This work aims to verify how the Web portals of Universities Hospital located in the northeast of Brazil are contributing to the expansion of knowledge of its users from the analysis of interactive features associated...This work aims to verify how the Web portals of Universities Hospital located in the northeast of Brazil are contributing to the expansion of knowledge of its users from the analysis of interactive features associated with the three mechanisms of knowledge management： knowledge access （KA）, knowledge creation （KC）, and knowledge transfer （KT）. The study is exploratory, descriptive, and qualitative type, such as a survey, developed through an adaptation of a relevant research, which involves the standardization of data collection instruments （questionnaires and interviews） applied directly to persons of a specific population, to assess knowledge management tools present in the University Hospital portals in the northeast region of Brazil. The results indicated that the resources from knowledge access were more prevalent than the others, ratifying the results found in research developed in Asian and North American Hospital portals.展开更多
China’s Supercomputer Helps Construct"Smart Cities"Developers of China’s Tianhe-1A,one of the world’s fastest supercomputers,are tapping into the digital brain’s higher functions,moving it beyond animati...China’s Supercomputer Helps Construct"Smart Cities"Developers of China’s Tianhe-1A,one of the world’s fastest supercomputers,are tapping into the digital brain’s higher functions,moving it beyond animation and Internet financing to help in the construction of new"smart cities."The Tianhe-1A can digitize the planning,design,construction,展开更多
An important task of Internet congestion control is inhibiting sporadic data flow to maintain a suitable window size or route queue length. Such a requirement is just consistent with the basic idea and function of a m...An important task of Internet congestion control is inhibiting sporadic data flow to maintain a suitable window size or route queue length. Such a requirement is just consistent with the basic idea and function of a moving average filter. In this paper one prior Internet congestion control model, named transmission control protocol (TCP)/random early detection (RED) stroboscopic model, is studied, and then one new scheme is proposed to enlarge its stable domain, where a simple moving average filter is introduced to inhibit sporadic data flow as possible. In the novel scheme the bifurcation phenomenon is postponed without any extra controller. The effectiveness of the new scheme is verified by theoretical analyses and numerical simulations.展开更多
TRIM5α restricts retroviruses in a species-specific manner. Cyclophilin A was independently retrotransposed into the TRIM5 loci in different species, leading to the generation of antiviral TR1M5-cyclophilin A （TRIM...TRIM5α restricts retroviruses in a species-specific manner. Cyclophilin A was independently retrotransposed into the TRIM5 loci in different species, leading to the generation of antiviral TR1M5-cyclophilin A （TRIMCyp） proteins. Previously, we found that assam macaques express a TRIMCyp chimera （amTRIMCyp）, along with a TRIM5α allelic protein （amTRIM5α）. Herein, we investigated the antiviral activity of amTRIMCyp and amTRIM5α individually, as well as their interaction and joint effects. amTRIMCyp showed a divergent restriction pattern from amTRIM5αc Although both proteins potently restricted the replication of HIV-1, only amTRIM5αt inhibited N-MLV. Remarkably, cellular anti-HIV-1 activity increased when amTRIMCyp and amTRIM5αt were coexpressed, indicating a synergistic block of HIV-1 replication. Consistently, PMBCs from heterozygous amTRIM50t/TRIMCyp showed stronger resistance to HIV-1 infection than those from amTRIM5a/TRIM5α homozygotes. The anti-HIV-1 synergistic effect was dependent on the amTRIMCyp-amTRIM5α interaction. In contrast, amTRIMCyp completely abrogated the anti-N-MLV activity mediated by amTRIM5α, showing a dominant-negative effect, indicating that the generation of amTRIMCyp was involved in the trade-off between divergent restriction activities. Our results provide a new paradigm to study functional trade-offs mediated by allelic proteins, a theoretical basis for utilizing animal models with various TRIM5 alleles, as well as novel HIV-1 gene therapy strategies.展开更多
文摘This work aims to verify how the Web portals of Universities Hospital located in the northeast of Brazil are contributing to the expansion of knowledge of its users from the analysis of interactive features associated with the three mechanisms of knowledge management： knowledge access （KA）, knowledge creation （KC）, and knowledge transfer （KT）. The study is exploratory, descriptive, and qualitative type, such as a survey, developed through an adaptation of a relevant research, which involves the standardization of data collection instruments （questionnaires and interviews） applied directly to persons of a specific population, to assess knowledge management tools present in the University Hospital portals in the northeast region of Brazil. The results indicated that the resources from knowledge access were more prevalent than the others, ratifying the results found in research developed in Asian and North American Hospital portals.
文摘China’s Supercomputer Helps Construct"Smart Cities"Developers of China’s Tianhe-1A,one of the world’s fastest supercomputers,are tapping into the digital brain’s higher functions,moving it beyond animation and Internet financing to help in the construction of new"smart cities."The Tianhe-1A can digitize the planning,design,construction,
基金the National Natural Science Foundation of China (No. 70571017)the Research Foundation from Provincial Education Department of Zhejiang of China (No. 20070928)
文摘An important task of Internet congestion control is inhibiting sporadic data flow to maintain a suitable window size or route queue length. Such a requirement is just consistent with the basic idea and function of a moving average filter. In this paper one prior Internet congestion control model, named transmission control protocol (TCP)/random early detection (RED) stroboscopic model, is studied, and then one new scheme is proposed to enlarge its stable domain, where a simple moving average filter is introduced to inhibit sporadic data flow as possible. In the novel scheme the bifurcation phenomenon is postponed without any extra controller. The effectiveness of the new scheme is verified by theoretical analyses and numerical simulations.
基金supported by grants from the National Natural Science Foundation of China (81471620, 81671627, 81571606, 81172876, U0832601)the 13th Five-Year Key Scientific and Technological Program of China (2017ZX10304402-002-004, 2017ZX10202102-001-005)+2 种基金the Knowledge Innovation Program of the Chinese Academy of Sciences (KJZD-EW-L1002, KSCX2-EW-R-13)the National Key Research & Development Plan (2016YFC1201000)the National Basic Research Program of China (2012CBA01305)
文摘TRIM5α restricts retroviruses in a species-specific manner. Cyclophilin A was independently retrotransposed into the TRIM5 loci in different species, leading to the generation of antiviral TR1M5-cyclophilin A （TRIMCyp） proteins. Previously, we found that assam macaques express a TRIMCyp chimera （amTRIMCyp）, along with a TRIM5α allelic protein （amTRIM5α）. Herein, we investigated the antiviral activity of amTRIMCyp and amTRIM5α individually, as well as their interaction and joint effects. amTRIMCyp showed a divergent restriction pattern from amTRIM5αc Although both proteins potently restricted the replication of HIV-1, only amTRIM5αt inhibited N-MLV. Remarkably, cellular anti-HIV-1 activity increased when amTRIMCyp and amTRIM5αt were coexpressed, indicating a synergistic block of HIV-1 replication. Consistently, PMBCs from heterozygous amTRIM50t/TRIMCyp showed stronger resistance to HIV-1 infection than those from amTRIM5a/TRIM5α homozygotes. The anti-HIV-1 synergistic effect was dependent on the amTRIMCyp-amTRIM5α interaction. In contrast, amTRIMCyp completely abrogated the anti-N-MLV activity mediated by amTRIM5α, showing a dominant-negative effect, indicating that the generation of amTRIMCyp was involved in the trade-off between divergent restriction activities. Our results provide a new paradigm to study functional trade-offs mediated by allelic proteins, a theoretical basis for utilizing animal models with various TRIM5 alleles, as well as novel HIV-1 gene therapy strategies.
