Objective:To determine whether treatment with amoxicillinsulbactam in women with threatened idiopathic preterm labour will prolong the gestation and reduce preterm birth rates in a Latin- American population. Methods:...Objective:To determine whether treatment with amoxicillinsulbactam in women with threatened idiopathic preterm labour will prolong the gestation and reduce preterm birth rates in a Latin- American population. Methods: A double- blind, placebo- controlled, randomized trial was conducted in 96 women who were hospitalized for preterm labour between 24 and 34 weeks of gestation at the Pereira Rossell Hospital, in Montevideo, Uruguay. The primary outcome measure was prematurity. The sample size was calculated a priori based on the hospital database. Statistical analyses were performed using the t- test, chi square, weighted mean difference (WMD) and relative risk (RR) with their confidence intervals (95% CI). Analysis by intention- to- treat. Results: Out of 47 patients assigned for antibiotics, 43 completed the treatment. There were no significant statistical differences between antibiotics and placebo group in prematurity (RR:1.04, 95% CI: 0.59, 1.84), prolongation of pregnancy (WMD:0.23, 95% CI: - 0.96, 1.42) and other perinatal outcomes. Conclusion: Antibiotics did not prove to have benefits in improving perinatal outcomes in this Latin American population.展开更多
Wilson disease is an hereditary disorder of copper metabolism, caused by mutations in the ATP7B gene, and leading to hepatic or neurologic disease. We examined whether H1069Q, the most common ATP7B mutation, is associ...Wilson disease is an hereditary disorder of copper metabolism, caused by mutations in the ATP7B gene, and leading to hepatic or neurologic disease. We examined whether H1069Q, the most common ATP7B mutation, is associated with a specific phenotype. Genotyping results in 70 Dutch patients were related to clinical presentation. Subsequently a meta-analysis for genotype-phenotype correlation was performed on all patients available from literature, combined with the current Dutch group, a total of 577 patients. The Dutch patients homozygous or heterozygous for the H1069Q mutation presented more frequently with neurologic disease (63%and 43%vs. 15%), and at a later age (20.9 and 15.9 vs. 12.6 years) than patients without the H1069Q mutation. In the meta-analysis the odds-ratio for neurologic presentation in homozygous or heterozygous H1069Q vs. non-H1069Q patients was 3.50 (95%CI 2.01-6.09) and 2.13 (95%CI 1.18-3.83), respectively. Age at presentation was 21.1, 19.2 and 16.5 years, respectively, corresponding to a weighted mean difference (WMD) of 4.41 (95%CI 1.56-7.26) for homozygous H1069Q vs. heterozygous patients and 6.68 (95%CI 4.33-9.38) for homozygous H1069Q vs. non-H1069Q patients. Our results indicate that the H1069Q mutation is associated with a late and neurologic presentation.展开更多
文摘Objective:To determine whether treatment with amoxicillinsulbactam in women with threatened idiopathic preterm labour will prolong the gestation and reduce preterm birth rates in a Latin- American population. Methods: A double- blind, placebo- controlled, randomized trial was conducted in 96 women who were hospitalized for preterm labour between 24 and 34 weeks of gestation at the Pereira Rossell Hospital, in Montevideo, Uruguay. The primary outcome measure was prematurity. The sample size was calculated a priori based on the hospital database. Statistical analyses were performed using the t- test, chi square, weighted mean difference (WMD) and relative risk (RR) with their confidence intervals (95% CI). Analysis by intention- to- treat. Results: Out of 47 patients assigned for antibiotics, 43 completed the treatment. There were no significant statistical differences between antibiotics and placebo group in prematurity (RR:1.04, 95% CI: 0.59, 1.84), prolongation of pregnancy (WMD:0.23, 95% CI: - 0.96, 1.42) and other perinatal outcomes. Conclusion: Antibiotics did not prove to have benefits in improving perinatal outcomes in this Latin American population.
文摘Wilson disease is an hereditary disorder of copper metabolism, caused by mutations in the ATP7B gene, and leading to hepatic or neurologic disease. We examined whether H1069Q, the most common ATP7B mutation, is associated with a specific phenotype. Genotyping results in 70 Dutch patients were related to clinical presentation. Subsequently a meta-analysis for genotype-phenotype correlation was performed on all patients available from literature, combined with the current Dutch group, a total of 577 patients. The Dutch patients homozygous or heterozygous for the H1069Q mutation presented more frequently with neurologic disease (63%and 43%vs. 15%), and at a later age (20.9 and 15.9 vs. 12.6 years) than patients without the H1069Q mutation. In the meta-analysis the odds-ratio for neurologic presentation in homozygous or heterozygous H1069Q vs. non-H1069Q patients was 3.50 (95%CI 2.01-6.09) and 2.13 (95%CI 1.18-3.83), respectively. Age at presentation was 21.1, 19.2 and 16.5 years, respectively, corresponding to a weighted mean difference (WMD) of 4.41 (95%CI 1.56-7.26) for homozygous H1069Q vs. heterozygous patients and 6.68 (95%CI 4.33-9.38) for homozygous H1069Q vs. non-H1069Q patients. Our results indicate that the H1069Q mutation is associated with a late and neurologic presentation.
