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调肝导浊汤调节ApoE^(-/-)小鼠ADMA的分泌量干预主动脉血流速度及峰压的实验研究
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作者 索艳荣 曾文赟 +5 位作者 高青 王一婧 卢斌 李虎虎 范英昌 郭茂娟 《辽宁中医杂志》 CAS 北大核心 2016年第2期394-397,I0002,共5页
目的:观察调肝导浊方干预后Apo E-/-小鼠血清中e NOS、ADMA含量的变化,以及其对主动脉血流速度和峰压的影响,探讨调肝导浊方抗动脉粥样硬化的机制是否与上述因素有关。方法:将Apo E-/-小鼠随机分成模型组和调肝导浊组,每日给予高脂饮食,... 目的:观察调肝导浊方干预后Apo E-/-小鼠血清中e NOS、ADMA含量的变化,以及其对主动脉血流速度和峰压的影响,探讨调肝导浊方抗动脉粥样硬化的机制是否与上述因素有关。方法:将Apo E-/-小鼠随机分成模型组和调肝导浊组,每日给予高脂饮食,C57BL/6L小鼠作为对照组给予普通饮食,经不同方法干预12周后,HE观察各组小鼠主动脉病理变化;VEVO2100小动物超声检测各组小鼠主动脉血流速度及峰压的变化;ELISA法检测血清中e NOS及ADMA的含量变化。结果:HE结果显示对照组主动脉结构完整,未见斑块形成;模型组主动脉组织结构紊乱,内膜明显增厚,斑块形成;调肝导浊组主动脉结构相对完整,内膜轻度增厚。小动物超声结果显示,模型组与对照组相比,血流速度减慢,血管峰压降低,具有统计学差异(P<0.05);相较于模型组,调肝导浊组血流速度增快,血管峰压升高,差异具有显著性(P<0.05)。ELISA结果显示,与对照组相比,模型组e NOS和ADMA含量增高,具有显著性差异(P<0.05);调肝导浊组相较于模型组,ADMA含量降低,差异具有统计学意义(P<0.05),而e NOS含量未见明显变化(P>0.05)。结论:调肝导浊汤抗动脉粥样硬化作用可能与其调节ADMA的含量变化,干预主动脉血流速度与峰压有关。 展开更多
关键词 调肝导浊汤 动脉粥样硬化 ADMA 血流速度 动脉峰压
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Wind tunnel testing of wind pressures on a large gymnasium roof
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作者 傅继阳 吴玖荣 梁枢果 《Journal of Central South University》 SCIE EI CAS 2011年第2期521-529,共9页
A wind tunnel test was conducted for a large steel gymnasium structure. Simultaneous pressure measurements were made on its entire ellipsoidal roof in a simulated suburban boundary layer flow field. Special attention ... A wind tunnel test was conducted for a large steel gymnasium structure. Simultaneous pressure measurements were made on its entire ellipsoidal roof in a simulated suburban boundary layer flow field. Special attention is paid to the charaeteristics of fluctuating wind pressures in different zones on the roof. Some selected results are presented: 1) correlations between fluctuating wind pressures on both roof surfaces, 2) eigenvalues and eigenvectors of covariance matrices of the fluctuating wind pressures, 3) probability distributions of the fluctuating wind pressures, and 4) statistical characteristics of peak factor. Furthermore, the applicability of the quasi-steady approach is discussed in detail. Based on the results, an empirical formula for estimating the minimum pressure coefficients, using a peak factor approach, is presented. Comparison of the minimum pressure coefficients determined by the proposed formula and those obtained from the wind tunnel tests is made to examine the applicability and accuracy of the proposed formula. 展开更多
关键词 long-span roof wind pressure wind tunnel test gymnasium roof
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