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我国大豆生产波动动因分析——基于省际面板模型的实证研究 被引量:6
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作者 李维刚 张晓东 +1 位作者 宋继华 孙丹 《农业经济与管理》 CSSCI 北大核心 2023年第2期48-63,共16页
在我国大豆生产波动频繁的情况下,找出影响大豆单产、种植面积的影响因素是实现“提单产、稳面积”的首要举措。研究采用1999~2020年21个省份面板数据,在分析大豆单产、种植面积的变化趋势基础上,根据大豆单产增减趋势,把大豆产区划分... 在我国大豆生产波动频繁的情况下,找出影响大豆单产、种植面积的影响因素是实现“提单产、稳面积”的首要举措。研究采用1999~2020年21个省份面板数据,在分析大豆单产、种植面积的变化趋势基础上,根据大豆单产增减趋势,把大豆产区划分成增产区、减产区和波动区,采用改进的面板数据模型分别对三个产区的大豆单产和种植面积的影响因素进行实证分析。结果表明,机械化收割、产研结合、农药投入、小型拖拉机的投入是影响不同区域大豆单产的显著因素;机械化耕作是提升所有区域种植面积的显著因素,玉米种植面积、化肥投入、农药投入、灌溉条件、科研资金与人员投入、产研结合、机械化收割是影响不同区域大豆种植面积显著因素。根据分析,提出了相应政策建议。 展开更多
关键词 大豆生产 大豆单产 大豆种植面积
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曲面分型多方位斜向抽芯注塑模设计 被引量:15
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作者 简发萍 郑得庆 +1 位作者 陈小红 李厚佳 《塑料工业》 CAS CSCD 北大核心 2022年第1期94-98,共5页
针对滑块盖板曲面分型面,三维空间6方位斜向侧向抽芯的结构难点,提出了斜抽芯方向与主开模方向一致的减少斜抽芯数量的方法,成功将6方位斜向侧向抽芯简化为4方位斜向侧向抽芯。设计了T型块内侧斜向抽芯机构、斜导柱外侧斜向抽芯机构。... 针对滑块盖板曲面分型面,三维空间6方位斜向侧向抽芯的结构难点,提出了斜抽芯方向与主开模方向一致的减少斜抽芯数量的方法,成功将6方位斜向侧向抽芯简化为4方位斜向侧向抽芯。设计了T型块内侧斜向抽芯机构、斜导柱外侧斜向抽芯机构。为配合二次抽芯,模具采用动模一侧二次分型。为完成二次分型,设计了顺序定距分型机构和推出机构随行机构。经试模,该模具工作可靠,满足实际要求。 展开更多
关键词 曲面分型面方位 多方位斜向抽芯 T型块斜向抽芯 斜导柱斜向抽芯 一侧二次分型
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多向抽芯的三次分型注塑模具设计 被引量:4
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作者 尹甜甜 杨茜 李辉 《塑料科技》 CAS 北大核心 2022年第10期95-98,共4页
结合塑件具有多方位结构特征,设计了一副多向抽芯的三次分型注塑模具。针对塑件曲面分型面设计,通过减少与主开模方向不一致的抽芯数量,确定塑件存在3个不同方位抽芯的结构难点。针对结构难点,通过设计弯销+滑块的定模斜抽芯机构实现斜... 结合塑件具有多方位结构特征,设计了一副多向抽芯的三次分型注塑模具。针对塑件曲面分型面设计,通过减少与主开模方向不一致的抽芯数量,确定塑件存在3个不同方位抽芯的结构难点。针对结构难点,通过设计弯销+滑块的定模斜抽芯机构实现斜向通孔成型,设计弯销+滑块的动模内抽芯机构实现卡扣成型,设计斜抽镶件的动模斜抽芯机构实现凸起孔成型。为确保3种抽芯机构顺利脱模,模具结构采用三次分型设计,通过合理控制开模顺序实现塑件推出。为配合动模斜抽芯机构运动,模具结构采用动定模分型后,动模一侧再分型,并提出一种新的顶杆机械式动模分型机构。模具结构形式新颖,动作可靠,可为同类设计提供参考。 展开更多
关键词 多向抽芯 斜抽芯 内抽芯 斜抽芯 动模分型
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Water quality changing trends of the Miyun Reservoir 被引量:6
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作者 王建平 程声通 贾海峰 《Journal of Southeast University(English Edition)》 EI CAS 2005年第2期215-219,共5页
In order to simulate changes in the water quality of the Miyun Reservoir dueto continuous descent of surface water level, a 3-D ecological hydrodynamic model was developedthrough coupling the water quality analysis si... In order to simulate changes in the water quality of the Miyun Reservoir dueto continuous descent of surface water level, a 3-D ecological hydrodynamic model was developedthrough coupling the water quality analysis simulation program (WASP) with the environmental fluiddynamics code (EFDC). The model was then calibrated and verified. Four scenarios (S1, S21, S22 andS23) were simulated using the model. Results show that the water quality of the Miyun Reservoirunder conditions of low surface water level is apparently affected by different amounts of inflowand different total phosphorus (TP) loadings. The chlorophyll-a concentration might exceed 10 μg/Lin many areas of the Miyun Reservoir (This limitative value is seen as a critical value ofeutrophication) when large loadings of TP enter due to the amount of inflow increasing. Results ofscenario S23 indicate that control of TP loadings can decrease chlorophyll-a concentrationeffectively, and the water quality of the Miyun Reservoir will improve or retain its status quo. 展开更多
关键词 water quality model hydrodynamic model scenario analysis changing trends
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Application of the Sub-Model Method in the Engine Strength Analysis 被引量:9
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作者 邹文胜 左正兴 +1 位作者 冯慧华 廖日东 《Journal of Beijing Institute of Technology》 EI CAS 2001年第3期260-265,共6页
On the basis of introducing the fundamental theory and the basic analysis steps of the sub model method, the strength of the new engine complex assembly structure was analyzed according to the properties of the engin... On the basis of introducing the fundamental theory and the basic analysis steps of the sub model method, the strength of the new engine complex assembly structure was analyzed according to the properties of the engine structures, some of the key parts of the engine were analyzed with refined mesh by sub model method and the error of the FEM solution was estimated by the extrapolation method. The example showed that the sub model can not only analyze the comlex structures without the restriction of the software and hardware of the computers, but get the more precise analysis result also. This method is more suitable for the strength analysis of the complex assembly structure. 展开更多
关键词 sub model method ENGINE strength analysis FEM
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Analysis to the Driving Force Model and Driving Factor on the Utilized Changes of Cultivated Land in Gonghe County 被引量:14
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作者 俞文政 刘丹 +1 位作者 祁英香 史军 《Agricultural Science & Technology》 CAS 2009年第4期178-182,共5页
Using gradually regression analysis to establish the driving force model of utilized change of cultivated land in Gonghe County, and using path analysis, correlation analysis, partial correlation analysis and system d... Using gradually regression analysis to establish the driving force model of utilized change of cultivated land in Gonghe County, and using path analysis, correlation analysis, partial correlation analysis and system dynamics method to inspect the effect of driving changing on cultivated land change under different change situations. Driving factors, action mechanism and process of utilized change of cultivated land were analyzed from the county territory scale level. At last, some corresponding policies and measures were put forward. 展开更多
关键词 Gonghe County Utilized Change of cultivated land Driving force model Driving factors
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Numerical simulation of flow regions in red mud separation thickener's feedwell by analysis of residence-time distribution 被引量:4
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作者 周天 李茂 +3 位作者 李秋龙 雷波 周谦 周孑民 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第4期1117-1124,共8页
The residence-time distribution (RTD) and the compartment model were applied to characterizing the flow regions in red mud separation thickener’s feedwells. Combined with the experimental work, validated mathematic... The residence-time distribution (RTD) and the compartment model were applied to characterizing the flow regions in red mud separation thickener’s feedwells. Combined with the experimental work, validated mathematical model as well as three-dimensional computational fluid dynamics (CFD) model was established to analyze the flow regions of feedwells on an industrial scale. The concept of RTD, although a well-known method for the characterization of mixing behavior in conventional mixers and reactors, is still a novel measure for the characterization of mixing in feedwells. Numerical simulation results show that the inlet feed rate and the aspect ratio of feedwells are the most critical parameters which affect the RTD of feedwell. Further simulation experiments were then carried out. Under the optimal operation conditions, the volume fraction of dead zone can reduce by10.8% and an increasement of mixing flow volume fraction by 6.5% is also observed. There is an optimum feed inlet rate depending on the feedwell design. The CFD model in conjunction with the RTD analysis then can be used as an effective tool in the design, evaluation and optimization of thickener feedwell in the red mud separation. 展开更多
关键词 computational fluid dynamics residence-time distribution compartment model feedwell
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Studies on stand dynamic growth model for larch in Jilin in China 被引量:1
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作者 翁国庆 陈雪峰 《Journal of Forestry Research》 SCIE CAS CSCD 2004年第4期323-326,共4页
The stand growth and yield dynamic models for Larch in Jilin Province were developed based on the forest growth theories with the forest continuous inventory data. The results indicated that the developed models had h... The stand growth and yield dynamic models for Larch in Jilin Province were developed based on the forest growth theories with the forest continuous inventory data. The results indicated that the developed models had high precision, and they could be used for the updating data of inventory of planning and designing and optimal decision of forest management. 展开更多
关键词 Stand Dynamics Growth Prediction Model
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Adsorption Dynamics of Calyx Aroma onto Basic Tea in Scenting Process of Calyx-scented Tea 被引量:1
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作者 陈昌辉 《Agricultural Science & Technology》 CAS 2012年第9期2017-2020,共4页
[Objective] The paper was to study adsorption dynamics of calyx aroma onto basic tea in scenting process of calyx-scented tea, so as to increase aroma and quality of products. [Method] Adsorption experiment was carrie... [Objective] The paper was to study adsorption dynamics of calyx aroma onto basic tea in scenting process of calyx-scented tea, so as to increase aroma and quality of products. [Method] Adsorption experiment was carried out in a hermetic container, and the effect of calyx amount, contact time, moisture content of basic tea and temperature on the scenting process was studied. [Result] The optimal moisture and temperature for scenting process was 4% and 10 ℃, respectively. [Conclusion] The scenting process accorded pseudo-first-order kinetic model, and the adsorption dynamic data of total process could better fit pseudo-second-order kinetic model. 展开更多
关键词 TEA Odor and taste threshold KINETIC ADSORPTION Sensory panel Calyxcanthus
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Simulation study on non-linear effects of initial melt temperatures on microstructures during solidification process of liquid Mg_7Zn_3 alloy 被引量:3
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作者 刘让苏 梁永超 +5 位作者 刘海蓉 郑乃超 莫云飞 侯兆阳 周丽丽 彭平 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第4期1052-1060,共9页
The non-linear effects of different initial melt temperatures on the microstructure evolution during the solidification process of liquid Mg7Zn3 alloys were investigated by molecular dynamics simulation, The microstru... The non-linear effects of different initial melt temperatures on the microstructure evolution during the solidification process of liquid Mg7Zn3 alloys were investigated by molecular dynamics simulation, The microstructure transformation mechanisms were analyzed by several methods. The system was found to be solidified into amorphous structures from different initial melt temperatures at the same cooling rate of 1×10^12 K/s, and the 1551 bond-type and the icosahedron basic cluster (12 0 12 0 ) played a key role in the microstructure transition. Different initial melt temperatures had significant effects on the final microstructures. These effects only can be clearly observed below the glass transition temperature Tg; and these effects are non-linearly related to the initial melt temperatures, and fluctuated in a certain range. However, the changes of the average atomic energy of the systems are still linearly related with the initial melt temperatures, namely, the higher the initial melt temperature is, the more stable the amorphous structure is and the stronger the glass forming ability will be. 展开更多
关键词 liquid Mg-Zn alloy initial melt temperature microstructure evolution molecular dynamics simulation cluster-typeindex method
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Bayesian analysis for mixed-effects model defined by stochastic differential equations
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作者 言方荣 张萍 +1 位作者 陆涛 林金官 《Journal of Southeast University(English Edition)》 EI CAS 2014年第1期122-127,共6页
The nonlinear mixed-effects model with stochastic differential equations (SDEs) is used to model the population pharmacokinetic (PPK) data that are extended from ordinary differential equations (ODEs) by adding ... The nonlinear mixed-effects model with stochastic differential equations (SDEs) is used to model the population pharmacokinetic (PPK) data that are extended from ordinary differential equations (ODEs) by adding a stochastic term to the state equation. Compared with the ODEs, the SDEs can model correlated residuals which are ubiquitous in actual pharmacokinetic problems. The Bayesian estimation is provided for nonlinear mixed-effects models based on stochastic differential equations. Combining the Gibbs and the Metropolis-Hastings algorithms, the population and individual parameter values are given through the parameter posterior predictive distributions. The analysis and simulation results show that the performance of the Bayesian estimation for mixed-effects SDEs model and analysis of population pharmacokinetic data is reliable. The results suggest that the proposed method is feasible for population pharmacokinetic data. 展开更多
关键词 population pharmacokinetics mixed-effectsmodels stochastic differential equations Bayesian analysis
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Modeling, Simulation of a Simulated Moving Bed for Separation of Phosphatidylcholine from Soybean Phospholipids 被引量:5
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作者 吕裕斌 危凤 +2 位作者 沈波 任其龙 吴平东 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第2期171-177,共7页
A rate model, which considers axial dispersion, external mass transfer, intraparticle diffusion and nonlinear isotherms, and ports periodic switching is adopted to simulate the simulated moving bed (SMB) process. Th... A rate model, which considers axial dispersion, external mass transfer, intraparticle diffusion and nonlinear isotherms, and ports periodic switching is adopted to simulate the simulated moving bed (SMB) process. The effects of flow rate in Sections 2 and 3 and switching time on the operating performance parameters: purity, recovery, productivity and dcsorbent consumption are studied. A simulation approach is applied to simulate the operation and performance of the SMB. The model predicts the performance of the transient and cyclic steady state behavior to a reasonably good extent, and provides guidance operation condition of the SMB process. 展开更多
关键词 simulated moving bed MODELING SIMULATION soybean phosphatidylcholine
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Finite difference method for dynamic response analysis of anchorage system 被引量:5
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作者 言志信 段建 +3 位作者 江平 刘子振 赵红亮 黄文贵 《Journal of Central South University》 SCIE EI CAS 2014年第3期1098-1106,共9页
Based on some assumptions, the dynamic analysis model of anchorage system is established. The dynamic governing equation is expressed as finite difference format and programmed by using MATLAB language. Compared with ... Based on some assumptions, the dynamic analysis model of anchorage system is established. The dynamic governing equation is expressed as finite difference format and programmed by using MATLAB language. Compared with theoretical method, the finite difference method has been verified to be feasible by a case study. It is found that under seismic loading, the dynamic response of anchorage system is synchronously fluctuated with the seismic vibration. The change of displacement amplitude of material points is slight, and comparatively speaking, the displacement amplitude of the outside point is a little larger than that of the inside point, which shows amplification effect of surface. While the axial force amplitude transforms considerably from the inside to the outside. It increases first and reaches the peak value in the intersection between the anchoring section and free section, then decreases slowly in the free section. When considering damping effect of anchorage system, the finite difference method can reflect the time attenuation characteristic better, and the calculating result would be safer and more reasonable than the dynamic steady-state theoretical method. What is more, the finite difference method can be applied to the dynamic response analysis of harmonic and seismic random vibration for all kinds of anchor, and hence has a broad application prospect. 展开更多
关键词 anchorage system dynamic response finite difference method attenuation characteristic
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Experimental study on operative methods of pancreaticojejunostomy with reference to anastomotic patency and postoperative pancreatic exocrine function 被引量:9
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作者 Ming-Dong Bai Liang-Qun Rong +6 位作者 Lian-Chen Wang Hai Xu Rui-Fang Fan Pei Wang Xiao-Peng Chen Liu-Bin Shi Shu-You Peng 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第3期441-447,共7页
AIM:To assess the patency of pancreaticoenterostomy and pancreatic exocrine function after three surgical methods. METHODS: A pig model of pancreatic ductal dilation was made by ligating the main pancreatic duct. Afte... AIM:To assess the patency of pancreaticoenterostomy and pancreatic exocrine function after three surgical methods. METHODS: A pig model of pancreatic ductal dilation was made by ligating the main pancreatic duct. After 4 wk ligation, a total of 36 piglets were divided randomly into four groups. The piglets in the control group underwent laparotomy only; the others were treated by three anastomoses: (1) end-to-end pancreaticojejunostomy invagination (EEPJ); (2) end-to-side duct-to- mucosa sutured anastomosis (ESPJ); or (3) binding pancreaticojejunostomy (BPJ). Anastomotic patency was assessed after 8 wk by body weight gain, intrapancreatic ductal pressure, pancreatic exocrine function secretin test, pancreatography, and macroscopic and histologic features of the anastomotic site. RESULTS: The EEPJ group had significantly slower weight gain than the ESPJ and BPJ groups on postoperative weeks 6 and 8 (P < 0.05). The animals in both the ESPJ and BPJ groups had a similar body weight gain.Intrapancreatic ductal pressure was similar in ESPJ and BPJ. However, pressure in EEPJ was significantly higher than that in ESPJ and BPJ (P < 0.05). All three functional parameters, the secretory volume, the flow rate of pancreatic juice, and bicarbonate concentration, were significantly higher in ESPJ and BPJ as compared to EEPJ (P < 0.05). However, the three parameters were similar in ESPJ and BPJ. Pancreatography performed after EEPJ revealed dilation and meandering of the main pancreatic duct, and the anastomotic site exhibited a variable degree of occlusion, and even blockage. Pancreatography of ESPJ and BPJ, however, showed normal ductal patency. Histopathology showed that the intestinal mucosa had fused with that of the pancreatic duct, with a gradual and continuous change from one to the other. For EEPJ, the portion of the pancreatic stump protruding into the jejunal lumen was largely replaced by cicatricial fibrous tissue. CONCLUSION: A mucosa-to-mucosa pancreatico- jejunostomy is the best choice for anastomotic patency when compared with EEPJ. BPJ can effectively maintain anastomotic patency and preserve pancreatic exocrine function as well as ESPJ. 展开更多
关键词 PANCREATICOJEJUNOSTOMY Animal model anastomotic patency Pancreatic exocrine function HISTOPATHOLOGY Pancreatography
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Insights into restrictive cardiomyopathy from clinical and animal studies 被引量:3
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作者 Pierre-Yves Jean-Charles Yue-Jin Li Chang-Long Nan Xu-Pei Huang 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2011年第3期168-183,共16页
Cardiomyopathies are diseases that primarily affect the myocardium, leading to serious cardiac dysfunction and heart failure. Out of the three major categories of cardiomyopathies (hypertrophic, dilated and restrict... Cardiomyopathies are diseases that primarily affect the myocardium, leading to serious cardiac dysfunction and heart failure. Out of the three major categories of cardiomyopathies (hypertrophic, dilated and restrictive), restrictive cardiomyopathy (RCM) is less common and also the least studied. However, the prognosis for RCM is poor as some patients dying in their childhood. The molecular mechanisms behind the disease development and progression are not very clear and the treatment of RCM is very difficult and often ineffective. In this article, we reviewed the recent progress in RCM research from the clinical studies and the translational studies done on diseased transgenic animal models. This will help for a better understanding of the mechanisms underlying the etiology and development of RCM and for the design of better treatments for the disease. 展开更多
关键词 ETIOLOGY myocardial gene mutation restrictive cardiomyopathy transgenic mice
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FEM modeling for 3D dynamic analysis of deep-ocean mining pipeline and its experimental verification 被引量:5
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作者 王刚 刘少军 李力 《Journal of Central South University of Technology》 EI 2007年第6期808-813,共6页
3D dynamic analysis models of 1000 m deep-ocean mining pipeline, including steel lift pipe, pump, buffer and flexible hose, were established by finite element method (FEM). The coupling effect of steel lift pipe and f... 3D dynamic analysis models of 1000 m deep-ocean mining pipeline, including steel lift pipe, pump, buffer and flexible hose, were established by finite element method (FEM). The coupling effect of steel lift pipe and flexible hose, and main external loads of pipeline were considered in the models, such as gravity, buoyancy, hydrodynamic forces, internal and external fluid pressures, concentrated suspension buoyancy on the flexible hose, torsional moment and axial force induced by pump working. Some relevant FEM models and solution techniques were developed, according to various 3D transient behaviors of integrated deep-ocean mining pipeline, including towing motions of track-keeping operation and launch process of pipeline. Meanwhile, an experimental verification system in towing water tank that had similar characteristics of designed mining pipeline was developed to verify the accuracy of the FEM models and dynamic simulation. The experiment results show that the experimental records and simulation results of stress of pipe are coincided. Based on the further simulations of 1 000 m deep-ocean mining pipeline, the simulation results show that, to form configuration of a saddle shape, the total concentrated suspension buoyancy of flexible hose should be 95%?105% of the gravity of flexible hose in water, the first suspension point occupies 1/3 of the total buoyancy, and the second suspension point occupies 2/3 of the total buoyancy. When towing velocity of mining system is less than 0.5 m/s, the towing track of buffer is coincided with the setting route of ship on the whole and the configuration of flexible hose is also kept well. 展开更多
关键词 deep-ocean mining pipeline modeling dynamic analysis finite element method
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Simulation of Screening Process Based on MATLAB/Simulink 被引量:4
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作者 YANG Ying-jie DENG Hui-yong LI Xia 《Journal of China University of Mining and Technology》 EI 2006年第3期330-332,337,共4页
Screening is an important process in mineral industry. In this paper, a study has been made to simulate the screening process based on a high-performance MATLAB/Simulink software, with an example of simulating the sie... Screening is an important process in mineral industry. In this paper, a study has been made to simulate the screening process based on a high-performance MATLAB/Simulink software, with an example of simulating the sieving process of a vibrating screen. A simulation model of the sieving process with a vibrating screen (SMSPVS) was proposed, using correlative mathematical models and Simulink blocks. The results show that the simulation data was very close to the actual data, The minimum errors of size distribution of oversize and undersize are 0.65% and 0.20%, resoectivelv. The sieving orocess can be accurately simulated by the SMSPVS. 展开更多
关键词 SIMULATION SIMULINK mathematical model SCREENING vibrating screen
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Modeling of dynamic recrystallization volume fraction evolution for AlCu4SiMg alloy and its application in FEM 被引量:10
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作者 Guo-zheng QUAN Rui-ju SHI +3 位作者 Jiang ZHAO Qiao LIU Wei XIONG Hui-min QIU 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2019年第6期1138-1151,共14页
To improve the understanding of coupling effect between dynamic recrystallization(DRX)behaviors and flow behaviors of as-cast AlCu4 SiMg, a finite element(FE) simulation equipped with the models of DRX evolution was i... To improve the understanding of coupling effect between dynamic recrystallization(DRX)behaviors and flow behaviors of as-cast AlCu4 SiMg, a finite element(FE) simulation equipped with the models of DRX evolution was implemented. A series of isothermal compression tests were performed primarily on a Gleeble-3500 thermo-mechanical simulator in a temperature range of 648-748 K and a strain rate range of 0.01-10 s-1.According to the measured true stress-strain data,the strain hardening rate curves(dσ/dε versus σ) were plotted to identify the critical strains for DRX initiation(εc). By further derivation of the related material constants, the DRX volume fraction equation and the strain for 50% DRX(ε0.5) equation were solved. Accordingly, the aforementioned DRX equations were implanted into the FE model to conduct a series of simulations for the isothermal compression tests. The results show that during the evolution of DRX volume fraction at a fixed strain rate, the strain required for the same amount of DRX volume fraction increases with decreasing temperature. In contrast, at a fixed temperature, it increases with increasing strain rate. Ultimately, the DRX kinetics model of AlCu4 SiMg alloy and the consequence of the FE analysis were validated by microstructure observations. 展开更多
关键词 AlCu4SiMg alloy DRX kinetics model DRX volume fraction flow behavior
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Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats 被引量:8
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作者 Ying-Jie Sun Wei-Min Chen +2 位作者 Tie-Zheng Zhang Hui-Juan Cao Jin Zhou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第38期5868-5875,共8页
AIM: To investigate the tight junction protein expressions of intestinal mucosa in an experimental model of cardiopulmonary bypass (CPB) in rats. METHODS: Thirty anesthetized rats were randomly divided into two gr... AIM: To investigate the tight junction protein expressions of intestinal mucosa in an experimental model of cardiopulmonary bypass (CPB) in rats. METHODS: Thirty anesthetized rats were randomly divided into two groups: Group S (n = 10) served as sham operation and group C (n = 20) served as CPB which underwent CPB for 1 h. Expression of occludin and zonula occludens-1 (ZO-1) were determined by Western blotting and immunotochemistry, respectively. Plasma levels of diamine oxidase (DAO) and d-lactate were determined using an enzymatic spectrophotometry. RESULTS: Immunohistochemical localization of occludin and ZO-1 showed disruption of the tight junctions in enterocytes lining villi at the end of CPB and 2 h after CPB. The intensities of the occludin and ZO-i at the end of CPB were lower than those of control group (76.4% ± 22.5% vs 96.5% ± 28.5% and 62.4% ± 10.1% vs 85.5% ±25.6%, P 〈 0.05) and were further lower at 2 h after CPB (50.5% ± 10.5% and 45.3% ± 9.5%, P 〈 0.05). Plasma d-lactate and DAO levels increased significantly (8.688 ± 0.704 vs 5.745 ± 0.364 and 0.898 ± 0.062 vs 0.562 ± 0.035, P 〈 0.05) at the end of CPB compared with control group and were significantly higher at 2 h after CPB than those at the end of CPB (9.377 ± 0.769 and 1.038 ± 0.252, P 〈 0.05). There were significant negative correlations between occludin or ZO-1 expression and DAO (r^2 = 0.5629,r^2 = 0.5424, P 〈 0.05) or d-lactate levels (r^2 = 0.6512,r^2 = 0.7073, P 〈 0.05) both at the end of CPB and 2 h after CPB. CONCLUSION: CPB markedly down-regulates the expression of occludin and ZO-1 proteins in intestinal mucosa of rats. The close correlation between expression of tight junctions (TJs) and plasma levels of DAO or d-lactate supports the hypothesis that intestinal permeability increases during and after CPB because of decreases in the expressions of TJs. 展开更多
关键词 Cardiopulmonary bypass OCCLUDIN ZO-1 Tight junction Diamine oxidase D-LACTATE
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Joint application of feature extraction based on EMD-AR strategy and multi-class classifier based on LS-SVM in EMG motion classification 被引量:5
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作者 YAN Zhi-guo WANG Zhi-zhong REN Xiao-mei 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2007年第8期1246-1255,共10页
This paper presents an effective and efficient combination of feature extraction and multi-class classifier for motion classification by analyzing the surface electromyografic(sEMG) signals. In contrast to the existin... This paper presents an effective and efficient combination of feature extraction and multi-class classifier for motion classification by analyzing the surface electromyografic(sEMG) signals. In contrast to the existing methods,considering the non-stationary and nonlinear characteristics of EMG signals,to get the more separable feature set,we introduce the empirical mode decomposition(EMD) to decompose the original EMG signals into several intrinsic mode functions(IMFs) and then compute the coefficients of autoregressive models of each IMF to form the feature set. Based on the least squares support vector machines(LS-SVMs) ,the multi-class classifier is designed and constructed to classify various motions. The results of contrastive experiments showed that the accuracy of motion recognition is improved with the described classification scheme. Furthermore,compared with other classifiers using different features,the excellent performance indicated the potential of the SVM techniques embedding the EMD-AR kernel in motion classification. 展开更多
关键词 Electromyografic signal Empirical mode decomposition (EMD) Auto-regression model Wavelet packet transform Least squares support vector machines (LS-SVM) Neural network
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