Weight matrix models for signal sequence motif are simple. A main limitation of the models is the assumption of independence between positions. Signal enhancement is achieved by taking the total likelihood as the obje...Weight matrix models for signal sequence motif are simple. A main limitation of the models is the assumption of independence between positions. Signal enhancement is achieved by taking the total likelihood as the objective function for maximization to cluster sequences into groups with different patterns. As an example, the initial and terminal signals for translation in rice genome are examined.展开更多
Let A be a j x d (0,1) matrix. It is known that if j = 2k - 1 is odd, then det(AAT) ≤ (j+1)((j+1)d/4j)j; if j is even, then det(AAT) ≤ (j+1)((j+2)d/4(j+1))j. A is called a regular D-optimal matrix if it satisfies th...Let A be a j x d (0,1) matrix. It is known that if j = 2k - 1 is odd, then det(AAT) ≤ (j+1)((j+1)d/4j)j; if j is even, then det(AAT) ≤ (j+1)((j+2)d/4(j+1))j. A is called a regular D-optimal matrix if it satisfies the equality of the above bounds. In this note, it is proved that if j = 2k - 1 is odd, then A is a regular D-optimal matrix if and only if A is the adjacent matrix of a (2k - 1, k, (j + l)d/4j)-BIBD; if j = 2k is even, then A is a regular D-optimal matrix if and only if A can be obtained from the adjacent matrix B of a (2k + 1,k + 1,(j + 2)d/4(j +1))-BIBD by deleting any one row from B. Three 21 x 42 regular D-optimal matrices, which were unknown in [11], are also provided.展开更多
基金the Special Funds for Major National Basic Research Projects，国家自然科学基金，Research Project 248 of Beijing
文摘Weight matrix models for signal sequence motif are simple. A main limitation of the models is the assumption of independence between positions. Signal enhancement is achieved by taking the total likelihood as the objective function for maximization to cluster sequences into groups with different patterns. As an example, the initial and terminal signals for translation in rice genome are examined.
基金Project supported by the Science Foundation of China for Postdoctors (No.5(2001)).
文摘Let A be a j x d (0,1) matrix. It is known that if j = 2k - 1 is odd, then det(AAT) ≤ (j+1)((j+1)d/4j)j; if j is even, then det(AAT) ≤ (j+1)((j+2)d/4(j+1))j. A is called a regular D-optimal matrix if it satisfies the equality of the above bounds. In this note, it is proved that if j = 2k - 1 is odd, then A is a regular D-optimal matrix if and only if A is the adjacent matrix of a (2k - 1, k, (j + l)d/4j)-BIBD; if j = 2k is even, then A is a regular D-optimal matrix if and only if A can be obtained from the adjacent matrix B of a (2k + 1,k + 1,(j + 2)d/4(j +1))-BIBD by deleting any one row from B. Three 21 x 42 regular D-optimal matrices, which were unknown in [11], are also provided.
