Surface modification of medical implants was considered as an effective method to improve the cellular behaviors and the integration of tissue onto materials. The micro-nanostructured surface on the titanium alloy was...Surface modification of medical implants was considered as an effective method to improve the cellular behaviors and the integration of tissue onto materials. The micro-nanostructured surface on the titanium alloy was prepared by laser treatment and multiple acid etching. The surface morphologies of different titanium alloy substrates were characterized by scanning electron microscopy (SEM). The effects of micro-nanostructured surfaces on the cellular responses were investigated in vitro by observing hydroxyapatite formation, cell morphology and cell adhesion. The results indicate that the micro-sized structure promoted the adhesion and proliferation of cultured osteoblasts. Furthermore, the micro-nanostructured surface was more conducive to cell adhension stretching compared with the micro-structured surface. All results suggest that the micro-nanostructured surface improved the biocompatibility and integration of tissue onto titanium alloy implants.展开更多
Emission of volatile organic compounds (VOCs) during drying of wood particles for particleboard manufacture, or for production of refined biofuels, is a potential environmental problem. The aim of this work is to stud...Emission of volatile organic compounds (VOCs) during drying of wood particles for particleboard manufacture, or for production of refined biofuels, is a potential environmental problem. The aim of this work is to study the emissions of VOCs during drying, and the influence on the emissions by different drying parameters.The experiments have mainly been done in a batch fluidized bed dryer, but measurements have also been done in a, pilot scale, continuous fluidized bed dryer. The parameters studied are air flow rate through the bed, air temperature, air dewpoint, and bed height. Since the present trend in biofuels and particle drying is towards very high dewpoints during drying, some measurements have been made at dewpoints up to 95℃, corresponding to a water content of 3.2 kg water per kilogram dry air. The emissions have been measured in two different ways,online during drying with a flame ionization detector and through wood analyses of the terpene content in the wood particles before and after drying. Substantial work has been made in developing the latter method as well as developing the drying equipment to be able to produce a wide range of conditions of the drying medium. It was shown that the VOCs emitted, during wood particle drying, mainly consist of terpenes. The behavior of the emissions was typical, at first contact with the drying gas a sharp peak in the release rate was detected. After that,the release rate stabilizes and declines slowly to a point where the material temperature increases and results in a second small peak in the release rate. Typically 80%-90% of the initial terpene content in the material was emitted during drying to low moisture content and it is not possible to significantly influence this release by changing the drying conditions. Up to 50% of the emitted terpenes are released during a very short period after contact with the drying medium. This fact could be utilized by employing a 2-step drying process. The fact that the VOC concentration in the inert gas gets much higher when drying at higher dewpoints could be taken into consideration when dealing with closed loop applications where the inert gas after the dryer is burnt.展开更多
The hydrogenation reaction characteristics and the properties of its hydrides for the magnetic regenerative material HoCu_2(CeCu_2-type) of a cryocooler were investigated. The XRD testing reveals that the hydrides of ...The hydrogenation reaction characteristics and the properties of its hydrides for the magnetic regenerative material HoCu_2(CeCu_2-type) of a cryocooler were investigated. The XRD testing reveals that the hydrides of HoCu_2 were a mixture of Cu, unknown hydride Ⅰ, and unknown hydride Ⅱ. Based on the PCT(pressure-concentration-temperature) curves under different reaction temperatures, the relationships among reaction temperature, equilibrium pressure, and maximum hydrogen absorption capacity were analyzed and discussed. The enthalpy change ΔH and entropy change ΔS as a result of the whole hydrogenation process were also calculated from the PCT curves. The magnetization and volumetric specific heat capacity of the hydride were also measured by SQUID magnetometer and PPMS, respectively.展开更多
To evaluate the effects of γ irradiation on the edible quality of sun-cured crispy radish after γ irradiation, we measured volatile components, microstructure,color, and texture. Gamma irradiation had certain effect...To evaluate the effects of γ irradiation on the edible quality of sun-cured crispy radish after γ irradiation, we measured volatile components, microstructure,color, and texture. Gamma irradiation had certain effects on the composition and content of volatile components in sun-cured crispy radish, which increased the content of aldehydes, ketones and sulfur-containing substances. Increasing doses of irradiation caused declines in characteristics such as crispness, hardness,cohesiveness, and chewiness. Compared with the control, there were no obvious effects of γ irradiation on brightness L*, red-green value a* and yellow-blue value b*,and the total color difference ΔE was not significant. Scanning electron microscopy revealed that, after γ irradiation at a dose of 13.72 kGy, the vascular tissue in the radish root-skin was slightly damaged, and some small folds appeared on the cell wall of parenchymal cells in the flesh part, covered with a small amount of tiny particles. Considering the effects of γ irradiation on the quality of sun-cured crispy radish, low doses of γ irradiation are recommended, and this study can be a reference for the application of γ irradiation in the preservations of radish and similar vegetable products.展开更多
Fruit processing is the appropriative way to augment fruit intake. The present paper shows production technology, which is based on the characteristics of selected raw materials and does not use sugar (saccharose). ...Fruit processing is the appropriative way to augment fruit intake. The present paper shows production technology, which is based on the characteristics of selected raw materials and does not use sugar (saccharose). The objective of the present paper is to produce healthful and disease preventive beverages based on "Saperavi" red wine and bilberries, using grape juice concentrate and stevioside, a natural sweetener, instead of saccharose. The technology is based on the removal of alcohol at a low temperature and low pressure. In these conditions about 50% of moisture is evaporated. The extract is then diluted with 0.25% of stevioside liquid and the ratio is 1:1. The working name is "Saperavi-S". Bilberry juice is added to this beverage at the ratio of 1: l in order to enrich it with biologically active substances. The working name of this beverage is "Marnidan". The products have high contents of phenolic compounds, mainly-anthocyanins. The main idea of technology uses bilberry juice with grape juice concentrate. Bilberries have quite high antioxidant activity, amounting to 55% against l,l-Diphenyl-2-picrylhydrazyl. It is the first time we have produced a beverage based on dealcoholized red wine, stevioside and bilberry juice. This beverage is of special importance in terms of its disease-preventive qualities, including prevention of diabetes, one of the most widespread chronic diseases.展开更多
Retinal degenerative diseases may induce the degeneration of outer retina and in turn,blindness.Nevertheless,due to the maintenance of inner retina,the coding and processing of visual neurons responses are still able ...Retinal degenerative diseases may induce the degeneration of outer retina and in turn,blindness.Nevertheless,due to the maintenance of inner retina,the coding and processing of visual neurons responses are still able to be executed naturally.Therefore,an effective retinal prosthesis device may be developed by mimicking the function of outer retina:transferring the visual light into artificial stimulus and delivering the stimulus to the retina aiming to evoke the neural responses.As two main developing directions for current retinal prosthesis,epiretinal(ER)and subretinal(SR)prosthesis are both undergoing experimental stage and possessing advantages and limitations.Further investigations in power supply,biocompatibility,etc.are still required.Additionally,suprachoroidal transretinal stimulation(STS)and neurotransmitter-induced stimulation as some other alternatives in retinal prosthesis are also considered as promising research directions,although they are not mature enough to be applied commercially,either.展开更多
Solid phase orientation of polymers is one of the most successful routes to enhancement of polymer properties.It unlocks the potential of molecular orientation for the achievement of a range of enhanced physical prope...Solid phase orientation of polymers is one of the most successful routes to enhancement of polymer properties.It unlocks the potential of molecular orientation for the achievement of a range of enhanced physical properties.We provide here an overview of techniques developed in our laboratories for structuring polymers by solid phase orientation processing routes,with a particular focus on die drawing,which have allowed control of significant enhancements of a single property or combinations of properties,including Young's modulus,strength,and density.These have led to notable commercial exploitations,and examples of load bearing low density materials and shape memory materials are discussed.展开更多
Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylat...Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associ- ated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-i/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfoxl/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.展开更多
We develop here a simple wet chemistry to prepare covalent functionalized graphenes (FGs) through epoxide aminolysis espe- cially under alkaline aqueous condition. Remarkably, a series of typical monoamines, such as...We develop here a simple wet chemistry to prepare covalent functionalized graphenes (FGs) through epoxide aminolysis espe- cially under alkaline aqueous condition. Remarkably, a series of typical monoamines, such as industrial Huntsman Jeffamine M-2070 and M-2005 polymer with hydrophilic or hydrophobic polyetheramine chains, positively-charged 2-amino-N,N,N- trimethylpropanaminium, negatively-charged sulfanilic acid, even oligopeptide sequence, can be effectively grafted on the platelets of graphene oxide precursor with covalent functionalization and partially reduced features. This strategy provides the researchers a facile and convenient approach to design and synthesize solution processable, biocompatible and functionalized graphenes for the potent applications in electronic inks, drug carriers and biomedicines. Expansion of the current study is actively ongoing in our laboratory.展开更多
Low-carbon advanced nanostructured steels have been developed for various structural engineering applications, including bridges, automobiles, and other strength-critical applications such as the reactor pressure vess...Low-carbon advanced nanostructured steels have been developed for various structural engineering applications, including bridges, automobiles, and other strength-critical applications such as the reactor pressure vessels in nuclear power stations. The mechanical performances and applications of these steels are strongly dependent on their microstructural features. By controlling the size,number density, distribution, and types of precipitates, it is possible to produce nanostructured steels with a tensile strength reaching as high as 2 GPa while keeping a decent tensile elongation above 10% and a reduction of area as high as 40%. Besides, through a careful control of strength contributions from multiple strengthening mechanisms, the nanostructured steels with superior strengths and low-temperature impact toughness can be obtained by avoiding the temper embrittlement regime. With appropriate Mn additions, these nanostructured steels can achieve a triple enhancement in ductility(total tensile elongation, TE of ~30%) at no expense of strengths(yield strength, YS of ~1100 to 1300 MPa, ultimate tensile strength, UTS of ~1300 to 1400 MPa). More importantly, these steels demonstrate good fabricability and weldability. In this paper, the microstructure-property relationships of these advanced nanostructured steels are comprehensively reviewed. In addition, the current limitations and future development of these nanostructured steels are carefully discussed and outlined.展开更多
基金Projects(5117530651575320)supported by the National Natural Science Foundation of China+1 种基金Project(TS20130922)supported by the Taishan Scholar Foundation,ChinaProject(2014JC020)supported by the Fundamental Research Funds for the Central Universities of China
文摘Surface modification of medical implants was considered as an effective method to improve the cellular behaviors and the integration of tissue onto materials. The micro-nanostructured surface on the titanium alloy was prepared by laser treatment and multiple acid etching. The surface morphologies of different titanium alloy substrates were characterized by scanning electron microscopy (SEM). The effects of micro-nanostructured surfaces on the cellular responses were investigated in vitro by observing hydroxyapatite formation, cell morphology and cell adhesion. The results indicate that the micro-sized structure promoted the adhesion and proliferation of cultured osteoblasts. Furthermore, the micro-nanostructured surface was more conducive to cell adhension stretching compared with the micro-structured surface. All results suggest that the micro-nanostructured surface improved the biocompatibility and integration of tissue onto titanium alloy implants.
文摘Emission of volatile organic compounds (VOCs) during drying of wood particles for particleboard manufacture, or for production of refined biofuels, is a potential environmental problem. The aim of this work is to study the emissions of VOCs during drying, and the influence on the emissions by different drying parameters.The experiments have mainly been done in a batch fluidized bed dryer, but measurements have also been done in a, pilot scale, continuous fluidized bed dryer. The parameters studied are air flow rate through the bed, air temperature, air dewpoint, and bed height. Since the present trend in biofuels and particle drying is towards very high dewpoints during drying, some measurements have been made at dewpoints up to 95℃, corresponding to a water content of 3.2 kg water per kilogram dry air. The emissions have been measured in two different ways,online during drying with a flame ionization detector and through wood analyses of the terpene content in the wood particles before and after drying. Substantial work has been made in developing the latter method as well as developing the drying equipment to be able to produce a wide range of conditions of the drying medium. It was shown that the VOCs emitted, during wood particle drying, mainly consist of terpenes. The behavior of the emissions was typical, at first contact with the drying gas a sharp peak in the release rate was detected. After that,the release rate stabilizes and declines slowly to a point where the material temperature increases and results in a second small peak in the release rate. Typically 80%-90% of the initial terpene content in the material was emitted during drying to low moisture content and it is not possible to significantly influence this release by changing the drying conditions. Up to 50% of the emitted terpenes are released during a very short period after contact with the drying medium. This fact could be utilized by employing a 2-step drying process. The fact that the VOC concentration in the inert gas gets much higher when drying at higher dewpoints could be taken into consideration when dealing with closed loop applications where the inert gas after the dryer is burnt.
基金Project(51276154)supported by the National Natural Science Foundation of ChinaProject(2012010111014)supported by the University Doctoral Subject Special Foundation of China
文摘The hydrogenation reaction characteristics and the properties of its hydrides for the magnetic regenerative material HoCu_2(CeCu_2-type) of a cryocooler were investigated. The XRD testing reveals that the hydrides of HoCu_2 were a mixture of Cu, unknown hydride Ⅰ, and unknown hydride Ⅱ. Based on the PCT(pressure-concentration-temperature) curves under different reaction temperatures, the relationships among reaction temperature, equilibrium pressure, and maximum hydrogen absorption capacity were analyzed and discussed. The enthalpy change ΔH and entropy change ΔS as a result of the whole hydrogenation process were also calculated from the PCT curves. The magnetization and volumetric specific heat capacity of the hydride were also measured by SQUID magnetometer and PPMS, respectively.
基金Supported by Agricultural Science and Technology Innovation Fund of Hunan Province(2017XC12)Scientific and Technological Innovation Project in Hunan Academy of Agricultural Sciences(2016QN11)+1 种基金Hunan Province Engineering Technology Research Center of Agricultural Biological Irradiation(2017PT03)Platform Scientific Fund Project(2016KF006)~~
文摘To evaluate the effects of γ irradiation on the edible quality of sun-cured crispy radish after γ irradiation, we measured volatile components, microstructure,color, and texture. Gamma irradiation had certain effects on the composition and content of volatile components in sun-cured crispy radish, which increased the content of aldehydes, ketones and sulfur-containing substances. Increasing doses of irradiation caused declines in characteristics such as crispness, hardness,cohesiveness, and chewiness. Compared with the control, there were no obvious effects of γ irradiation on brightness L*, red-green value a* and yellow-blue value b*,and the total color difference ΔE was not significant. Scanning electron microscopy revealed that, after γ irradiation at a dose of 13.72 kGy, the vascular tissue in the radish root-skin was slightly damaged, and some small folds appeared on the cell wall of parenchymal cells in the flesh part, covered with a small amount of tiny particles. Considering the effects of γ irradiation on the quality of sun-cured crispy radish, low doses of γ irradiation are recommended, and this study can be a reference for the application of γ irradiation in the preservations of radish and similar vegetable products.
文摘Fruit processing is the appropriative way to augment fruit intake. The present paper shows production technology, which is based on the characteristics of selected raw materials and does not use sugar (saccharose). The objective of the present paper is to produce healthful and disease preventive beverages based on "Saperavi" red wine and bilberries, using grape juice concentrate and stevioside, a natural sweetener, instead of saccharose. The technology is based on the removal of alcohol at a low temperature and low pressure. In these conditions about 50% of moisture is evaporated. The extract is then diluted with 0.25% of stevioside liquid and the ratio is 1:1. The working name is "Saperavi-S". Bilberry juice is added to this beverage at the ratio of 1: l in order to enrich it with biologically active substances. The working name of this beverage is "Marnidan". The products have high contents of phenolic compounds, mainly-anthocyanins. The main idea of technology uses bilberry juice with grape juice concentrate. Bilberries have quite high antioxidant activity, amounting to 55% against l,l-Diphenyl-2-picrylhydrazyl. It is the first time we have produced a beverage based on dealcoholized red wine, stevioside and bilberry juice. This beverage is of special importance in terms of its disease-preventive qualities, including prevention of diabetes, one of the most widespread chronic diseases.
文摘Retinal degenerative diseases may induce the degeneration of outer retina and in turn,blindness.Nevertheless,due to the maintenance of inner retina,the coding and processing of visual neurons responses are still able to be executed naturally.Therefore,an effective retinal prosthesis device may be developed by mimicking the function of outer retina:transferring the visual light into artificial stimulus and delivering the stimulus to the retina aiming to evoke the neural responses.As two main developing directions for current retinal prosthesis,epiretinal(ER)and subretinal(SR)prosthesis are both undergoing experimental stage and possessing advantages and limitations.Further investigations in power supply,biocompatibility,etc.are still required.Additionally,suprachoroidal transretinal stimulation(STS)and neurotransmitter-induced stimulation as some other alternatives in retinal prosthesis are also considered as promising research directions,although they are not mature enough to be applied commercially,either.
基金the support of the Engineering & Physical Sciences Research Council,the Technology Strategy Boardvarious industrial partners including Bridon International,Dow Building Products Inc and Smith & Nephew Ltd
文摘Solid phase orientation of polymers is one of the most successful routes to enhancement of polymer properties.It unlocks the potential of molecular orientation for the achievement of a range of enhanced physical properties.We provide here an overview of techniques developed in our laboratories for structuring polymers by solid phase orientation processing routes,with a particular focus on die drawing,which have allowed control of significant enhancements of a single property or combinations of properties,including Young's modulus,strength,and density.These have led to notable commercial exploitations,and examples of load bearing low density materials and shape memory materials are discussed.
基金Zhou HuaLin is supported by National Basic Research Program of China(2013CB917803)research fund for the State Key Laboratory of Cog-nitive Neuroscience and Learning from Institute of Biophysics,Chinese Academy of Sciences(7Y1SNY7007)+3 种基金supported by the Ross Maclean Senior Research Fellowship and the Peter Goodenough BequestZhu Li and Liu JiangHong are supported by grants from the Na-tional Major Basic Research Program of China(2010CB529603)the National Natural Science Foundation of China(91132710,31200561)Jane Y.Wu is supported by the US National Institutes of Health
文摘Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associ- ated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-i/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfoxl/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
基金supported by the Ministry of Science and Technology of China (2014CB239402, 2013CB834505, 2013CB834804)the National Natural Science Foundation of China (91427303, 21372232, 21204052)+1 种基金the Key Research Programme of the Chinese Academy of Sciences (KGZD-EW-T05)the Foundation of Director of TIPC
文摘We develop here a simple wet chemistry to prepare covalent functionalized graphenes (FGs) through epoxide aminolysis espe- cially under alkaline aqueous condition. Remarkably, a series of typical monoamines, such as industrial Huntsman Jeffamine M-2070 and M-2005 polymer with hydrophilic or hydrophobic polyetheramine chains, positively-charged 2-amino-N,N,N- trimethylpropanaminium, negatively-charged sulfanilic acid, even oligopeptide sequence, can be effectively grafted on the platelets of graphene oxide precursor with covalent functionalization and partially reduced features. This strategy provides the researchers a facile and convenient approach to design and synthesize solution processable, biocompatible and functionalized graphenes for the potent applications in electronic inks, drug carriers and biomedicines. Expansion of the current study is actively ongoing in our laboratory.
基金supported by the National Natural Science Foundation of China (51801169)Hong Kong Research Grant Council (CityU Grant 9360161, 9042635, 9042879)the internal funding from the City University of Hong Kong (CityU 9380060)。
文摘Low-carbon advanced nanostructured steels have been developed for various structural engineering applications, including bridges, automobiles, and other strength-critical applications such as the reactor pressure vessels in nuclear power stations. The mechanical performances and applications of these steels are strongly dependent on their microstructural features. By controlling the size,number density, distribution, and types of precipitates, it is possible to produce nanostructured steels with a tensile strength reaching as high as 2 GPa while keeping a decent tensile elongation above 10% and a reduction of area as high as 40%. Besides, through a careful control of strength contributions from multiple strengthening mechanisms, the nanostructured steels with superior strengths and low-temperature impact toughness can be obtained by avoiding the temper embrittlement regime. With appropriate Mn additions, these nanostructured steels can achieve a triple enhancement in ductility(total tensile elongation, TE of ~30%) at no expense of strengths(yield strength, YS of ~1100 to 1300 MPa, ultimate tensile strength, UTS of ~1300 to 1400 MPa). More importantly, these steels demonstrate good fabricability and weldability. In this paper, the microstructure-property relationships of these advanced nanostructured steels are comprehensively reviewed. In addition, the current limitations and future development of these nanostructured steels are carefully discussed and outlined.