目的:观察连续肾替代治疗(CRRT)加用不同剂量血必净对脓毒症合并急性肾损伤(AKI)患者的影响及安全性。方法:选取2012年6月-2015年8月我院ICU的脓毒症合并AKI患者104例。按照随机数字表法将其分为小、中、大剂量组和对照组,各26例。4组...目的:观察连续肾替代治疗(CRRT)加用不同剂量血必净对脓毒症合并急性肾损伤(AKI)患者的影响及安全性。方法:选取2012年6月-2015年8月我院ICU的脓毒症合并AKI患者104例。按照随机数字表法将其分为小、中、大剂量组和对照组,各26例。4组患者均给予基础治疗;小剂量组患者给予血必净注射液50 m L加入0.9%氯化钠注射液(NS)100 m L中,ivgtt,bid;中剂量组患者给予血必净注射液100 m L加入NS 100 m L中,ivgtt,bid;大剂量组患者给予血必净注射液100 m L加入NS 100 m L中,ivgtt,qid。4组患者均治疗1周。观察4组患者治疗前后血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、和超敏C反应蛋白(hs-CRP)等炎症因子水平,血尿素氮(BUN)、血肌酐(SCr)和胱抑素(Cys C)等肾功能指标水平,凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)和纤维蛋白原(Fib)等凝血功能指标水平,急性生理与慢性健康状况评分系统Ⅱ(APACHEⅡ)、多器官功能障碍评分系统(Marshall)评分,并记录治疗过程中不良反应发生情况。结果:脱落9例后,本研究最终纳入统计的合格病例数95例,小、中、大剂量组和对照组分别为23、24、25、23例。治疗前,4组患者上述指标比较,差异均无统计学意义(P>0.05)。治疗后,4组患者血清IL-6、TNF-α、CRP、PT、APTT水平和APACEⅡ及Marshall评分均明显降低/缩短,血清BUN、SCr、Cys C、Fib水平均明显升高,小、中、大剂量组患者上述指标改善均明显优于对照组,大剂量组明显优于小、中剂量组,差异均有统计学意义(P<0.05)。4组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:CRRT加用大剂量血必净可显著抑制脓毒症合并AKI患者的炎症反应,改善肾功能和凝血功能,且不增加不良反应发生风险。展开更多
The short-range wireless communication technology has advanced considerably and provides the feasibility of train-train(T2T)communication link in the communication-based train control system.The introduction of the T2...The short-range wireless communication technology has advanced considerably and provides the feasibility of train-train(T2T)communication link in the communication-based train control system.The introduction of the T2T link would reduce the headway and improve operational efficiency.Formal methods are system design techniques that use rigorously specified mathematical models to ensure all behaviors work as expected.And it is exactly the functional safety verification needed.Therefore,to deal with the functional safety verification of the T2T link,an untimed colored petri net model is first constructed.Secondly,the verification process is performed.Conclusions can be drawn from the state space report and the computation tree logic queries.Lastly,the model is parameterized,and then data log files are obtained for further performance measurement.Results show that the proposed criteria are satisfied and there are no defects in the basic design requirements.The transmission delay has considered the reconnection,transmission errors and the interruption.The probability of the delay lower than 150 ms accounts for 98.106%,which meets the specification and the previous field test.展开更多
Objective:The aim of this study was to investigate renal insufficiency in patients with chemotherapy.Methods:Prescribing chemotherapy in a regular hemodialysis patient with renal failure,and monitoring of serum drug c...Objective:The aim of this study was to investigate renal insufficiency in patients with chemotherapy.Methods:Prescribing chemotherapy in a regular hemodialysis patient with renal failure,and monitoring of serum drug concentrations to determine its safety and effectiveness.Results:Chemotherapy assessment efficiency:SD(better),hemodialysis did not affect THP treatment,their safety was guaranteed.Conclusion:The chemotherapy of renal dysfunction is not an absolute contraindication to fully assess the patient's adverse effects and tolerability,the reasonable arrangements for hemodialysis and the timing of administration can be safe and effective chemotherapy.展开更多
HPP （high pressure processing） is one of the novel technologies to produce microbiologically safe food. HPP is a non-thermal food processing method, wherein the food is subjected to a very high pressure ranging betw...HPP （high pressure processing） is one of the novel technologies to produce microbiologically safe food. HPP is a non-thermal food processing method, wherein the food is subjected to a very high pressure ranging between 100-800 MPa in order to prevent undesirable chemical and microbiological reactions, and hence, prolong the shelf-life. HPP is also called as ＂high hydrostatic processing, ultra-high pressure processing or isostatic processing＂. In dairy products, HHP has the potential to modify the functional properties of proteins, polysaccharides and alter biochemical reactions without significantly affecting the nutritional and sensory properties. HPP treatment induces significant changes in milk components particularly in proteins （whey proteins and caseins）, as well as on their applicability in innovative dairy productions. HPP influences technological properties of various milk products such as firmness, water-holding capacity of the gel and network structure, cheese yield, rennet coagulation time and ripening.展开更多
Overall purpose of a power uprate and lifetime extension project （PLEX） is to modernize the power station cost-efficiently resulting in fulfilling the following overall requirements. The primary target is to meet th...Overall purpose of a power uprate and lifetime extension project （PLEX） is to modernize the power station cost-efficiently resulting in fulfilling the following overall requirements. The primary target is to meet the requirements provided by the local regulations from the regulatory offices. The controlling, monitoring and power supply of safety functions have to comply with these regulations. Any deviations from the existing safety analysis report （SAR） have to be corrected. On top of the safety measures the general technical status should be raised to extend the lifetime to 60 years. A high availability during the modernization has to be assured.展开更多
Consumption of functional foods with health promoting benefits and/or disease prevention has been on the increase globally. The study aimed at evaluating the potential of utilizing Kenyan orange fleshed sweet potato ...Consumption of functional foods with health promoting benefits and/or disease prevention has been on the increase globally. The study aimed at evaluating the potential of utilizing Kenyan orange fleshed sweet potato （Ipomoea batatas Lam.） for functional food production with aesthetics benefits. Purees from three different varieties of orange fleshed sweet potato （OFSP） were analyzed for nutritional, physicochemical and microbial quality, The findings of the study show that the three purees were all microbiologically safe and of near neutral pH, but differed significantly （P 〈 0.05） in nutrient content （dry matter content, 12.76-28.23%; crude fiber, 1.37-2.90% fresh weight basis （FWB）; 13-carotene, 0.94-9.27 mg/100g dry weight basis （DWB）; starch, 10.20-18.30% FWB ＆ total sugar 27.08-31.76% DWB）. The purees had attractive appearance （ranging from yellow to dark orange）, with varying significantly different spectrophotometer hunters color scale （P 〈 0.05）, and flow ability. Conclusions from the findings show great potential of utilizing the varying properties of OFSP puree to produce enriched functional food products such as probiotic/prebiotic dairy, beverages, bakery and baby foods.展开更多
Small modular reactors(SMRs) are beneficial in providing electricity power safely and viable for specific applications such as seawater desalination and heat production. Due to its inherent safety feature, the modular...Small modular reactors(SMRs) are beneficial in providing electricity power safely and viable for specific applications such as seawater desalination and heat production. Due to its inherent safety feature, the modular high temperature gas-cooled reactor(MHTGR) is considered as one of the best candidates for SMR-based nuclear power plants. Since its dynamics presents high nonlinearity and parameter uncertainty, it is necessary to develop adaptive power-level control, which is beneficial to safe, stable, and efficient operation of MHTGR and is easy to be implemented. In this paper, based on the physically-based control design approach, an adaptive outputfeedback power-level control is proposed for MHTGRs. This control can guarantee globally bounded closedloop stability and has a simple form. Numerical simulation results show the correctness of the theoretical analysis and satisfactory regulation performance of this control.展开更多
文摘目的:观察连续肾替代治疗(CRRT)加用不同剂量血必净对脓毒症合并急性肾损伤(AKI)患者的影响及安全性。方法:选取2012年6月-2015年8月我院ICU的脓毒症合并AKI患者104例。按照随机数字表法将其分为小、中、大剂量组和对照组,各26例。4组患者均给予基础治疗;小剂量组患者给予血必净注射液50 m L加入0.9%氯化钠注射液(NS)100 m L中,ivgtt,bid;中剂量组患者给予血必净注射液100 m L加入NS 100 m L中,ivgtt,bid;大剂量组患者给予血必净注射液100 m L加入NS 100 m L中,ivgtt,qid。4组患者均治疗1周。观察4组患者治疗前后血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、和超敏C反应蛋白(hs-CRP)等炎症因子水平,血尿素氮(BUN)、血肌酐(SCr)和胱抑素(Cys C)等肾功能指标水平,凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)和纤维蛋白原(Fib)等凝血功能指标水平,急性生理与慢性健康状况评分系统Ⅱ(APACHEⅡ)、多器官功能障碍评分系统(Marshall)评分,并记录治疗过程中不良反应发生情况。结果:脱落9例后,本研究最终纳入统计的合格病例数95例,小、中、大剂量组和对照组分别为23、24、25、23例。治疗前,4组患者上述指标比较,差异均无统计学意义(P>0.05)。治疗后,4组患者血清IL-6、TNF-α、CRP、PT、APTT水平和APACEⅡ及Marshall评分均明显降低/缩短,血清BUN、SCr、Cys C、Fib水平均明显升高,小、中、大剂量组患者上述指标改善均明显优于对照组,大剂量组明显优于小、中剂量组,差异均有统计学意义(P<0.05)。4组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:CRRT加用大剂量血必净可显著抑制脓毒症合并AKI患者的炎症反应,改善肾功能和凝血功能,且不增加不良反应发生风险。
基金National Natural Science Foundation of China(No.61963023)。
文摘The short-range wireless communication technology has advanced considerably and provides the feasibility of train-train(T2T)communication link in the communication-based train control system.The introduction of the T2T link would reduce the headway and improve operational efficiency.Formal methods are system design techniques that use rigorously specified mathematical models to ensure all behaviors work as expected.And it is exactly the functional safety verification needed.Therefore,to deal with the functional safety verification of the T2T link,an untimed colored petri net model is first constructed.Secondly,the verification process is performed.Conclusions can be drawn from the state space report and the computation tree logic queries.Lastly,the model is parameterized,and then data log files are obtained for further performance measurement.Results show that the proposed criteria are satisfied and there are no defects in the basic design requirements.The transmission delay has considered the reconnection,transmission errors and the interruption.The probability of the delay lower than 150 ms accounts for 98.106%,which meets the specification and the previous field test.
文摘Objective:The aim of this study was to investigate renal insufficiency in patients with chemotherapy.Methods:Prescribing chemotherapy in a regular hemodialysis patient with renal failure,and monitoring of serum drug concentrations to determine its safety and effectiveness.Results:Chemotherapy assessment efficiency:SD(better),hemodialysis did not affect THP treatment,their safety was guaranteed.Conclusion:The chemotherapy of renal dysfunction is not an absolute contraindication to fully assess the patient's adverse effects and tolerability,the reasonable arrangements for hemodialysis and the timing of administration can be safe and effective chemotherapy.
文摘HPP （high pressure processing） is one of the novel technologies to produce microbiologically safe food. HPP is a non-thermal food processing method, wherein the food is subjected to a very high pressure ranging between 100-800 MPa in order to prevent undesirable chemical and microbiological reactions, and hence, prolong the shelf-life. HPP is also called as ＂high hydrostatic processing, ultra-high pressure processing or isostatic processing＂. In dairy products, HHP has the potential to modify the functional properties of proteins, polysaccharides and alter biochemical reactions without significantly affecting the nutritional and sensory properties. HPP treatment induces significant changes in milk components particularly in proteins （whey proteins and caseins）, as well as on their applicability in innovative dairy productions. HPP influences technological properties of various milk products such as firmness, water-holding capacity of the gel and network structure, cheese yield, rennet coagulation time and ripening.
文摘Overall purpose of a power uprate and lifetime extension project （PLEX） is to modernize the power station cost-efficiently resulting in fulfilling the following overall requirements. The primary target is to meet the requirements provided by the local regulations from the regulatory offices. The controlling, monitoring and power supply of safety functions have to comply with these regulations. Any deviations from the existing safety analysis report （SAR） have to be corrected. On top of the safety measures the general technical status should be raised to extend the lifetime to 60 years. A high availability during the modernization has to be assured.
文摘Consumption of functional foods with health promoting benefits and/or disease prevention has been on the increase globally. The study aimed at evaluating the potential of utilizing Kenyan orange fleshed sweet potato （Ipomoea batatas Lam.） for functional food production with aesthetics benefits. Purees from three different varieties of orange fleshed sweet potato （OFSP） were analyzed for nutritional, physicochemical and microbial quality, The findings of the study show that the three purees were all microbiologically safe and of near neutral pH, but differed significantly （P 〈 0.05） in nutrient content （dry matter content, 12.76-28.23%; crude fiber, 1.37-2.90% fresh weight basis （FWB）; 13-carotene, 0.94-9.27 mg/100g dry weight basis （DWB）; starch, 10.20-18.30% FWB ＆ total sugar 27.08-31.76% DWB）. The purees had attractive appearance （ranging from yellow to dark orange）, with varying significantly different spectrophotometer hunters color scale （P 〈 0.05）, and flow ability. Conclusions from the findings show great potential of utilizing the varying properties of OFSP puree to produce enriched functional food products such as probiotic/prebiotic dairy, beverages, bakery and baby foods.
文摘Small modular reactors(SMRs) are beneficial in providing electricity power safely and viable for specific applications such as seawater desalination and heat production. Due to its inherent safety feature, the modular high temperature gas-cooled reactor(MHTGR) is considered as one of the best candidates for SMR-based nuclear power plants. Since its dynamics presents high nonlinearity and parameter uncertainty, it is necessary to develop adaptive power-level control, which is beneficial to safe, stable, and efficient operation of MHTGR and is easy to be implemented. In this paper, based on the physically-based control design approach, an adaptive outputfeedback power-level control is proposed for MHTGRs. This control can guarantee globally bounded closedloop stability and has a simple form. Numerical simulation results show the correctness of the theoretical analysis and satisfactory regulation performance of this control.
