环境化学品分布于生物特定器官或组织(如肝、肾)的靶点浓度,是评价其毒性效应所需的关键信息.受实验技术和条件等限制,仅通过整体动物实验难以实现化学品生物体内靶点浓度的高通量获取.生理毒代动力学(physiologically based toxicokine...环境化学品分布于生物特定器官或组织(如肝、肾)的靶点浓度,是评价其毒性效应所需的关键信息.受实验技术和条件等限制,仅通过整体动物实验难以实现化学品生物体内靶点浓度的高通量获取.生理毒代动力学(physiologically based toxicokinetics,PBTK)模型则可定量描述化学品在生物体内吸收、分布、代谢、排泄过程,预测化学品在生物体内浓度随时间的变化,关联化学品的环境暴露浓度及靶点浓度.PBTK模型可进一步用于体内(in vivo)-体外(in vitro)毒性测试数据的外推、生物的跨物种外推等,在化学品生态风险评价与管理中发挥重要作用.本文概述了PBTK模型的基本概念及构建PBTK的方法,介绍了现有PBTK模型在化学品生态风险评价中的应用,并对PBTK模型的发展趋势进行了展望.展开更多
The environmental risk of chemical spills near coastal zones threatens abundant marine ecological resources. By appraising the ecological damage value of the environmental risk of marine chemical spills, we can facili...The environmental risk of chemical spills near coastal zones threatens abundant marine ecological resources. By appraising the ecological damage value of the environmental risk of marine chemical spills, we can facilitate decision-making for the development of a coastal zone and establishment of economic policy on coastal zone management. In this study, the ecological effect of the environmental risk of a chemical spill in the Haicang chemical industrial park in Xiamen was identified, after which its impact was forecasted and its ecological damage value was assessed. The information generated in this study will be useful in future studies evaluating marine ecological compensation based on environmental risk analysis.展开更多
文摘环境化学品分布于生物特定器官或组织(如肝、肾)的靶点浓度,是评价其毒性效应所需的关键信息.受实验技术和条件等限制,仅通过整体动物实验难以实现化学品生物体内靶点浓度的高通量获取.生理毒代动力学(physiologically based toxicokinetics,PBTK)模型则可定量描述化学品在生物体内吸收、分布、代谢、排泄过程,预测化学品在生物体内浓度随时间的变化,关联化学品的环境暴露浓度及靶点浓度.PBTK模型可进一步用于体内(in vivo)-体外(in vitro)毒性测试数据的外推、生物的跨物种外推等,在化学品生态风险评价与管理中发挥重要作用.本文概述了PBTK模型的基本概念及构建PBTK的方法,介绍了现有PBTK模型在化学品生态风险评价中的应用,并对PBTK模型的发展趋势进行了展望.
基金supported by Marine Science Fund of SOA for Young Scholars (No.2008121)
文摘The environmental risk of chemical spills near coastal zones threatens abundant marine ecological resources. By appraising the ecological damage value of the environmental risk of marine chemical spills, we can facilitate decision-making for the development of a coastal zone and establishment of economic policy on coastal zone management. In this study, the ecological effect of the environmental risk of a chemical spill in the Haicang chemical industrial park in Xiamen was identified, after which its impact was forecasted and its ecological damage value was assessed. The information generated in this study will be useful in future studies evaluating marine ecological compensation based on environmental risk analysis.
