AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its components.METHODS:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-S...AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its components.METHODS:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005.A total of 3455(1981 men and 1474 women) subjects were included in final analyses.Fatty liver was diagnosed using abdominal ultrasonography by trained gastroenterologists.The modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic syndrome.The associations between smoking,fatty liver and metabolic syndrome were analyzed using multiple logistic regression.RESULTS:Subjects with fatty liver,and who smoked tobacco,had the highest odds ratios(ORs) for high waist circumference [OR,4.5(95% CI:3.3-6.1) ,P < 0.05],hypertriglyceridemia [OR,8.1(95% CI:6.0-10.9) ,P < 0.05],low serum high-density lipoprotein cholesterol(HDL-C) [OR,8.3(95% CI:6.1-11.3) ,P < 0.05],and metabolic syndrome [OR,9.5(95% CI:6.7-13.4) ,P < 0.05] compared to subjects without fatty liver who did not smoke tobacco.We also found that the ORs for hypertriglyceridemia,low serum HDL-C,and metabolic syndrome for subjects with fatty liver who smoked tobacco had greater than the sum of the ORs for subjects with fatty liver who did not smokeplus those who did not have fatty liver and who did smoke.CONCLUSION:Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components,especially for hypertriglyceridemia and low serum HDL-C.展开更多
The existing collaborative recommendation algorithms have lower robustness against shilling attacks.With this problem in mind,in this paper we propose a robust collaborative recommendation algorithm based on k-distanc...The existing collaborative recommendation algorithms have lower robustness against shilling attacks.With this problem in mind,in this paper we propose a robust collaborative recommendation algorithm based on k-distance and Tukey M-estimator.Firstly,we propose a k-distancebased method to compute user suspicion degree(USD).The reliable neighbor model can be constructed through incorporating the user suspicion degree into user neighbor model.The influence of attack profiles on the recommendation results is reduced through adjusting similarities among users.Then,Tukey M-estimator is introduced to construct robust matrix factorization model,which can realize the robust estimation of user feature matrix and item feature matrix and reduce the influence of attack profiles on item feature matrix.Finally,a robust collaborative recommendation algorithm is devised by combining the reliable neighbor model and robust matrix factorization model.Experimental results show that the proposed algorithm outperforms the existing methods in terms of both recommendation accuracy and robustness.展开更多
Northeast China, as the most important production base of agriculture, forestry, and livestock-breeding as well as the old industrial base in the whole country, has been playin a key role in the construction and deve...Northeast China, as the most important production base of agriculture, forestry, and livestock-breeding as well as the old industrial base in the whole country, has been playin a key role in the construction and development of China's economy. However, after the policy of reform and open-up was taken in China. the economic development speed and efficiency ofthis area have turned to be evidently lower than those of coastal area and the national average level as well, which is so-called 'Northeast Phenomenon' and 'Neo-Northeast Phenomenon'. In terms of those phenomena, this paper firstly reviews the spatial and temporal features of the regional evolution of this area so as to unveil the profound forming causes of 'Northeast Phenomena' and 'Neo-Northeast Phenomena'. And then the paper makes a further exploration into the status quo of this region and its forming causes by analyzing its economy gross, industrial structure, product structure, regional eco-categories, etc. At the end of the paper, the authors put forward the basic coordinated development strategies for Northeast China. namely we can revitalize this area by means of adjustment of economic structure, regional coordination, planning urban and rural areas as a whole, institutional innovation, etc.展开更多
Considering the influence of reagent adjustment in different flotation bank on the final production index and the difficulty of establishing an effective mathematical model,a coordinated optimization method for dosage...Considering the influence of reagent adjustment in different flotation bank on the final production index and the difficulty of establishing an effective mathematical model,a coordinated optimization method for dosage reagent based on key characteristics variation tendency and case-based reasoning is proposed.On the basis of the expert reagent regulation method in antimony flotation process,the reagent dosage pre-setting model of the roughing–scavenging bank is constructed based on case-based reasoning.Then,the sensitivity index is used to calculate the key features of reagent dosage.The reagent dosage compensation model is constructed based on the variation tendency of the key features in the roughing and scavenging process.At last,the prediction model is used to finish the classification and discriminant analysis.The simulation results and industrial experiment in antimony flotation process show that the proposed method reduces fluctuation of the tailings indicators and the cost of reagent dosage.It can lay a foundation for optimizing the whole process of flotation.展开更多
Covariant helicity amplitude analysis for the process of J/ψ →γPP is discussed.Starting from the S- matrix elements of decay process,we deduce the formulae of helicity coupling amplitudes for two-body decay process...Covariant helicity amplitude analysis for the process of J/ψ →γPP is discussed.Starting from the S- matrix elements of decay process,we deduce the formulae of helicity coupling amplitudes for two-body decay process. These formulae are used to analyze intermediate resonance states in the process of J/ψ decay to γππ,γKK,γηη' etc.展开更多
The most recognized and employed model of the solvation equilibration in the ionic solutions was proposed by Eigen and Tamm, in which there are four major states for an ion pair in the solution: the completely solvat...The most recognized and employed model of the solvation equilibration in the ionic solutions was proposed by Eigen and Tamm, in which there are four major states for an ion pair in the solution: the completely solvated state, 2SIP (double solvent separate ion pair), SIP (single solvent separate ion pair), and CIP (contact ion pair). Eigen and Tamm suggested that the transition from SIP to CIP is always the slowest step during the whole pairing process, due to a high free energy barrier between these two states. We carried out a series of potential of mean force calculations to study the pairing free energy profiles of two sets of model mono- atomic 1:1 ion pairs 2.0:x and x:2.0. For 2.0:x pairs the free energy barrier between the SIP and CIP states is largely reduced due to the salvation shell water structure. For these pairs the SIP to CIP transition is thus not the slowest step in the ion pair formation course. This is a deviation from the Eigen-Tamm model.展开更多
Collaborative f iltering, as one of the most popular techniques, plays an important role in recommendation systems. However,when the user-item rating matrix is sparse,its performance will be degenerate. Recently,domai...Collaborative f iltering, as one of the most popular techniques, plays an important role in recommendation systems. However,when the user-item rating matrix is sparse,its performance will be degenerate. Recently,domain-specific recommendation approaches have been developed to address this problem.The basic idea is to partition the users and items into overlapping domains, and then perform recommendation in each domain independently. Here, a domain means a group of users having similar preference to a group of products. However, these domain-specific methods consisting of two sequential steps ignore the mutual benefi t of domain segmentation and recommendation. Hence, a unified framework is presented to simultaneously realize recommendation and make use of the domain information underlying the rating matrix in this paper. Based on matrix factorization,the proposed model learns both user preferences of multiple domains and preference selection vectors to select relevant features for each group of products. Besides, local context information is utilized from the user-item rating matrix to enhance the new framework.Experimental results on two widely used datasets, e.g., Ciao and Epinions, demonstrate the effectiveness of our proposed model.展开更多
AIM:To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS:We enrolled a total of 1308 male workers aged from...AIM:To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS:We enrolled a total of 1308 male workers aged from 22 to 63 years.Data was extracted from the workers'periodic health check-ups in hospitals.All cases were from the community of northern Taiwan. This was a cross-sectional observational study from July to September in 2004.We grouped all cases into four groups,based on the quartile of homeostasis model assessment.The top fourth quartile group was defined as the group with insulin resistance.We performed multivariate logistic regression analysis for the odds ratio of the risk factors for insulin resistance. RESULTS:Compared with metabolic syndrome,the coexistence of both factors had a 4.3-fold(95%CI: 2.7-6.8)increased risk,which was more than metabolic syndrome with a 3.6-fold(95%CI:2.6-5.0)increased risk.The two factors had a synergistic effect.The synergistic index of obesity and elevated alanine aminotransferase(ALT)was 2.1(95%CI:1.01-4.3).CONCLUSION:Obesity and elevated ALT are associatedwith insulin resistance.The effects are synergistic. Coexistence of them is better than metabolic syndrome in predicting insulin resistance.展开更多
The application of ensemble optimal interpolation in wave data assimilation in the South China Sea is presented. A sampling strategy for a stationary ensemble is first discussed. The stationary ensemble is constructed...The application of ensemble optimal interpolation in wave data assimilation in the South China Sea is presented. A sampling strategy for a stationary ensemble is first discussed. The stationary ensemble is constructed by sampling from 24-h-interval significant wave height differences of model outputs over a long period,and is validated with altimeter significant wave height data,indicating that the ensemble errors have nearly the same probability distribution function. The background error covariance fields expressed by the ensemble sampled are anisotropic. Updating the static samples by season,the seasonal characteristics of the correlation coefficient distribution are reflected. Hindcast experiments including assimilation and control runs are conducted for the summer of 2010 in the South China Sea. The effect of ensemble optimal interpolation assimilation on wave hindcasts is validated using different satellite altimeter data(Jason-1 and 2 and ENVISAT) and buoy observations. It is found that the ensemble-optimal-interpolation-based wave assimilation scheme for the South China Sea achieves improvements similar to those of the previous optimal-interpolation-based scheme,indicating that the practical application of this computationally cheap ensemble method is feasible.展开更多
Aimed at the problems of infrared image recognition under varying illumination,face disguise,etc.,we bring out an infrared human face recognition algorithm based on 2DPCA.The proposed algorithm can work out the covari...Aimed at the problems of infrared image recognition under varying illumination,face disguise,etc.,we bring out an infrared human face recognition algorithm based on 2DPCA.The proposed algorithm can work out the covariance matrix of the training sample easily and directly;at the same time,it costs less time to work out the eigenvector.Relevant experiments are carried out,and the result indicates that compared with the traditional recognition algorithm,the proposed recognition method is swift and has a good adaptability to the changes of human face posture.展开更多
RNA-Seq promises to be used in clinical settings as a gene-expression profiling tool;however,questions about its variability and biases remain and need to be addressed.Thus,RNA controls with known concentrations and s...RNA-Seq promises to be used in clinical settings as a gene-expression profiling tool;however,questions about its variability and biases remain and need to be addressed.Thus,RNA controls with known concentrations and sequence identities originally developed by the External RNA Control Consortium(ERCC) for microarray and qPCR platforms have recently been proposed for RNA-Seq platforms,but only with a limited number of samples.In this study,we report our analysis of RNA-Seq data from 92 ERCC controls spiked in a diverse collection of 447 RNA samples from eight ongoing studies involving five species(human,rat,mouse,chicken,and Schistosoma japonicum) and two mRNA enrichment protocols,i.e.,poly(A) and RiboZero.The entire collection of datasets consisted of 15650143175 short sequence reads,131603796(i.e.,0.84%) of which were mapped to the 92 ERCC references.The overall ERCC mapping ratio of 0.84% is close to the expected value of 1.0% when assuming a 2.0% mRNA fraction in total RNA,but showed a difference of 2.8-fold across studies and 4.3-fold among samples from the same study with one tissue type.This level of fluctuation may prevent the ERCC controls from being used for cross-sample normalization in RNA-Seq.Furthermore,we observed striking biases of quantification between poly(A) and RiboZero which are transcript-specific.For example,ERCC-00116 showed a 7.3-fold under-enrichment in poly(A) compared to RiboZero.Extra care is needed in integrative analysis of multiple datasets and technical artifacts of protocol differences should not be taken as true biological findings.展开更多
This paper presents a new spatial steganography model for covert communications over voice over internet protocol(Vo IP), providing a solution to the issue of increasing the capacity of covert Vo IP channels without c...This paper presents a new spatial steganography model for covert communications over voice over internet protocol(Vo IP), providing a solution to the issue of increasing the capacity of covert Vo IP channels without compromising the imperceptibility of the channels. Drawing from Orthogonal Modulation Theory in communications, the model introduced two concepts, orthogonal data hiding features and data hiding vectors, to covert Vo IP communications. By taking into account the variation characteristics of Vo IP audio streams in the time domain, a hiding vector negotiation mechanism was suggested to achieve dynamic self-adaptive steganography in media streams. Experimental results on Vo IP steganography show that the proposed steganographic method effectively depicted the spatial and temporal characteristics of Vo IP audio streams, and enhanced robustness against detection of steganalysis tools, thereby improving the security of covert Vo IP communications.展开更多
In this paper, the authors derive the asymptotic joint distributions of theeigenvalues of some random matrices which arise from components of covariance model.
A coordination control strategy is developed for 3-bearing swivel duct (3BSD) nozzles. A 3BSD nozzle's deflection angle and direction are changed through rotations of three revolute pairs. There is a nonlinear rela...A coordination control strategy is developed for 3-bearing swivel duct (3BSD) nozzles. A 3BSD nozzle's deflection angle and direction are changed through rotations of three revolute pairs. There is a nonlinear relationship between the deflection an- gle/direction and the rotation angles. The rotation speed of a revolute pair is limited by the power of the actuator. The moment of inertia and the aerodynamic load for each revolute pair are different and time-varying. A high-precision control system of 3BSD nozzles is required for applications on vertical and/or short take-off and landing (V/STOL) aircrafts. Difficulties of co- ordination control of 3BSD nozzles are distinct travel ranges, speed constraints, time^xarying dynamic models, and disturb- ances. The proposed control strategy is a combination of the characteristic model and tlF e dynamic control allocation method. A dynamic control allocation module is used as the coordination supervisor, which is aware of the kinematic model, the con- straints, and the dynamic models of the revolute pairs. Second-order characteristic models are used to represent the dynamic behavior of the revolute pairs. The gradient projection algorithm is modified for parameter estimation. A modified all-coefficient adaptive controller is developed to reject the disturbances. Experimental results of a scaled 3BSD nozzle indi- cate that the coordination control strategy is effective.展开更多
文摘AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its components.METHODS:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005.A total of 3455(1981 men and 1474 women) subjects were included in final analyses.Fatty liver was diagnosed using abdominal ultrasonography by trained gastroenterologists.The modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic syndrome.The associations between smoking,fatty liver and metabolic syndrome were analyzed using multiple logistic regression.RESULTS:Subjects with fatty liver,and who smoked tobacco,had the highest odds ratios(ORs) for high waist circumference [OR,4.5(95% CI:3.3-6.1) ,P < 0.05],hypertriglyceridemia [OR,8.1(95% CI:6.0-10.9) ,P < 0.05],low serum high-density lipoprotein cholesterol(HDL-C) [OR,8.3(95% CI:6.1-11.3) ,P < 0.05],and metabolic syndrome [OR,9.5(95% CI:6.7-13.4) ,P < 0.05] compared to subjects without fatty liver who did not smoke tobacco.We also found that the ORs for hypertriglyceridemia,low serum HDL-C,and metabolic syndrome for subjects with fatty liver who smoked tobacco had greater than the sum of the ORs for subjects with fatty liver who did not smokeplus those who did not have fatty liver and who did smoke.CONCLUSION:Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components,especially for hypertriglyceridemia and low serum HDL-C.
基金National Natural Science Foundation of China under Grant No.61379116,Natural Science Foundation of Hebei Province under Grant No.F2015203046 and No.F2013203124,Key Program of Research on Science and Technology of Higher Education Institutions of Hebei Province under Grant No.ZH2012028
文摘The existing collaborative recommendation algorithms have lower robustness against shilling attacks.With this problem in mind,in this paper we propose a robust collaborative recommendation algorithm based on k-distance and Tukey M-estimator.Firstly,we propose a k-distancebased method to compute user suspicion degree(USD).The reliable neighbor model can be constructed through incorporating the user suspicion degree into user neighbor model.The influence of attack profiles on the recommendation results is reduced through adjusting similarities among users.Then,Tukey M-estimator is introduced to construct robust matrix factorization model,which can realize the robust estimation of user feature matrix and item feature matrix and reduce the influence of attack profiles on item feature matrix.Finally,a robust collaborative recommendation algorithm is devised by combining the reliable neighbor model and robust matrix factorization model.Experimental results show that the proposed algorithm outperforms the existing methods in terms of both recommendation accuracy and robustness.
基金Under the auspices of National Natural Science Foundation of China (No. 40471040)
文摘Northeast China, as the most important production base of agriculture, forestry, and livestock-breeding as well as the old industrial base in the whole country, has been playin a key role in the construction and development of China's economy. However, after the policy of reform and open-up was taken in China. the economic development speed and efficiency ofthis area have turned to be evidently lower than those of coastal area and the national average level as well, which is so-called 'Northeast Phenomenon' and 'Neo-Northeast Phenomenon'. In terms of those phenomena, this paper firstly reviews the spatial and temporal features of the regional evolution of this area so as to unveil the profound forming causes of 'Northeast Phenomena' and 'Neo-Northeast Phenomena'. And then the paper makes a further exploration into the status quo of this region and its forming causes by analyzing its economy gross, industrial structure, product structure, regional eco-categories, etc. At the end of the paper, the authors put forward the basic coordinated development strategies for Northeast China. namely we can revitalize this area by means of adjustment of economic structure, regional coordination, planning urban and rural areas as a whole, institutional innovation, etc.
基金Project(61725306)supported by the National Science Foundation for Distinguished Young Scholars of ChinaProjects(61473318,61403136,61703157,61751312)supported by the National Natural Science Foundation of ChinaProject(16C0940)supported by Foundation of Hunan Educational Committee,China
文摘Considering the influence of reagent adjustment in different flotation bank on the final production index and the difficulty of establishing an effective mathematical model,a coordinated optimization method for dosage reagent based on key characteristics variation tendency and case-based reasoning is proposed.On the basis of the expert reagent regulation method in antimony flotation process,the reagent dosage pre-setting model of the roughing–scavenging bank is constructed based on case-based reasoning.Then,the sensitivity index is used to calculate the key features of reagent dosage.The reagent dosage compensation model is constructed based on the variation tendency of the key features in the roughing and scavenging process.At last,the prediction model is used to finish the classification and discriminant analysis.The simulation results and industrial experiment in antimony flotation process show that the proposed method reduces fluctuation of the tailings indicators and the cost of reagent dosage.It can lay a foundation for optimizing the whole process of flotation.
文摘Covariant helicity amplitude analysis for the process of J/ψ →γPP is discussed.Starting from the S- matrix elements of decay process,we deduce the formulae of helicity coupling amplitudes for two-body decay process. These formulae are used to analyze intermediate resonance states in the process of J/ψ decay to γππ,γKK,γηη' etc.
文摘The most recognized and employed model of the solvation equilibration in the ionic solutions was proposed by Eigen and Tamm, in which there are four major states for an ion pair in the solution: the completely solvated state, 2SIP (double solvent separate ion pair), SIP (single solvent separate ion pair), and CIP (contact ion pair). Eigen and Tamm suggested that the transition from SIP to CIP is always the slowest step during the whole pairing process, due to a high free energy barrier between these two states. We carried out a series of potential of mean force calculations to study the pairing free energy profiles of two sets of model mono- atomic 1:1 ion pairs 2.0:x and x:2.0. For 2.0:x pairs the free energy barrier between the SIP and CIP states is largely reduced due to the salvation shell water structure. For these pairs the SIP to CIP transition is thus not the slowest step in the ion pair formation course. This is a deviation from the Eigen-Tamm model.
基金supported in part by the Humanity&Social Science general project of Ministry of Education under Grants No.14YJAZH046National Science Foundation of China under Grants No.61402304the Beijing Educational Committee Science and Technology Development Planned under Grants No.KM201610028015
文摘Collaborative f iltering, as one of the most popular techniques, plays an important role in recommendation systems. However,when the user-item rating matrix is sparse,its performance will be degenerate. Recently,domain-specific recommendation approaches have been developed to address this problem.The basic idea is to partition the users and items into overlapping domains, and then perform recommendation in each domain independently. Here, a domain means a group of users having similar preference to a group of products. However, these domain-specific methods consisting of two sequential steps ignore the mutual benefi t of domain segmentation and recommendation. Hence, a unified framework is presented to simultaneously realize recommendation and make use of the domain information underlying the rating matrix in this paper. Based on matrix factorization,the proposed model learns both user preferences of multiple domains and preference selection vectors to select relevant features for each group of products. Besides, local context information is utilized from the user-item rating matrix to enhance the new framework.Experimental results on two widely used datasets, e.g., Ciao and Epinions, demonstrate the effectiveness of our proposed model.
文摘AIM:To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS:We enrolled a total of 1308 male workers aged from 22 to 63 years.Data was extracted from the workers'periodic health check-ups in hospitals.All cases were from the community of northern Taiwan. This was a cross-sectional observational study from July to September in 2004.We grouped all cases into four groups,based on the quartile of homeostasis model assessment.The top fourth quartile group was defined as the group with insulin resistance.We performed multivariate logistic regression analysis for the odds ratio of the risk factors for insulin resistance. RESULTS:Compared with metabolic syndrome,the coexistence of both factors had a 4.3-fold(95%CI: 2.7-6.8)increased risk,which was more than metabolic syndrome with a 3.6-fold(95%CI:2.6-5.0)increased risk.The two factors had a synergistic effect.The synergistic index of obesity and elevated alanine aminotransferase(ALT)was 2.1(95%CI:1.01-4.3).CONCLUSION:Obesity and elevated ALT are associatedwith insulin resistance.The effects are synergistic. Coexistence of them is better than metabolic syndrome in predicting insulin resistance.
基金Supported by the National Special Research Fund for Non-Profit Marine Sector(Nos.201005033,201105002)the National Natural Science Foundation of China(No.U1133001)+1 种基金the National High Technology Research and Development Program of China(863 Program)(No.2012AA091801)the NSFC-Shandong Joint Fund for Marine Science Research Centers(No.U1406401)
文摘The application of ensemble optimal interpolation in wave data assimilation in the South China Sea is presented. A sampling strategy for a stationary ensemble is first discussed. The stationary ensemble is constructed by sampling from 24-h-interval significant wave height differences of model outputs over a long period,and is validated with altimeter significant wave height data,indicating that the ensemble errors have nearly the same probability distribution function. The background error covariance fields expressed by the ensemble sampled are anisotropic. Updating the static samples by season,the seasonal characteristics of the correlation coefficient distribution are reflected. Hindcast experiments including assimilation and control runs are conducted for the summer of 2010 in the South China Sea. The effect of ensemble optimal interpolation assimilation on wave hindcasts is validated using different satellite altimeter data(Jason-1 and 2 and ENVISAT) and buoy observations. It is found that the ensemble-optimal-interpolation-based wave assimilation scheme for the South China Sea achieves improvements similar to those of the previous optimal-interpolation-based scheme,indicating that the practical application of this computationally cheap ensemble method is feasible.
基金Sponsored by the Natural Science Fund of Heilongjiang province(Grant No. F2007-13)Science and Technology Research Projects in Office of Education of Heilongjiang province(Grant No.11531034)the Heilongjiang Postdoctoral Science Foundation(Grant No.LBH-Z06054)
文摘Aimed at the problems of infrared image recognition under varying illumination,face disguise,etc.,we bring out an infrared human face recognition algorithm based on 2DPCA.The proposed algorithm can work out the covariance matrix of the training sample easily and directly;at the same time,it costs less time to work out the eigenvector.Relevant experiments are carried out,and the result indicates that compared with the traditional recognition algorithm,the proposed recognition method is swift and has a good adaptability to the changes of human face posture.
文摘RNA-Seq promises to be used in clinical settings as a gene-expression profiling tool;however,questions about its variability and biases remain and need to be addressed.Thus,RNA controls with known concentrations and sequence identities originally developed by the External RNA Control Consortium(ERCC) for microarray and qPCR platforms have recently been proposed for RNA-Seq platforms,but only with a limited number of samples.In this study,we report our analysis of RNA-Seq data from 92 ERCC controls spiked in a diverse collection of 447 RNA samples from eight ongoing studies involving five species(human,rat,mouse,chicken,and Schistosoma japonicum) and two mRNA enrichment protocols,i.e.,poly(A) and RiboZero.The entire collection of datasets consisted of 15650143175 short sequence reads,131603796(i.e.,0.84%) of which were mapped to the 92 ERCC references.The overall ERCC mapping ratio of 0.84% is close to the expected value of 1.0% when assuming a 2.0% mRNA fraction in total RNA,but showed a difference of 2.8-fold across studies and 4.3-fold among samples from the same study with one tissue type.This level of fluctuation may prevent the ERCC controls from being used for cross-sample normalization in RNA-Seq.Furthermore,we observed striking biases of quantification between poly(A) and RiboZero which are transcript-specific.For example,ERCC-00116 showed a 7.3-fold under-enrichment in poly(A) compared to RiboZero.Extra care is needed in integrative analysis of multiple datasets and technical artifacts of protocol differences should not be taken as true biological findings.
基金supported by the National Natural Science Foundation of China(Grant Nos.61271392U1405254&61272469)the British Government(Grant No.ktp008263)
文摘This paper presents a new spatial steganography model for covert communications over voice over internet protocol(Vo IP), providing a solution to the issue of increasing the capacity of covert Vo IP channels without compromising the imperceptibility of the channels. Drawing from Orthogonal Modulation Theory in communications, the model introduced two concepts, orthogonal data hiding features and data hiding vectors, to covert Vo IP communications. By taking into account the variation characteristics of Vo IP audio streams in the time domain, a hiding vector negotiation mechanism was suggested to achieve dynamic self-adaptive steganography in media streams. Experimental results on Vo IP steganography show that the proposed steganographic method effectively depicted the spatial and temporal characteristics of Vo IP audio streams, and enhanced robustness against detection of steganalysis tools, thereby improving the security of covert Vo IP communications.
文摘In this paper, the authors derive the asymptotic joint distributions of theeigenvalues of some random matrices which arise from components of covariance model.
基金supported by the National Natural Science Foundation of China(Grant Nos.60974339,61104082)
文摘A coordination control strategy is developed for 3-bearing swivel duct (3BSD) nozzles. A 3BSD nozzle's deflection angle and direction are changed through rotations of three revolute pairs. There is a nonlinear relationship between the deflection an- gle/direction and the rotation angles. The rotation speed of a revolute pair is limited by the power of the actuator. The moment of inertia and the aerodynamic load for each revolute pair are different and time-varying. A high-precision control system of 3BSD nozzles is required for applications on vertical and/or short take-off and landing (V/STOL) aircrafts. Difficulties of co- ordination control of 3BSD nozzles are distinct travel ranges, speed constraints, time^xarying dynamic models, and disturb- ances. The proposed control strategy is a combination of the characteristic model and tlF e dynamic control allocation method. A dynamic control allocation module is used as the coordination supervisor, which is aware of the kinematic model, the con- straints, and the dynamic models of the revolute pairs. Second-order characteristic models are used to represent the dynamic behavior of the revolute pairs. The gradient projection algorithm is modified for parameter estimation. A modified all-coefficient adaptive controller is developed to reject the disturbances. Experimental results of a scaled 3BSD nozzle indi- cate that the coordination control strategy is effective.