目的:观察九味化斑方治疗寻常型银屑病的临床疗效。方法:筛选符合入组条件的寻常型银屑病患者40例,采用九味化斑方治疗,平均治疗时间(86.08±42.55)d,通过银屑病皮损面积和严重程度指数(Psoriasis Area and Severity Index,PASI)进...目的:观察九味化斑方治疗寻常型银屑病的临床疗效。方法:筛选符合入组条件的寻常型银屑病患者40例,采用九味化斑方治疗,平均治疗时间(86.08±42.55)d,通过银屑病皮损面积和严重程度指数(Psoriasis Area and Severity Index,PASI)进行疗效评价。结果:40例患者治疗前后PASI评分的改善有显著差异(P<0.01),40例患者中痊愈18例,显效13例,有效5例,无效4例,总有效率90%(36/40)。结论九味化斑方能显著改善寻常型银屑病患者的皮损面积和严重程度,疗效显著。展开更多
目的观察化斑解毒方对咪喹莫特诱导银屑病样皮炎小鼠模型的抗炎作用。方法采用咪喹莫特诱导小鼠银屑病样皮炎,以随机数字表法将60只小鼠随机分为空白组、模型组、化斑解毒方低、中、高剂量组及甲氨蝶呤组,每组10只。观察各组小鼠银屑病...目的观察化斑解毒方对咪喹莫特诱导银屑病样皮炎小鼠模型的抗炎作用。方法采用咪喹莫特诱导小鼠银屑病样皮炎,以随机数字表法将60只小鼠随机分为空白组、模型组、化斑解毒方低、中、高剂量组及甲氨蝶呤组,每组10只。观察各组小鼠银屑病皮损严重程度指数(psoriasis area and severity index,PASI)评分,苏木素—伊红染色观察组织病理学变化,酶联免疫吸附法检测肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、干扰素-γ(interferon-γ,IFN-γ)、白细胞介素-23(interleukin-23,IL-23)、白细胞介素-1β(interleukin-1β,IL-1β)表达水平,蛋白免疫印迹法测定核转录因子-κB(nuclear factor-κB,NF-κB)水平。结果(1)模型组与空白组PASI评分具有统计学差异(P<0.05),各药物组PASI评分较模型组均降低,差异有统计学意义(P<0.05);(2)模型组TNF-α、IFN-γ、IL-1β、IL-23表达水平较空白组显著升高(P<0.05);与模型组相比,各药物组TNF-α、IFN-γ、IL-1β表达水平显著降低(P<0.05),甲氨蝶呤组、化斑解毒方中、高剂量组IL-23水平显著降低(P<0.05);化斑解毒方低剂量组IL-23表达水平与模型组无显著差异(P>0.05);(3)与空白组相比,模型组NF-кB表达水平显著升高(P<0.05);各用药组NF-κB表达水平较模型组显著降低(P<0.05);化斑解毒方各剂量组NF-кB表达水平与甲氨蝶呤组相比无显著差异(P>0.05)。结论化斑解毒方可以明显改善银屑病样皮损症状及病理学改变,并通过调节细胞炎性因子表达改善炎症。展开更多
Analyzing raw material＇s structure and performance of bentonite from Panzhihua in Sichuan, the authors think that it is adequate for agglomerant of iron smelting. According to its composition and property we have res...Analyzing raw material＇s structure and performance of bentonite from Panzhihua in Sichuan, the authors think that it is adequate for agglomerant of iron smelting. According to its composition and property we have researched the purification and modification of I/S bentonite under conditions of different dispersants and sodium agent. XRD test result reveals that the essential minerals of Panzhihua bentonite are I/S mixed-layer ones, and FTIR analysis shows that when adding 1.5% sodium pyrophosphate to the bentonite slurry during purification, the composition of quartz in bentonite decreases to less than 4% and I/S is more than 90%. The optimized modification technic conditions are Na2CO3 （4%） and CMC-Na （3%） as modified agents, the clay and water are 10 vs. 1, and the temperature is 75℃. It is 40 min for stirring time and reacting time is 4 h. Under the conditions we can get the modified I/S bentonite with colloid index more than 500 nd/15 g.展开更多
Forty-two Cenozoic （mostly Miocene） basalt samples from Jining, Chifeng, Fansi, Xiyang, and Zuoquan areas of the North China Craton （the NCC basalts hereafter） were analyzed for platinum-group elements （PGE, incl...Forty-two Cenozoic （mostly Miocene） basalt samples from Jining, Chifeng, Fansi, Xiyang, and Zuoquan areas of the North China Craton （the NCC basalts hereafter） were analyzed for platinum-group elements （PGE, including Os, It, Ru, Rh, Pt, and Pd）. Most of them are alkaline basalts and tholeiites and all of them display little crustal contamination. The total PGE contents of the NCC basalts vary from 0.1 to 0.9 ppb, much lower than those of the primitive mantle values of 23.5 ppb. Primitive man- tie-normalized PGE patterns of these basalts define positive slopes and Pd/Ir ratios vary from 1.2 to 25. In terms of both PGE contents and Pd/Ir ratios, they are quite similar to the mid-ocean ridge basalts. There are no obvious negative correlations be- tween PGE vs. MgO, Ni, and Cu in the NCC basalts, indicating that fractional crystallization of olivine, pyroxene, and/or sul- fides during magmatic process cannot be the controlling factor for the observed PGE variation. The observed Pd/Ir variations of the NCC basalts require involvement of non-chondritic heterogeneous mantle sources. Based on Sr-Nd-Pb-Hf isotopic sys- tematics and incompatible-element signatures, a mixing of partial melts from both asthenospheric peridotites and enclosed mantle eclogites at the top of asthenosphere was proposed for the origin of these NCC basalts. The lenses of eclogites are de- rived from upwelling of recycled continental crust during the westward subduction of the Pacific plate from the -600 km dis- continuity zone. The PGE geochemistry of these basalts provides independent evidence to support this conclusion and the ob- served Pd/Ir variations may reflect variations in proportions of tapped peridotitic and eclogitic melts.展开更多
文摘目的:观察九味化斑方治疗寻常型银屑病的临床疗效。方法:筛选符合入组条件的寻常型银屑病患者40例,采用九味化斑方治疗,平均治疗时间(86.08±42.55)d,通过银屑病皮损面积和严重程度指数(Psoriasis Area and Severity Index,PASI)进行疗效评价。结果:40例患者治疗前后PASI评分的改善有显著差异(P<0.01),40例患者中痊愈18例,显效13例,有效5例,无效4例,总有效率90%(36/40)。结论九味化斑方能显著改善寻常型银屑病患者的皮损面积和严重程度,疗效显著。
文摘目的观察化斑解毒方对咪喹莫特诱导银屑病样皮炎小鼠模型的抗炎作用。方法采用咪喹莫特诱导小鼠银屑病样皮炎,以随机数字表法将60只小鼠随机分为空白组、模型组、化斑解毒方低、中、高剂量组及甲氨蝶呤组,每组10只。观察各组小鼠银屑病皮损严重程度指数(psoriasis area and severity index,PASI)评分,苏木素—伊红染色观察组织病理学变化,酶联免疫吸附法检测肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、干扰素-γ(interferon-γ,IFN-γ)、白细胞介素-23(interleukin-23,IL-23)、白细胞介素-1β(interleukin-1β,IL-1β)表达水平,蛋白免疫印迹法测定核转录因子-κB(nuclear factor-κB,NF-κB)水平。结果(1)模型组与空白组PASI评分具有统计学差异(P<0.05),各药物组PASI评分较模型组均降低,差异有统计学意义(P<0.05);(2)模型组TNF-α、IFN-γ、IL-1β、IL-23表达水平较空白组显著升高(P<0.05);与模型组相比,各药物组TNF-α、IFN-γ、IL-1β表达水平显著降低(P<0.05),甲氨蝶呤组、化斑解毒方中、高剂量组IL-23水平显著降低(P<0.05);化斑解毒方低剂量组IL-23表达水平与模型组无显著差异(P>0.05);(3)与空白组相比,模型组NF-кB表达水平显著升高(P<0.05);各用药组NF-κB表达水平较模型组显著降低(P<0.05);化斑解毒方各剂量组NF-кB表达水平与甲氨蝶呤组相比无显著差异(P>0.05)。结论化斑解毒方可以明显改善银屑病样皮损症状及病理学改变,并通过调节细胞炎性因子表达改善炎症。
文摘Analyzing raw material＇s structure and performance of bentonite from Panzhihua in Sichuan, the authors think that it is adequate for agglomerant of iron smelting. According to its composition and property we have researched the purification and modification of I/S bentonite under conditions of different dispersants and sodium agent. XRD test result reveals that the essential minerals of Panzhihua bentonite are I/S mixed-layer ones, and FTIR analysis shows that when adding 1.5% sodium pyrophosphate to the bentonite slurry during purification, the composition of quartz in bentonite decreases to less than 4% and I/S is more than 90%. The optimized modification technic conditions are Na2CO3 （4%） and CMC-Na （3%） as modified agents, the clay and water are 10 vs. 1, and the temperature is 75℃. It is 40 min for stirring time and reacting time is 4 h. Under the conditions we can get the modified I/S bentonite with colloid index more than 500 nd/15 g.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.41173036,40534022)the Chinese Academy of Sciences(Grant No.KZCX2-YW-103)
文摘Forty-two Cenozoic （mostly Miocene） basalt samples from Jining, Chifeng, Fansi, Xiyang, and Zuoquan areas of the North China Craton （the NCC basalts hereafter） were analyzed for platinum-group elements （PGE, including Os, It, Ru, Rh, Pt, and Pd）. Most of them are alkaline basalts and tholeiites and all of them display little crustal contamination. The total PGE contents of the NCC basalts vary from 0.1 to 0.9 ppb, much lower than those of the primitive mantle values of 23.5 ppb. Primitive man- tie-normalized PGE patterns of these basalts define positive slopes and Pd/Ir ratios vary from 1.2 to 25. In terms of both PGE contents and Pd/Ir ratios, they are quite similar to the mid-ocean ridge basalts. There are no obvious negative correlations be- tween PGE vs. MgO, Ni, and Cu in the NCC basalts, indicating that fractional crystallization of olivine, pyroxene, and/or sul- fides during magmatic process cannot be the controlling factor for the observed PGE variation. The observed Pd/Ir variations of the NCC basalts require involvement of non-chondritic heterogeneous mantle sources. Based on Sr-Nd-Pb-Hf isotopic sys- tematics and incompatible-element signatures, a mixing of partial melts from both asthenospheric peridotites and enclosed mantle eclogites at the top of asthenosphere was proposed for the origin of these NCC basalts. The lenses of eclogites are de- rived from upwelling of recycled continental crust during the westward subduction of the Pacific plate from the -600 km dis- continuity zone. The PGE geochemistry of these basalts provides independent evidence to support this conclusion and the ob- served Pd/Ir variations may reflect variations in proportions of tapped peridotitic and eclogitic melts.
