AIM:To develop orthotopic gastric cancer mouse models from different cell lines and characterize the tumor features to assist further in preclinical trials and clinical treatment strategies.METHODS:Human gastric cance...AIM:To develop orthotopic gastric cancer mouse models from different cell lines and characterize the tumor features to assist further in preclinical trials and clinical treatment strategies.METHODS:Human gastric cancer SGC-7901 and BGC823 cell suspensions were injected subcutaneously into nude mice to develop solid tumors,and tumor tissue pieces were then implanted under the serous coat of the stomach.An autopsy was performed on all animals of the SGC-7901 and BGC-823 models to observe the primary tumor growth and metastases using pathological and immunohistochemical methods.RESULTS:Both models showed large tumors in situ resulting in pressure and infiltration of the adjacent organs.The gastric cavity became smaller,along with stenosis of the cardia or pylorus.There were biological and statistical differences between the two models.The metastasis rate in involved organs (lymph nodes,kidney,spleen,testis) was significantly higher in the BGC-823 model compared to the SGC-7901 model (P < 0.05 or P < 0.01).The median survival of the BGC-823 model was shorter than that of SGC-7901 (23 d vs 84 d,P < 0.05).Histopathologically,the primary tumor and metastatic lesions of the two models showed obvious atypia and mucus in the cytoplasm.Compared with the SGC-7901 model,BGC-823 appeared more poorly differentiated (absence of adenoid structure),had a smaller volume,and richer capillary structure.Immunohistochemical staining revealed cytokeratin 20 and epithelial membrane antigen expression was positive in the SGC-7901 tumors,while negative in BGC-823 ones.CONCLUSION:Models using the SGC-7901 and BGC-823 cell lines were established which could function in gastric cancer research on carcinogenesis mechanism and drug discovery.The two models showed different tumor behavior and the latter was more malignant than the former.展开更多
In a manufacturing company, certain departments can be characterized as production departments and others as service departments. This paper expands and simplifies the results by the author and his co-author （Lowenth...In a manufacturing company, certain departments can be characterized as production departments and others as service departments. This paper expands and simplifies the results by the author and his co-author （Lowenthal ＆ Malek, 2005; 2013）, by explaining in a simple way how to obtain the fair-price per unit to pay to external suppliers that replace service departments. The paper also proves that replacing several service departments at once produces exactly the same fair-price per unit if they were replaced sequentially.展开更多
Types of industry are manifold, patterns used in the determination of the cost of production can also vary. Elements of the cost of production are raw materials, direct labor, and factory overhead. Value of raw materi...Types of industry are manifold, patterns used in the determination of the cost of production can also vary. Elements of the cost of production are raw materials, direct labor, and factory overhead. Value of raw materials used in aquaculture industry in particular needs to calculate the cost of feed consumed by fish, thus greatly affect the price of fish feed cost of production. The calculation of the value of raw materials in fish production cost element to consider is the calculation of the value of raw material components, namely, （1） biomass of harvestable fish as the basic multiplication cost of production per kilogram or per fish harvested fish; （2） the ratio of fish feed intake by the amount of fish produced or often called the Feed Conversion Ratio （FCR）; and （3） the average purchase price of feed on fish harvest period is used as the basis for calculating the cost of production as well. This research is applied research that uses data archive aquaculture companies. The results in the observed period, the value FCR is 0.80, which means to fish have been consumed as much as 0.80 kg of fish feed. Biomass of fish that are harvested at 47,399.95 kg or 1,869,647 individuals. The average purchase price of fish feed on the observation period amounted to IDR 4,855.79. So the price of raw materials contained in harvested fish in the observation period calculates the value of multiplying all the components of raw materials （i.e., IDR 184,131,362.57）. Method of calculating the cost of production companies is process method and charging method used is the full costing method.展开更多
The authors prove a Schwarz lemma for harmonic mappings between the unit balls in real Euclidean spaces. Roughly speaking, this result says that under a harmonic mapping between the unit balls in real Euclidean spaces...The authors prove a Schwarz lemma for harmonic mappings between the unit balls in real Euclidean spaces. Roughly speaking, this result says that under a harmonic mapping between the unit balls in real Euclidean spaces, the image of a smaller ball centered at origin can be controlled. This extends the related result proved by Chen in complex plane.展开更多
On the setting of the unit ball U the author considers Toeplitz operators on Bergman space.The Bergman space Bp(U) (1≤ p < ∞) is the closed subspace of the usual Lebesgue space LP(U) consisting of holomorphic fun...On the setting of the unit ball U the author considers Toeplitz operators on Bergman space.The Bergman space Bp(U) (1≤ p < ∞) is the closed subspace of the usual Lebesgue space LP(U) consisting of holomorphic functions. For a function β ∈ L2(U), the Toeplitz operator Tβ with symbol β is defined by Tβf = (βf) for function f ∈ B2(U). Here is the Bergman projection from L2(U) onto B2(U). Two bounded linear operators S, T on the Hilbert H are said to be essentially commuting on H if the commutator ST - TS is compact on H. In this paper, a criterion of essentially Toeplitz operators with the vanishing property is obtained.展开更多
基金Supported by A grant from the Natural Science Foundation of China,No.30830040
文摘AIM:To develop orthotopic gastric cancer mouse models from different cell lines and characterize the tumor features to assist further in preclinical trials and clinical treatment strategies.METHODS:Human gastric cancer SGC-7901 and BGC823 cell suspensions were injected subcutaneously into nude mice to develop solid tumors,and tumor tissue pieces were then implanted under the serous coat of the stomach.An autopsy was performed on all animals of the SGC-7901 and BGC-823 models to observe the primary tumor growth and metastases using pathological and immunohistochemical methods.RESULTS:Both models showed large tumors in situ resulting in pressure and infiltration of the adjacent organs.The gastric cavity became smaller,along with stenosis of the cardia or pylorus.There were biological and statistical differences between the two models.The metastasis rate in involved organs (lymph nodes,kidney,spleen,testis) was significantly higher in the BGC-823 model compared to the SGC-7901 model (P < 0.05 or P < 0.01).The median survival of the BGC-823 model was shorter than that of SGC-7901 (23 d vs 84 d,P < 0.05).Histopathologically,the primary tumor and metastatic lesions of the two models showed obvious atypia and mucus in the cytoplasm.Compared with the SGC-7901 model,BGC-823 appeared more poorly differentiated (absence of adenoid structure),had a smaller volume,and richer capillary structure.Immunohistochemical staining revealed cytokeratin 20 and epithelial membrane antigen expression was positive in the SGC-7901 tumors,while negative in BGC-823 ones.CONCLUSION:Models using the SGC-7901 and BGC-823 cell lines were established which could function in gastric cancer research on carcinogenesis mechanism and drug discovery.The two models showed different tumor behavior and the latter was more malignant than the former.
文摘In a manufacturing company, certain departments can be characterized as production departments and others as service departments. This paper expands and simplifies the results by the author and his co-author （Lowenthal ＆ Malek, 2005; 2013）, by explaining in a simple way how to obtain the fair-price per unit to pay to external suppliers that replace service departments. The paper also proves that replacing several service departments at once produces exactly the same fair-price per unit if they were replaced sequentially.
文摘Types of industry are manifold, patterns used in the determination of the cost of production can also vary. Elements of the cost of production are raw materials, direct labor, and factory overhead. Value of raw materials used in aquaculture industry in particular needs to calculate the cost of feed consumed by fish, thus greatly affect the price of fish feed cost of production. The calculation of the value of raw materials in fish production cost element to consider is the calculation of the value of raw material components, namely, （1） biomass of harvestable fish as the basic multiplication cost of production per kilogram or per fish harvested fish; （2） the ratio of fish feed intake by the amount of fish produced or often called the Feed Conversion Ratio （FCR）; and （3） the average purchase price of feed on fish harvest period is used as the basis for calculating the cost of production as well. This research is applied research that uses data archive aquaculture companies. The results in the observed period, the value FCR is 0.80, which means to fish have been consumed as much as 0.80 kg of fish feed. Biomass of fish that are harvested at 47,399.95 kg or 1,869,647 individuals. The average purchase price of fish feed on the observation period amounted to IDR 4,855.79. So the price of raw materials contained in harvested fish in the observation period calculates the value of multiplying all the components of raw materials （i.e., IDR 184,131,362.57）. Method of calculating the cost of production companies is process method and charging method used is the full costing method.
基金supported by the National Natural Science Foundation of China(Nos.11201199,11671361)
文摘The authors prove a Schwarz lemma for harmonic mappings between the unit balls in real Euclidean spaces. Roughly speaking, this result says that under a harmonic mapping between the unit balls in real Euclidean spaces, the image of a smaller ball centered at origin can be controlled. This extends the related result proved by Chen in complex plane.
文摘On the setting of the unit ball U the author considers Toeplitz operators on Bergman space.The Bergman space Bp(U) (1≤ p < ∞) is the closed subspace of the usual Lebesgue space LP(U) consisting of holomorphic functions. For a function β ∈ L2(U), the Toeplitz operator Tβ with symbol β is defined by Tβf = (βf) for function f ∈ B2(U). Here is the Bergman projection from L2(U) onto B2(U). Two bounded linear operators S, T on the Hilbert H are said to be essentially commuting on H if the commutator ST - TS is compact on H. In this paper, a criterion of essentially Toeplitz operators with the vanishing property is obtained.
