Most GPS positioning errors can be eliminated or removed by the differential technique or the modeling method,but the multipath effect is a special kind of system or gross error,so it is difficult to be simulated or e...Most GPS positioning errors can be eliminated or removed by the differential technique or the modeling method,but the multipath effect is a special kind of system or gross error,so it is difficult to be simulated or eliminated.In order to improve the accuracy of GPS positioning,the single-epoch pseudorange multipath effects at GPS station were calculated,and firstly modeled based on the spherical cap harmonic（SCH）,which is the function of satellite longitude and latitude with the robust method.The accuracy of the kinematic point positioning technique was improved by correcting pseudorange observations with the multipath effect calculated by the SCH model,especially in the elevation direction.The spherical cap harmonic can be used to model the pseudorange multipath effect.展开更多
Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations.Based on the reported down-regulation of RELN in schizophrenia patient...Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations.Based on the reported down-regulation of RELN in schizophrenia patients compared with normal subjects,we speculated that variants in the RELN promoter region may confer risk for schizophrenia.In this study,we investigated the associations of three SNPs in the promoter region of RELN with schizophrenia in a case-control sample from southwestern China（940 cases and 13 69 controls）.The results suggested that none of the SNPs showed significant associations in our sample,indicating the risk variants for schizophrenia in RELN may not be located in the promoter region.We also performed meta-analysis by combining our data with previously reported data on the Chinese population with a total sample size of 2 843 individuals,and the result remained nonsignificant.Collectively,our results suggested variants in the RELN promoter may not harbor risk SNPs associated with schizophrenia in the Chinese population.展开更多
基金Project (41374009) supported by the National Natural Science Foundation of ChinaProjects (TJES1101,TJES1203) supported by the Key Laboratory of Advanced Engineering Surveying of NASMG,China+1 种基金Project (ZR2013DM009) supported by the Shandong Natural Science Foundation of ChinaProject (201412001) supported by the Public Benefit Scientific Research Project of China
文摘Most GPS positioning errors can be eliminated or removed by the differential technique or the modeling method,but the multipath effect is a special kind of system or gross error,so it is difficult to be simulated or eliminated.In order to improve the accuracy of GPS positioning,the single-epoch pseudorange multipath effects at GPS station were calculated,and firstly modeled based on the spherical cap harmonic（SCH）,which is the function of satellite longitude and latitude with the robust method.The accuracy of the kinematic point positioning technique was improved by correcting pseudorange observations with the multipath effect calculated by the SCH model,especially in the elevation direction.The spherical cap harmonic can be used to model the pseudorange multipath effect.
文摘Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations.Based on the reported down-regulation of RELN in schizophrenia patients compared with normal subjects,we speculated that variants in the RELN promoter region may confer risk for schizophrenia.In this study,we investigated the associations of three SNPs in the promoter region of RELN with schizophrenia in a case-control sample from southwestern China（940 cases and 13 69 controls）.The results suggested that none of the SNPs showed significant associations in our sample,indicating the risk variants for schizophrenia in RELN may not be located in the promoter region.We also performed meta-analysis by combining our data with previously reported data on the Chinese population with a total sample size of 2 843 individuals,and the result remained nonsignificant.Collectively,our results suggested variants in the RELN promoter may not harbor risk SNPs associated with schizophrenia in the Chinese population.
