Measuring the top coal movement and abutment pressure about Teaching ThirdMine that belonged to the National Energy Investment and Development.It shows that thetop coal's strong compression occurs 6 m in front of ...Measuring the top coal movement and abutment pressure about Teaching ThirdMine that belonged to the National Energy Investment and Development.It shows that thetop coal's strong compression occurs 6 m in front of the face, the top coal is in front of sideabutment pressure concentration increase area at this time, and the top coal horizontaldisplacement increase rapidly.Also analyzed the top coal mechanical properties, and thetop coal under abutment pressure turned into block state.Finally, analyzed the top coalfailure mechanism and the structure of the mechanical model, and also made a theoreticalanalysis of the top coal's ultimate bearing capacity.展开更多
Dysregulation of intracellular Ca2+ homeostasis is associated with various pathological conditions and arrhythmogenesis of the heart.The objective of this study was to investigate the effects of an acute increase in i...Dysregulation of intracellular Ca2+ homeostasis is associated with various pathological conditions and arrhythmogenesis of the heart.The objective of this study was to investigate the effects of an acute increase in intracellular Ca2+ concentration ([Ca2+] i) on the electrophysiology of ventricular myocytes by mimicking intracellular Ca 2+ overload.The [Ca2+] i was clamped to either a controlled (65-100 nmol L-1) or increased (1 μmol L-1) level.The transmembrane action potentials and ionic currents were recorded using whole-cell patch clamp techniques.We found that the acute increase in [Ca2+] i shortened the action potential duration,reduced the action potential amplitude,maximum depolarization velocity and resting membrane potential,caused delayed after-depolarizations (DADs),and triggered activity--compared with these parameters in the control.The increased [Ca2+] i augmented late I Na in a time-dependent manner,reduced ICaL and IK1,and increased IKr but not IKs.The results of this study can be used to explain calcium overload-induced ventricular arrhythmias.展开更多
文摘Measuring the top coal movement and abutment pressure about Teaching ThirdMine that belonged to the National Energy Investment and Development.It shows that thetop coal's strong compression occurs 6 m in front of the face, the top coal is in front of sideabutment pressure concentration increase area at this time, and the top coal horizontaldisplacement increase rapidly.Also analyzed the top coal mechanical properties, and thetop coal under abutment pressure turned into block state.Finally, analyzed the top coalfailure mechanism and the structure of the mechanical model, and also made a theoreticalanalysis of the top coal's ultimate bearing capacity.
基金supported by the National Natural Science Foundation of China(Grant No. 30870912)Department of Biology,Gilead Sciences,Inc.,USA.
文摘Dysregulation of intracellular Ca2+ homeostasis is associated with various pathological conditions and arrhythmogenesis of the heart.The objective of this study was to investigate the effects of an acute increase in intracellular Ca2+ concentration ([Ca2+] i) on the electrophysiology of ventricular myocytes by mimicking intracellular Ca 2+ overload.The [Ca2+] i was clamped to either a controlled (65-100 nmol L-1) or increased (1 μmol L-1) level.The transmembrane action potentials and ionic currents were recorded using whole-cell patch clamp techniques.We found that the acute increase in [Ca2+] i shortened the action potential duration,reduced the action potential amplitude,maximum depolarization velocity and resting membrane potential,caused delayed after-depolarizations (DADs),and triggered activity--compared with these parameters in the control.The increased [Ca2+] i augmented late I Na in a time-dependent manner,reduced ICaL and IK1,and increased IKr but not IKs.The results of this study can be used to explain calcium overload-induced ventricular arrhythmias.
