IMAGING CHARACTERISTICS OF RAT MODELS OF PARKINSON DISEASE

Imaging technologies are utilized to study the brain morphology and the functions of rat models of Parkinson disease （PD）. Magnetic resonance imaging （MRI） and magnetic resonance angiography （MRA） are used to obtain morphological imaging data. Functional imaging data, such as the spectrum and blood flow changes are obtained by proton magnetic resonance spectroscopy （1H-MRS） and CT perfusion （CTP）. Results show that PD rat models have no characteristic morphological imaging abnormalities, but exist regional cerebral blood flow （CBF） reductions and spectral changes in the striatum.

Imaging of the small bowel in Crohn's disease: A review of old and new techniques

The investigation of small bowel morphology is often mandatory in many patients with Crohn's disease. Traditional radiological techniques (small bowel enteroclysis and small bowel follow-through) have long been the only suitable methods for this purpose. In recent years, several alternative imaging techniques have been proposed. To review the most recent advances in imaging studies of the small bowel, with particular reference to their possible application in Crohn's disease, we conducted a complete review of the most important studies in which traditional and newer imaging methods were performed and compared in patients with Crohn's disease. Several radiological and endoscopic techniques are now available for the study of the small bowel; each of them is characterized by a distinct profile of favourable and unfavourable features. In some cases, they may also be used as complementary rather than alternative techniques. In everyday practice, the choice of the technique to be used stands upon its availability and a careful evaluation of diagnostic accuracy, clinical usefulness, safety and cost. The recent development ofinnovative imaging techniques has opened a new and exciting area in the exploration of the small bowel in Crohn's disease patients.

Under the narrative medicine theory to establish the evidence-based medical record written by doctors and patients through integrated therapy of traditional Chinese and western on digestive system diseases

Objective:The aim of this article was to discuss the theory of doctor-patient co-operated evidence-based medical record and set up the preliminary frame of the doctor-patient co-operated evidence-based medical record following the concept of narrative evidence-based medicine.Methods:The information was searched from Pubmed,Embase,CBMdisc,CNKI.A preliminary agreement was reached by referring to the principles of narrative medicine and advises given by experts of digestive system and evidence-based medicine in both Traditional Chinese Medicine and Western Medicine.Result:This research is a useful attempt to discuss the establishment of doctor-patient co-operated evidence-based medical record guided by the direction of narrative evidence-based medicine.Reflection and outlook:Doctor-patient co-operated medical record can be a key factor of the curative effect evaluation methodology system of integrated therapy of Tradition Chinese Medicine and Western Medicine on spleen and stomach diseases.

The difference of endothelial adherence between the clinical and commensal strains of Staphylococcus epidermidis

Staphylococcus epidermidis is one of the leading pathogens of nosocomial infections. Twenty- eight strains of biofilm-negative Staphylococcus epidermidis, of which thirteen strains considered as the clinical strains were isolated from catheters, blood and urine of patients in Huashan Hospital （Shanghai, China） and fifteen strains considered as commensal strains were isolated from the skin of healthy students who had no contact with hospitals in recent half year, were investigated for the adherence to human umbilical vein endothelial cell line ECV304 and human cervical adenocarcinoma cell line Hela, respectively. Our results showed that the clinical strains were much more adhesive to both cells than commensal ones. The endothelial adherence may be a virulence factor associated with this bacterial pathogenesis.

小儿重度喉软化症临床特点及手术疗效影响因素分析

目的:探讨重度喉软化症患儿的临床特点及影响手术疗效的因素。方法:回顾性分析2015年1月-2019年5月在重庆医科大学附属儿童医院进行声门上成形术的重度喉软化症患儿的临床资料,探讨重度喉软化症患儿的临床特点,评估术后不同时期主要症状的改善情况,分析手术年龄和医学共病对手术疗效的影响。结果:在重症喉软化的解剖分型中,Ⅳ型所占比例最高(37例,66.1%),Ⅰ型最少(2例,3.6%);所有患儿均存在喉鸣和呼吸困难,其次是喂养困难(46例,82.1%)和生长发育不良(38例,67.9%)。56例重度喉软化症患儿中,伴有医学共病的患儿35例(62.5%),先天性心脏疾病22例(39.3%),发病率最高。不伴医学共病的重度喉软化症手术有效率为100.0%,伴一种类型共病的手术有效率为96.0%,伴多种类型共病的手术有效率为30.0%(P<0.01)。绝大多数患儿的喉鸣、呼吸困难、喂养困难在术后1个月可以得到明显改善。手术年龄<3个月,伴共病组术后1、3、6个月的手术有效率分别为61.5%、61.5%、69.2%,不伴共病组术后1、3、6个月的手术有效率均为100.0%,两者比较差异无统计学意义(P>0.05);手术年龄>3个月,无论是否伴有共病,术后1、3、6个月的手术有效率均为100.0%。不伴共病患儿的手术失败率和再手术率均为0,而伴共病患儿的手术失败率和再手术率分别为22.9%和20.0%,两者比较差异有统计学意义(P<0.05),其中伴多种共病患儿的手术失败率及再手术率显著高于伴一种共病的患儿(70.0%和4.0%,60.0%和4.0%),两者比较差异有统计学意义(P<0.01)。重度喉软化症总体手术成功率为85.7%。结论:大部分重度喉软化症患儿伴有不同类型和数量的共病,有着更复杂的解剖分型。声门上成形术可改善绝大部分患儿的喉鸣、呼吸困难、喂养困难及生长发育不良,手术成功率高;手术疗效不受手术年龄的影响;多种共病的存在是手术失败和再手术的主要原因。