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青年人血清ApoA-1/ApoB-100水平的调查
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作者 刘斌哲 李维红 曹海霞 《河北医药》 CAS 2002年第12期996-996,共1页
关键词 青年人 血清 ApoA-1/ApoB-100 调查 动脉粥样变化
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Androgen actions on endothelium functions and cardiovascular diseases 被引量:3
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作者 Jing-Jing CAI Juan WEN +3 位作者 Wei-Hong JIANG Jian LIN Yuan HONG Yuan-Shan ZHU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第2期183-196,共14页
The roles of androgens on cardiovascular physiology and pathophysiology are controversial as both beneficial and detrimental effects have been reported. Although the reasons for this discrepancy are unclear, multiple ... The roles of androgens on cardiovascular physiology and pathophysiology are controversial as both beneficial and detrimental effects have been reported. Although the reasons for this discrepancy are unclear, multiple factors such as genetic and epigenetic variation, sex-specificity, hormone interactions, drug preparation and route of administration may contribute. Recently, growing evidence suggests that androgens exhibit beneficial effects on cardiovascular function though the mechanism remains to be elucidated. Endothelial cells (ECs) which line the interior surface of blood vessels are distributed throughout the circulatory system, and play a crucial role in cardiovascular function. Endothelial progenitor cells (EPCs) are considered an indispensable element for the reconstitution and maintenance of an intact endothelial layer. Endothelial dysfunction is regarded as an initiating step in development of atherosclerosis and cardiovascular diseases. The modulation of endothelial functions by androgens through either genornic or nongenomic signal pathways is one possible mechanism by which androgens act on the cardiovascular system. Obtaining insight into the mechanisms by which androgens affect EC and EPC functions will allow us to determine whether androgens possess beneficial effects on the cardiovascular system. This in turn may be critical in the prevention and therapy of cardiovascular diseases. This article seeks to review recent progress in androgen regulation of endothelial function, the sex-specificity of androgen actions, and its clinical applications in the cardiovascular system. 展开更多
关键词 ANDROGEN Cardiovascular diseases Endothelial cells ENDOTHELIUM ESTROGEN
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Pathology of diabetic myocardiac microangiopathy
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作者 Yiqun Yao Yanmei Chen Guang Liu Zhiyong Pei 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2009年第2期79-81,共3页
Objective To investigate the cause of high cardiovascular lethality in patients with diabetics mellitus. Methods Sections from autopsied coronary arteries and myocardium of dead patients with non-insulin-dependent dia... Objective To investigate the cause of high cardiovascular lethality in patients with diabetics mellitus. Methods Sections from autopsied coronary arteries and myocardium of dead patients with non-insulin-dependent diabetics mellitus and 12 dead control subjects were used for histomorphometric studies. Results The coronary atherosclerotic lesion in diabetics patients was not different in severity fi'om those in controls. Nor was there difference in number ofmyofibers or diameters of myoeardic fibers and capillaries.But the capillary density and the ratio of capillary number to myocardic fiber number in diabetics group were significeantly reduced compared with control group(P〈0.0 l),and the capillary basement membrane in the former was significantly thicker than in the latter(P〈0.01).Conclision The decrease in number of capillaries and the thickening of basement membrane enhance myocardiac vulnerability to further ischemia and hypoxia,which may undelie high lethality of myocardiopathy in diabetic patients. 展开更多
关键词 Non-insulin-dependent diabetes mellitus HISTOMORPHOMETRY myocardiac microvessels coronary atherosclerosis
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老年人急性脑梗死患者血清C反应蛋白含量的动态变化及临床意义
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作者 王书霞 张焕新 +1 位作者 杨思莲 郝丽华 《实用心脑肺血管病杂志》 2008年第2期102-106,共5页
目的探讨急性脑梗死(ACI)患者血清C反应蛋白(CRP)含量的动态变化及其临床意义。方法检测50例ACI患者发病<48h、第3天和第5天的血清CRP含量,按牛津郡社区卒中项目(OCSP)和CT分型对患者的血清CRP含量进行比较,并分析其与病情、预后的... 目的探讨急性脑梗死(ACI)患者血清C反应蛋白(CRP)含量的动态变化及其临床意义。方法检测50例ACI患者发病<48h、第3天和第5天的血清CRP含量,按牛津郡社区卒中项目(OCSP)和CT分型对患者的血清CRP含量进行比较,并分析其与病情、预后的关系。结果血清中CRP浓度改变具有以下特征:发病后48小时内CRP水平升高并明显高于正常对照组(P<0.05),第3天和第5天仍继续上升,病情严重,梗死范围面积大,皮层加皮层下梗死者或完全前循环梗死者均较其他病例明显升高(P<0.05~P<0.01),与国立卫生研究所卒中量表(NIHSS)评分对比分析呈显著正相关(r=0.412,P<0.01)。结论ACI后血清CRP含量的变化可反映病灶大小和病情的严重程度,为指导临床的诊治提供依据。 展开更多
关键词 脑梗死 C反应蛋白 动脉粥样变化
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