Tongue diagnosis is one of the most precious and widely used diagnostic methods in Traditional Chinese Medicine (TCM). However, due to its subjective, qualitative and experience-dependent nature, the studies on tongue...Tongue diagnosis is one of the most precious and widely used diagnostic methods in Traditional Chinese Medicine (TCM). However, due to its subjective, qualitative and experience-dependent nature, the studies on tongue characterization have been widely emphasized. This paper surveys recent progresses in analysis of tongue manifestation. These new developments include the cross-network and cross-media color reproduction of tongue image, the automatic segmentation of tongue body based on knowledge, the automatic analysis of curdiness and griminess for the tongue fur and the automatic analysis of plumpness, wryness and dot -thorn of tongue body. The clinic experiments verify the validity of these new methods.展开更多
RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human ...RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human cells.RNAi-based gene therapies, especially in viral diseases have become more and more interesting and promising. Recently,small interfering RNA (siRNA) can be used to protect host from viral infection, inhibit the expression of viral antigen and accessory genes, control the transcription and replication of viral genome, hinder the assembly of viral particles, and display influences in virus-host interactions. In this review, we attempt to present recent progresses of this breakthrough technology in the above fields and summarize the possibilities of siRNA-based drugs.展开更多
AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.METHODS:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid ...AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.METHODS:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy(FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications.Upper endoscopy using high definition whitelight,2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination.Two patients used as controls had normal endoscopy and histological results.Prospectively,videos were watched blind from histological results by three trained FICE technique endoscopists.RESULTS:The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined.Videos did not identify irregular vascular patterns using high definition white light endoscopy,while acid acetic-FICE combined visualised one in 86% of cases.CONCLUSION:Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus.展开更多
This paper introduces the techniques of direct volume rendering in VTK and discusses ray-casting--the most popular technique of direct volume rendering. The visualizations for medical volumetric data by three function...This paper introduces the techniques of direct volume rendering in VTK and discusses ray-casting--the most popular technique of direct volume rendering. The visualizations for medical volumetric data by three functions of raycasting are offered. Visualization effects prove that VTK is easy to get satisfied resuits with good quality in short time.展开更多
AIM: To introduce the American Pittsburgh's method of rapid liver procurement under the condition of brain death and factors influencing the quality of donor liver.METHODS: To analyze 32 cases of allograft liver p...AIM: To introduce the American Pittsburgh's method of rapid liver procurement under the condition of brain death and factors influencing the quality of donor liver.METHODS: To analyze 32 cases of allograft liver procurement retrospectively and observe the clinical outcome of orthotopic liver transplantation.RESULTS: Average age of donors was 38.24±12.78 years,with a male:female ratio of 23:9. The causes of brain death included 21 cases of trauma (65.63%) and nine cases of cerebrovascular accident (28.13%). Fourteen grafts (43.75%) had hepatic arterial anomalies, seven cases only right hepatic arterial anomalies (21.88%), five cases only left hepatic arterial anomalies (15.63%) and two cases of both right and left hepatic arterial anomalies (6.25%) among them. Eight cases (57.14%) of hepatic arterial anomalies required arterial reconstruction prior to transplantation. Of the 32 grafts evaluated for early function, 27 (84.38%) functioned well, whereas three (9.38%) functioned poorly and two (6.25%) failed to function at all. Only one recipient died after transplantation and thirty-one recipients recovered. Four recipients needed retransplantation. The variables associated with less than optimal function of the graft consisted of donor age (35.6±12.9 years vs 54.1±4.3 years, P<0.05), duration of donor's stay in the intensive care unit (ICU) (3.5±2.4 d vs 7.4±2.1 d, P<0.005), abnormal graft appearance (19.0% vs 100%, P<0.05), and such recipient problems as vascular thromboses during or immediately following transplantation (89.3% vs 50.0%, P<0.005).CONCLUSION: During liver procurement, complete heparization, perfusion in situ with localized low temperature and standard technique procedures are the basis ensuring the quality of the graft. The hepatic arterial anomalies should be taken care of to avoid injury. The donor age,duration of donor's staying in ICU, abnormal graft appearance and recipient problem are important factors influencing the quality of the liver graft.展开更多
Objective: Phase-contrast X-ray imaging which reduces radiation exposure, is a promising technique for observing the inner structures of biological soft tissues without the aid of contrast agents. The present study in...Objective: Phase-contrast X-ray imaging which reduces radiation exposure, is a promising technique for observing the inner structures of biological soft tissues without the aid of contrast agents. The present study intends to depict blood vessels of rabbits and human livers with hard X-ray in-line outline imaging without contrast agents using synchrotron radiation. Methods: All samples were fixed with formalin and sliced into 6 mm sections. The imaging experiments were performed with Fuji-IX80 films on the 4W1A light beam of the first generation synchrotron radiation in Beijing, China. The device of the experiment, which supplies a maximum light spot size of 20×10 mm was similar to that of in-line holography. The photon energy was set at 8 KeV and high quality imagines were obtained by altering the distance between the sample and the film. Results: The trees of rabbit-liver blood vessels and the curved vessels of the cirrhotic human liver were revealed on the images, where vessels < 20 μm in diameter were differentiated. Conclusion: These results show that the blood vessels of liver samples can be revealed by using hard X-ray in-line outline imaging with the first generation synchrotron radiation without contrast agents.展开更多
Chitosan of different molecular weight (M. W. ) was added into SBR bioreactor to treat domestic wastewater. From comparison of treatment efficiency, sludge activity, sludge structure etc., we revealed the mechanism ...Chitosan of different molecular weight (M. W. ) was added into SBR bioreactor to treat domestic wastewater. From comparison of treatment efficiency, sludge activity, sludge structure etc., we revealed the mechanism that chitosan enhanced the biological treatment function of activated sludge. The results proved that, chitosan is certain to restrain the reaction of activated sludge, but it do improve the structure of sludge floes and increase the treatment efficiency of activated sludge. The bigger the M. W. of chitosan is, the better the efficiency of enhancing biological treatment can be.展开更多
Thanks to the development of new medical technologies and improvement in medical care the last decades are characterized by the growth of elderly's number. The median age of the world's population is increasing beca...Thanks to the development of new medical technologies and improvement in medical care the last decades are characterized by the growth of elderly's number. The median age of the world's population is increasing because of a decline in birth rates and a 20-year increase in the average life span during the second half of the 20th century.展开更多
Dr. Schmid was a former dean of the University of California, San Francisco School of Medicine and a liver specialist whose early studies of porphyrins led to several significant fundamental discoveries. He was the fi...Dr. Schmid was a former dean of the University of California, San Francisco School of Medicine and a liver specialist whose early studies of porphyrins led to several significant fundamental discoveries. He was the first to demonstrate that there were different forms of porphyria. He also developed the first experimental model for hepatic porphyria, a model that for many years was used for most of the work in this field and cited in hundreds of papers. His contributions were recognized when he was awarded the 1990 Friedenwald Medal by the American Gastroenterological Association, its most coveted award for lifetime achievement.展开更多
9th NPY Meeting was held for the f irst time in Japan in March 2008, which was organized by Akio Inui, Profes-sor and Chairman, Department of Psychosomatic In-ternal Medicine, Kagoshima University Graduate School of M...9th NPY Meeting was held for the f irst time in Japan in March 2008, which was organized by Akio Inui, Profes-sor and Chairman, Department of Psychosomatic In-ternal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. We have invited him to write TOPIC HIGHLIGHT for WJG focused on ghrelin along the gut-brain axis.This TOPIC HIGHLIGHT is the 'ghrelin version' of the proceedings of 9th NPY Meeting and presents ex-amples of the critical interplay in ghrelin-NPY pathway in response to environmental,展开更多
Lancet needle, having three planes at the tip to generate a sharp lancet point, is the most common needle tip geometry and used for medical procedures. This research presents two five-plane lancet needle designs, the ...Lancet needle, having three planes at the tip to generate a sharp lancet point, is the most common needle tip geometry and used for medical procedures. This research presents two five-plane lancet needle designs, the five-plane lancet needle with two back bevels (FLN-B) and five-plane lancet needle with two front bevels (FLN-F), to study the effects of two additional bevel planes on the reduction of soft tissue cutting force. Mathematical models to calculate the inclination angle and rake angle along the cutting edges of FLN-B and FLN-F are developed. By using the grinding process, the prototype FLN-B and FLN-F needles are fabricated. And their inclination and rake angles along the cutting edges are investigated and compared to that of regular lancet needle. Needles insertion tests were conducted on soft PVC phantom which mimics the soft tissue. The initial peak insertion force and steady-state cutting force during needle insertion were identified, and the effect of cutting edge on needle soft tissue cutting force was studied. Compared to lancet needle, FLN-B and FLN-F both have higher inclination and rake angles at the tip cutting edge, could reduce the initial peak needle insertion force and tissue cutting forces, and thus can efficiently cut the soft tissue for medical applications.展开更多
One of the emerging technologies is wireless handheld technology. Implication of these devices is enormous for business community and healthcare domain is not an exception to this phenomena. This research paper provid...One of the emerging technologies is wireless handheld technology. Implication of these devices is enormous for business community and healthcare domain is not an exception to this phenomena. This research paper provides some useful findings about the use of PDA's in the healthcare environment through actual usage of PDA in the healthcare ward. A qualitative and quantitative approach is adopted to explore these phenomena due to the exploratory nature of the research. Findings of this study identify some of the motivators and issues associated with the wireless handheld technology in healthcare environment. Furthermore, it is also found that these wireless handheld devices can help to improve the quality of care through better decision making processes. This study is limited to only one sate of Australian and further research is needed to see the implication of the findings to wider community and other domains in the Australian environment.展开更多
To perceive the epithelial dysplasia from the light scattering spectroscopy (LSS) is an inverse problem, which can be transformed into the inversion of the size distribution of epithelial-cell nuclei. Based on the sim...To perceive the epithelial dysplasia from the light scattering spectroscopy (LSS) is an inverse problem, which can be transformed into the inversion of the size distribution of epithelial-cell nuclei. Based on the simulation of single polarized LSS for epithelial-cell nuclei, Chahine algorithm is adopted to retrieve the size distribution. Numerical results show that Chahine algorithm has high inversion precision for both single-peaked and bimodal models, which implies the potential to increase diagnostic resolution of LSS.展开更多
基金This work is supported by the Natural Science Fund of China under grant number 60301003, 60227101 and 60431020, and bythe Natural Science Fund of Beijing,under grant number 3052005,China
文摘Tongue diagnosis is one of the most precious and widely used diagnostic methods in Traditional Chinese Medicine (TCM). However, due to its subjective, qualitative and experience-dependent nature, the studies on tongue characterization have been widely emphasized. This paper surveys recent progresses in analysis of tongue manifestation. These new developments include the cross-network and cross-media color reproduction of tongue image, the automatic segmentation of tongue body based on knowledge, the automatic analysis of curdiness and griminess for the tongue fur and the automatic analysis of plumpness, wryness and dot -thorn of tongue body. The clinic experiments verify the validity of these new methods.
文摘RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human cells.RNAi-based gene therapies, especially in viral diseases have become more and more interesting and promising. Recently,small interfering RNA (siRNA) can be used to protect host from viral infection, inhibit the expression of viral antigen and accessory genes, control the transcription and replication of viral genome, hinder the assembly of viral particles, and display influences in virus-host interactions. In this review, we attempt to present recent progresses of this breakthrough technology in the above fields and summarize the possibilities of siRNA-based drugs.
文摘AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.METHODS:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy(FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications.Upper endoscopy using high definition whitelight,2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination.Two patients used as controls had normal endoscopy and histological results.Prospectively,videos were watched blind from histological results by three trained FICE technique endoscopists.RESULTS:The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined.Videos did not identify irregular vascular patterns using high definition white light endoscopy,while acid acetic-FICE combined visualised one in 86% of cases.CONCLUSION:Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus.
基金The author gratefully acknowledges the support of Youth for NWPUTeachers Scientific and Technological Innovation Foundation (5210102-0800-M016206)This work is supported by a grant for PH.D Site from Chinese Educational Department (20040699015)The authors are thankful to Guiqing He, PhD and Chongyang Hao, professor for many help and interesting discussions.
文摘This paper introduces the techniques of direct volume rendering in VTK and discusses ray-casting--the most popular technique of direct volume rendering. The visualizations for medical volumetric data by three functions of raycasting are offered. Visualization effects prove that VTK is easy to get satisfied resuits with good quality in short time.
文摘AIM: To introduce the American Pittsburgh's method of rapid liver procurement under the condition of brain death and factors influencing the quality of donor liver.METHODS: To analyze 32 cases of allograft liver procurement retrospectively and observe the clinical outcome of orthotopic liver transplantation.RESULTS: Average age of donors was 38.24±12.78 years,with a male:female ratio of 23:9. The causes of brain death included 21 cases of trauma (65.63%) and nine cases of cerebrovascular accident (28.13%). Fourteen grafts (43.75%) had hepatic arterial anomalies, seven cases only right hepatic arterial anomalies (21.88%), five cases only left hepatic arterial anomalies (15.63%) and two cases of both right and left hepatic arterial anomalies (6.25%) among them. Eight cases (57.14%) of hepatic arterial anomalies required arterial reconstruction prior to transplantation. Of the 32 grafts evaluated for early function, 27 (84.38%) functioned well, whereas three (9.38%) functioned poorly and two (6.25%) failed to function at all. Only one recipient died after transplantation and thirty-one recipients recovered. Four recipients needed retransplantation. The variables associated with less than optimal function of the graft consisted of donor age (35.6±12.9 years vs 54.1±4.3 years, P<0.05), duration of donor's stay in the intensive care unit (ICU) (3.5±2.4 d vs 7.4±2.1 d, P<0.005), abnormal graft appearance (19.0% vs 100%, P<0.05), and such recipient problems as vascular thromboses during or immediately following transplantation (89.3% vs 50.0%, P<0.005).CONCLUSION: During liver procurement, complete heparization, perfusion in situ with localized low temperature and standard technique procedures are the basis ensuring the quality of the graft. The hepatic arterial anomalies should be taken care of to avoid injury. The donor age,duration of donor's staying in ICU, abnormal graft appearance and recipient problem are important factors influencing the quality of the liver graft.
基金Supported by National Natural Science Foundation of China (10275087)Shanghai Optic Science Fund (022261023)Shanghai Natural Science Fund (02ZF14116)
文摘Objective: Phase-contrast X-ray imaging which reduces radiation exposure, is a promising technique for observing the inner structures of biological soft tissues without the aid of contrast agents. The present study intends to depict blood vessels of rabbits and human livers with hard X-ray in-line outline imaging without contrast agents using synchrotron radiation. Methods: All samples were fixed with formalin and sliced into 6 mm sections. The imaging experiments were performed with Fuji-IX80 films on the 4W1A light beam of the first generation synchrotron radiation in Beijing, China. The device of the experiment, which supplies a maximum light spot size of 20×10 mm was similar to that of in-line holography. The photon energy was set at 8 KeV and high quality imagines were obtained by altering the distance between the sample and the film. Results: The trees of rabbit-liver blood vessels and the curved vessels of the cirrhotic human liver were revealed on the images, where vessels < 20 μm in diameter were differentiated. Conclusion: These results show that the blood vessels of liver samples can be revealed by using hard X-ray in-line outline imaging with the first generation synchrotron radiation without contrast agents.
文摘Chitosan of different molecular weight (M. W. ) was added into SBR bioreactor to treat domestic wastewater. From comparison of treatment efficiency, sludge activity, sludge structure etc., we revealed the mechanism that chitosan enhanced the biological treatment function of activated sludge. The results proved that, chitosan is certain to restrain the reaction of activated sludge, but it do improve the structure of sludge floes and increase the treatment efficiency of activated sludge. The bigger the M. W. of chitosan is, the better the efficiency of enhancing biological treatment can be.
文摘Thanks to the development of new medical technologies and improvement in medical care the last decades are characterized by the growth of elderly's number. The median age of the world's population is increasing because of a decline in birth rates and a 20-year increase in the average life span during the second half of the 20th century.
文摘Dr. Schmid was a former dean of the University of California, San Francisco School of Medicine and a liver specialist whose early studies of porphyrins led to several significant fundamental discoveries. He was the first to demonstrate that there were different forms of porphyria. He also developed the first experimental model for hepatic porphyria, a model that for many years was used for most of the work in this field and cited in hundreds of papers. His contributions were recognized when he was awarded the 1990 Friedenwald Medal by the American Gastroenterological Association, its most coveted award for lifetime achievement.
文摘9th NPY Meeting was held for the f irst time in Japan in March 2008, which was organized by Akio Inui, Profes-sor and Chairman, Department of Psychosomatic In-ternal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. We have invited him to write TOPIC HIGHLIGHT for WJG focused on ghrelin along the gut-brain axis.This TOPIC HIGHLIGHT is the 'ghrelin version' of the proceedings of 9th NPY Meeting and presents ex-amples of the critical interplay in ghrelin-NPY pathway in response to environmental,
文摘Lancet needle, having three planes at the tip to generate a sharp lancet point, is the most common needle tip geometry and used for medical procedures. This research presents two five-plane lancet needle designs, the five-plane lancet needle with two back bevels (FLN-B) and five-plane lancet needle with two front bevels (FLN-F), to study the effects of two additional bevel planes on the reduction of soft tissue cutting force. Mathematical models to calculate the inclination angle and rake angle along the cutting edges of FLN-B and FLN-F are developed. By using the grinding process, the prototype FLN-B and FLN-F needles are fabricated. And their inclination and rake angles along the cutting edges are investigated and compared to that of regular lancet needle. Needles insertion tests were conducted on soft PVC phantom which mimics the soft tissue. The initial peak insertion force and steady-state cutting force during needle insertion were identified, and the effect of cutting edge on needle soft tissue cutting force was studied. Compared to lancet needle, FLN-B and FLN-F both have higher inclination and rake angles at the tip cutting edge, could reduce the initial peak needle insertion force and tissue cutting forces, and thus can efficiently cut the soft tissue for medical applications.
文摘One of the emerging technologies is wireless handheld technology. Implication of these devices is enormous for business community and healthcare domain is not an exception to this phenomena. This research paper provides some useful findings about the use of PDA's in the healthcare environment through actual usage of PDA in the healthcare ward. A qualitative and quantitative approach is adopted to explore these phenomena due to the exploratory nature of the research. Findings of this study identify some of the motivators and issues associated with the wireless handheld technology in healthcare environment. Furthermore, it is also found that these wireless handheld devices can help to improve the quality of care through better decision making processes. This study is limited to only one sate of Australian and further research is needed to see the implication of the findings to wider community and other domains in the Australian environment.
基金Supported partially by the Young Scholar Foundation of NanjingUniversity of Science and Technology(Grant No. NJUST200204)
文摘To perceive the epithelial dysplasia from the light scattering spectroscopy (LSS) is an inverse problem, which can be transformed into the inversion of the size distribution of epithelial-cell nuclei. Based on the simulation of single polarized LSS for epithelial-cell nuclei, Chahine algorithm is adopted to retrieve the size distribution. Numerical results show that Chahine algorithm has high inversion precision for both single-peaked and bimodal models, which implies the potential to increase diagnostic resolution of LSS.