通络化癥膏外敷辅治乙型肝炎肝硬化代偿期临床观察

目的:观察通络化癥膏外敷辅治乙型肝炎肝硬化代偿期的疗效。方法:66例随机分为两组各33例,两组均用替诺福韦、保肝降酶治疗,治疗组加用通络化癥膏外敷。结果:治疗6个月后观察组肝功能指标、肝纤维化指标均比对照组低而凝血功能指标比对照组短(P<0.05)。观察组HBeAg及HBV-DNA转阴率比对照组高(P<0.05)。观察组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:通络化癥膏外敷辅治乙型肝炎肝硬化代偿期可提高疗效。

温阳化癥膏联合盐酸羟考酮缓释片治疗癌性疼痛的临床观察

目的:观察温阳化癥膏联合盐酸羟考酮缓释片治疗癌性疼痛(痰瘀交阻)的临床疗效。方法:将160例患者随机分为治疗组(n=100)与对照组(n=60)。对照组给予盐酸羟考酮缓释片口服,10 mg为起始剂量,每12小时1次;治疗组在对照组治疗基础上予以温阳化癥膏外贴,每天1贴,每贴6~8 h,7 d为一疗程。治疗期间两组病例均可对等使用支持治疗,伴爆发痛时及时使用短效速释药物治疗,并依据滴定剂量调整盐酸羟考酮缓释片服用量。结果:总有效率治疗组为98.9%,对照组为95%,两组比较差异无统计学意义(P>0.05)。治疗组爆发痛次数、止痛药使用剂量明显少于对照组,两组比较差异有统计学意义(P<0.05)。结论:温阳化癥膏治疗癌性疼痛的止痛效果满意,患者生活质量得到明显改善,其治疗安全有效,毒副作用小,且简单易行,为中西医结合治疗癌性疼痛提供了新途径。

疏肝化癥膏的急性毒性研究

采用健康昆明小鼠,以灌胃给药方式进行急性毒性试验。结果发现,疏肝化癥膏对小鼠的形态和体重变化均无明显影响。组织学观察结果表明,中、低剂量的疏肝化癥膏对小鼠的肝脏和不同浓度的疏肝化癥膏对小鼠肾脏无明显损伤。经计算,疏肝化癥膏对小鼠的半数致死量(LD50)大于15g/kg。根据国际卫生组织的标准判定,该药的毒性分级为无毒。本研究可为疏肝化癥膏的临床应用提供重要依据,并为其生物活性研究奠定基础。

芝莲化癥方药不同组方对移植肝癌小鼠益气化癥作用的影响

目的：观察芝莲化癥不同组方对移植肝癌小鼠瘤体质量、抑瘤率、巨噬细胞吞噬率、吞噬指数、半数溶血值、淋巴细胞转化率水平的影响。方法：选择雄性8~10周龄健康清洁级C57小鼠50只,采用随机数字表法分为模型组、芝莲化癥药效组分组、芝莲化癥配方颗粒组、芝莲化癥膏方组、健康对照组各10只。除健康组外,各组小鼠腋下皮下接种肝癌Hepa 1-6瘤株。接种1周后给予芝莲化癥灌胃,连续治疗10 d。观察各项指标水平。结果：中药治疗各组较模型组瘤体质量明显下降,其中芝莲化癥配方颗粒组、芝莲化癥膏方组与模型组比较,差异有统计学意义（P〈0.05）。芝莲化癥膏方组抑瘤率（45.22±2.70）%较芝莲化癥药效组分组（35.22±2.46）%、芝莲化癥配方颗粒组（42.68±2.13）%升高,但组间比较,差异无统计学意义（P〉0.05）。中药治疗各组吞噬率、吞噬指数（0.60±0.03、0.63±0.04）较模型组明显提高,中药治疗各组与模型组（0.51±0.01）吞噬指数比较,差异有统计学意义（P〈0.05）。中药治疗各组半数溶血值较模型组均有升高,芝莲化癥膏方组与模型组（19.68±1.93 vs15.20±2.40）比较,差异有统计学意义（P〈0.05）。中药治疗各组淋巴细胞转化率均有升高,芝莲化癥配方颗粒组（40.61±3.50）%、芝莲化癥膏方组（41.22±3.61）%与模型组（25.06±1.60）%比较,差异有统计学意义（P〉0.05）。结论：芝莲化癥方药不同组方能调节巨噬细胞吞噬率、淋巴细胞转化率,抑瘤效果明显,尤其是芝莲化癥膏方具有显著的调节免疫功能抗肿瘤功效。

Effect of a comprehensive therapy plus Gushenyutai plaster administered at Guanyuan(CV 4) on male infertility associated with semen non-liquefaction

OBJECTIVE: To observe the clinical effect of Gushenyutai plaster administered at the Guanyuan(CV4) acupoint on male infertility associated with semen non-liquefaction.METHODS: Sixty-two male patients with infertility caused by semen non-liquefaction were random-ized into a treatment and control group. The control group received comprehensive therapy, which included oral administration of clarithromycin sustained release tablets, hip bath with Zhongyaoxiaoyan granules, prostate massage, and transurethral microwave treatment. The treatment group was administered Gushenyutai plaster in addition to the comprehensive therapy. Both groups were treated for 8 weeks. After treatment, the clinical effect and pregnancy rate were assessed and compared between the two groups.RESULTS: The effective rate of the treatment group was significantly higher than that of the control group(96.77% vs 70.97%, P<0.05) and the pregnancy rates of the treatment group and control groups were 38.71% and 16.13%, respectively(P<0.05).CONCLUSION: The effect of Gushenyutai plaster plus comprehensive therapy was better than that of the comprehensive therapy alone on male infertility induced by semen non-liquefaction.