5-硝基苯并呋喃-2-乙酸乙酯的合成研究

5-硝基苯并呋喃-2-乙酸乙酯是盐酸维拉唑酮重要的合成中间体。本文分别考察了两种合成方法，并在运用单因素试验方法对其合成工艺条件进行探索。

Strain and Culture Medium Optimization for Production Enhancement of Prodiginines from Marine-Derived Streptomyces sp. GQQ-10

A mutant (GQQ-M6) of a Sponge-Derived streptomyces sp. GQQ-10 obtained by UV-induced mutation was used for producing prodiginines (PGs). Single factor experiments and orthogonal array design (OAD) methods were employed for medium optimization. In the single factor method, the effects of soluble starch, glucose, soybean flour, yeast extract and sodium acetate on PGs production were investigated individually. In the subsequent OAD experiments, the concentrations of these 5 key nutritional components combined with salinity were further adjusted. The mutant strain GQQ-M6 gave a 2.2-fold higher PGs production than that of the parent strain; OAD experiments offered a PGs yield of 61mg L-1, which was 10 times higher than that of the initial GQQ-10 strain under the original cultivation mode.

筒形件错距旋压圆度误差研究

采用单因素试验设计方法,以筒形件错距旋压关键工艺参数：减薄率、进给比、径向错距为试验变量,以基于最小二乘法评定的旋压后工件外表面圆度误差为评价指标,获得了各工艺参数对旋后工件圆度误差的影响规律。结果表明：当减薄率为25%-35%时,其值的变化对旋压件的圆度误差影响不大;当减薄率超过35%时,旋压件的圆度误差随减薄率的增大而增大;随着进给比的增加,旋压件的圆度误差先减小后增大;适当减小旋轮径向错距,即增加首轮的壁厚减薄量,有利于减小旋压件的圆度误差。