Background. A 63-year-old man with therapy-resistant Se′ zary syndrome was enrolled in a multicenter trial of oral bexarotene for advanced-stage cutaneous T-cell lymphoma(CTCL). Methods. Monthly evaluations for effic...Background. A 63-year-old man with therapy-resistant Se′ zary syndrome was enrolled in a multicenter trial of oral bexarotene for advanced-stage cutaneous T-cell lymphoma(CTCL). Methods. Monthly evaluations for efficacy and side-effects were conducted and documented. Results. Gradual improvement in erythema, pruritus, and scale was noted during the initial 16week trial period and treatment was extended to 40 weeks. From week 20 to week 40, the erythroderma continued to improve and the lymph node burden decreased, but the absolute Se′ zary cell count inversely increased. By week 40, intractable pruritus and erythroderma abruptly recurred, and bexarotene was discontinued. Conclusions. Bexarotene is well tolerated and can be efficacious in patients with Se′ zary syndrome. Shifting of Se′ zary cells between different compartments was noted. Further studies on the interaction between the skin, lymph nodes, and peripheral blood compartments during bexarotene treatment in this subset of patients with CTCL are needed.展开更多
【目的】分析中川208四个器官(根、茎、叶、花)的细菌群落多样性与物种组成,为利用中川208内生细菌资源提供科学依据。【方法】以中川208的根、茎、叶、花为研究对象,采用高通量测序与生物信息学分析方法,解析中川208不同器官内生细菌...【目的】分析中川208四个器官(根、茎、叶、花)的细菌群落多样性与物种组成,为利用中川208内生细菌资源提供科学依据。【方法】以中川208的根、茎、叶、花为研究对象,采用高通量测序与生物信息学分析方法,解析中川208不同器官内生细菌的群落结构与物种组成,探讨植物养分特征对优势细菌菌群的调控作用。【结果】(1)从中川208四种样品中共获得5460条特征序列(amplicon sequence variants:ASVs),归属于19门、72纲、161目、285科和389属。(2)各样本的细菌群落多样性为根>茎≥花>叶。Beta多样性和聚类分析表明,中川208的根和叶内生细菌群落组成较相似,与花和茎有明显区别。(3)物种组成上,根、茎、叶内以变形菌门和放线菌门相对丰度最高,花中以厚壁菌门和拟杆菌门的相对丰度最高。LEfSe分析结果表明,中川208不同器官中的细菌群落构成在属水平上存在显著差异性,特别是细菌属不动杆菌、短波单胞菌、异根瘤菌、芽孢杆菌、金黄杆菌、肠杆菌、另枝菌、毛螺菌、普拉梭菌、瘤胃球菌和Rosenbergiella的相对丰度在茎、叶、花内差异显著。(4)冗余分析表明,烟株总N(R2=0.730, P <0.001)、总糖(R2=0.883, P <0.001)和Mg(R2=0.907, P <0.01)含量与各器官中的优势细菌群落分布密切相关。【结论】中川208内生细菌群落多样性自根依次向花、茎、叶呈递减趋势,且不同器官中的内生细菌群落在物种组成上具有明显差异性。中川208植物器官中存在多种显著富集的细菌菌群,值得进一步研究与开发利用。展开更多
近年来,免疫系统区室化(compartmentalization of immune system)的概念逐渐引起了人们的重视。对各类免疫及非免疫器官中的免疫区室化现象进行深入研究,有助于进一步了解机体免疫系统、免疫应答以及免疫相关疾病的发病机制,并可提供新...近年来,免疫系统区室化(compartmentalization of immune system)的概念逐渐引起了人们的重视。对各类免疫及非免疫器官中的免疫区室化现象进行深入研究,有助于进一步了解机体免疫系统、免疫应答以及免疫相关疾病的发病机制,并可提供新的应对策略。上皮细胞体内广泛分布,承载机体多种重要生理功能。它作为免疫防御首道防线参与免疫系统区室化形成,并在免疫反应局部微环境中,既可与免疫细胞相互作用发挥固有免疫调节作用,亦可通过自身转分化调节后续适应性免疫应答,在抵御及清除病原体入侵、调控局部炎症免疫反应以及促进组织损伤修复中,发挥了不可或缺的重要作用。病理状态下,上皮细胞又可能是免疫稳态失衡甚或肿瘤发生发展的关键因素。结合免疫系统区室化,对上皮细胞在局部微环境中的免疫调节作用作一综述,为免疫相关疾病的研究以及临床诊疗提供新的思路和策略。展开更多
文摘Background. A 63-year-old man with therapy-resistant Se′ zary syndrome was enrolled in a multicenter trial of oral bexarotene for advanced-stage cutaneous T-cell lymphoma(CTCL). Methods. Monthly evaluations for efficacy and side-effects were conducted and documented. Results. Gradual improvement in erythema, pruritus, and scale was noted during the initial 16week trial period and treatment was extended to 40 weeks. From week 20 to week 40, the erythroderma continued to improve and the lymph node burden decreased, but the absolute Se′ zary cell count inversely increased. By week 40, intractable pruritus and erythroderma abruptly recurred, and bexarotene was discontinued. Conclusions. Bexarotene is well tolerated and can be efficacious in patients with Se′ zary syndrome. Shifting of Se′ zary cells between different compartments was noted. Further studies on the interaction between the skin, lymph nodes, and peripheral blood compartments during bexarotene treatment in this subset of patients with CTCL are needed.
文摘【目的】分析中川208四个器官(根、茎、叶、花)的细菌群落多样性与物种组成,为利用中川208内生细菌资源提供科学依据。【方法】以中川208的根、茎、叶、花为研究对象,采用高通量测序与生物信息学分析方法,解析中川208不同器官内生细菌的群落结构与物种组成,探讨植物养分特征对优势细菌菌群的调控作用。【结果】(1)从中川208四种样品中共获得5460条特征序列(amplicon sequence variants:ASVs),归属于19门、72纲、161目、285科和389属。(2)各样本的细菌群落多样性为根>茎≥花>叶。Beta多样性和聚类分析表明,中川208的根和叶内生细菌群落组成较相似,与花和茎有明显区别。(3)物种组成上,根、茎、叶内以变形菌门和放线菌门相对丰度最高,花中以厚壁菌门和拟杆菌门的相对丰度最高。LEfSe分析结果表明,中川208不同器官中的细菌群落构成在属水平上存在显著差异性,特别是细菌属不动杆菌、短波单胞菌、异根瘤菌、芽孢杆菌、金黄杆菌、肠杆菌、另枝菌、毛螺菌、普拉梭菌、瘤胃球菌和Rosenbergiella的相对丰度在茎、叶、花内差异显著。(4)冗余分析表明,烟株总N(R2=0.730, P <0.001)、总糖(R2=0.883, P <0.001)和Mg(R2=0.907, P <0.01)含量与各器官中的优势细菌群落分布密切相关。【结论】中川208内生细菌群落多样性自根依次向花、茎、叶呈递减趋势,且不同器官中的内生细菌群落在物种组成上具有明显差异性。中川208植物器官中存在多种显著富集的细菌菌群,值得进一步研究与开发利用。
文摘近年来,免疫系统区室化(compartmentalization of immune system)的概念逐渐引起了人们的重视。对各类免疫及非免疫器官中的免疫区室化现象进行深入研究,有助于进一步了解机体免疫系统、免疫应答以及免疫相关疾病的发病机制,并可提供新的应对策略。上皮细胞体内广泛分布,承载机体多种重要生理功能。它作为免疫防御首道防线参与免疫系统区室化形成,并在免疫反应局部微环境中,既可与免疫细胞相互作用发挥固有免疫调节作用,亦可通过自身转分化调节后续适应性免疫应答,在抵御及清除病原体入侵、调控局部炎症免疫反应以及促进组织损伤修复中,发挥了不可或缺的重要作用。病理状态下,上皮细胞又可能是免疫稳态失衡甚或肿瘤发生发展的关键因素。结合免疫系统区室化,对上皮细胞在局部微环境中的免疫调节作用作一综述,为免疫相关疾病的研究以及临床诊疗提供新的思路和策略。
