AIM: The role of motor dysfunction in early diagnosis of low-grade hepatic encephalopathy remains uncertain. We performed a pilot study to comparatively investigate the kinematic characteristics of small and large rap...AIM: The role of motor dysfunction in early diagnosis of low-grade hepatic encephalopathy remains uncertain. We performed a pilot study to comparatively investigate the kinematic characteristics of small and large rapid alternating movements in patients with liver cirrhosis and low-grade hepatic encephalopathy.METHODS: A kinematic analysis of alternating handwriting (7.5 mm) and large drawing movements (DM, 175 mm) was performed in 30 patients with liver cirrhosis (no hepatic encephalopathy: n = 10; minimal hepatic encephalopathy: n = 9; grade I hepatic encephalopathy: n = 11; healthy controls: n = 12). The correlation between kinematic parameters, clinical neuro-psychiatric symptoms of cerebral dysfunction and the grade of encephalopathy was investigated.RESULTS: Both movement types, handwriting and drawing, were significantly slower in cirrhotic patients. In contrast to large DM, the deterioration of handwriting movements significantly correlated with the increase of symptoms of motor dysfunction and differentiated significantly within the group of cirrhosis patients corresponding to the degree of hepatic encephalopathy. CONCLUSION: The deterioration of fine motor control is an important symptom of low-grade hepatic encephalopathy. The kinematic analysis of handwriting allows the quantitative analysis of alterations of motor function and is a possible tool for diagnostics and monitoring of motor dysfunction in patients with low-grade hepatic encephalopathy.展开更多
The performance of the power assist, global optimization solved by dynamic programming （DP） method, Chery and Insight control strategies are analyzed using the mild parallel hybrid electric vehicle （PHEV） model ba...The performance of the power assist, global optimization solved by dynamic programming （DP） method, Chery and Insight control strategies are analyzed using the mild parallel hybrid electric vehicle （PHEV） model based on Insight structure. The influence of the four control strategies to the load power of the electric motor system used on parallel hybrid electric vehicle is studied. It is found that 80 percent of the motor load power points are under 1/5 of the electric peak power. The motor load power of the power assist control strategy is distributed in the widest range during generating operation, and the motor load power of the global optimization control strategy has the smallest one.展开更多
Objective To observe the effects on functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor treated with electroacupuncture. Methods Twenty-nine cases of functional gastrointestinal mo...Objective To observe the effects on functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor treated with electroacupuncture. Methods Twenty-nine cases of functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor were randomized into electroacupuncture group （19 cases） and control group （10 cases）. In electroacupuncture group, routine treatment after gastrointestinal operation and electroacupucture treatment were applied, Zusanli （足三里 ST 36）, Shangjuxu （上巨虚 ST 37）, Xiajuxu （下巨虚 ST 39） and Hegu （合谷 LI 4） were applied with electroacupuncture; in control group, the routine treatment after gastrointestinal operation was only applied. Anus exhaust, defecation, abdominal distension, stomachache, amount of gastrointestinal decompression drainage and changes of borborygmus were observed in two groups. Results Anus exhaust, defecation, abdominal distension, stomachache, amount of gastrointestinal decompression drainage and changes of borborygmus were relieved in two groups; and the effects of abdominal distension, anus exhaust, defecation, amount of gastrointestinal decompression drainage and borborygmus in electroacupuncture group were superior to those in control group （all P〈0.05）. Conclusion For the functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor, the theraputic effect of electroacupuncture combined with routine treatment after operation is better than the routine treatment after operation.展开更多
As an important life support treatment, mechanical ventilation is usually adopted in clinics. With the development of the res-piratory diagnostic and treatment technologies, air flow dynamics of mechanical ventilation...As an important life support treatment, mechanical ventilation is usually adopted in clinics. With the development of the res-piratory diagnostic and treatment technologies, air flow dynamics of mechanical ventilation is usually referenced in the evaluation of pulmonary status and assessment of respiratory therapy. In order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, in this paper, a new mathematical model of mechanical ventilation system was set up. Furthermore, a prototype mechanical ventilation system for an artificial simulating lung was designed and experimentally studied. Lastly, in order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, the air flow dynamics of the mechanical ventilation system was illustrated through simulation and experimental studies. The study can be helpful to the optimization of the mechanical ventilation system.展开更多
The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convi...The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.展开更多
In this paper, we present a diffusive predator prey system with Beddington-DeAngelis funetionM response, where the prey species can disperse between the two patches, and there is competition between the two predators....In this paper, we present a diffusive predator prey system with Beddington-DeAngelis funetionM response, where the prey species can disperse between the two patches, and there is competition between the two predators. Sufficient conditions for the permanence and extinction of system are established based on the upper and lower solution meth- ods and comparison theory of differential equation. Furthermore, the global asymptotic stability of positive solutions is obtained by constructing a suitable Lyapunov function. By using the continuation theorem in coincidence degree theory, we show the periodicity of positive solutions. Finally, we illustrate global asymptotic stability of the model by a simulation figure.展开更多
To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors ...To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors during the atherosclerotic progress, a comprehensive study combining long-term animal experiment and numerical solving was conducted in this paper. An experimentally induced hypercholesterolemic porcine model was developed and the chronic EECP intervention was subjected. Basic hemodynamic measurement was performed in vivo, as well as the arterial endothelial samples were extracted for physiological examination. Meanwhile, a numerical model was introduced to solve the complex hemodynamic factors such as WSS and OSI. The results show that EECP treatment resulted in significant increase of the instant levels of arterial WSS, blood pressure, and OSI. During EECP treatment, the instant OSI level of the common carotid arteries over cardiac cycles raised to a mean value of 8.58 ×10-2±2.13 ×10-2. Meanwhile, the chronic intervention of EECP treatment significantly reduced the atherosclerotic lesions in abdominal aortas and the endothelial cellular adherence. The present study suggests that the unique blood flow pattern induced by EECP treatment and the augmentation of WSS level in cardiac cycles may be the most important hemodynamic mechanism that contribute to its anti-atherogenesis effect. And as one of the indices that cause great concern in current hemodynamic study, OSI may not play a key role during the initiation of atherosclerosis.展开更多
In this paper, we investigate the dynamics of a diffusive predator prey model with Holling-II functional response and the additive Allee effect in prey. We show the local and global asymptotical stability of the posit...In this paper, we investigate the dynamics of a diffusive predator prey model with Holling-II functional response and the additive Allee effect in prey. We show the local and global asymptotical stability of the positive equilibrium, and give the conditions of the existence of the Hopf bifurcation. By carrying out global qualitative and bifurcation analysis, it is shown that the weak and strong Allee effects in prey can induce different dynamical behavior in the predator-prey model. Furthermore, we use some numerical simulations to illustrate the dynamics of the model. The results may be helpful for controlling and managing the predator-prey system.展开更多
文摘AIM: The role of motor dysfunction in early diagnosis of low-grade hepatic encephalopathy remains uncertain. We performed a pilot study to comparatively investigate the kinematic characteristics of small and large rapid alternating movements in patients with liver cirrhosis and low-grade hepatic encephalopathy.METHODS: A kinematic analysis of alternating handwriting (7.5 mm) and large drawing movements (DM, 175 mm) was performed in 30 patients with liver cirrhosis (no hepatic encephalopathy: n = 10; minimal hepatic encephalopathy: n = 9; grade I hepatic encephalopathy: n = 11; healthy controls: n = 12). The correlation between kinematic parameters, clinical neuro-psychiatric symptoms of cerebral dysfunction and the grade of encephalopathy was investigated.RESULTS: Both movement types, handwriting and drawing, were significantly slower in cirrhotic patients. In contrast to large DM, the deterioration of handwriting movements significantly correlated with the increase of symptoms of motor dysfunction and differentiated significantly within the group of cirrhosis patients corresponding to the degree of hepatic encephalopathy. CONCLUSION: The deterioration of fine motor control is an important symptom of low-grade hepatic encephalopathy. The kinematic analysis of handwriting allows the quantitative analysis of alterations of motor function and is a possible tool for diagnostics and monitoring of motor dysfunction in patients with low-grade hepatic encephalopathy.
文摘The performance of the power assist, global optimization solved by dynamic programming （DP） method, Chery and Insight control strategies are analyzed using the mild parallel hybrid electric vehicle （PHEV） model based on Insight structure. The influence of the four control strategies to the load power of the electric motor system used on parallel hybrid electric vehicle is studied. It is found that 80 percent of the motor load power points are under 1/5 of the electric peak power. The motor load power of the power assist control strategy is distributed in the widest range during generating operation, and the motor load power of the global optimization control strategy has the smallest one.
文摘Objective To observe the effects on functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor treated with electroacupuncture. Methods Twenty-nine cases of functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor were randomized into electroacupuncture group （19 cases） and control group （10 cases）. In electroacupuncture group, routine treatment after gastrointestinal operation and electroacupucture treatment were applied, Zusanli （足三里 ST 36）, Shangjuxu （上巨虚 ST 37）, Xiajuxu （下巨虚 ST 39） and Hegu （合谷 LI 4） were applied with electroacupuncture; in control group, the routine treatment after gastrointestinal operation was only applied. Anus exhaust, defecation, abdominal distension, stomachache, amount of gastrointestinal decompression drainage and changes of borborygmus were observed in two groups. Results Anus exhaust, defecation, abdominal distension, stomachache, amount of gastrointestinal decompression drainage and changes of borborygmus were relieved in two groups; and the effects of abdominal distension, anus exhaust, defecation, amount of gastrointestinal decompression drainage and borborygmus in electroacupuncture group were superior to those in control group （all P〈0.05）. Conclusion For the functional gastrointestinal motility disorder of postoperation of gastrointestinal tumor, the theraputic effect of electroacupuncture combined with routine treatment after operation is better than the routine treatment after operation.
基金supported by the National Natural Science Foundation of China(Grant No.51575020)
文摘As an important life support treatment, mechanical ventilation is usually adopted in clinics. With the development of the res-piratory diagnostic and treatment technologies, air flow dynamics of mechanical ventilation is usually referenced in the evaluation of pulmonary status and assessment of respiratory therapy. In order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, in this paper, a new mathematical model of mechanical ventilation system was set up. Furthermore, a prototype mechanical ventilation system for an artificial simulating lung was designed and experimentally studied. Lastly, in order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, the air flow dynamics of the mechanical ventilation system was illustrated through simulation and experimental studies. The study can be helpful to the optimization of the mechanical ventilation system.
基金supported by the National Basic Research Program of China (Grant Nos. 2011CB944401 and 2010CB945002)the National Natural Science Foundation of China(Grant Nos. 30825015 and 81130009)
文摘The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.
基金The authors are grateful to their classmates and teachers for comments and valuable suggestions. This work is supported by the National Natural Science Foundation of China （No. 70672103）.
文摘In this paper, we present a diffusive predator prey system with Beddington-DeAngelis funetionM response, where the prey species can disperse between the two patches, and there is competition between the two predators. Sufficient conditions for the permanence and extinction of system are established based on the upper and lower solution meth- ods and comparison theory of differential equation. Furthermore, the global asymptotic stability of positive solutions is obtained by constructing a suitable Lyapunov function. By using the continuation theorem in coincidence degree theory, we show the periodicity of positive solutions. Finally, we illustrate global asymptotic stability of the model by a simulation figure.
基金Key Clinical Project from the Ministry of Healthgrant number:25400+1 种基金National Natural Science Foundation of Chinagrant number:81170272
文摘To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors during the atherosclerotic progress, a comprehensive study combining long-term animal experiment and numerical solving was conducted in this paper. An experimentally induced hypercholesterolemic porcine model was developed and the chronic EECP intervention was subjected. Basic hemodynamic measurement was performed in vivo, as well as the arterial endothelial samples were extracted for physiological examination. Meanwhile, a numerical model was introduced to solve the complex hemodynamic factors such as WSS and OSI. The results show that EECP treatment resulted in significant increase of the instant levels of arterial WSS, blood pressure, and OSI. During EECP treatment, the instant OSI level of the common carotid arteries over cardiac cycles raised to a mean value of 8.58 ×10-2±2.13 ×10-2. Meanwhile, the chronic intervention of EECP treatment significantly reduced the atherosclerotic lesions in abdominal aortas and the endothelial cellular adherence. The present study suggests that the unique blood flow pattern induced by EECP treatment and the augmentation of WSS level in cardiac cycles may be the most important hemodynamic mechanism that contribute to its anti-atherogenesis effect. And as one of the indices that cause great concern in current hemodynamic study, OSI may not play a key role during the initiation of atherosclerosis.
文摘In this paper, we investigate the dynamics of a diffusive predator prey model with Holling-II functional response and the additive Allee effect in prey. We show the local and global asymptotical stability of the positive equilibrium, and give the conditions of the existence of the Hopf bifurcation. By carrying out global qualitative and bifurcation analysis, it is shown that the weak and strong Allee effects in prey can induce different dynamical behavior in the predator-prey model. Furthermore, we use some numerical simulations to illustrate the dynamics of the model. The results may be helpful for controlling and managing the predator-prey system.
