The main purpose of this study is determining the extent of achieving American Diabetes Association （ADA） targets in diabetes type I and II at KFUH （King Fahd Hospital of University） in the year of 2012. Observati...The main purpose of this study is determining the extent of achieving American Diabetes Association （ADA） targets in diabetes type I and II at KFUH （King Fahd Hospital of University） in the year of 2012. Observational, cross sectional, retrospective study was conducted on 479 patients; the informations were reviewed using Quadramed CPR system. All the data obtainedwere analyzed by medical statistician using SPSS program. The results show that only 19.0% was achieved the target of HbA~; and the targets of LDL, HDL and TG were achieved in 38.4%, 35.9%, and 48.2% respectively. The routine ophthalmology and dietitian review were found to be in only 32.1% and 27.3%, respectively. The use of medications recommended by ADA was 51.4% for aspirin and 54.7 % for both statin and ACE inhibitor. The present study indicated that most of the ADA guidelines were not achieved in our diabetic patients being followed in our center, which is almost similar to other studies in most of the parameters. The achievement of diabetes targets is a difficult task but may not be impossible. It requires a multidisciplinary approach. So, further studies are needed to determine the reasons behind the gap between practice and guidelines.展开更多
To facilitate the species identification and quality assessment of Chaihu （Bupleuri Radix）, a simple and valid chromatographic fingerprint method was developed. The method uses high-performance liquid chromatography...To facilitate the species identification and quality assessment of Chaihu （Bupleuri Radix）, a simple and valid chromatographic fingerprint method was developed. The method uses high-performance liquid chromatography coupled with evaporative light scattering detector （HPLC-ELSD） and the data analysis is assisted by professional analytical software recommended by the State Food and Drug Administration （SFDA）. The results indicate that Nan Chaihu raw materials and Chaihu decoction pieces vary markedly in chemical quality, while Bei Chaihu raw materials are relatively more stable. Furthermore, it is obvious that Nan Chaihu is chemically very different from Bei Chaihu, suggesting that Nan Chaihu may not be suitable for medicinal use. In addition, the obvious differences between the chromatograms of decoction pieces and raw materials, especially the peaks between 30 and 40 rain and after 45 rain, indicate possible effects of the processing procedures on the chemicals. By analyzing the fingerprints of all samples, 12 main saponin-like fingerprint peaks, of which at least three are characteristic peaks of saikosaponins a, c, and d, are proposed to be considered for further characterization and quality evaluation of Chaihu.展开更多
文摘The main purpose of this study is determining the extent of achieving American Diabetes Association （ADA） targets in diabetes type I and II at KFUH （King Fahd Hospital of University） in the year of 2012. Observational, cross sectional, retrospective study was conducted on 479 patients; the informations were reviewed using Quadramed CPR system. All the data obtainedwere analyzed by medical statistician using SPSS program. The results show that only 19.0% was achieved the target of HbA~; and the targets of LDL, HDL and TG were achieved in 38.4%, 35.9%, and 48.2% respectively. The routine ophthalmology and dietitian review were found to be in only 32.1% and 27.3%, respectively. The use of medications recommended by ADA was 51.4% for aspirin and 54.7 % for both statin and ACE inhibitor. The present study indicated that most of the ADA guidelines were not achieved in our diabetic patients being followed in our center, which is almost similar to other studies in most of the parameters. The achievement of diabetes targets is a difficult task but may not be impossible. It requires a multidisciplinary approach. So, further studies are needed to determine the reasons behind the gap between practice and guidelines.
基金The project of Quality Standards for Chinese Medicines and Information System Platform (Grant No.2009ZX09308004)National Natural Science Foundation of China (Grant No.21172008)
文摘To facilitate the species identification and quality assessment of Chaihu （Bupleuri Radix）, a simple and valid chromatographic fingerprint method was developed. The method uses high-performance liquid chromatography coupled with evaporative light scattering detector （HPLC-ELSD） and the data analysis is assisted by professional analytical software recommended by the State Food and Drug Administration （SFDA）. The results indicate that Nan Chaihu raw materials and Chaihu decoction pieces vary markedly in chemical quality, while Bei Chaihu raw materials are relatively more stable. Furthermore, it is obvious that Nan Chaihu is chemically very different from Bei Chaihu, suggesting that Nan Chaihu may not be suitable for medicinal use. In addition, the obvious differences between the chromatograms of decoction pieces and raw materials, especially the peaks between 30 and 40 rain and after 45 rain, indicate possible effects of the processing procedures on the chemicals. By analyzing the fingerprints of all samples, 12 main saponin-like fingerprint peaks, of which at least three are characteristic peaks of saikosaponins a, c, and d, are proposed to be considered for further characterization and quality evaluation of Chaihu.
