Background/aim: In patients with acute central retinal vein occlusion (CRVO), dynamic angiographymay reveal the presence of pulsatile flow (termed here pulsat ile venular outflow, PVO)-within first order veins (that i...Background/aim: In patients with acute central retinal vein occlusion (CRVO), dynamic angiographymay reveal the presence of pulsatile flow (termed here pulsat ile venular outflow, PVO)-within first order veins (that is, the large veins). The main goal of this study was to investigate the mechanism underlying PVO. Met hods: 10 patients with CRVO and PVO were included. Quantitative and qualitative analysis of venous flow on dynamic angiograms allowed the correlation, temporall y, of second and first order vein flow on the one hand, and venous flow and syst olic cycle on the other. Results: Analysis of the time-velocity curve showed th at (1) the onset of arterial systole preceded the onset of PVO by less than 0.08 seconds (n=5); (2) PVO onsetwas simultaneous to the time of onset of minimal fl ow (Vmin) in first order veins (n=10); (3) the time of onset of maximal flow (Vm ax) in first order veins occurred 0.20-0.44 seconds after the onset of PVO (n=6 ). Conclusions: During CRVO with severe reduction in blood flow, the presence of PVO is the result of the existence of a distinct haemodynamic regimen in first and second order veins. These data support the hypothesis that second order vein s flow is synchronous with the arterial flow, while the delayed peak flow in fir st order veins may reflect the consequences of the delayed IOP curve and/or of i ntermittent venous compression.展开更多
文摘Background/aim: In patients with acute central retinal vein occlusion (CRVO), dynamic angiographymay reveal the presence of pulsatile flow (termed here pulsat ile venular outflow, PVO)-within first order veins (that is, the large veins). The main goal of this study was to investigate the mechanism underlying PVO. Met hods: 10 patients with CRVO and PVO were included. Quantitative and qualitative analysis of venous flow on dynamic angiograms allowed the correlation, temporall y, of second and first order vein flow on the one hand, and venous flow and syst olic cycle on the other. Results: Analysis of the time-velocity curve showed th at (1) the onset of arterial systole preceded the onset of PVO by less than 0.08 seconds (n=5); (2) PVO onsetwas simultaneous to the time of onset of minimal fl ow (Vmin) in first order veins (n=10); (3) the time of onset of maximal flow (Vm ax) in first order veins occurred 0.20-0.44 seconds after the onset of PVO (n=6 ). Conclusions: During CRVO with severe reduction in blood flow, the presence of PVO is the result of the existence of a distinct haemodynamic regimen in first and second order veins. These data support the hypothesis that second order vein s flow is synchronous with the arterial flow, while the delayed peak flow in fir st order veins may reflect the consequences of the delayed IOP curve and/or of i ntermittent venous compression.
基金supported by grants from The National Natural Science Foundation of China(61605026,11474053,61471123,61771139,81601534,61705036)Natural Science Foundation of Guangdong Province(2015A030313639,2017A030313386)the College Students Innovation and Entrensurship Training Program of Guangdong Province(XJ2018039)~~