针对当前病例临床信息与样品管理存在交叉需求的空缺,开发一种将临床信息与样品管理相结合的医学病例信息管理系统。以MS SQL Server 2000建立数据库,以Visual C++6.0开发基于Client/Server模式的客户端应用程序,以实现对病例资料及相...针对当前病例临床信息与样品管理存在交叉需求的空缺,开发一种将临床信息与样品管理相结合的医学病例信息管理系统。以MS SQL Server 2000建立数据库,以Visual C++6.0开发基于Client/Server模式的客户端应用程序,以实现对病例资料及相关样品信息的录入、浏览、查询选择、分级统计、样品管理及自动生成病例信息综合文档等功能,从而达到按科研所需对群体病例资料及其样品的管理。该系统有助于提高临床科研工作的效率、质量及管理水平,为医学病例及样品信息的综合动态管理提供了新的技术平台。展开更多
知识图谱提供的服务质量在很大程度上取决于知识图谱构建的质量.自动构建知识图谱的方法已被广泛应用于许多领域,但知识图谱在医学领域的应用却面临着很多困难,原因有:医学概念/关系/事件的复杂和模糊性;数据标准不一致,源数据质量差;...知识图谱提供的服务质量在很大程度上取决于知识图谱构建的质量.自动构建知识图谱的方法已被广泛应用于许多领域,但知识图谱在医学领域的应用却面临着很多困难,原因有:医学概念/关系/事件的复杂和模糊性;数据标准不一致,源数据质量差;医疗数据异构多元化严重,如电子医学病例(electronic medical record,简称EMR)等.在构建过程中,需要来自医学专家的大量先验知识和人工辅助.引入一个系统架构,该架构明确了在何时何处引入医学专家的相关工作,从而提高医疗健康知识图谱构建的质量和效率.展开更多
AIM: To study the long-term effects of endoscopic sphincterotomy on biliary epithelium. METHODS: This is a prospective case-control study. A total of 25 patients with a median age of 71 years (range 49-89 years) and p...AIM: To study the long-term effects of endoscopic sphincterotomy on biliary epithelium. METHODS: This is a prospective case-control study. A total of 25 patients with a median age of 71 years (range 49-89 years) and prior endoscopic sphincterotomy (ES) for benign disease formed the fi rst group. The median time from ES was 42 mo (range 8-144 mo). Another 25 patients with a median age of 76 years (range 44-94 mo) and similar characteristics who underwent current endoscopic retrograde cholangio-pancreatography (ERCP) and ES for benign disease formed the second group (control group). Brush cytology of the biliary tree with p53 immunocytology was performed in all patients of both groups. ERCPs and recruitment were conducted at the Endoscopic Unit of Aretaieion University Hospital and Tzaneio Hospital, Athens, from October 2006 to June 2010. RESULTS: No cases were positive or suspicious for malignancy. Epithelial atypia was higher in the first group (32% vs 8% in the second group, P = 0.034). Acute cholangitis and previous biliary operation rates were also higher in the fi rst group (acute cholangitis, 60% vs 24% in the second group, P = 0.01; previous biliary operation, 76% vs 24% in the second group, P = 0.001). Subgroup analysis showed that previous ES was the main causal factor for atypia, which was not related to the time interval from the ES (P = 0.407). Two patients (8%) with atypia in the fi rst group were p53-positive. CONCLUSION: ES causes biliary epithelial atypia that represents mostly reactive/proliferative rather than premalignant changes. The role of p53 immunoreactivity in biliary atypia needs to be further studied.展开更多
KETAMINE is an anaesthetic agent characterized by a rapid onset and short duration of action, but it has increasingly been abused as a ＂clubdrug＂ since the late 1980s. It can causeinflammation and contraction of the...KETAMINE is an anaesthetic agent characterized by a rapid onset and short duration of action, but it has increasingly been abused as a ＂clubdrug＂ since the late 1980s. It can causeinflammation and contraction of the bladder, leading to possibly irreversible kidney damage. Since 2007, case reports are appearing in the medical literature describing severe bladder dysfunction and kidney injury in ketamine abusers. In this article, we report a case of obstructive nephropathy and kidney injury in a ketamine abuser.展开更多
文摘针对当前病例临床信息与样品管理存在交叉需求的空缺,开发一种将临床信息与样品管理相结合的医学病例信息管理系统。以MS SQL Server 2000建立数据库,以Visual C++6.0开发基于Client/Server模式的客户端应用程序,以实现对病例资料及相关样品信息的录入、浏览、查询选择、分级统计、样品管理及自动生成病例信息综合文档等功能,从而达到按科研所需对群体病例资料及其样品的管理。该系统有助于提高临床科研工作的效率、质量及管理水平,为医学病例及样品信息的综合动态管理提供了新的技术平台。
文摘知识图谱提供的服务质量在很大程度上取决于知识图谱构建的质量.自动构建知识图谱的方法已被广泛应用于许多领域,但知识图谱在医学领域的应用却面临着很多困难,原因有:医学概念/关系/事件的复杂和模糊性;数据标准不一致,源数据质量差;医疗数据异构多元化严重,如电子医学病例(electronic medical record,简称EMR)等.在构建过程中,需要来自医学专家的大量先验知识和人工辅助.引入一个系统架构,该架构明确了在何时何处引入医学专家的相关工作,从而提高医疗健康知识图谱构建的质量和效率.
基金Supported by GC Medical Hellas who offered us free cytology brushes
文摘AIM: To study the long-term effects of endoscopic sphincterotomy on biliary epithelium. METHODS: This is a prospective case-control study. A total of 25 patients with a median age of 71 years (range 49-89 years) and prior endoscopic sphincterotomy (ES) for benign disease formed the fi rst group. The median time from ES was 42 mo (range 8-144 mo). Another 25 patients with a median age of 76 years (range 44-94 mo) and similar characteristics who underwent current endoscopic retrograde cholangio-pancreatography (ERCP) and ES for benign disease formed the second group (control group). Brush cytology of the biliary tree with p53 immunocytology was performed in all patients of both groups. ERCPs and recruitment were conducted at the Endoscopic Unit of Aretaieion University Hospital and Tzaneio Hospital, Athens, from October 2006 to June 2010. RESULTS: No cases were positive or suspicious for malignancy. Epithelial atypia was higher in the first group (32% vs 8% in the second group, P = 0.034). Acute cholangitis and previous biliary operation rates were also higher in the fi rst group (acute cholangitis, 60% vs 24% in the second group, P = 0.01; previous biliary operation, 76% vs 24% in the second group, P = 0.001). Subgroup analysis showed that previous ES was the main causal factor for atypia, which was not related to the time interval from the ES (P = 0.407). Two patients (8%) with atypia in the fi rst group were p53-positive. CONCLUSION: ES causes biliary epithelial atypia that represents mostly reactive/proliferative rather than premalignant changes. The role of p53 immunoreactivity in biliary atypia needs to be further studied.
文摘KETAMINE is an anaesthetic agent characterized by a rapid onset and short duration of action, but it has increasingly been abused as a ＂clubdrug＂ since the late 1980s. It can causeinflammation and contraction of the bladder, leading to possibly irreversible kidney damage. Since 2007, case reports are appearing in the medical literature describing severe bladder dysfunction and kidney injury in ketamine abusers. In this article, we report a case of obstructive nephropathy and kidney injury in a ketamine abuser.
