2020 is the final year of China’s 13th Five-Year Plan period and an intersection between the“two centennial goals.”It is also a vital year for drafting the 14th Five-year Plan and embarking on a new journey of soci...2020 is the final year of China’s 13th Five-Year Plan period and an intersection between the“two centennial goals.”It is also a vital year for drafting the 14th Five-year Plan and embarking on a new journey of socialist modernization.What socio-economic progress has China achieved during the 13th Five-Year Plan period and what are the opportunities,challenges and countermeasures for the 14th Five-Year Plan period?In May 2020,the China Economist conducted a questionnaire survey among economists.Results suggest that during the 13th Five-Year Plan period,China has achieved remarkable progress in the following areas:significant socio-economic development,deepening industry-ICT integration,and rapid growth of new economy;mass entrepreneurship and mass innovation,and enhanced R&D capabilities for cutting-edge technologies;green production and the abatement of air and water pollution;and poverty reduction.In the 14th Five-Year Plan period,opportunities co-exist with challenges for China’s socio-economic development,which brims with resiliency.Surveyed economists felt sanguine about China’s development outlook.Based on the results,surveyed economists believed that the Chinese government should focus on the following priorities during the 14th Five-Year Plan period:expediting industrial transition,strengthening the real economy,and exploring domestic consumption potentials;ramping up research in fundamental science,and accelerating the research of critical technologies;increasing equal access to basic public services;and promoting green development in all respects,including green consumption,production,distribution,innovation,and finance.展开更多
Epithelial–mesenchymal transition(EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration,and cancer ...Epithelial–mesenchymal transition(EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration,and cancer metastasis. A hallmark of EMT is the switch-like behavior during state transition, which is characteristic of phase transitions. Hence, detecting the tipping point just before mesenchymal state transition is critical for understanding molecular mechanism of EMT. Through dynamic network biomarkers(DNB) model, a DNB group with 37 genes was identified which can provide the early-warning signals of EMT. Particularly, we found that two DNB genes, i.e., SMAD7 and SERPINE1 promoted EMT by switching their regulatory network which was further validated by biological experiments. Survival analyses revealed that SMAD7 and SERPINE1 as DNB genes further acted as prognostic biomarkers for lung adenocarcinoma.展开更多
文摘2020 is the final year of China’s 13th Five-Year Plan period and an intersection between the“two centennial goals.”It is also a vital year for drafting the 14th Five-year Plan and embarking on a new journey of socialist modernization.What socio-economic progress has China achieved during the 13th Five-Year Plan period and what are the opportunities,challenges and countermeasures for the 14th Five-Year Plan period?In May 2020,the China Economist conducted a questionnaire survey among economists.Results suggest that during the 13th Five-Year Plan period,China has achieved remarkable progress in the following areas:significant socio-economic development,deepening industry-ICT integration,and rapid growth of new economy;mass entrepreneurship and mass innovation,and enhanced R&D capabilities for cutting-edge technologies;green production and the abatement of air and water pollution;and poverty reduction.In the 14th Five-Year Plan period,opportunities co-exist with challenges for China’s socio-economic development,which brims with resiliency.Surveyed economists felt sanguine about China’s development outlook.Based on the results,surveyed economists believed that the Chinese government should focus on the following priorities during the 14th Five-Year Plan period:expediting industrial transition,strengthening the real economy,and exploring domestic consumption potentials;ramping up research in fundamental science,and accelerating the research of critical technologies;increasing equal access to basic public services;and promoting green development in all respects,including green consumption,production,distribution,innovation,and finance.
基金supported by the National Key Research and Development Program of China (2017YFA0505500)the National Natural Science Foundation of China (31930022, 31771476, 61773196)+5 种基金Shanghai Municipal Science and Technology Major Project (2017SHZDZX01)Key Project of Zhangjiang National Innovation Demonstration Zone Special Development Fund (ZJ2018ZD-013)Ministry of Science and Technology Project (2017YFC0907505)Guangdong Provincial Key Laboratory Funds (2017B030301018, 2019B030301001)Shenzhen Research Funds (JCYJ20170307104535585, ZDSYS20140509142721429)Shenzhen Peacock Plan (KQTD2016053117035204)
文摘Epithelial–mesenchymal transition(EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration,and cancer metastasis. A hallmark of EMT is the switch-like behavior during state transition, which is characteristic of phase transitions. Hence, detecting the tipping point just before mesenchymal state transition is critical for understanding molecular mechanism of EMT. Through dynamic network biomarkers(DNB) model, a DNB group with 37 genes was identified which can provide the early-warning signals of EMT. Particularly, we found that two DNB genes, i.e., SMAD7 and SERPINE1 promoted EMT by switching their regulatory network which was further validated by biological experiments. Survival analyses revealed that SMAD7 and SERPINE1 as DNB genes further acted as prognostic biomarkers for lung adenocarcinoma.
