选取2016年6月至2017年11月,河南省胸科医院收治的乳腺癌化疗患者74例,随机分为对照组和观察组,每组37例。对照组给予常规护理,观察组于此基础给予化疗监测日志联合QCC活动。分析化疗监测日志联合品管圈(quality control circle,QCC)活...选取2016年6月至2017年11月,河南省胸科医院收治的乳腺癌化疗患者74例,随机分为对照组和观察组,每组37例。对照组给予常规护理,观察组于此基础给予化疗监测日志联合QCC活动。分析化疗监测日志联合品管圈(quality control circle,QCC)活动对乳腺癌化疗患者疾病相关知识知晓率及护理工作满意度的影响。结果显示,护理后,观察组乳腺癌相关知识知晓率比对照组高,差异有统计学意义(P<0.05)。观察组满意度97.30%,对照组81.08%,差异有统计学意义(χ~2=3.945,P=0.047)。护理后观察组PFS-R评分比对照组低,差异有统计学意义(P=0.000)。乳腺癌化疗患者中给予化疗监测日志联合QCC活动有助于提升疾病知识知晓率及满意度,并改善癌因性疲乏。展开更多
Objective: To evaluate the plasma concentration of thrombus precursor protein (TPP) in patients after mechanical heart valve replacement, and to explore whether it can be used as a marker for monitoring anticoagulatio...Objective: To evaluate the plasma concentration of thrombus precursor protein (TPP) in patients after mechanical heart valve replacement, and to explore whether it can be used as a marker for monitoring anticoagulation. Methods: Totally 60 patients who took warfarin after mitral valve replacement and 20 control patients with non-valvular heart diseases were subjected in this study. Their plasma TPP concentration and international normalized ratio (INR) were determined, and compared not only between the anticoagulant patients and the control patients, but also between the patients with atrial fibrillaiton (AF, n=37) and the patients with sinus rhythm (SR, n=23) after mechanical valve replacement. The relationship between plasma TPP concentration and INR in the 60 anticoagulant patients was analyzed with linear regression. Results: It was found that the anticoagulant therapy effectively decreased plasma TPP concentration and elevated INR. In the anticoagulant group, the patients with AF had higher plasma TPP concentration than the others with sinus rhythm (P<0.05), although there was no significant difference in INR level between these 2 groups of patients (P>0.05). No significant correlation was found between plasma TPP concentration and INR in the anticoagulant patients (P>0.05). INR did not accord with plasma TPP concentration in several patients. Conclusion: INR can’t reflect the coagulation status and guide the anticoagulation correctly sometimes; TPP may be a valuable assistant marker for monitoring anticoagulation in patients with mechanical heart valve prothesis; Patients with AF may require higher density of anticoagulation and TPP is strongly suggested to be monitored in these patients.展开更多
The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and thei...The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst(Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solutiongated graphene transistor(SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.展开更多
文摘选取2016年6月至2017年11月,河南省胸科医院收治的乳腺癌化疗患者74例,随机分为对照组和观察组,每组37例。对照组给予常规护理,观察组于此基础给予化疗监测日志联合QCC活动。分析化疗监测日志联合品管圈(quality control circle,QCC)活动对乳腺癌化疗患者疾病相关知识知晓率及护理工作满意度的影响。结果显示,护理后,观察组乳腺癌相关知识知晓率比对照组高,差异有统计学意义(P<0.05)。观察组满意度97.30%,对照组81.08%,差异有统计学意义(χ~2=3.945,P=0.047)。护理后观察组PFS-R评分比对照组低,差异有统计学意义(P=0.000)。乳腺癌化疗患者中给予化疗监测日志联合QCC活动有助于提升疾病知识知晓率及满意度,并改善癌因性疲乏。
文摘Objective: To evaluate the plasma concentration of thrombus precursor protein (TPP) in patients after mechanical heart valve replacement, and to explore whether it can be used as a marker for monitoring anticoagulation. Methods: Totally 60 patients who took warfarin after mitral valve replacement and 20 control patients with non-valvular heart diseases were subjected in this study. Their plasma TPP concentration and international normalized ratio (INR) were determined, and compared not only between the anticoagulant patients and the control patients, but also between the patients with atrial fibrillaiton (AF, n=37) and the patients with sinus rhythm (SR, n=23) after mechanical valve replacement. The relationship between plasma TPP concentration and INR in the 60 anticoagulant patients was analyzed with linear regression. Results: It was found that the anticoagulant therapy effectively decreased plasma TPP concentration and elevated INR. In the anticoagulant group, the patients with AF had higher plasma TPP concentration than the others with sinus rhythm (P<0.05), although there was no significant difference in INR level between these 2 groups of patients (P>0.05). No significant correlation was found between plasma TPP concentration and INR in the anticoagulant patients (P>0.05). INR did not accord with plasma TPP concentration in several patients. Conclusion: INR can’t reflect the coagulation status and guide the anticoagulation correctly sometimes; TPP may be a valuable assistant marker for monitoring anticoagulation in patients with mechanical heart valve prothesis; Patients with AF may require higher density of anticoagulation and TPP is strongly suggested to be monitored in these patients.
基金supported by the Postdoctoral Science Foundation of China (2019M653052)the Fundamental Research Funds for the Central Universities (WK2060120002)+1 种基金the National Key R&D Program of China (2017YFA, 0208300)the National Natural Science Foundation of China (21671180)。
文摘The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst(Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solutiongated graphene transistor(SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.
