In order to examine the severity of reflux esophagitis and the methods of manometry and 24 hour ambulatory pHmonitoring, 100 gastroesophageal reflux disease (GERD) patients were examined. The results were compared wit...In order to examine the severity of reflux esophagitis and the methods of manometry and 24 hour ambulatory pHmonitoring, 100 gastroesophageal reflux disease (GERD) patients were examined. The results were compared with acontrol group which consisted of 30 healthy individuals. Endoscopy was performed, and esophageal mucosa biopsieswere taken in all patients. Esophageal manometry was recorded using a four tune water perfused system. The severi-ty of esophagitis, determined by both endoscopy and histology, was related to the amplitude of esophageal perista1ticwaves, in partictilar the cardioesophageal sphincter (CES) dysfunction (P < 0. 01), 24 hour reflux total score. Wehave concluded that the severity of reflux esophagitis is related to the duration of reflux, which in turn is associatedwith the impairment of esophageal body motility and CES dysfunction.展开更多
[目的]研究胃远端部分切除术后患者泌酸功能及其与黏膜病理改变和幽门螺杆菌(Hp)感染的相关性。[方法]采用24 h pH监测仪测定51例残胃患者空腹胃内pH值,根据24 h胃内平均pH值分为低泌酸组(pH≥3)和正常泌酸组(pH<3)。胃镜观察残胃黏...[目的]研究胃远端部分切除术后患者泌酸功能及其与黏膜病理改变和幽门螺杆菌(Hp)感染的相关性。[方法]采用24 h pH监测仪测定51例残胃患者空腹胃内pH值,根据24 h胃内平均pH值分为低泌酸组(pH≥3)和正常泌酸组(pH<3)。胃镜观察残胃黏膜以及Hp检测。[结果]低泌酸组患者35例,其中29例黏膜呈重度萎缩;正常泌酸组16例,其中4例呈重度黏膜炎症(P=0.006)。两组间Hp感染率无明显差异。62.7%的患者胃酸分泌减少,但却接受了抑酸药物治疗。[结论]24 h动态胃pH监测可有效评价残胃患者胃黏膜泌酸功能。残胃炎程度与黏膜泌酸功能有明显相关性。展开更多
文摘In order to examine the severity of reflux esophagitis and the methods of manometry and 24 hour ambulatory pHmonitoring, 100 gastroesophageal reflux disease (GERD) patients were examined. The results were compared with acontrol group which consisted of 30 healthy individuals. Endoscopy was performed, and esophageal mucosa biopsieswere taken in all patients. Esophageal manometry was recorded using a four tune water perfused system. The severi-ty of esophagitis, determined by both endoscopy and histology, was related to the amplitude of esophageal perista1ticwaves, in partictilar the cardioesophageal sphincter (CES) dysfunction (P < 0. 01), 24 hour reflux total score. Wehave concluded that the severity of reflux esophagitis is related to the duration of reflux, which in turn is associatedwith the impairment of esophageal body motility and CES dysfunction.
文摘[目的]研究胃远端部分切除术后患者泌酸功能及其与黏膜病理改变和幽门螺杆菌(Hp)感染的相关性。[方法]采用24 h pH监测仪测定51例残胃患者空腹胃内pH值,根据24 h胃内平均pH值分为低泌酸组(pH≥3)和正常泌酸组(pH<3)。胃镜观察残胃黏膜以及Hp检测。[结果]低泌酸组患者35例,其中29例黏膜呈重度萎缩;正常泌酸组16例,其中4例呈重度黏膜炎症(P=0.006)。两组间Hp感染率无明显差异。62.7%的患者胃酸分泌减少,但却接受了抑酸药物治疗。[结论]24 h动态胃pH监测可有效评价残胃患者胃黏膜泌酸功能。残胃炎程度与黏膜泌酸功能有明显相关性。
