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五子衍宗丸对化疗性肠黏膜炎小鼠的保护作用及其机制研究 被引量:2
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作者 周卫东 卢汉祺 +4 位作者 陈泽伟 田春阳 孙晓敏 赵晓山 谭为 《光明中医》 2021年第5期729-733,共5页
目的观察五子衍宗丸(WYP)对5-氟尿嘧啶(5-FU)引起的肠道炎的保护作用并探讨其作用机制。方法将小鼠随机分为正常组、对照组、雷莫司琼(RAM)组、五子衍宗丸高剂量(HWYP)组、五子衍宗丸中剂量(MWYP)组、五子衍宗丸低剂量(LWYP)组,对照组、... 目的观察五子衍宗丸(WYP)对5-氟尿嘧啶(5-FU)引起的肠道炎的保护作用并探讨其作用机制。方法将小鼠随机分为正常组、对照组、雷莫司琼(RAM)组、五子衍宗丸高剂量(HWYP)组、五子衍宗丸中剂量(MWYP)组、五子衍宗丸低剂量(LWYP)组,对照组、WYP组和RAM组使用5-FU造模。观测小鼠腹泻和体质量情况;将小鼠处死后,取小鼠空肠组织,通过测量小肠绒毛高度和隐窝深度进行形态学评价,检测小肠组织IL-1β、IL-6、TNF-α的含量,测定组织细胞凋亡率。结果给药第5天,WYP组、RAM组5-FU引起的体质量减轻、腹泻;缓解5-FU对小肠绒毛、隐窝的损伤;与RAM组相比,HWYP组、MWYP组小鼠空肠隐窝深度更小(P<0.05)。与对照组相比,WYP组、RAM组TNF-α、IL-1β、IL-6水平显著更低(P<0.05或P<0.01)。给药后1 d(24 h)或第3天,与对照组比,MWYP组凋亡率均显著降低(P<0.01)。结论五子衍宗丸能显著改善5-FU引起的肠道黏膜炎症状,对空肠隐窝的保护作用优于雷莫司琼,其作用机制可能与其抑制TNF-α、IL-1β、IL-6水平和抗细胞凋亡的作用有关。 展开更多
关键词 五子衍宗丸 5-氟尿嘧啶 化疗性肠炎 细胞凋亡
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Fulminant amoebic colitis during chemotherapy for advanced gastric cancer
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作者 Noboru Hanaoka Katsuhiko Higuchi +5 位作者 Satoshi Tanabe Tohru Sasaki Kenji Ishido Takako Ae Wasaburo Koizumi Katsunori Saigenji 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第27期3445-3447,共3页
A 52-year-old man had bloody stools during chemo-therapy for gastric cancer. A colonoscopy revealed necrotizing ulcer-like changes. A biopsy confirmed the presence of amoebic trophozoites. Subsequently, peritonitis wi... A 52-year-old man had bloody stools during chemo-therapy for gastric cancer. A colonoscopy revealed necrotizing ulcer-like changes. A biopsy confirmed the presence of amoebic trophozoites. Subsequently, peritonitis with intestinal perforation developed, and emergency peritoneal lavage and colostomy were performed. After surgery, endotoxin adsorption therapy was performed and metronidazole was given. Symptoms of peritonitis and colonitis resolved. However, the patient's general condition worsened with the progression of gastric cancer. The patient died 50 d after surgery. Fulminant amoebic colitis is very rarely associated with chemotherapy. Amoebic colitis should be considered in the differential diagnosis of patients who have bloody stools during chemotherapy. 展开更多
关键词 Fulminant amoebic colitis Gastric cancer CHEMOTHERAPY AMOEBIASIS
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