A dynamic hierarchical description method for workflow is presented. The method provides a dynamic hierarchical way to define a workflow with non-determinate or dynamic factors. With this method, the main process defi...A dynamic hierarchical description method for workflow is presented. The method provides a dynamic hierarchical way to define a workflow with non-determinate or dynamic factors. With this method, the main process defined at build-time can be reified and extended by the principle of the sub-organizations at either the build-time or the run-time. To ensure the consistency and integrity of the description, a series of constraint rules are also discussed to realize seamless integration between a decomposed process and its original one. This approach supports the description of unpredictable uncertainties, the dynamic hierarchy of business process, and the dynamic modification of enterprise organizations, and all of these improve the flexibility and extendability of workflow management systems dramatically.展开更多
Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat...Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat ventricular myocytes. Methods The whole cell patch-clamptechniques were used to study the changes of I_(k1), I_(to), I_(Ca-L) and APD in rat ventricularmyocytes. Results Cyclovirobuxine D (1-10 μmol·L^(-1)) significantly prolonged APD_(50) andAPD_(90) in isolated rat ventricular myocytes. Resting potential (RP) was decreased by 10μmol·L^(-1) of cyclovirobuxine D. Cyclovirobuxine D significantly decreased both inward andoutward components of I_(k1) . At - 100 mV, 1 and 10 μmol·L^(-1) of cyclovirobuxine D decreasedI_(k1), density from (-8.0+- 1.1) pA/pF to ( - 4.1 +- 0.7) pA/pF and ( - 3.4 +- 0.8) pA/pF,respectively, whereas at - 30 mV, I-(k1) density was decreased from (1.10 +-0.24) pA/pF to (0.61+-0.18) pA/pF and (0.36+- 0.11) pA/pF, respectively. 1_(to) was markedly inhibited bycyclovirobuxine D from the test potential of 0 mV to + 60 mV. At + 40 mV, 1 and 10μmol·L^(-1) ofcyclovirobuxine D decreased I_(to) density from (8.9+- 2.0) pA/pF to (5.5 +- 1.2) pA/pF and (4.9+-0.9) pA/pF, respectively. Cyclovirobuxine D inhibited I_(Ca-L) in a concentration-dependentmanner. At 10 mV, 1 and 10μmol·L^(-1) of cyclovirobuxine D decreased I_(Ca-L) density from ( - 9.9+- 1.8) pA/pF to ( - 6.4 +- 1.4) pA/pF and (-4.2+-0.6) pA/pF, respectively. ConclusionCyclovirobuxine D significantly prolonged APD and inhibited I_(k1), I_(to), and I_(Ca-L) in ratventricular myocytes. The inhibitory effects of cyclovirobuxine D on _(k1) and I_(to) are majormolecular mechanisms of APD prolongation in rat.展开更多
Heat transfer coefficients between an immersed horizontal tube and an aerated vibrated fluidized bed are measured. There is a maximum value in the h-P experimental curve. The heat transfer coefficient increases with d...Heat transfer coefficients between an immersed horizontal tube and an aerated vibrated fluidized bed are measured. There is a maximum value in the h-P experimental curve. The heat transfer coefficient increases with decreases in particle diameter in the fully fluidized region. The particle density has less effect on the heat transfer coefficients. High amplitude and low frequency, or low amplitude and high frequency are favorable to heat transfer. Exceedingly high gas velocity is unfavorable to the surface-bed heat transfer. A model based on the 'pocket' theory was proposed for predicting the surface-to-bed heat transfer coefficients in fully fluidized region. The predictions from the model were compared with observed data. The reasonable fit suggests the adequacy of the model.展开更多
Objectives To evaluate the association between a KCNQ 1 mutation, R259H, and short QT syndrome (SQTS) and to explore the elec- trophysiological mechanisms underlying their association. Methods We performed genetic s...Objectives To evaluate the association between a KCNQ 1 mutation, R259H, and short QT syndrome (SQTS) and to explore the elec- trophysiological mechanisms underlying their association. Methods We performed genetic screening of SQTS genes in 25 probands and their family members (63 patients). We used direct sequencing to screen the exons and intron-exon boundaries of candidate genes that en- code ion channels which contribute to the repolarization of the ventricular action potential, including KCNQI, KCNH2, KCNE1, KCNE2, KCNJ2, CACNAlc, CACNB2b and CACNA2D1. In one of the 25 SQTS probands screened, we discovered a KCNQ1 mutation, R259H. We cloned R259H and transiently expressed it in HEK-293 cells; then, currents were recorded using whole cell patch clamp techniques. Results R259H-KCNQ 1 showed significantly increased current density, which was approximately 3-fold larger than that of wild type (WT) after a depolarizing pulse at 1 s. The steady state voltage dependence of the activation and inactivation did not show significant differences between the WT and R259H mutation (P 〉 0.05), whereas the time constant of deactivation was markedly prolonged in the mutant compared with the WT in terms of the test potentials, which indicated that the deactivation of R259H was markedly slower than that of the WT. These results suggested that the R259H mutation can effectively increase the slowly activated delayed rectifier potassium current (Irs) in phase 3 of the cardiac action potential, which may be an infrequent cause of QT interval shortening. Conclusions R259H is a gain-of-function muta- tion of the KCNQ1 channel that is responsible for SQTS2. This is the first time that the R259H mutation was detected in Chinese people.展开更多
In order to study the effect of dynamic recrystallization on the metal flow behavior during thermal deformation,the elevated temperature compression experiments of CuCrZr alloy and 35CrMo steel are carried out using G...In order to study the effect of dynamic recrystallization on the metal flow behavior during thermal deformation,the elevated temperature compression experiments of CuCrZr alloy and 35CrMo steel are carried out using Gleeble-3810 thermal simulator.It is proved that the samples underwent obvious dynamic recrystallization behavior during thermal deformation by microstructure observation of deformed specimens.The size of recrystallized grains increases as the temperature improved and the strain rate decreased.Meanwhile,the net softening rate caused by dynamic recrystallization is determined based on the stress-dislocation relationship.It can be found that the value of net softening rate increases quadratically as the Z parameter decreases,and the dynamic recrystallization net softening rate of CuCrZr alloy and 35CrMo steel are calculated to be 21.9%and 29.8%,respectively.Based on the dynamic recrystallization softening effect proposed,the novel elevated temperature flow constitutive models of two different alloys are proposed,and the related parameters are well defined and solved in detail.The predicted values of the obtained models are agreed well with the experimental values.展开更多
Dam breaks are easily triggered by heavy rains due to extreme weather such as typhoons,causing serious economic losses and casualties.Through the investigation of Chaoshan coastal zone,it is found that there have been...Dam breaks are easily triggered by heavy rains due to extreme weather such as typhoons,causing serious economic losses and casualties.Through the investigation of Chaoshan coastal zone,it is found that there have been dam breaks caused by geological disasters.In the design and management of water conservancy project,it is very important to analyze the effect of disastrous flow caused by dam break on the building.In this paper,the effect of the dam break flow on the cylinder is simulated numerically by taking the water body with initial velocity as the dam break flow,and the flow characteristics around the cylinder and the water body are analyzed.Numerical model adopted the Renault Average Navier-Stokes(RANS)model and volume of fluid(VOF)method to analyze the evolution of free water surface.It is found that there are different patterns of water movement in the process of dam break resulting in the creation of several isolated convex hull forms of dam-break waves on the stationary water surface,which causes longer disturbances in the water near the cylinder and makes the cylinder more vulnerable to fatigue damage.The increase of the height of the dam breaking water will lead to the increase of the hydrodynamic force on the pipeline.This study has guiding significance for the study of dam break and dam body design in water conservancy projects.展开更多
Taking into account moisture in virtue of general potential temperature,the author derive a three-dimensional(3D) pseudomomentum wave-activity relation for the moist atmosphere from the primitive equations in Cartesia...Taking into account moisture in virtue of general potential temperature,the author derive a three-dimensional(3D) pseudomomentum wave-activity relation for the moist atmosphere from the primitive equations in Cartesian coordinates using the Momentum-Casimir method.Since the wave-activity relation is constructed in an ageostrophic and non-hydrostatic dynamical framework,it may be applicable to diagnosing the evolution and propagation of mesoscale systems leading to heavy rainfall.The theoretical analysis shows that,besides the local change of wave-activity flux divergence and source or sink,the wave-activity relation includes two additional forcing terms.The first is the zonal gradient of difference between general potential temperature and potential temperature perturbations,and the second is the covariance of the solenoid and gradient of water vapor,denoting the direct influence of moisture on wave-activity density.The wave-activity density was applied to a heavy precipitation event occurring in the Jianghuai region of China.The calculation showed that the wave-activity density was consistent with 6-h accumulated precipitation observations,in terms of both spatial distribution and temporal tendency.This suggested that the disturbance represented by wave-activity density was closely related to the heavy precipitation.Although the wave-activity flux divergence and the covariance of the solenoid and gradient of water vapor made the primary contribution to the local change of wave-activity density,the covariance was more remarkable.The zonal gradient of difference between general potential temperature and potential temperature perturbations made a weaker contribution to the waveactivity density.展开更多
文摘A dynamic hierarchical description method for workflow is presented. The method provides a dynamic hierarchical way to define a workflow with non-determinate or dynamic factors. With this method, the main process defined at build-time can be reified and extended by the principle of the sub-organizations at either the build-time or the run-time. To ensure the consistency and integrity of the description, a series of constraint rules are also discussed to realize seamless integration between a decomposed process and its original one. This approach supports the description of unpredictable uncertainties, the dynamic hierarchy of business process, and the dynamic modification of enterprise organizations, and all of these improve the flexibility and extendability of workflow management systems dramatically.
文摘Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat ventricular myocytes. Methods The whole cell patch-clamptechniques were used to study the changes of I_(k1), I_(to), I_(Ca-L) and APD in rat ventricularmyocytes. Results Cyclovirobuxine D (1-10 μmol·L^(-1)) significantly prolonged APD_(50) andAPD_(90) in isolated rat ventricular myocytes. Resting potential (RP) was decreased by 10μmol·L^(-1) of cyclovirobuxine D. Cyclovirobuxine D significantly decreased both inward andoutward components of I_(k1) . At - 100 mV, 1 and 10 μmol·L^(-1) of cyclovirobuxine D decreasedI_(k1), density from (-8.0+- 1.1) pA/pF to ( - 4.1 +- 0.7) pA/pF and ( - 3.4 +- 0.8) pA/pF,respectively, whereas at - 30 mV, I-(k1) density was decreased from (1.10 +-0.24) pA/pF to (0.61+-0.18) pA/pF and (0.36+- 0.11) pA/pF, respectively. 1_(to) was markedly inhibited bycyclovirobuxine D from the test potential of 0 mV to + 60 mV. At + 40 mV, 1 and 10μmol·L^(-1) ofcyclovirobuxine D decreased I_(to) density from (8.9+- 2.0) pA/pF to (5.5 +- 1.2) pA/pF and (4.9+-0.9) pA/pF, respectively. Cyclovirobuxine D inhibited I_(Ca-L) in a concentration-dependentmanner. At 10 mV, 1 and 10μmol·L^(-1) of cyclovirobuxine D decreased I_(Ca-L) density from ( - 9.9+- 1.8) pA/pF to ( - 6.4 +- 1.4) pA/pF and (-4.2+-0.6) pA/pF, respectively. ConclusionCyclovirobuxine D significantly prolonged APD and inhibited I_(k1), I_(to), and I_(Ca-L) in ratventricular myocytes. The inhibitory effects of cyclovirobuxine D on _(k1) and I_(to) are majormolecular mechanisms of APD prolongation in rat.
基金Supported by the National Natural Science Foundation of China(No.29576253).
文摘Heat transfer coefficients between an immersed horizontal tube and an aerated vibrated fluidized bed are measured. There is a maximum value in the h-P experimental curve. The heat transfer coefficient increases with decreases in particle diameter in the fully fluidized region. The particle density has less effect on the heat transfer coefficients. High amplitude and low frequency, or low amplitude and high frequency are favorable to heat transfer. Exceedingly high gas velocity is unfavorable to the surface-bed heat transfer. A model based on the 'pocket' theory was proposed for predicting the surface-to-bed heat transfer coefficients in fully fluidized region. The predictions from the model were compared with observed data. The reasonable fit suggests the adequacy of the model.
基金grants obtained from the National Natural Science Foundation of China (No.: 81170177, 81030002) and science and Technology De- partment of Gansu Province Project (145RJZ104).
文摘Objectives To evaluate the association between a KCNQ 1 mutation, R259H, and short QT syndrome (SQTS) and to explore the elec- trophysiological mechanisms underlying their association. Methods We performed genetic screening of SQTS genes in 25 probands and their family members (63 patients). We used direct sequencing to screen the exons and intron-exon boundaries of candidate genes that en- code ion channels which contribute to the repolarization of the ventricular action potential, including KCNQI, KCNH2, KCNE1, KCNE2, KCNJ2, CACNAlc, CACNB2b and CACNA2D1. In one of the 25 SQTS probands screened, we discovered a KCNQ1 mutation, R259H. We cloned R259H and transiently expressed it in HEK-293 cells; then, currents were recorded using whole cell patch clamp techniques. Results R259H-KCNQ 1 showed significantly increased current density, which was approximately 3-fold larger than that of wild type (WT) after a depolarizing pulse at 1 s. The steady state voltage dependence of the activation and inactivation did not show significant differences between the WT and R259H mutation (P 〉 0.05), whereas the time constant of deactivation was markedly prolonged in the mutant compared with the WT in terms of the test potentials, which indicated that the deactivation of R259H was markedly slower than that of the WT. These results suggested that the R259H mutation can effectively increase the slowly activated delayed rectifier potassium current (Irs) in phase 3 of the cardiac action potential, which may be an infrequent cause of QT interval shortening. Conclusions R259H is a gain-of-function muta- tion of the KCNQ1 channel that is responsible for SQTS2. This is the first time that the R259H mutation was detected in Chinese people.
基金Project(2019zzts525)supported by the Fundamental Research Funds for the Central Universities,ChinaProjects(U1837207,U1637601)supported by the National Natural Science Foundation of China
文摘In order to study the effect of dynamic recrystallization on the metal flow behavior during thermal deformation,the elevated temperature compression experiments of CuCrZr alloy and 35CrMo steel are carried out using Gleeble-3810 thermal simulator.It is proved that the samples underwent obvious dynamic recrystallization behavior during thermal deformation by microstructure observation of deformed specimens.The size of recrystallized grains increases as the temperature improved and the strain rate decreased.Meanwhile,the net softening rate caused by dynamic recrystallization is determined based on the stress-dislocation relationship.It can be found that the value of net softening rate increases quadratically as the Z parameter decreases,and the dynamic recrystallization net softening rate of CuCrZr alloy and 35CrMo steel are calculated to be 21.9%and 29.8%,respectively.Based on the dynamic recrystallization softening effect proposed,the novel elevated temperature flow constitutive models of two different alloys are proposed,and the related parameters are well defined and solved in detail.The predicted values of the obtained models are agreed well with the experimental values.
文摘Dam breaks are easily triggered by heavy rains due to extreme weather such as typhoons,causing serious economic losses and casualties.Through the investigation of Chaoshan coastal zone,it is found that there have been dam breaks caused by geological disasters.In the design and management of water conservancy project,it is very important to analyze the effect of disastrous flow caused by dam break on the building.In this paper,the effect of the dam break flow on the cylinder is simulated numerically by taking the water body with initial velocity as the dam break flow,and the flow characteristics around the cylinder and the water body are analyzed.Numerical model adopted the Renault Average Navier-Stokes(RANS)model and volume of fluid(VOF)method to analyze the evolution of free water surface.It is found that there are different patterns of water movement in the process of dam break resulting in the creation of several isolated convex hull forms of dam-break waves on the stationary water surface,which causes longer disturbances in the water near the cylinder and makes the cylinder more vulnerable to fatigue damage.The increase of the height of the dam breaking water will lead to the increase of the hydrodynamic force on the pipeline.This study has guiding significance for the study of dam break and dam body design in water conservancy projects.
基金supported by the National Basic Research Program of China (Grant No.2009CB421505)the Key Program of the Chinese Academy of Sciences (Grant No.KZZD-EW-05)+2 种基金the project of Chinese Academy of Meteorological Sciences (Grant No.2011LASW-B15)the Spectial Scientific Research Fund of Meteorological Public Welfare of the Ministry of Sciences and Technology (Grant No.GYHY200906004)and the National Natural Science Foundation of China (Grant Nos.41175060,41075098,and 41005005)
文摘Taking into account moisture in virtue of general potential temperature,the author derive a three-dimensional(3D) pseudomomentum wave-activity relation for the moist atmosphere from the primitive equations in Cartesian coordinates using the Momentum-Casimir method.Since the wave-activity relation is constructed in an ageostrophic and non-hydrostatic dynamical framework,it may be applicable to diagnosing the evolution and propagation of mesoscale systems leading to heavy rainfall.The theoretical analysis shows that,besides the local change of wave-activity flux divergence and source or sink,the wave-activity relation includes two additional forcing terms.The first is the zonal gradient of difference between general potential temperature and potential temperature perturbations,and the second is the covariance of the solenoid and gradient of water vapor,denoting the direct influence of moisture on wave-activity density.The wave-activity density was applied to a heavy precipitation event occurring in the Jianghuai region of China.The calculation showed that the wave-activity density was consistent with 6-h accumulated precipitation observations,in terms of both spatial distribution and temporal tendency.This suggested that the disturbance represented by wave-activity density was closely related to the heavy precipitation.Although the wave-activity flux divergence and the covariance of the solenoid and gradient of water vapor made the primary contribution to the local change of wave-activity density,the covariance was more remarkable.The zonal gradient of difference between general potential temperature and potential temperature perturbations made a weaker contribution to the waveactivity density.