牛磺酸对不同龄雄性大鼠性功能的影响

目的:研究牛磺酸对不同龄雄性大鼠性功能的影响。方法:通过在青年和老年雄性大鼠饮水中添加牛磺酸和β-丙氨酸(牛磺酸转运抑制剂)30天后,进行阴茎勃起实验和交配实验观测。结果:牛磺酸对青年大鼠勃起次数、勃起潜伏期、乘骑次数、插入次数、射精次数、捕捉潜伏期均没有影响,但可显著提高老年大鼠勃起次数、乘骑次数、射精次数,明显缩短勃起潜伏期和捕捉潜伏期。结论:牛磺酸对维持雄大鼠正常的性功能具有重要作用,并可增强老年雄性大鼠的性功能。

Chronic kidney disease and erectile dysfunction

Erectile dysfunction(ED) is a common condition among male chronic kidney disease(CKD) patients.Its prevalence is estimated to be approximately 80% among these patients.It has been well established that the production of nitric oxide from the cavernous nerve and vascular endothelium and the subsequent production of cyclic GMP are critically important in initiating and maintaining erection.Factors affecting these pathways can induce ED.The etiology of ED in CKD patients is multifactorial.Factors including abnormalities in gonadal-pituitary system,disturbance in autonomic nervous system,endothelial dysfunction,anemia(and erythropoietin deficiency),secondary hyperparathyroidism,drugs,zinc deficiency,and psychological problems are implicated in the occurrence of ED.An improvement of general conditions is the first step of treatment.Sufficient dialysis and adequate nutritional intake are necessary.In addition,control of anemia and secondary hyperparathyroidism is required.Changes of drugs that potentially affect erectile function may be necessary.Further,zinc supplementation may be necessary whenzinc deficiency is suspected.Phosphodiesterase type 5 inhibitors(PDE5Is) are commonly used for treating ED in CKD patients,and their efficacy was confirmed by many studies.Testosterone replacement therapy in addition to PDE5 Is may be useful,particularly for CKD patients with hypogonadism.Renal transplantation may restore erectile function.ED is an early marker of cardiovascular disease(CVD),which it frequently precedes; therefore,it is crucial to examine the presence of ED in CKD patients not only for the improvement of the quality of life but also for the prevention of CVD attack.

Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies

Eurycoma longifolia(EL) has been well recognized as a booster of male sexual health. Over the past few decades, numerous in vivo animal studies and human clinical trials have been conducted across the globe to explore the promising role of EL in managing various male sexual disorders, which include erectile dysfunction, male infertility, low libido, and downregulated testosterone levels. The aim of the present review is to analyze and summarize the literature on human clinical trials which revealed the clinical significance and therapeutic feasibility of EL in improving male sexual health. This systematic review is focused on the following databases: Medline, Wiley Online Library, Bio Med Central, Hindawi, Web of Knowledge, Pub Med Central and Google Scholar, using search terms such as "Eurycoma longifolia", "EL", "Tongkat Ali", "male sexual health", "sexual infertility", "erectile dysfunction", "male libido", and "testosterone levels". Notably, only human clinical studies published between 2000 and 2014 were selected and thoroughly reviewed for relevant citations. Out of 150 articles, 11 met the inclusion criteria. The majority of articles included were randomized placebo-controlled trials, multiple cohort studies, or pilot trials. All these studies demonstrated considerable effects of EL on male sexual health disorders. Among them, 7 studies revealed remarkable association between the use of EL and the efficacy in the treatment of male sexual disorders, and remaining 4 studies failed to demonstrate sufficient effects on male sexual health. In summary, there is convincing evidence for the prominence of EL in improving the male sexual health. The review also substantiates the use of current methodology in the development of novel and more rationale natural herbal medicines for the management of male sexual disorders.

Clinical observation on warm needling moxibustion for erectile dysfunction

Objective： To observe the therapeutic effect of warm needling moxibustion for erectile dysfunction （ED）. Methods： A total of 46 eligible ED patients were randomized into a treatment group （n=24） and a control group （n=22）. The treatment group was intervened by warm needling moxibustion while the control group by conventional acupuncture treatment, for a total of 4 courses. The therapeutic effect was evaluated by the international index of erectile function 5 （IIEF-5）. Results： After 4 courses of treatment, the overall effective rate was 91.3% in the treatment group （23 completed）, versus 75.0% in the control group （20 completed）, with a significant difference （P〈0.05）. After the treatment, the change of IIEF-5 score in the treatment group was significantly different from that in the control group （P〈0.05）. Conclusion： Warm needling moxibustion can produce a more significant efficacy than conventional acupuncture in the treatment of ED.

Examples of Acupuncture Treatment for Intractable Diseases

1 Spermatorrhea A patient, 16 years old, suffered from spermatorrhea for over one year. At the beginning, it happened once several days, and recently it happened once every other day or every night, accompanied by a withered complexion, soreness and weakness in the lower back and legs, poor sleep, poor memory, a red tongue tip with thin tongue coating, and a thready and rapid pulse. The condition is attributed to kidney deficiency leading to poor containing ability, seminal emissions, and intemal disturbance of monarch fire. Therefore, bilateral Tongli （HT 5）, Shenshu （BL 23）, Guanyuan （CV 4） and Taixi （KI 3） were punctured by the twisting technique for reinforcement,

Assessment of the safety and efficacy of acupuncture in erectile dysfunction treatment

Objective To assess the safety and efficacy of acupuncture in erectile dysfunction treatment.Methods A systematic literature search was conducted to identify relevant studies.Seven electronic databases including Popline,World Health Organization(WHO)Global Health Library(GHL),System for Information on Grey Literature in Europe(SIGLE),Scopus,Institute for Scientific Information(ISI)Web of Science,PubMed and Virtual Health Library(VHL)were utilized to carry out the search.A manual search was further conducted for relevant publications from references of the included articles,relevant papers in PubMed and Google Scholar,and primary studies that had cited the included papers.Hand-search using each keyword to avoid missing any relevant publications was also carried out.Results The literature search yielded 2818 reports after removing duplicates using Endnote software.There were 21 studies eligible for full-text screening and five of which were subsequently included.After two studies identified from the manual search were added,a total of seven studies were found suitable to carry out the systematic review and meta-analysis.Five of them were used for quantitative and qualitative analysis,while two were only used for qualitative analysis.There were four clinical trials,one pilot study,one case report,and one animal study.Conclusion Acupuncture can improve male erectile function.