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盆地形成与演化的动力学类型及其地球动力学机制 被引量:9
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作者 琚宜文 孙盈 +1 位作者 王国昌 谭锋奇 《地质科学》 CAS CSCD 北大核心 2015年第2期503-523,共21页
借鉴国内外已有的盆地研究成果,在盆地分析的基础上,从岩石圈板块作用、岩石圈深部作用和岩石圈表生作用3个方面,兼顾系统性、科学性和应用性,确立了盆地新的分类原则,由此深入研究了盆地形成与演化的动力学类型,并进一步阐述了盆地形... 借鉴国内外已有的盆地研究成果,在盆地分析的基础上,从岩石圈板块作用、岩石圈深部作用和岩石圈表生作用3个方面,兼顾系统性、科学性和应用性,确立了盆地新的分类原则,由此深入研究了盆地形成与演化的动力学类型,并进一步阐述了盆地形成与演化的地球动力学机制。研究结果表明:在盆地分类中,首先主要根据盆地形成的地球动力学环境如岩石圈板块作用环境、深部作用环境以及表生作用环境来划分大类;再根据盆地形成与演化的各种地质作用及其动力学过程如构造作用(伸展、挤压或剪切过程)、热力作用及重力作用进行主要类型划分;再根据盆地的基底性质和地壳类型(如陆壳、洋壳或过渡壳)以及盆地的沉积充填史和构造古地理等(如海相盆地、陆相盆地或过渡相盆地)细分亚类。盆地形成与演化的动力学类型主要包括:单一构造或热体制下盆地演化时的原型盆地类型、单一重力体制下盆地演化的原型盆地类型、多种构造-热体制下盆地演化的叠合盆地类型以及多种构造-热体制下盆地演化的残留盆地类型。在单一构造或热体制下,从板块作用或壳幔作用角度原型盆地动力学类型主要划分为:伸展盆地(陆内伸展盆地、陆间伸展盆地、大洋伸展盆地和弧后伸展盆地),挠曲盆地(弧后挠曲盆地、周缘挠曲盆地、陆内挠曲盆地),走滑盆地(走滑伸展盆地、走滑挠曲盆地)以及克拉通盆地(克拉通退缩盆地、克拉通扩展盆地和克拉通迁移盆地);单一重力体制下原型盆地动力学类型有负载盆地和撞击盆地;多种构造-热体制下的叠合盆地动力学类型有叠加盆地和复合盆地;多种构造-热体制下盆地演化的残留盆地动力学类型有伸展隆起下局部沉降引起的残留盆地、推覆褶皱隆起引起的残留盆地、俯冲至局部碰撞引起的残留盆地及周边抬升隆起引起的残留盆地。关于盆地形成与演化的地球动力学机制包括:岩石圈的板块作用机制,岩石圈的深部作用机制以及岩石圈的表生作用机制。岩石圈的板块作用机制包括板块伸展、挤压和剪切作用;岩石圈的深部作用机制包括软流圈与超级地幔柱对岩石圈的作用,尤其是壳幔作用;岩石圈的表生作用机制也很重要,包括盆地的重力作用、大气作用、海洋作用和生物作用。通过本文的研究,可以为研究整个岩石圈演化、壳幔作用、地球动力学过程以及成藏成矿机制奠定重要理论基础;同时,对于沉积盆地矿产资源、能源资源、水资源勘探和开发,以及灾害防治和环境保护也具有重要应用价值。 展开更多
关键词 盆地 演化 动力学类型 地球动力学 机制
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中国主要含气盆地构造动力学类型与天然气地质条件 被引量:2
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作者 黄华芳 刘子贵 周晓峰 《沉积学报》 CAS CSCD 北大核心 1999年第A12期805-810,共6页
以板块构造理论为指导,遵循盆地构造动力学类型分析的理想模式和地质实际相结合的原则,将我国主要含气盆地划分为6类9型15种,并系统分析了各类盆地的天然气地质条件。认为在中国东部边缘海裂谷盆地具有形成大中型气田的优越地质条件... 以板块构造理论为指导,遵循盆地构造动力学类型分析的理想模式和地质实际相结合的原则,将我国主要含气盆地划分为6类9型15种,并系统分析了各类盆地的天然气地质条件。认为在中国东部边缘海裂谷盆地具有形成大中型气田的优越地质条件,陆内裂谷盆地可寻找由中小型气田连片而成的大中型气区;在中国西部,寻找大中型气田的重要领域是克拉通转化盆地。 展开更多
关键词 含气盆地 构造动力学类型 裂谷化环境 天然气
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口服补液盐治疗血管迷走性晕厥疗效及与血流动力学类型的关系 被引量:3
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作者 胡婷 钟亮 《临床和实验医学杂志》 2018年第6期595-598,共4页
目的观察口服补液盐治疗血管迷走性晕厥(VVS)的临床疗效,并评价其对不同血流动力学类型VVS患者的影响。方法采用前瞻性研究方法,选择2013年9月至2016年6月东莞东华医院收治的80例VVS患者作为研究对象,采用随机数字表法随机分为两组,对照... 目的观察口服补液盐治疗血管迷走性晕厥(VVS)的临床疗效,并评价其对不同血流动力学类型VVS患者的影响。方法采用前瞻性研究方法,选择2013年9月至2016年6月东莞东华医院收治的80例VVS患者作为研究对象,采用随机数字表法随机分为两组,对照组(n=25)给予健康教育,观察组(n=55)在健康教育基础上给予口服补液盐治疗。比较两组患者直立倾斜试验(HUTT)转阴率、平卧血压和心率;另外根据不同血流动力学类型,观察组又分为血管抑制型(n=29)和混合型及心脏抑制型(n=26),观察口服补液盐对不同血流动力学类型VVS患者的影响;对照组和观察组治疗6个月后若无晕厥或晕厥先兆发展则停止治疗并随访12个月,观察晕厥或晕厥先兆复发率。结果治疗6个月后,观察组HUTT转阴率(70.9%)明显高于对照组(24.0%),差异有显著性(P<0.05);两组患者治疗前后的平卧血压和心率差异均无统计学意义(P>0.05),但两组患者治疗后的HUTT过程中倾斜开始与基础平卧位血压和心率差值的变化差异均有统计学意义(P<0.05);随访12个月,观察组的晕厥或晕厥先兆复发率(43.6%)明显低于低于对照组(68.0%),差异有显著性(P<0.05);血管抑制型HUTT转阴率(79.3%)、随访晕厥或晕厥先兆复发率(34.5%)略优于混合型及心脏抑制型(61.5%,53.8%),但差异均无统计学意义(P>0.05)。结论口服补液盐治疗VVS的疗效要优于单纯健康教育;口服补液盐适用于不同血流动力学类型VVS患者,疗效相似。 展开更多
关键词 血管迷走性晕厥 口服补液盐 临床疗效 血流动力学类型
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临床常见循环衰竭的血流动力学类型和处理原则 被引量:1
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作者 张育才 陈容欣 《中国小儿急救医学》 CAS 2012年第3期220-223,共4页
通常按血流动力学变化将循环衰竭分为“暖休克”和“冷休克”,严重循环衰竭患儿往往这两种情况并存。小儿循环功能衰竭特点是血流动力学变化迅速,常伴有血管床的张力改变、血容量相对或绝对不足、心肌抑制、血流分布异常和细胞代谢障... 通常按血流动力学变化将循环衰竭分为“暖休克”和“冷休克”,严重循环衰竭患儿往往这两种情况并存。小儿循环功能衰竭特点是血流动力学变化迅速,常伴有血管床的张力改变、血容量相对或绝对不足、心肌抑制、血流分布异常和细胞代谢障碍等。主要治疗手段是通过容量复苏、正性肌力药物和血管活性药物的应用,提高心输出量和组织灌注,实现SVO2〉70%和心脏指数达到3.3—6.0L/(min·Tn2),以保障血管内容量和心脏负荷的最佳化调节。 展开更多
关键词 血流动力学类型 循环衰竭 儿童
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子痫前期患者血流动力学类型及在妊娠不良结局预测中的应用 被引量:2
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作者 郝丽英 王琪 李阳 《中华临床医师杂志(电子版)》 CAS 2010年第8期150-152,共3页
目的探讨子痫前期患者血流动力学类型及其在妊娠不良结局预测中的应用。方法回顾性分析2007年1月至2008年12月在首都医科大学附属北京妇产医院分娩的子痫前期孕妇605例,分为水肿组430例和无水肿组175例。根据应用MP妊娠高血压疾病监测... 目的探讨子痫前期患者血流动力学类型及其在妊娠不良结局预测中的应用。方法回顾性分析2007年1月至2008年12月在首都医科大学附属北京妇产医院分娩的子痫前期孕妇605例,分为水肿组430例和无水肿组175例。根据应用MP妊娠高血压疾病监测仪的检测结果进行血流动力学分型,统计各型在子痫前期中的比例和胎儿生长受限(FGR)、早产、低出生体重儿及围产儿死亡的发生率。结果 (1)子痫前期患者的血流动力学类型多表现为低排高阻型,占67.8%,水肿组低排高阻型发生率高于无水肿组,差异有统计学意义(P<0.05);(2)低排高阻型FGR、早产和低出生体重儿发生率均高于正常阻或低阻型及正常排或高排型,低排高阻型低出生体重儿发生率高于高排高阻型,低排高阻型FGR发生率高于低排低阻型,差异均有统计学意义(P<0.05);(3)高排高阻型早产和低出生体重儿发生率高于正常阻或低阻型,低排低阻型早产和低出生体重儿发生率高于正常排或高排型,差异均有统计学意义(P<0.05)。结论临床上应对血流动力学为低排高阻型孕妇进行重点监测,做到在亚临床阶段给予干预;此型预后较差,应及早干预,以改善其预后。 展开更多
关键词 妊娠结局 子痫前期 血流动力学类型
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慢性便秘的粪流动力学类型
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作者 昌耘冰 《国际外科学杂志》 北大核心 1991年第5期315-315,共1页
直肠和直肠颈(肛管)的疾病可导致排便功能紊乱。最常见的是便秘。慢性特发性便秘病因复杂,可能与直肠内调节排便的肌群不协调有关。
关键词 动力学类型 慢性特发性便秘 排便 最大流量 直肠内 慢性便秘 腹内压 压力曲线 特征性 功能紊乱
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超声对壳聚糖降解作用的研究 被引量:8
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作者 刘石生 丘泰球 +1 位作者 蔡纯 韩松涛 《广东工业大学学报》 CAS 2002年第3期83-86,共4页
本实验对超声波对壳聚糖降解作用的主要机制进行了探讨,证明空化作用是其主要作用机制;对其降解反应类型的分析表明,反应属于高斯降解类型;红外吸收和X射线衍射结果表明,降解时1-4苷键发生断裂。
关键词 超声波 壳聚糖 降解 动力学类型 甲壳素
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Simulation study on non-linear effects of initial melt temperatures on microstructures during solidification process of liquid Mg_7Zn_3 alloy 被引量:3
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作者 刘让苏 梁永超 +5 位作者 刘海蓉 郑乃超 莫云飞 侯兆阳 周丽丽 彭平 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第4期1052-1060,共9页
The non-linear effects of different initial melt temperatures on the microstructure evolution during the solidification process of liquid Mg7Zn3 alloys were investigated by molecular dynamics simulation, The microstru... The non-linear effects of different initial melt temperatures on the microstructure evolution during the solidification process of liquid Mg7Zn3 alloys were investigated by molecular dynamics simulation, The microstructure transformation mechanisms were analyzed by several methods. The system was found to be solidified into amorphous structures from different initial melt temperatures at the same cooling rate of 1×10^12 K/s, and the 1551 bond-type and the icosahedron basic cluster (12 0 12 0 ) played a key role in the microstructure transition. Different initial melt temperatures had significant effects on the final microstructures. These effects only can be clearly observed below the glass transition temperature Tg; and these effects are non-linearly related to the initial melt temperatures, and fluctuated in a certain range. However, the changes of the average atomic energy of the systems are still linearly related with the initial melt temperatures, namely, the higher the initial melt temperature is, the more stable the amorphous structure is and the stronger the glass forming ability will be. 展开更多
关键词 liquid Mg-Zn alloy initial melt temperature microstructure evolution molecular dynamics simulation cluster-typeindex method
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APPLICATION OF ROUGH SET THEORY TO MAINTENANCE LEVEL DECISION-MAKING FOR AERO-ENGINE MODULES BASED ON INCREMENTAL KNOWLEDGE LEARNING 被引量:3
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作者 陆晓华 左洪福 蔡景 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期366-373,共8页
The maintenance of an aero-engine usually includes three levels,and the maintenance cost and period greatly differ depending on the different maintenance levels.To plan a reasonable maintenance budget program, airline... The maintenance of an aero-engine usually includes three levels,and the maintenance cost and period greatly differ depending on the different maintenance levels.To plan a reasonable maintenance budget program, airlines would like to predict the maintenance level of aero-engine before repairing in terms of performance parameters,which can provide more economic benefits.The maintenance level decision rules are mined using the historical maintenance data of a civil aero-engine based on the rough set theory,and a variety of possible models of updating rules produced by newly increased maintenance cases added to the historical maintenance case database are investigated by the means of incremental machine learning.The continuously updated rules can provide reasonable guidance suggestions for engineers and decision support for planning a maintenance budget program before repairing. The results of an example show that the decision rules become more typical and robust,and they are more accurate to predict the maintenance level of an aero-engine module as the maintenance data increase,which illustrates the feasibility of the represented method. 展开更多
关键词 civil aero-engine maintenance level decision-making rough set incremental learning
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GAS PATH ELECTROSTATIC SENSOR MONITORING AND COMPARISON EXPERIMENT ON TURBOJET ENGINE 被引量:2
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作者 付宇 左洪福 +2 位作者 刘鹏鹏 蔡景 刘君强 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期361-365,共5页
A monitoring and comparison experiment with two types of sensors on a turbojet engine is carried out. Compared with a probe-typed sensor,which is designed successfully before,signals are collected to verify the validi... A monitoring and comparison experiment with two types of sensors on a turbojet engine is carried out. Compared with a probe-typed sensor,which is designed successfully before,signals are collected to verify the validity and better feasibility of the circular sensor.According to the signals monitored over 131h,the typical signals of 125—129 phases are analyzed.The results show that the unusual exhaust particles are carbon depositions from fuel spray nozzle.Therefore,with the electrostatic sensor,early warning can be provided for initial fault condition, as well as real-time reference for the condition-based maintenance. 展开更多
关键词 turbojet enginel gas monitoring electrostatic sensor carbon fault condition-based maintenance
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OPTIMIZED STRAPDOWN CONING CORRECTION ALGORITHM 被引量:2
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作者 黄磊 刘建业 曾庆化 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期343-349,共7页
Traditional coning algorithms are based on the first-order coning correction reference model.Usually they reduce the algorithm error of coning axis(z)by increasing the sample numbers in one iteration interval.But the ... Traditional coning algorithms are based on the first-order coning correction reference model.Usually they reduce the algorithm error of coning axis(z)by increasing the sample numbers in one iteration interval.But the increase of sample numbers requires the faster output rates of sensors.Therefore,the algorithms are often limited in practical use.Moreover,the noncommutivity error of rotation usually exists on all three axes and the increase of sample numbers has little positive effect on reducing the algorithm errors of orthogonal axes(x,y).Considering the errors of orthogonal axes cannot be neglected in the high-precision applications,a coning algorithm with an additional second-order coning correction term is developed to further improve the performance of coning algorithm.Compared with the traditional algorithms,the new second-order coning algorithm can effectively reduce the algorithm error without increasing the sample numbers.Theoretical analyses validate that in a coning environment with low frequency,the new algorithm has the better performance than the traditional time-series and frequency-series coning algorithms,while in a maneuver environment the new algorithm has the same order accuracy as the traditional time-series and frequency-series algorithms.Finally,the practical feasibility of the new coning algorithm is demonstrated by digital simulations and practical turntable tests. 展开更多
关键词 SINS rotation vector coning algorithm coning correctness
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DYNAMIC RESPONSE ANALYSIS OF CARRIER-BASED AIRCRAFT DURING LANDING 被引量:1
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作者 段萍萍 聂宏 魏小辉 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期306-316,共11页
In view of the complexity of landing on the deck of aircraft carrier,a systematic model,composed of sixdegree-of-freedom mathematic model of carrier-based aircraft,four-degree-of-freedom model of landing gears and six... In view of the complexity of landing on the deck of aircraft carrier,a systematic model,composed of sixdegree-of-freedom mathematic model of carrier-based aircraft,four-degree-of-freedom model of landing gears and six-degree-of-freedom mathematic model of carrier,is established in the Matlab-Simulink environment,with damping function of landing gears and dynamic characteristics of tires being considered.The model,where the carrier movement is introduced,is applicable for any abnormal landing condition.Moreover,the equations of motion and relevant parameter are also derived.The dynamic response of aircraft is calculated via the variable step-size RungeKuta algorithm.The effect of attitude angles of aircraft and carrier movement during the process of landing is illustrated in details.The analytical results can provide some reference for carrier-based aircraft design and maintenance. 展开更多
关键词 carrier-based aircraft LANDING carrier movement dynamic response landing gear
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V-BLAST BASED LDPC-CODED RELAY COOPERATION 被引量:1
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作者 唐蕾 仰枫帆 +1 位作者 张顺外 范立行 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期374-382,共9页
An efficient LDPC-coded multi-relay cooperation architecture is proposed based on virtual vertical Bell Labs layered space-time (V-BLAST) processing for uplink communication, where minimum-mean-square-error (MMSE)... An efficient LDPC-coded multi-relay cooperation architecture is proposed based on virtual vertical Bell Labs layered space-time (V-BLAST) processing for uplink communication, where minimum-mean-square-error (MMSE) and BP-based joint iterative decoding based on the introduced muhi-layer Tanner graph are effectively de- signed to detect and decode the corrupted received sequence at the destination. By introducing V-BLAST transmis- sion to the coded multi-relay cooperation, relays send their streams of symbols simultaneously, which increases the data rate and significantly reduces the transmission delay. The theoretical analysis and numerical results show that the new LDPC coded cooperation scheme outperforms the coded non-cooperation under the same code rate, and it also achieves a good trade-off among the performance, signal delay, and the encoding complexity associated with the number of relays. The performance gain can be credited to the proposed V-BLAST processing architecture and BP-based joint iterative decoding by the introduced multi-layer Tanner graph at a receiver-side. 展开更多
关键词 coded multi-relay cooperation vertical Bell Labs layered space-time processing (V-BLAST) mini-mum-mean-square-error detector~ joint decoding multi-layer Tanner graph
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SIMULATION OF COMPOSITE NON-LINEAR MECHANICAL BEHAVIOR OF CMCS BY FEM-BASED MULTI-SCALE APPROACH 被引量:1
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作者 高希光 王绍华 宋迎东 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期328-334,共7页
The non-linear behavior of continuous fiber reinforced C/SiC ceramic matrix composites(CMCs)under tensile loading is modeled by three-dimensional representative volume element(RVE)models of the composite. The theoreti... The non-linear behavior of continuous fiber reinforced C/SiC ceramic matrix composites(CMCs)under tensile loading is modeled by three-dimensional representative volume element(RVE)models of the composite. The theoretical background of the multi-scale approach solved by the finite element method(FEM)is recalled firstly.Then the geometric characters of three kinds of damage mechanisms,i.e.micro matrix cracks,fiber/matrix interface debonding and fiber fracture,are studied.Three kinds of RVE are proposed to model the microstructure of C/SiC with above damage mechanisms respectively.The matrix cracking is modeled by critical matrix strain energy(CMSE)principle while a maximum shear stress criterion is used for modeling fiber/matrix interface debonding. The behavior of fiber fracture is modeled by the famous Weibull statistic theory.A numerical example of continuous fiber reinforced C/SiC composite under tensile loading is performed.The results show that the stress/strain curve predicted by the developed model agrees with experimental data. 展开更多
关键词 ceramic-matrix composites (CMCs) mechanical properties microstrueture computational modelingmicro-mechanics
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FAST FEATURE RANKING AND ITS APPLICATION TO FACE RECOGNITION 被引量:1
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作者 潘锋 王建东 +2 位作者 宋广为 牛奔 顾其威 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期389-396,共8页
A fast feature ranking algorithm for classification in the presence of high dimensionahty and small sample size is proposed. The basic idea is that the important features force the data points of the same class to mai... A fast feature ranking algorithm for classification in the presence of high dimensionahty and small sample size is proposed. The basic idea is that the important features force the data points of the same class to maintain their intrinsic neighbor relations, whereas neighboring points of different classes are no longer to stick to one an- other. Applying this assumption, an optimization problem weighting each feature is derived. The algorithm does not involve the dense matrix eigen-decomposition which can be computationally expensive in time. Extensive exper- iments are conducted to validate the significance of selected features using the Yale, Extended YaleB and PIE data- sets. The thorough evaluation shows that, using one-nearest neighbor classifier, the recognition rates using 100-- 500 leading features selected by the algorithm distinctively outperform those with features selected by the baseline feature selection algorithms, while using support vector machine features selected by the algorithm show less prominent improvement. Moreover, the experiments demonstrate that the proposed algorithm is particularly effi- cient for multi-class face recognition problem. 展开更多
关键词 feature selection feature ranking manifold learning Laplacian matrix
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NOVEL RADAR SIGNAL SORTING METHOD BASED ON GEOMETRIC COVERING 被引量:1
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作者 万建 国强 宋文明 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期383-388,共6页
With the increase of complexity of electromagnetic environment and continuous appearance of advanced system radars,signals received by radar reconnaissance receivers become even more intensive and complex.Therefore,tr... With the increase of complexity of electromagnetic environment and continuous appearance of advanced system radars,signals received by radar reconnaissance receivers become even more intensive and complex.Therefore,traditional radar sorting methods based on neural network algorithms and support vector machine(SVM) cannot process them effectively.Aiming at solving this problem,a novel radar signal sorting method based on the cloud model theory and the geometric covering algorithm is proposed.By applying the geometric covering algorithm to divide input signals into different covering domains based on their distribution characteristics,the method can overcome a typical problem that it is easy for traditional sorting algorithms to fall into the local extrema due to the use of complex nonlinear equation to describe input signals.The method uses the cloud model to describe the membership degree between signals to be sorted and their covering domains,thus it avoids the disadvantage that traditional sorting methods based on hard clustering cannot deinterleave the signal samples with overlapped parameters. Experimental results show that the presented method can effectively sort advanced system radar signals with overlapped parameters in complex electromagnetic environment. 展开更多
关键词 radar emitter signal sorting geometric covering
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Entanglement Dynamics of Two-Qubit System in Different Types of Noisy Channels 被引量:1
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作者 SHAN Chuan-Jia LIU Ji-Bing CHENG Wei-Wen LIU Tang-Kun HUANG Yan-Xia LI Hong 《Communications in Theoretical Physics》 SCIE CAS CSCD 2009年第6期1013-1016,共4页
In this paper, we study entanglement dynamics of a two-qubit extended Werner-like state locally, interacting with independent noisy channels, i.e., amplitude damping, phase damping, and depolarizing channels. We show ... In this paper, we study entanglement dynamics of a two-qubit extended Werner-like state locally, interacting with independent noisy channels, i.e., amplitude damping, phase damping, and depolarizing channels. We show that the purity of initial entangled state has direct impacts on the entanglement robustness in each noisy channel. That is, if the initial entangled state is prepared in mixed instead of pure form, the state may exhibit entanglement sudden death (ESD) and/or be decreased for the critical probability at which the entanglement disappear. 展开更多
关键词 entanglement dynamics entanglement sudden death PURITY
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Thymoquinone and Poloxin are slow-irreversible inhibitors to human Polo-like kinase 1 Polo-box domain 被引量:3
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作者 Yin Zhou Chen Jianhua Peter H. Rehse 《Journal of Medical Colleges of PLA(China)》 CAS 2010年第3期136-142,共7页
Objective: To provide a kinetic model(s) and reveal the mechanism of thymoquinone and Poloxin blocking an emerging anti-cancer target, human Polo-like kinase 1 (hPlkl) Polo-box domain (PBD). Methods: The bindi... Objective: To provide a kinetic model(s) and reveal the mechanism of thymoquinone and Poloxin blocking an emerging anti-cancer target, human Polo-like kinase 1 (hPlkl) Polo-box domain (PBD). Methods: The binding kinetics was determined by using a fluorescence polarization based assay. The putative mechanism was examined with a competition test. Results: Thymoquinone follows a one-step binding with an association rate constant (k1) of 6.635× 10^3 L.mol^-1 min^-1.Poloxin fit a two-step binding with a dissociation constant (Ki) of 118 μmol/L for the intermediate complex and its isomerization rate (k4) of 0.131 5 minJ to form an irreversible adduct. No significant dissociation was observed for either ligand up to 13 h. The inhibitors responded insignificantly to the presence of Michael donors as hPIkl-PBD competitors. Conclusion: Thymoquinone and Poloxin are slow-tight ligands to the hPlkl-PBD with kinetic models distinct from each other. Michael addition as the mechanism is excluded. 展开更多
关键词 Polo-like kinase Irreversible inhibitor KINETICS Fluorescence polarization
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HIGH CYCLE FATIGUE RELIABILITY ANALYSIS ON ROTOR HUB BASED ON APPROXIMATION TECHNIQUE
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作者 姜年朝 倪俊 +3 位作者 周光明 张逊 戴勇 张志清 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期335-342,共8页
A high cycle fatigue reliability analysis approach to helicopter rotor hub is proposed under working load spectrum. Automatic calculation for the approach is implemented through writing the calculating programs. In th... A high cycle fatigue reliability analysis approach to helicopter rotor hub is proposed under working load spectrum. Automatic calculation for the approach is implemented through writing the calculating programs. In the system, the modification of geometric model of rotor hub is controlled by several parameters, and finite element method and S-N curve method are then employed to solve the fatigue life by automatically assigned parameters. A database between assigned parameters and fatigue life is obtained via Latin Hypercube Sampling (LHS) on toler- ance zone of rotor hub. Different data-fitting technologies are used and compared to determine a highest-precision approximation for this database. The parameters are assumed to he independent of each other and follow normal distributions. Fatigue reliability is then computed by the Monte Carlo (MC) method and the mean-value first order second moment (MFOSM) method. Results show that the approach has high efficiency and precision, and is suit- able for engineering application. 展开更多
关键词 helicopters rotor hub PARAMETERIZATION high cycle fatigue RELIABILITY approximate model
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DAMAGE MECHANISM ANALYSIS OF 2D 1×1 BRAIDED COMPOSITES UNDER UNIDIRECTIONAL TENSION
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作者 张超 许希武 陈康 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2013年第4期317-327,共11页
Coupling with the periodical displacement boundary condition,a representative volume element(RVE) model is established to simulate the progressive damage behavior of 2D1×1 braided composites under unidirectional ... Coupling with the periodical displacement boundary condition,a representative volume element(RVE) model is established to simulate the progressive damage behavior of 2D1×1 braided composites under unidirectional tension by using the nonlinear finite element method.Tsai-Wu failure criterion with various damage modes and Mises criterion are considered for predicting damage initiation and progression of yarns and matrix.The anisotropic damage model for yarns and the isotropic damage model for matrix are used to simulate the microscopic damage propagation of 2D1×1braided composites.Murakami′s damage tensor is adopted to characterize each damage mode.In the simulation process,the damage mechanisms are revealed and the tensile strength of 2D1×1braided composites is predicted from the calculated average stress-average strain curve.Numerical results show good agreement with experimental data,thus the proposed simulation method is verified for damage mechanism analysis of 2D braided composites. 展开更多
关键词 2D braided composites representative volume element (RVE) failure modes damage mechanism strength prediction
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