分析基于快速康复外科理念的多学科协作围术期护理对前列腺癌根治术患者术后疼痛评分、并发症及睡眠质量的影响

目的:分析基于快速康复外科理念的多学科协作围术期护理对前列腺癌根治术患者术后疼痛评分、并发症及睡眠质量的影响。方法:选取2022年1月至2023年1月福建医科大学附属第一医院泌尿外科收治的采取前列腺癌根治术治疗的患者62例作为研究对象,按照随机数字表法划分为对照组(n=31)和观察组(n=31),对照组给予常规围术期护理干预,观察组给予基于FTS理念的多学科协作围术期护理干预,采用疼痛数字评分法(NRS)比较2组患者干预前后的疼痛感受,采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后睡眠质量的变化,同时比较2组患者干预前后并发症的发生率。结果:护理干预后,观察组NRS评分、PSQI评分显著低于对照组,观察组并发症的发生率显著低于对照组,差异均有统计学意义(均P<0.05)。结论:前列腺癌根治术中基于FTS理念应用多学科协作围术期护理能够减轻前列腺癌根治术患者的疼痛感受,改善患者的睡眠质量,具有较高借鉴价值。

协作式围手术期护理在无痛人流术患者中的应用效果分析

目的：探讨病房与手术室护士，在无痛人流术患者中应用协作式围手术期护理，对患者的心理生理应激反应情况。方法：选择妇科痛区120例待无痛人流患者随机将其分为对照组与干预组，每组各60例。结果：对两组无痛人流患者进入手术室后麻醉前的收缩压、心率进行比较有统计学意义（P〈0．01）。结论：对无痛人流患者进行协作式围术期护理能减轻患者的心理生理应激反应。

远程开放教育中的团队精神

培养应用性人才是远程开放教育的主要目标,要实现上述目标,各个远程开放教育机构开始重视协同工作。"团队精神"在未来的远程开放教育模式中将起着重要的作用。通常情况下团队发展需要四个阶段,在团队协同工作中,应注意聆听别人的意见,有效的团队通过使团队多元化来避免出现集体审议情况,团队要在年龄上、性别上、背景上、经验上和接受培训程度上多元化。

Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

AIM: To examine the ability of cyclin-dependent kinase inhibitor (CDKI) roscovitine (Rosco) to enhance the antitumor effects of conventional chemotherapeutic agents acting by different mechanisms against human colorectal cancer. METHODS: Human colorectal cancer cells were treat-ed, individually and in combination, with Rosco, taxol, 5-Fluorouracil (5-FU), doxorubicine or vinblastine. The antiproliferative effects and the type of interaction of Rosco with tested chemotherapeutic drugs were de-termined. Cell cycle alterations were investigated by fluorescence-activated cell sorter FACS analysis. Apop-tosis was determined by DNA fragmentation assay. RESULTS: Rosco inhibited the proliferation of tumor cells in a time-and dose-dependent manner. The ef-ficacies of all tested chemotherapeutic drugs were markedly enhanced 3.0-8.42 × 103 and 130-5.28 × 103 fold in combination with 5 and 10 μg/mL Rosco, re-spectively. The combination of Rosco and chemothera-peutic drugs inhibited the growth of human colorectal cancer cells in an additive or synergistic fashion, and in a time and dose dependent manner. Rosco induced apoptosis and synergized with tested chemothera-peutic drugs to induce efficient apoptosis in human colorectal cancer cells. Sequential, inverted sequential and simultaneous treatment of cancer cells with combi-nations of chemotherapeutic drugs and Rosco arrested the growth of human colorectal cancer cells at various phases of the cell cycle as follows: Taxol/Rosco (G2/M-and S-phases), 5-FU/Rosco (S-phase), Dox/Rosco (S-phase) and Vinb/Rosco (G2/M-and S-phases). CONCLUSION: Since the eff icacy of many anticancer drugs depends on their ability to induce apoptotic cell death, modulation of this parameter by cell cycle inhibi-tors may provide a novel chemo-preventive and chemo-therapeutic strategy for human colorectal cancer.

Collaborative Problem in Multi-agent System

In the MAS, system goal task can be decomposed into many transactions, which will be achieved by special agents distributed in different physical space. Due to complex coupling relations among transactions, transactions may form Waiting-Circle resulting in deadlock. Concerning the problem, this paper proposes two theorems developed for Waiting-Circle detection in transaction set and ensures the implement of goal task decomposition result. Furthermore, Circle-First Search is put forward to search all of the Waiting-Circle, which prnvide the basic guideline for decomposing goal task again and eliminate Waiting-Circle.

Dominance network structure across reproductive contexts in the cooperatively breeding cichlid fish Neolamprologus pulcher

While a large number of studies have described animal social networks, we have a poor understanding of how these networks vary with ecological and social conditions. For example, reproductive periods are an important life-history stage that may involve changes in dominance relationships among individuals, yet no study to date has compared social networks of do- minance interactions （i.e. dominance networks） across reproductive contexts. We first analyzed a long-term dataset on captive so- cial groups of the cooperatively breeding cichlid Neolamprologuspulcher, and found that eviction events were significantly more common around reproduction than expected by chance. Next, we compared the structure of dominance networks during early pa- rental care and non-reproductive periods, using one of the first applications of exponential random graph models in behavioral biology. Contrary to our predictions, we found that dominance networks showed few changes between early parental care and non-reproductive periods. We found no evidence that dominance interactions became more skewed towards larger individuals, became more frequent between similar-sized individuals, or became more biased towards a particular sex during parental care. However, we did find that there were relatively more dominance interactions between opposite-sex dyads in the early parental care period, which may be a by-product of increased sexual interactions during this time. This is the first study in behavioral ecology to compare social networks using exponential random graph modeling, and demonstrates a powerful analytical framework for future studies in the field [Current Zoology 61 （1）： 45-54, 2015].

Nanoparticle mediated controlled delivery of dual growth factors

Peripheral nerve functional recovery after nerve injury generally requires multiple growth factors by synergistic effect.However,the optical combination of multiple synergistic growth factors for axonal regeneration has been scarcely considered up to now.Meanwhile,the use of growth factors in promoting nerve regeneration was limited by its short biological half-life in vivo,its vulnerability to structure disruption or hydrolyzation,leading to loss of bioactivity.Herein,a novel polymeric nanoparticle delivery system composed of heparin andε-poly-L-lysine(PL)was prepared for control release of nerve growth factor(NGF)and basic fibroblast growth factor(bFGF).The nanoparticles were synthesized by polyelectrolyte complexation in aqueous solution at room temperature,followed by cross-linking with biological genipin.The obtained nanoparticles had a spherical shape,with a mean diameter of about 246 nm,and high growth factors encapsulation efficiency as well as good stability.NGF and bFGF were encapsulated in the nanoparticles and showed a continuous and slow release behavior in vitro.The bioactivities of the released growth factors were evaluated,and exhibited the synergistic effect.The controlled release of the dual synergistic growth factors would improve the treatment of peripheral nerve injury to mimic the natural cellular microenvironments.