Reversing the syntactic format of program inputs and data structures in binaries plays a vital role for understanding program behaviors in many security applications.In this paper,we propose a collaborative reversing ...Reversing the syntactic format of program inputs and data structures in binaries plays a vital role for understanding program behaviors in many security applications.In this paper,we propose a collaborative reversing technique by capturing the mapping relationship between input fields and program data structures.The key insight behind our paper is that program uses corresponding data structures as references to parse and access different input fields,and every field could be identified by reversing its corresponding data structure.In details,we use a finegrained dynamic taint analysis to monitor the propagation of inputs.By identifying base pointers for each input byte,we could reverse data structures and conversely identify fields based on their referencing data structures.We construct several experiments to evaluate the effectiveness.Experiment results show that our approach could effectively reverse precise input formats,and provide unique benefits to two representative security applications,exploit diagnosis and malware analysis.展开更多
Ferroptosis and autophagy, playing significant roles in tumor treatment, are two typical forms of the programmed cell death. However, the rational combination of ferroptosis and autophagy for synergistic tumor therapy...Ferroptosis and autophagy, playing significant roles in tumor treatment, are two typical forms of the programmed cell death. However, the rational combination of ferroptosis and autophagy for synergistic tumor therapy is still highly challenging. Herein, we report on an intriguing nanomedicine strategy for achieving autophagy-enhanced ferroptosis on efficiently combating cancer, which was based on the construction of trehalose-loaded mSiO_(2)@MnO_(x)-mPEG(Tre MMM) nanoparticles with satisfactory biocompatibility. The nanoparticles are endowed with high glutathione(GSH) consumption efficiency, thereby inducing cancer-cell ferroptosis via inactivating glutathione peroxidases 4(GPX4). Subsequently, the Tre MMM degradation due to the GSH depletion and p H sensitivity contributed to the trehalose release for inducing autophagy, promoting/enhancing ferroptosis by NCOA4-mediated degradation of ferritin.A substantial in vitro and in vivo antitumor effect was achieved by such an intriguing autophagyenhanced ferroptosis. Therefore, the rational combination of GSH-consumption-induced ferroptosis and trehalose-induced autophagy by nanomedicine design provides an alternative but effective strategy for tumor treatment.展开更多
基金the National Natural Science Foundation of China，the foundation of State Key Lab.for Novel Software Technology in Nanjing University,the foundation of Key Laboratory of Information Assurance Technology
文摘Reversing the syntactic format of program inputs and data structures in binaries plays a vital role for understanding program behaviors in many security applications.In this paper,we propose a collaborative reversing technique by capturing the mapping relationship between input fields and program data structures.The key insight behind our paper is that program uses corresponding data structures as references to parse and access different input fields,and every field could be identified by reversing its corresponding data structure.In details,we use a finegrained dynamic taint analysis to monitor the propagation of inputs.By identifying base pointers for each input byte,we could reverse data structures and conversely identify fields based on their referencing data structures.We construct several experiments to evaluate the effectiveness.Experiment results show that our approach could effectively reverse precise input formats,and provide unique benefits to two representative security applications,exploit diagnosis and malware analysis.
基金This work was supported by the National Key R&D Program of China(2016YFA0203700)the National Natural Science Foundation of China(51722211,51672303,and 51902334)+1 种基金Program of Shanghai Academic Research Leader(18XD1404300)the National Science Foundation for Young Scientists of China(81903178)。
文摘Ferroptosis and autophagy, playing significant roles in tumor treatment, are two typical forms of the programmed cell death. However, the rational combination of ferroptosis and autophagy for synergistic tumor therapy is still highly challenging. Herein, we report on an intriguing nanomedicine strategy for achieving autophagy-enhanced ferroptosis on efficiently combating cancer, which was based on the construction of trehalose-loaded mSiO_(2)@MnO_(x)-mPEG(Tre MMM) nanoparticles with satisfactory biocompatibility. The nanoparticles are endowed with high glutathione(GSH) consumption efficiency, thereby inducing cancer-cell ferroptosis via inactivating glutathione peroxidases 4(GPX4). Subsequently, the Tre MMM degradation due to the GSH depletion and p H sensitivity contributed to the trehalose release for inducing autophagy, promoting/enhancing ferroptosis by NCOA4-mediated degradation of ferritin.A substantial in vitro and in vivo antitumor effect was achieved by such an intriguing autophagyenhanced ferroptosis. Therefore, the rational combination of GSH-consumption-induced ferroptosis and trehalose-induced autophagy by nanomedicine design provides an alternative but effective strategy for tumor treatment.
