统计罹患急性缺血性脑卒中的82例患者应用标准化护理协作流程后对溶栓治疗时间的影响。方法 对罹患急性缺血性脑卒中的82例病患予以纳取,患者收集时间为2019.12月~2021.05月,分组,即为对照组(41例接受常规卒中护理)、观察组(41例在常...统计罹患急性缺血性脑卒中的82例患者应用标准化护理协作流程后对溶栓治疗时间的影响。方法 对罹患急性缺血性脑卒中的82例病患予以纳取,患者收集时间为2019.12月~2021.05月,分组,即为对照组(41例接受常规卒中护理)、观察组(41例在常规基础之上应用标准化护理协作流程)。就治疗情况[入院-用药(DNT)时间、入院-CT时间、CT完成-用药时间]、rt-PA静脉溶栓时间情(1h内溶栓完成、1-2h溶栓完成、2-3h溶栓完成、3-4.5h溶栓完成)、神经功能(NIHSS)加以归纳、整合、对比。结果 展开护理以后就治疗情况予以统计,观察组DNT时间、入院-CT时间、CT完成-用药时间相较对照组均居更短水平[(57.49±5.13)min vs (104.38±5.72)min,(13.79±4.22)min vs (35.84±4.28)min,(30.60±4.29)min vs (56.17±4.42)min,P<0.05];就rt-PA静脉溶栓时间予以统计,观察组1h内溶栓完成率相较对照组居更高水平(95.12% vs 78.05%,P<0.05);就神经功能予以统计,观察组NIHSS评分相较对照组居更低水平[(17.04±2.73)分 vs (22.57±2.69)分,P<0.05]。结论 对罹患急性缺血性脑卒中的患者施以标准化护理协作流程,可缩短DNT时间,及早进行溶栓治疗,且对于节约溶栓治疗时间、改善神经功能有益。展开更多
Background The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery （SYNTAX）-score is a validated tool for risk stratification and revascularization strategy selection in patients with c...Background The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery （SYNTAX）-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. Methods SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention （PCI）： 463 patients ≥ 75 years and 868 patients 〈 75 years. Outcomes of interest were all-cause mortality at one and two years. Results A significant interaction of age and SYNTAX-score for mortality was observed at two-year （Pinteraction= 0.019） but not at one-year follow-up （Pinteraction= 0.594）. In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups （〈 75 years, hazard ratio （HR）： 1.43, 95% confidence intervals （CI）： 1.03-2.00, P = 0.034; and 〉 75 years, HR： 1.37, 95% CI： 1.01-1.85, P = 0.042）, but only two-year mortality among younger patients （〈 75 years, HR： 1.33, 95% CI： 1.01-1.76, P = 0.041; and ≥ 75 years, HR： 1.11, 95% CI： 0.87-1.41, P = 0.394）. SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients 〈 75 years （SYNTAX-score 〈 9, 3.8%; 9-20, 5.3%; 〉 20, 10.3%; P = 0.004） and 〉 75 years （SYNTAX-score 〈 11, 5.7%; 11-22.5, 16.1%; 〉 22.5, 18.7%; P = 0.003）, but two-year mortality only among patients 〈 75 years （SYNTAX-score 〈 9, 6.5%; 9-20, 7.6%; ≥ 20, 15%; P 〈 0.001） and not among ≥ 75 years old patients （SYNTAX-score 〈 11, 19.4%; 11-22.5, 26.3%; _〉 22.5, 27.9%; P = 0.138）. Conclusions Age modi- fies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients 〈 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients 〉 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate revascularization strategy among elderly patients.展开更多
In the present study, we aimed to establish the 8th National Standard of Endotoxin using three batches of proposed National Standard of Endotoxin. We co-calibrated the potency of the proposed preparations against the ...In the present study, we aimed to establish the 8th National Standard of Endotoxin using three batches of proposed National Standard of Endotoxin. We co-calibrated the potency of the proposed preparations against the 3rd International Standard （10/178） using the gel-clot method, kinetic-turbidimetric test and kinetic-chromogenic test. A total of 14 laboratories participated in this collaborative study. By comparing precision of three approved candidates＇ calibration results and analyzing the differences among the three results from different methods, we ultimately selected one of candidates as 8th National Standard of Endotoxin, and its potency is 9000 EU/ampoule and lot is 150801-201601.展开更多
文摘统计罹患急性缺血性脑卒中的82例患者应用标准化护理协作流程后对溶栓治疗时间的影响。方法 对罹患急性缺血性脑卒中的82例病患予以纳取,患者收集时间为2019.12月~2021.05月,分组,即为对照组(41例接受常规卒中护理)、观察组(41例在常规基础之上应用标准化护理协作流程)。就治疗情况[入院-用药(DNT)时间、入院-CT时间、CT完成-用药时间]、rt-PA静脉溶栓时间情(1h内溶栓完成、1-2h溶栓完成、2-3h溶栓完成、3-4.5h溶栓完成)、神经功能(NIHSS)加以归纳、整合、对比。结果 展开护理以后就治疗情况予以统计,观察组DNT时间、入院-CT时间、CT完成-用药时间相较对照组均居更短水平[(57.49±5.13)min vs (104.38±5.72)min,(13.79±4.22)min vs (35.84±4.28)min,(30.60±4.29)min vs (56.17±4.42)min,P<0.05];就rt-PA静脉溶栓时间予以统计,观察组1h内溶栓完成率相较对照组居更高水平(95.12% vs 78.05%,P<0.05);就神经功能予以统计,观察组NIHSS评分相较对照组居更低水平[(17.04±2.73)分 vs (22.57±2.69)分,P<0.05]。结论 对罹患急性缺血性脑卒中的患者施以标准化护理协作流程,可缩短DNT时间,及早进行溶栓治疗,且对于节约溶栓治疗时间、改善神经功能有益。
文摘Background The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery （SYNTAX）-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. Methods SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention （PCI）： 463 patients ≥ 75 years and 868 patients 〈 75 years. Outcomes of interest were all-cause mortality at one and two years. Results A significant interaction of age and SYNTAX-score for mortality was observed at two-year （Pinteraction= 0.019） but not at one-year follow-up （Pinteraction= 0.594）. In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups （〈 75 years, hazard ratio （HR）： 1.43, 95% confidence intervals （CI）： 1.03-2.00, P = 0.034; and 〉 75 years, HR： 1.37, 95% CI： 1.01-1.85, P = 0.042）, but only two-year mortality among younger patients （〈 75 years, HR： 1.33, 95% CI： 1.01-1.76, P = 0.041; and ≥ 75 years, HR： 1.11, 95% CI： 0.87-1.41, P = 0.394）. SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients 〈 75 years （SYNTAX-score 〈 9, 3.8%; 9-20, 5.3%; 〉 20, 10.3%; P = 0.004） and 〉 75 years （SYNTAX-score 〈 11, 5.7%; 11-22.5, 16.1%; 〉 22.5, 18.7%; P = 0.003）, but two-year mortality only among patients 〈 75 years （SYNTAX-score 〈 9, 6.5%; 9-20, 7.6%; ≥ 20, 15%; P 〈 0.001） and not among ≥ 75 years old patients （SYNTAX-score 〈 11, 19.4%; 11-22.5, 26.3%; _〉 22.5, 27.9%; P = 0.138）. Conclusions Age modi- fies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients 〈 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients 〉 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate revascularization strategy among elderly patients.
文摘In the present study, we aimed to establish the 8th National Standard of Endotoxin using three batches of proposed National Standard of Endotoxin. We co-calibrated the potency of the proposed preparations against the 3rd International Standard （10/178） using the gel-clot method, kinetic-turbidimetric test and kinetic-chromogenic test. A total of 14 laboratories participated in this collaborative study. By comparing precision of three approved candidates＇ calibration results and analyzing the differences among the three results from different methods, we ultimately selected one of candidates as 8th National Standard of Endotoxin, and its potency is 9000 EU/ampoule and lot is 150801-201601.
