indicating the significance of ketyl radical inhibition when designing high performance holographic polymer composites.展开更多
A predator-prey discrete-time model with non-monotone functional response and den- sity dependence is investigated in this paper. By using the comparison theorem of the difference equation, some sufficient conditions ...A predator-prey discrete-time model with non-monotone functional response and den- sity dependence is investigated in this paper. By using the comparison theorem of the difference equation, some sufficient conditions are obtained for the permanence of the system with variable coefficients. At the same time, a set of sufficient conditions about permanent of the system with almost periodic coefficients is also set up, which utilizes almost periodic characteristics of the system. Furthermore, the criteria which guarantee the existence of a globally attractive positive almost periodic solution of the system is established. An example is given to illustrate the feasibility of the obtained results.展开更多
文摘Radioimmunoassay,enzyme linked immunospot assay and enzyme immunoassay were used for the determinations of plasma steroid hormone's level,antibody producing cell's counting and IgM level in this study.The decreased number of antibody producing cells and low IgM levels were observed in sexual immature rainbow trout during the spawning season.These fish were reared under almost constant water temperature and natural photoperiod.Moreover,low IgM level was also observed in immature rainbow trout,which were reared under short photoperiod,and IgM level was not changed by treatment of testosterone.The results suggest that photoperoid may cause the changes in immune competence.It is possible that circadian rhythm accompanied with photoperiod may influence physiological function of fish,so that immune competence is changed.
文摘I discuss the modification of Einstein's Theory of General Relativity based on a periodic functional approach. In this new approach, a corrected periodic gravitational coupling constant arises and plays the role of periodic damping term acting on the theory. It is found that it is achievable to have an oscillating universe dominated by dark energy and expanding aceeleratedly in time.
文摘IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger domain.We found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the factthat IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination byIAPs on signal transduction, cell cycle, and apoptosis.
基金Supported by the Natural Science Foundation of China(10802043 10826092) Acknowledgements We are grateful to Prof Li Ji-bin for his kind help and the referees' valuable suggestions.
文摘This paper is concerned with the number and distributions of limit cycles of a cubic Z2-symmetry Hamiltonian system under quintic perturbation.By using qualitative analysis of differential equation,bifurcation theory of dynamical systems and the method of detection function,we obtain that this system exists at least 14 limit cycles with the distribution C91 [C11 + 2(C32 2C12)].
基金National Natural Science Foundation of China (No. 50805014)Key Research Program of Ministry of Education of China(No. 109047)
文摘The relationship between second-order cyclostationary method and time-frequency distribution is studied, and cyclic autocorrelation(CA) function is indicated to be one sort of special time-frequency distribution method. Furthermore, a fault diagnosis method for reciprocating compressors based on empirical mode decomposition (EMD) and CA function is proposed, and then it is applied to the fault diagnosis of reciprocating compressor valve. Firstly, the vibration signal of reciprocating compressor valve is decomposed by using ENID method, and several intrinsic mode functions (IMFs) are obtained. Secondly, the IMFs are evaluated by some denoising criterions to remove the noise and interfering ones. Finally, the CA functions of the remained IMFs are calculated, which will be used to reconstruct the CA function of the original vibration signal. Engineering application indicates that this method can sufficiently inhibit the cross-interference items of CA function. Therefore, more explicit working conditions of reciprocating compressor components can be achieved.
基金supported by Shanghai Key Laboratory of Human Sport Competence Development and Maintenance,Shanghai University of Sport(NO.11DZ2261100)
文摘Background: Exercise-associated menstrual dysfunction (EAMD) is a common health problem in female athletes as a part of female athlete triad (FAT), a condition related to low energy availability. In this study, we explored the possibility that carbohydrate supplements can improve the status of EAMD and prevent exercise-induced ovarian injury in a FAT rat model. This research aimed to provide experimental evidence with regard to the relationship of energy intervention and EAMD. Methods: Forty-five female Sprague-Dawley rats (2 months old) were randomly divided into five experimental groups: control group (C), 9-week exercise as model for EAMD (E), post-EAMD recovery group (R), oligosaccharide intervention group (O), and glucose intervention group (G). All rats were sacrificed at the end of 9 weeks. Serum samples were collected for measuring gonadotropin releasing hormone, follicle stimulating hormone, luteinizing hormone, 1713-estradiol and progesterone levels. The ovaries were taken for investigation of exercise- and carbohydrate-induced follicular subcellular structure changes. Results: Exercise induced irregular menstrual cycles and ovary subcellular structural damages, such as swollenness of mitochondria in rats from groups E and R. Both glucose and oligosaccharide supplements restored well-differentiated mitochondria in the ovarian follicular cells, and a significant improvement of endoplasmic reticulum and Golgi in swollenness in theca cells in groups O and G compared to groups C, E, and R. There was no difference in mitochondria subcellular structural changes between groups O and G. Group E showed attenuation of serum levels of 17β-estradiol and progesterone compared to C. There were no differences of 17β-estradiol serum levels among groups O, G, and R, while group G showed a lower level of progesterone than C. Conclusion: Female adult rats with 9-week continuous exercise can cause menstrual dysregulation as a model for EAMD. Post-EAMD intervention with glucose and oligosaccharide intake can normalize the menstrual cycle, restore the follicular subcellular structure, and reverse the exercise-induced reduction of ovary sex hormones. It suggests a positive feedback of hypothalamus-pituitary-ovary axis might be involved in the molecular mechanisms of energy intake in treating EAMD.
基金supported by the Alexander von Humboldt Foundation,International Climate Protection Fellowship(Ref 3.5—1157991-IRN-IKS)This financial support is gratefully appreciated by Morteza Nikravan.Rafia Firdous and Dietmar Stephan highly acknowledge Bundesministerium fur Wirtschaft und Energie(BMWi)for funding number 16KN046744.
文摘The physical-mechanical,chemical,and durability characteristics of alkali-activated materials(AAMs)have been widely investigated.However,a critical gap in the literature is the lack of a comprehensive overview of recently published literature regarding the life cycle assessment(LCA)of these binders.This study aims to fill that gap by conducting a systematic literature review of globally published literature on the topic.This paper consolidates knowledge by searching different databases,focusing on LCA studies that used AAMs as pastes,mortars,concretes,bricks,and rammed earth/soil blocks.The selected articles were reviewed and categorized based on precursors,alkaline activators,functional units,system boundaries,life cycle inventory databases,allocation,impact methodologies,and software used.Additionally,this paper also critically analyzes the key challenges of LCA for AAMs.The major challenges were identified as selecting a functional unit,subjectivity in boundary systems,and data interpretation.This work concludes that AAMs show substantial advantages in global warming potential compared to ordinary Portland cement-based materials;however,the average of other categories such as marine ecotoxicity and ozone layer depletion has been reported to be higher than for the reference samples.
文摘Objective To observe the clinical efficacy of acupuncture and moxibustion in treatment of functional amenorrhea by establishing artificial cycle.Method One hundred and twelve eligible patients with functional amenorrhea were divided into an acupuncture-moxibustion group(64 cases) and a western medication group(48 cases) by adopting random method.According to the pattern differentiation of amenorrhea of traditional Chinese medicine,the patients in the acupuncture-moxibustion group were classified into two types:amenorrhea due to blood depletion and amenorrhea due to stagnation of blood.For patients with amenorrhea due to blood depletion,Guanyuan(关元 CV4),Zhongji(中极CV 3),GuiTlai(归来ST 29),Geshu(膈俞 BL 17),Ganshu(肝俞BL 18),Pishu(脾俞 BL 20) and Shenshu(肾俞 BL 23) were selected.At first,BL 17,BL 18,BL 20 and BL 23 were needled;after deqi,reinforcing method was applied,and the needles were not retained.Then,warmingneedle moxibustion was applied at CV 4,CV 3 and ST 29,and the needles were retained for 30 min.For patients with amenorrhea due to stagnation of blood,CV 3,Qihai(气海CV 6),Xuehai(血海 SP 10),Sanyinjiao(三阴交 SP 6)and Xingjian(行间 LR 2) were selected,reducing method was applied,and the needles were retained for 30 min.The treatment was performed once a day,and treatment for 15 consecutive days were the 1st cycle.The 2nd and3 rd cycles started from the 5th day of menstruation(for the patients still not menstruating,the 2nd and 3rd cycles started from the 29 th and 57 th days since the 1st day of treatment),and the treatment lasted for 15 days.Three cycles were needed.In the western medicine group,estrogen-progestogen was taken orally for 21 days(one cycle) to establish a artificial cycle.The levels of FSH and LH were tested and compared on the 3rd day of menstruation before treatment and after the 3rd cycle of treatment,and the adverse effects were analyzed statistically.Follow-up visit was conducted for the patients after treatment for three cycles,and the recurrence rate was calculated.Result The levels of FSH and LH of patients with functional amenorrhea were enhanced significantly through establishing artificial cycle by acupuncture and moxibustion.There was no significant difference between the acupuncture-moxibustion group and the western medication group in effective rate(P〉0.05);but the adverse effect rate(1.49%) and recurrence rate(25.0%) of the acupuncture-moxibustion group were lower than that of the western medication group(with the adverse effect rate of 4.14%,and recurrence rate of 69.8%)(both P〈0.05).Conclusion The levels of FSH and LH of patients with functional amenorrhea can be enhanced significantly through establishing artificial cycle by acupuncture and moxibustion.The efficacy of acupuncture and moxibustion in treatment of functional amenorrhea by establishing artificial cycle is equivalent to that of oral administration of estrogen-progestogen in treatment of functional amenorrhea by establishing artificial cycle,but the adverse effect rate and recurrence rate of acupuncture and moxibustion group are lower.
基金financial supports from the National Natural Science Foundation of China (51433002 and 51773073)HUST peak boarding program+1 种基金the National Science Foundation (NSF) of Hubei Scientific Committee (2016CFA001)the Fundamental Research Funds for the Central Universities (2019kfy RCPY089)
文摘Holographic polymer/liquid-crystal composites,which are periodically ordered materials with alternative polymer-rich and liquid-crystal-rich phases, have drawn increasing interest due to their unique capabilities of reconstructing colored three-dimensional(3 D) images and enabling the electro-optic response. They are formed via photopolymerization induced phase separation upon exposure to laser interference patterns, where a fast photopolymerization is required to facilitate the holographic patterning. Yet, the fast photopolymerization generally leads to depressed phase separation and it remains challenging to boost the holographic performance via kinetics control.Herein, we disclose that the ketyl radical inhibition is able to significantly boost the phase separation and holographic performance by preventing the proliferated diffusion of initiating radicals from the constructive to the destructive regions. Dramatically depressed phase separation is caused when converting the inhibiting ketyl radical to a new initiating radical, indicating the significance of ketyl radical inhibition when designing high performance holographic polymer composites.
文摘A predator-prey discrete-time model with non-monotone functional response and den- sity dependence is investigated in this paper. By using the comparison theorem of the difference equation, some sufficient conditions are obtained for the permanence of the system with variable coefficients. At the same time, a set of sufficient conditions about permanent of the system with almost periodic coefficients is also set up, which utilizes almost periodic characteristics of the system. Furthermore, the criteria which guarantee the existence of a globally attractive positive almost periodic solution of the system is established. An example is given to illustrate the feasibility of the obtained results.