Background: Frontotemporal dementia (FTD) is a behavioural syndrome caused by degeneration of the frontal and anterior temporal lobes. Behavioural disturbances include psychiatric features. Whether patients with FTD p...Background: Frontotemporal dementia (FTD) is a behavioural syndrome caused by degeneration of the frontal and anterior temporal lobes. Behavioural disturbances include psychiatric features. Whether patients with FTD present with psychiatric features varies with the initial neuroanatomical variability of FTD. Objective: To identify presenting psychiatric changes not part of diagnostic criteria of FTD and contrast them with the degree of hemispheric asymmetry and frontal and temporal hypoperfusion on single photon emission computed tomography (SPECT) imaging. Methods: 74 patients who met consensus criteria for FTD were evaluated at a two year follow up. All had brain SPECT on initial presentation. Results of an FTD psychiatric checklist were contrasted with ratings of regional hypoperfusion. Results: The regions of predominant hypoperfusion did not correlate with differences on FTD demographic variables but were associated with presenting psychiatric features. Dysthymia and anxiety were associated with right temporal hypoperfusion. “ Moria" or frivolous behaviour also occurred with temporal lobe changes, especially on the right. The only significant frontal lobe feature was the presence of a peculiar physical bearing in association with right frontal hypoperfusion. Conclusions: Patients with FTD may present with psychiatric changes distinct from the behavioural diagnostic criteria for this disorder. Early temporal involvement is associated with frivolous behaviour and right temporal involvement is associated with emotional disturbances. In contrast, those with right frontal disease may present with alterations in non-verbal behaviour.展开更多
肥胖症及减重后不能维持健康体质量的核心因素多为食物成瘾,食物成瘾在神经影像学中表现为奖赏网络与认知控制网络间神经环路的失衡。实时功能磁共振成像神经反馈(real time functional magnetic resonance imaging neurofeedback,rtfMR...肥胖症及减重后不能维持健康体质量的核心因素多为食物成瘾,食物成瘾在神经影像学中表现为奖赏网络与认知控制网络间神经环路的失衡。实时功能磁共振成像神经反馈(real time functional magnetic resonance imaging neurofeedback,rtfMRI-NF)作为一种新型生物反馈技术,已被应用于其他物质成瘾领域的临床研究和治疗中。在食物成瘾肥胖症中,rtfMRI-NF同样具有重塑异常脑功能、改善摄食行为并达到减重效果的潜力。本综述总结了肥胖患者食物成瘾的功能磁共振脑成像模型,探讨应用rtfMRI-NF作为其潜在治疗工具的可行神经靶点,并回顾了rtfMRI-NF在肥胖应用中的最新研究进展,为未来rtfMRI-NF在肥胖中的治疗策略和临床指导提供参考。展开更多
第107届北美放射学会(Radiological Society of North America,RSNA)年会关于中枢神经影像学的研究亮点主要有:(1)脑肿瘤:基因分子诊断分类与预测,治疗后病情评估;(2)脑卒中:MRI血管壁成像(vessel wall imaging,VWI)技术的优势,鼓励提升...第107届北美放射学会(Radiological Society of North America,RSNA)年会关于中枢神经影像学的研究亮点主要有:(1)脑肿瘤:基因分子诊断分类与预测,治疗后病情评估;(2)脑卒中:MRI血管壁成像(vessel wall imaging,VWI)技术的优势,鼓励提升VWI的图像质量和临床应用,人工智能(artificial intelligence,AI)大大提升了急性出血性卒中和缺血性卒中的影像诊断水平和效率;(3)脑发育和认知功能障碍:应用AI分析脑结构和功能成像更高效、更准确评估和预测脑发育及脑认知;(4)脑成像技术优化:AI助力影像技术创新,提升图像质量和减少对比剂用量;(5)超高场MRI:11.7 T MRI面世不断刷新着磁共振场强和分辨率的极限,将重新定义人脑解剖以及开辟更多崭新的研究领域;(6)新型冠状病毒肺炎与中枢神经系统。第107届RSNA年会主题为“重新定义放射学”,随着技术的优化、研究领域的创新和科技人文的结合,神经影像也将重新定义为以人为本的智能神经影像。本文将对相关研究进展进行综述。展开更多
文摘Background: Frontotemporal dementia (FTD) is a behavioural syndrome caused by degeneration of the frontal and anterior temporal lobes. Behavioural disturbances include psychiatric features. Whether patients with FTD present with psychiatric features varies with the initial neuroanatomical variability of FTD. Objective: To identify presenting psychiatric changes not part of diagnostic criteria of FTD and contrast them with the degree of hemispheric asymmetry and frontal and temporal hypoperfusion on single photon emission computed tomography (SPECT) imaging. Methods: 74 patients who met consensus criteria for FTD were evaluated at a two year follow up. All had brain SPECT on initial presentation. Results of an FTD psychiatric checklist were contrasted with ratings of regional hypoperfusion. Results: The regions of predominant hypoperfusion did not correlate with differences on FTD demographic variables but were associated with presenting psychiatric features. Dysthymia and anxiety were associated with right temporal hypoperfusion. “ Moria" or frivolous behaviour also occurred with temporal lobe changes, especially on the right. The only significant frontal lobe feature was the presence of a peculiar physical bearing in association with right frontal hypoperfusion. Conclusions: Patients with FTD may present with psychiatric changes distinct from the behavioural diagnostic criteria for this disorder. Early temporal involvement is associated with frivolous behaviour and right temporal involvement is associated with emotional disturbances. In contrast, those with right frontal disease may present with alterations in non-verbal behaviour.
文摘肥胖症及减重后不能维持健康体质量的核心因素多为食物成瘾,食物成瘾在神经影像学中表现为奖赏网络与认知控制网络间神经环路的失衡。实时功能磁共振成像神经反馈(real time functional magnetic resonance imaging neurofeedback,rtfMRI-NF)作为一种新型生物反馈技术,已被应用于其他物质成瘾领域的临床研究和治疗中。在食物成瘾肥胖症中,rtfMRI-NF同样具有重塑异常脑功能、改善摄食行为并达到减重效果的潜力。本综述总结了肥胖患者食物成瘾的功能磁共振脑成像模型,探讨应用rtfMRI-NF作为其潜在治疗工具的可行神经靶点,并回顾了rtfMRI-NF在肥胖应用中的最新研究进展,为未来rtfMRI-NF在肥胖中的治疗策略和临床指导提供参考。
文摘第107届北美放射学会(Radiological Society of North America,RSNA)年会关于中枢神经影像学的研究亮点主要有:(1)脑肿瘤:基因分子诊断分类与预测,治疗后病情评估;(2)脑卒中:MRI血管壁成像(vessel wall imaging,VWI)技术的优势,鼓励提升VWI的图像质量和临床应用,人工智能(artificial intelligence,AI)大大提升了急性出血性卒中和缺血性卒中的影像诊断水平和效率;(3)脑发育和认知功能障碍:应用AI分析脑结构和功能成像更高效、更准确评估和预测脑发育及脑认知;(4)脑成像技术优化:AI助力影像技术创新,提升图像质量和减少对比剂用量;(5)超高场MRI:11.7 T MRI面世不断刷新着磁共振场强和分辨率的极限,将重新定义人脑解剖以及开辟更多崭新的研究领域;(6)新型冠状病毒肺炎与中枢神经系统。第107届RSNA年会主题为“重新定义放射学”,随着技术的优化、研究领域的创新和科技人文的结合,神经影像也将重新定义为以人为本的智能神经影像。本文将对相关研究进展进行综述。
