喇萨杏油田表外储层动用机制分析

作为喇萨杏油田稳产潜力的重要组成部分———表外储层 ,在注水开发中动用程度一直是人们普遍关心的问题。在油水井测试及密闭取心检查井资料统计分析基础上 ,研究了注水开发过程中表外储层的动用机制 ,取得了非实体连通是导致表外储层难采的地质因素 ;层间干扰是导致表外储层难采的动力因素 ,表外储层动用状况取决于基质与压裂裂缝间能量交换的能力 ;压力下降导致裂缝渗透性下降影响了表外储层的渗流等认识。进而认为在目前井网开采条件下表外储层能否起到预期的稳产接替作用是个值得进一步深入研究的问题。

Application of clutch to clutch gear shift technology for a new automatic transmission

For the purpose of engineering development for a new 8-step speed automatic transmission,a simplified dynamic model for this gearbox was established and key parameters which affected the shift quality were analyzed.Aiming at four different shift types,the ideal characteristics of shift clutch and engine control were set up.By using torque estimation method,PI slip control algorithm and engine coordinated control principle,the control model and transmission controller were well developed for three shift phases which included rapid-fill phase,torque phase and inertia phase.The testing environment on the rig and prototype vehicle level was built and the testing results obtained in ultimate condition could verify the accuracy and feasibility of this shift control strategy.The peak jerk during shift process was controlled within ±2 g/s where the smooth gearshift was obtained.The development proposal and algorithm have a high value for engineering application.

Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress

AIM;Oxidative stress participates in the cell carcinogenesis by inducing DNA mutations.Our aim was to assess whether ascorbic acid,an antioxidant,could have a role in preventing ROS(Reactive Oxygen Species)generation in experimental gastric carcinoma in a rat model. METHODS:Experimental gastric cancer was induced in twelve Wistar male rats(weighting 250-350 g)by profound duodeno-gastric reflux throught split gastrojenunostomy.The rats were allocated to the following groups:Group Ⅰ(n=6) was the control;Group Ⅱ(n=6)which was mantained with daily intake of tape water with Vitamin C(30 mg/Kg).After 6 or 12 months,samples of gastric tumor or non tumor mucosa were taken from the anastomosis of both groups. Oxidative stress was measured by superoxide quantification through lucigenin-amplified chemiluminescence base and by staining with Nitrobluetetrazolium.The histopathologic confirmation of adenocarcinoma was made by eosin- hemathoxilin method. RESULTS:The intestinal type of gastric adenocarcinoma was microscopically identified in all animals of group Ⅰ whereas only 3 rats of group Ⅱ showed an adenocarcinoma without macroscopic evidence of them.The cancers were located in the anastomosis in all cases.Basal luminescence from tumor gastric tissue generated 38.4±6.8 count per minute/mg/×10~6(mean±SD)and 14.9±4.0 count per minute/mg/×10~6,respectively,in group Ⅰ and Ⅱ animals(P <0.05).The Nitrobluetetrazolium method showed intense staining in tumor tissues but not in non neoplasic mucosa. CONCLUSION:Experimental gastric tumors seem to produce more reactive oxygen species than non neoplasic gastric tissue.The reduction of oxidative stress and gastric tumor incidence in rats were induced by the intake of ascorbic acid.Therefore,it may have a role in the prevention of gastric carcinoma. Oliveira CPMS Kassab P Lopasso FP Souza HP Janiszewski M Laurindo FRM Iriya K Laudanna AA.Protective effect of ascorbic acid in experimental gastric cancer:reduction of oxidative stress.World J Gastroenterol 2003;9(3):446-448 http://www.wjgnet.com/1007-9327/9/446.htm

Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity

Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Enhancing brain activity, such as cortical stimulation that is found to be effective in relieving symptoms of these disorders, may reduce such hyperexcitability through homeostatic plasticity mechanism. Here we review current evidence of homeostatic plasticity in the mechanism of acquired epilepsy, neuropathic pain, and tinnitus and the effects and mechanism of cortical stimulation. Establishing a role of homeostatic plasticity in these disorders may provide a theoretical basis on their pathogenesis as well as guide the development and application of therapeutic approaches through electrically or pharmacologically stimulating brain activity for treating these disorders.

ROLE OF TRANSFORMING GROWTH FACTOR β(TGF-β)IN REPAIRING OF BONE DEFECTS

TGF-β is a multifunctional cytokine that regulates many aspects of cellular function, including periosteal mesenchymal cell proliferation, differentiation. This experiment is to study its effects on bone defect repair. A rabbit radial bone defect model was used to evaluate the effect of TGF-β, which was extracted and purified from bovine blood platelets, on the healing of a large segmental osteoperiosteal defect. A 1. 5-centimeter segmental defect was created in the mid-upper part of the radial shaft of adult rabbits. The defect was filled with implant containing TGF-β that consisted of carrier and bovine TGF-β. Limbs served as controls received carrier alone. The defectswere examined radiographically and histologically at 4, 8,12 , 16 and 20 weeks after implantation. The results showed that in TGF-β implant group . the defect areas at 12 weeks post operation were bridged by uniform new bone and the cut ends of cortex could not be seen;while in control group, the defects remained clear. Only a small amount of new bone formed as a cap on the cut bone ends. In the experimental group, new lamellar and woven bone formed in continuity with the cut ends of the cortex. An early medullar canal appears to be forming and contained normal-appearancing marrow elements; while the control group displayed entirely fibrous tissue within the defect site. Remnants of the cancellous bone carrier were observed in the control specimen. These data demonstrate that exogenous TGF-β initiate osteogenesis and stimulate the bone defects repair in animal model.

LAND USE/COVER CHANGE AND DRIVING FORCES IN SOUTHERN LIAONING PROVINCE SINCE 1950S

Land use/cover change (LUCC) is a key aspect of global environment change, and in a sense indicates the influence of human activities on natural environment. Regional case study is the core of LUCC research. Taking the southern Liaoning Province, a coastal area facing the Bohai Sea and the Huanghai Sea, as an example, supported by ARCVIEW and ARC/INFO, this paper reconstructed LUCC patterns in three periods of 1954, 1976 and 2000, and analyzed their spatial-temporal changes from 1954 to 2000. On the base of these, it also studied the LUCC’s driving mechanism. The results show that the land transformation mainly occurs among cultivated land, forestland and urban and industrial land. Industrialization and urbanization in rural area are the major driving forces for cultivated land change, and the extension of the built-up area in cities is mainly the result of economic development and tertiary industry development, etc., which is at expense of cultivated land.

Dynamic-static coupling analysis on rockburst mechanism in jointed rock mass

A numerical code called RFPA-Dynamics was used to study the rockburst mechanism under dynamic load based on coupled static-dynamic analysis.The results show that dynamic disturbance has a very distinct triggering effect on rockburst.Under the dynamic load,rockburst is motivated by tensile stress formed by the overlapping of dynamic waves in the form of instantaneous open and cutting through of cracks in weak planes and pre-damaged areas.Meanwhile,the orientation of joint sets has an obvious leading effect on rockburst locations.Finally,a higher initial static stress state before dynamic loading can cause more pre-damaged area,thus leading to a larger rockburst scope.

Computational Study on Interaction Between Swimming Fish and Drifting Vortices Behind the Cylinder

To predict the flow evolution of fish swimming problems,a flow solver based on the immersed boundary lattice Boltzmann method is developed.A flexible iterative algorithm based on the framework of implicit boundary force correction is used to save the computational cost and memory,and the momentum forcing is described by a simple direct force formula without complicated integral calculation when the velocity correction at the boundary node is determined.With the presented flow solver,the hydrodynamic interaction between the fish-induced dynamic stall vortices and the incoming vortices in unsteady flow is analyzed.Numerical simulation results unveil the mechanism of fish exploiting vortices to enhance their own hydrodynamic performances.The superior swimming performances originate from the relative movement between the“merged vortex”and the locomotion of the fishtail,which is controlled by the phase difference.Formation conditions of the“merged vortex”become the key factor for fish to exploit vortices to improve their swimming performance.We further discuss the effect of the principal components of locomotion.From the results,we conclude that lateral translation plays a crucial role in propulsion while body undulation in tandem with rotation and head motion reduce the locomotor cost.

EXPRESSION OF TISSUE－TYPE PLASMINOGENACTIVATOR IN SMOOTH MUSCLE CELLS OF INJUREDILIAC ARTERIES IN RABBITS

In this experiment, expression of tissue-type plasminogen activator (t-PA) in smooth muscle cells (SMCs) was measured at different intervals after the arterial injury. In the normal iliac arteries, only low levels of t-PA activity were estimated. t-PA activity in extracts of the iliac arteries increased significantlyat the 4th day after the injury, equivalent to the process that SMCs migrated from the media to the intima,and the t-PA activity was then decreased approximately to the normal level at the 7th day. Coexistent to the above data, results from in situ hybridization showed that the expression of t-PA mRNA in the intima as well as media increased also significantly at the 4th day after the arterial injury, and at the 7th day, tPA mRNA was detected only in those SMCs locating closely adjacent to the internal elastic lamina. These results suggest that t-PA might play an important role in SMC migration following endothelial injury, andantagonism of t-PA expression and/or activity within the vessel wall might be helpful in intervening the de velopment of restenosis following angioplasty.

STUDY ON INHIBITION OF PANCREATIC EXOCRINE SECRETION BY SOMATOSTATIN IN RATS

We used a potent and specific monoclonal antibody to somatostatin to test the physiologic inhibitory role of the tetradecapeptide somatostatin on pancreatic secretion.Somatostatin immunoneutralization increased both the total amylase and volume of pancreatic secretion.Cholecystokinin-A receptor antagonism abolished the stimulatory effect of somatostatin immunoneutralization.We conclude that somatostatin tonically inhibits pancreatic secretion in fasted rats via inhibition of the release or action of cholecystokinin.Furthermore,the source of these peptides is likely islet delta cells and intrapancreatic neurons,respectively.

Fluid structure interaction for circulation valve of hydraulic shock absorber

Based on the working principle and the damping characteristic of hydraulic shock absorber, a fluid structure interaction method was presented, which was used to analyze the microcosmic and high-frequency processing mechanism of fluid structure interaction between circulation valve and liquid of hydraulic shock absorber. The fluid mesh distortion was controlled by the CEL language, and the fluid struc^tre interaction mathematical model was established. The finite element model was established by ANSYS CFX software and was analyzed by dynamic mesh technique. The local sensitive computational area was meshed by prismatic grid, which could reduce the negative volume problem during the simulation. The circulation valve and liquid of hydraulic shock absorber were simulated and analyzed under the condition of sinusoidal inlet velocity loads. Flow characteristic and dynamics characteristic were obtained. The pressure distribution and the displacement of circulation value were obtained, and the acceleration curve of circulation valve was simulated and analyzed. The conformity of the final simulation results with the experimental datum indicates that this method is accurate and reliable to analyze the dynamics characteristic between circulation valve and liquid of hydraulic shock absorber, which can provide a theoretical foundation for optimizing hydraulic shock absorber in the future.

Decentralized Mobile SNS Architecture and Its Personal Information Management Mechanism

Mobile SNS popular topics of mobile is one of the most Internet. In order to fulfill the user demand for self-maintained independent social network and ensure the privacy of their personal information and resources, the paper proposes system architecture of decentralized mobile SNS.In the temporary scenarios, the system makes use of the existent specification of FOAF （Friend- of-a-Friend） to describe users＇ personal information and act as a certificate to be identified by SNS sites. Ticket-based Access Authorization System （TAAS） is provided to grant permission to acquire resources on personal portal. Meanwhile, the mechanism and algorithm are devised for user profile complete deletion when users are going to quit the service for the temporary scenarios.

CHANGES OF NITRIC OXIDE AND PROTECTIVE EFFECTS OF NITRIC OXIDE INHIBITORS IN NEWBORN RATS WITH SEPSIS

In a newborn rat model of sepsis, the changes of nitric oxide and the protective effects of methylene blue orland dexamethason were investigated. The results revealed that plasma nitric oxide levels were elevated at 6 h and peaked at 12 h after bacterial challenge. The treatment with methylene or/and dexamethasone was found to blunt hypoglycemia and hyperlacticemia, to reduce the occurrence rate of loss of response to pain, and to prolong the survival time. Moreover, therapy by dexamethasone was shown to decrease the 24 h mortality. The results suggested that nitric oxide play an important role during the course of fatal P. aeruginosa sepsis, but it is clear that the clinical value of nitric oxide and its inhibitors need to be further studied.

Application of direct torque control to electric screw presses for speeding up torque response and reducing starting current

Fast response and stable torque output are crucial to the performance of electric screw presses. This paper describes the design of a direct torque control （DTC） system for speeding up torque response and reducing the starting current of electric screw presses and its application to the J58K series of numerical control electric screw presses with a dual-motor drive. The DTC drive system encompasses speed control, torque reference control, and switching frequency control. Comparison of the DTC dual-AC induction motor drive with corresponding AC servo motor drive showed that for the J58K-315 electric screw press, the DTC drive system attains a higher maximum speed （786 r/min） within a shorter time （1.13 s） during a 250 nun stroke and undergoes smaller rise in temperature （42.0 ℃） in the motor after running for 2 h at a 12 min-1 strike frequency than the AC servo motor drive does （751 r/min within 1.19 s, and 50.6 ℃ rise）. Moreover, the DTC AC induction motor drive, with no need for a tachometer or position encoder to feed back the speed or position of the motor shaft, enjoys increased reliability in a strong-shock work environment.

A numerical error analysis method and its application on a 4RRR parallel kinematic machine

To guarantee the accuracy of error analysis and evaluate the manufacturing tolerance s influence,anumerical error analysis method for parallel kinematic machines (PKMs) is presented in this paper.Quasi-Newton method and genetic algorithm are introduced for the forward kinematic solution.Based onthe inverse and forward kinematic solutions,the end-effector s error calculation procedure is developed.To solve the accuracy problem caused by the length and angular parameters' different units,a normalizationmethod is proposed based on the manufacturing tolerance.Comparison between the error analysis resultscalculated by the traditional method and the numerical method for a 4RRR PKM shows that,this numericalerror analysis method is more accurate,simpler,and can evaluate the machine s real error basedon the manufacturing tolerance.

Performance Evaluation of Spark Ignited Engine Fueled with Gasoline-Ethanol-Methanol Blends

In this paper, experimental investigations are presented to assess the performance variations in a single cylinder spark ignited engine when run with three different gasoline-alcohol blends： （88% gasoline-12% methanol, 88% gasoline-12% ethanol and 88% gasoline-6% methanol-6% ethanol）. Additional tests are carried out with the basic gasoline fuel for comparison analysis and performance assessment. Engine performance is investigated under a variety of engine operating conditions. The results are presented in the domain of engine speed. In particular, the brake power of the engine is shown to be slightly increased. The brake thermal efficiency showed an increase compared with the basic gasoline engine. Similarly, it is shown that brake specific fuel consumption is enhanced compared with basic gasoline engine. The exhaust gas temperature showed a decrease compared with gasoline fuel which is preferable to reduce emissions. The alcohol additives are strongly recommended to enhance performance, increasing the mileage and reducing the emissions.

Shock Wave Smearing by Passive Control

Normal shock wave, terminating a local supersonic area on an airfoil, limits its performance and becomes a source of high speed impulsive noise. It is proposed to use passive control to disintegrate the shock wave. Details of the flow structure obtained by this method are studied numerically. A new boundary condition has been developed and the results of its application are verified against experiments in a nozzle flow. The method of shock wave disintegration has been confirmed and detailed analysis of the flow details is presented. The substitution of a shock wave by a gradual compression changes completely the source of the high speed impulsive noise and bears potential of its reduction.

Effect of electrolyzed oxidizing water and hydrocolloid occlusive dressings on excised burn-wounds in rats

Objective: To study the efficacy of electrolyzed oxidizing water ( EOW ) and hydrocolloid occlusive dressings in the acceleration of epithelialization in excised burn-wounds in rats.Methods: Each of the anesthetized Sprague-Dawley rats (n = 28) was subjected to a third-degree burn that covered approximately 10% of the total body surface area. Rats were assigned into four groups: Group Ⅰ ( no irrigation), Group Ⅱ (irrigation with physiologic saline), Group Ⅲ ( irrigation with EOW ) and Group Ⅳ ( hydrocolloid occlusive dressing after EOW irrigation). Wounds were observed macroscopically until complete epithelialization was present, then the epithelialized wounds were examined microscopically. Results: Healing of the burn wounds was the fastest in Group Ⅳ treated with hydrocolloid occlusive dressing together with EOW. Although extensive regenerative epidermis was seen in each Group, the proliferations of lymphocytes and macrophages associated with dense collagen deposition were more extensive in Group Ⅱ, Ⅲ and IV than in Group Ⅰ. These findings were particularly evident in Group Ⅲ and Ⅳ.Conclusions: Wound Healing may be accelerated by applying a hydrocolloid occlusive dressing on burn surfaces after they are cleaned with EOW.

Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits

Objective: To investigate the effect of recombinant human basic fibroblast growth factor ( rhbFGF) on angiogenesis during mandible fracture healing in rabbit.Methods: Fifty adult white rabbits were used for animal model and randomly divided into a control group (25 rabbits) and an experimental group (25 rabbits). The membranous complex of rhbFGF and bovine type I collagen was prepared and implanted into the rabbit mandible fracture site under periosteum. The animals were sacrificed on 7, 14, 28, 56 and 84 days respectively after operation and the whole mandibles were harvested. The expression of factor Vm related antigen (F8-RA) in callus was examined with immimohistochemical staining.Results: The amounts of microvascular formation in calluses in the rhbFGF-treating group on days 7, 14, 28 and 56 were more than those of the control group (P < 0.01).Conclusions: The results indicated that rhbFGF could stimulate microvascular formation during mandible fracture healing in rabbits.

Application of piezoelectric fiber composite actuator to aircraft wing for aerodynamic performance improvement

The application of actuator made of piezoelectric material,particularly the advanced piezoelectric fiber composite due to the rapid development of smart materials and structures and active control technology in aviation and aerospace industry,to aircraft for performance enhancements such as flight control,aerodynamic force optimization,structure weight reduction,and overall aircraft design represents a new challenge to researches.It is considered as one of the key technologies for developing future flight vehicle.An approach with virtual control surface instead of conventional control surface to control aerodynamic force distribution and flight performance by use of piezoelectric fiber composite actuators distributed on wing surface is presented here.Particularly,the design and implementation of increasing lift force,providing roll maneuver,decreasing induced drag and wing root moment in different flight environments by the same structure control platform are studied.The control effect and sensitivity are examined quantitatively.Generally speaking,better control effect can be obtained by making better use of aeroelastic character to enlarge the actuation strain produced by piezoelectric material.