疏肝降逆汤治疗溃疡型功能性消化不良疗效观察

目的观察疏肝降逆汤治疗功能性消化不良的效果。方法将108例符合纳入标准的功能性消化不良患者随机分为2组。治疗组55例,口服疏肝降逆汤每日1剂;对照组53例,口服雷贝拉唑10 mg 1次/d,疗程为2周。结果应用疏肝降逆汤和雷贝拉唑治疗功能性消化不良均能明显改善患者的临床症状,治疗组总有效率为95%,对照组总有效率为75%;2组治疗后各症状总积分均明显低于治疗前(P均<0.05),2组疗效指数相比,治疗组优于对照组(P<0.05)。结论疏肝降逆汤对功能性消化不良具有良好的疗效。

补气健脾升清法治疗糖尿病性功能性消化不良

目的补气健脾升清法治疗糖尿病性功能性消化不良的临床效果;方法选取2015年7月-2017年8月就诊于我院糖尿病和脾胃科门诊及住院的患者,共120例。随机分为治疗组和对照组各60例。2组病例均采用常规糖尿病治疗方法,治疗组予枸橼酸莫沙必利片联合自拟补气健脾升清方,对照组予莫沙必利片5 mg,1次/d口服,经治疗8周观察2组临床症状、生化指标的变化。结果治疗组总有效率为95%,对照组总效率为68%,治疗组临床症状体征改善显著优于对照组(P<0.05),对照组餐后不适、上腹部饱胀、早饱、恶心、呕吐、嗳气的发生率明显高于治疗组,2组治疗后生化结果变化明显,2组比较差异具有统计学意义(P<0.05)。结论补气健脾升清法治疗糖尿病性功能性消化不良,缓解症状有较好的作用。随着中医药对糖尿病性功能性消化不良的深入研究,其疗效确切、不良反应小等优势得到了体现,具有相当广泛的应用前景。

中医特色护理在小儿功能性消化不良性腹泻患儿中的运用及对复发情况的分析

目的:探讨中医特色护理在小儿功能性消化不良性腹泻患儿中的运用情况及对复发情况进行分析。方法:回顾性研究,选择2019年7月至2019年12月在安康市中医医院儿一科病房住院的功能性消化不良性腹泻患儿,根据入院先后顺序,将2019年7月至2019年9月,42例符合研究标准的患儿作为对照组,2019年10月至2019年12月,34例符合研究标准的患儿作为观察组,对照组采用常规护理干预,观察组在对照组的基础上给予中医特色护理干预,对比两组患儿干预前后的临床症状改善情况、家长对护理效果的满意度及复发情况。结果:干预前,两组临床症状积分及年龄、性别对比差异无统计学意义(P>0.05);干预后,干预后,两组临床症状积分明显降低,且观察组明显较对照组低,P<0.05;观察组护理满意度明显高于对照组,P<0.05;两组复发率相比较,观察组复发率2.94%低于对照组的19.05%,P<0.05。结论:中医特色护理可提高功能性消化不良性腹泻患儿的护理效果及患儿家长满意度,有效降低其复发率。

雷贝拉唑,莫沙必利联合米曲菌胰酶治疗反流性食管炎伴功能性消化不良的疗效分析

对反流性食管炎伴功能性消化不良临床治疗过程中使用雷贝拉唑、莫沙必利、米曲菌胰酶三种药物联合治疗,观察分析其临床治疗效果。方法 择取本科室半年多收治的反流性食管炎伴功能性消化不良疾病患者(观察例数为90例),通过随机分组方式将其划分为对照组(使用雷贝拉唑俩和莫沙必利治疗,45例)与观察组(雷贝拉唑、莫沙必利、米曲菌胰酶三药联合治疗,45例),对比观察不同药物联合治疗效果。结果 观察组治疗后临床总有效率、黏膜愈合率、症状积分、满意度以及生活质量指标更佳(P<0.05)。结论 药物雷贝拉唑、莫沙必利、米曲菌胰酶联合治疗下所获得的效果显著,对于反流性食管炎伴功能性消化不良者而言,可明显改善症状,稳定病情,非常具有临床价值,值得推荐。

活血化瘀法治疗非幽门螺杆菌感染性功能性消化不良1例

2014年幽门螺杆菌胃炎京都全球共识报告（Kyoto global consensus report on H.pylori gastritis）指出,幽门螺杆菌（helicobacter pylori,Hp）感染是部分患者产生消化不良症状的原因。根据罗马III标准,

Functional dyspepsia:The role of visceral hypersensitivity in its pathogenesis

Functional, or non-ulcer, dyspepsia （FD） is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process. The pathophysiology of FD remains unclear but several theories have been proposed including visceral hypersensitivity, gastric motor dysfunction, Helicobacter pylori infection and psychosocial factors. In this review, we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD.

Gastrointestinal hormone abnormalities and G and D cells in functional dyspepsia patients with gastric dysmotility

AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric emptying was assessed with solid radiopaque markers in 54 FD patients, and the patients were divided into two groups according to the results, one with delayed gastric emptying and the other with normal gastric emptying. Seventeen healthy volunteers acted as normal controls. Fasting and postprandial plasma levels and gastroduodenal mucosal levels of gastrointestinal hormones gastrin, somatostatin (SS) and neurotensin (NT)were measured by radioimmunoassay in all the subjects.G cells (gastrin-producing cells) and D cells (SS-producing cells) in gastric antral mucosa were immunostained with rabbit anti-gastrin polyclonal antibody and rabbit anti-SS polyclonal antibody, respectively, and analyzed quantitatively by computerized image analysis.RESULTS: The postprandial plasma gastrin levels, the fasting and postprandial plasma levels and the gastric and duodenal mucosal levels of NT were significantly higher in the FD patients with delayed gastric emptying than in those with normal gastric emptying and normal controls. The number and gray value of G and D cells and the G cell/D cell number ratio did not differ significantly between normal controls and the FD patients with or without delayed gastric emptying.CONCLUSION: Our findings suggest that the abnormalities of gastrin and NT may play a role in the pathophysiology of gastric dysmotility in FD patients, and the abnormality of postprandial plasma gastrin levels in FD patients with delayed gastric emptying is not related to the changes both in the number and gray value of G cells and in the G cell/D cell number ratio in gastric antral mucosa.