A method of 3D model reconstruction based on scattered point data in reverse engineering is presented here. The topological relationship of scattered points was established firstly, then the data set was triangulated ...A method of 3D model reconstruction based on scattered point data in reverse engineering is presented here. The topological relationship of scattered points was established firstly, then the data set was triangulated to reconstruct the mesh surface model. The curvatures of cloud data were calculated based on the mesh surface, and the point data were segmented by edge-based method; Every patch of data was fitted by quadric surface of freeform surface, and the type of quadric surface was decided by parameters automatically, at last the whole CAD model was created. An example of mouse model was employed to confirm the effect of the algorithm.展开更多
Srivastava and Jhajj [ 1 6] proposed a class of estimators for estimating population variance using multi auxiliary variables in simple random sampling and they utilized the means and variances of auxiliary variables....Srivastava and Jhajj [ 1 6] proposed a class of estimators for estimating population variance using multi auxiliary variables in simple random sampling and they utilized the means and variances of auxiliary variables. In this paper, we adapted this class and motivated by Searle [13], and we suggested more generalized class of estimators for estimating the population variance in simple random sampling. The expressions for the mean square error of proposed class have been derived in general form. Besides obtaining the minimized MSE of the proposed and adapted class, it is shown that the adapted classis the special case of the proposed class. Moreover, these theoretical findings are supported by an empirical study of original data.展开更多
Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage...Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design.展开更多
文摘A method of 3D model reconstruction based on scattered point data in reverse engineering is presented here. The topological relationship of scattered points was established firstly, then the data set was triangulated to reconstruct the mesh surface model. The curvatures of cloud data were calculated based on the mesh surface, and the point data were segmented by edge-based method; Every patch of data was fitted by quadric surface of freeform surface, and the type of quadric surface was decided by parameters automatically, at last the whole CAD model was created. An example of mouse model was employed to confirm the effect of the algorithm.
文摘Srivastava and Jhajj [ 1 6] proposed a class of estimators for estimating population variance using multi auxiliary variables in simple random sampling and they utilized the means and variances of auxiliary variables. In this paper, we adapted this class and motivated by Searle [13], and we suggested more generalized class of estimators for estimating the population variance in simple random sampling. The expressions for the mean square error of proposed class have been derived in general form. Besides obtaining the minimized MSE of the proposed and adapted class, it is shown that the adapted classis the special case of the proposed class. Moreover, these theoretical findings are supported by an empirical study of original data.
基金supported by the National Natural Science Foundation of China (21210003 and 81230076 to H.J., 81773634 to M.Z. and 81430084 to K.C.)the “Personalized Medicines-Molecular Signature-based Drug Discovery and Development”, Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12050201 to M.Z.)+1 种基金National Key Research & Development Plan (2016YFC1201003 to M.Z.)the National Basic Research Program (2015CB910304 to X.L.)
文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design.
