This paper,combined algebraical structure with analytical system,has studied the part of theory of C~*-modules over A by using the homolgical methods, where A is a commutative C~*-algebra over complex number field C. ...This paper,combined algebraical structure with analytical system,has studied the part of theory of C~*-modules over A by using the homolgical methods, where A is a commutative C~*-algebra over complex number field C. That is to say we have not only defined some relevant new concept,but also obtained some results about them.展开更多
Based on the analytical solution of electromagnetic scattering by a uniaxial anisotropic sphere in the spectral domain, an analytical solution to the electromagnetic scattering by a uniaxial left-handed materials (LHM...Based on the analytical solution of electromagnetic scattering by a uniaxial anisotropic sphere in the spectral domain, an analytical solution to the electromagnetic scattering by a uniaxial left-handed materials (LHMs) sphere is obtained in terms of spherical vector wave functions in a uniaxial anisotropic LHM medium. The expression of the analytical solution contains only some one-dimensional integral which can be calculated easily. Numerical results show that Mie series of plane wave scattering by an isotropic LHM sphere is a special case of the present method. Some numerical results of electromagnetic scattering of a uniaxial anisotropic sphere by a plane wave are given.展开更多
Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed wit...Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed with conventional single-poly pMOS transistors, based on the bi-directional Fowler-Nordheim tunneling effect, and the typical program/erase time is 10ms for every 16bits. A new ,single-ended sense amplifier is proposed to reduce the power dissipation in the current sensing scheme. The average current consumption of the whole memory chip is 0.8μA for the power supply voltage of 1.2V at a reading rate of 640kHz.展开更多
A thioester-functionalized triphenylamine hole-transporting molecule (TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surfac...A thioester-functionalized triphenylamine hole-transporting molecule (TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface was characterized by aqueous contact angle, ellipsometer, atomic force microscopy, X-ray photoelectron spectroscopy, and ultraviolet pho- toelectron spectrometer to substantiate the formation of compact and pinhole-free monolayers. The modified organic light emitting diode device [indium-tin oxide/Au (5 nm)/self-assembled monolayers (SAM)/TPD (50 nm)/Alq3 (40 nm)/TPBI (15 nm)/LiF (1 nm)/A1 (100 nm)] showed a luminance of 7303.90 cd/m^2 and a current efficiency of 8.49 cd/A with 1.78 and 2.29-fold increase, respectively, compared to the control device without SAM. The improvements were attributed to the enhanced compatibility of the organic-inorganic interface, matched energy level by introduction of an energy mediating step and superior hole-injection property of SAM molecules.展开更多
The scattering theory in periodic structures has many applications in modern microoptics and industry. Periodic structures are often referred to as diffraction gratings. In this paper we consider a planar dielectric-l...The scattering theory in periodic structures has many applications in modern microoptics and industry. Periodic structures are often referred to as diffraction gratings. In this paper we consider a planar dielectric-layer modulated grating problem. The diffraction problem may be modeled by a Helmholtz equation with periodic coefficients. Results on existence and uniqueness of the solution for the diffraction problem are obtained by variational method and integral equation method, respectively. At the end of the paper, we also discuss the Born approximation to the solution of an equivalent integral equation.展开更多
For over one hundred years, viruses have been recognized as capable of killing tumor cells. At present, people are still researching and constructing more suitable oncolytic viruses for treating different malignant tu...For over one hundred years, viruses have been recognized as capable of killing tumor cells. At present, people are still researching and constructing more suitable oncolytic viruses for treating different malignant tumors. Although extensive studies have demonstrated that herpes simplex virus type 1 (HSV-1) is the most potential oncolytic virus, therapies based on herpes simplex virus type 1 vectors still arouse bio-safety and risk management issues. Researchers have therefore introduced the new idea of treating cancer with HSV-1 mutants labeled with radionuclides, combining radionuclide and oncolytic virus therapies. This overview briefly summarizes the status and mechanisms by which oncolytic viruses kill tumor cells, discusses the application of HSV-1 and HSV-1 derived vectors for tumor therapy, and demonstrates the feasibility and prospect of HSV-1 mutants labeled with radionuclides for treating tumors.展开更多
It is known that certain one parameter families of unimodal maps of the interval have a topological universality with regard to their dynamic behavior [ 1, 2]. As a parameter is smoothly increased, a fascinating varie...It is known that certain one parameter families of unimodal maps of the interval have a topological universality with regard to their dynamic behavior [ 1, 2]. As a parameter is smoothly increased, a fascinating variety of dynamic behaviors are produced. For some families the behaviors are monotonic in the parameter, while in others they are not [3]. The question is what sort of conditions on a one parameter family will ensure this monotonicity of the behavior with the parameter? The answer is unknown and will not be given here. What we do instead is to investigate certain geometric-dynamic-combinatorial consequences of assuming that the family has this monotonicity. Specifically, using tools of symbolic dynamics, state space is "course grained" with a finite alphabet. We decompose a non-invertible map into nonlinear but invertible pieces. From these invertible pieces, we form inverse maps via composition along words. Equations of motion are developed for both forward and inverse orbits (in both the variables of state space and the parameter), and an equation relating forward and inverse motions at fix-points is exhibited. Finally, we deduce a list of conditions, each of which is equivalent to monotone behavior. One of these conditions states that simple parity characteristics of words correspond to definite dynamics near fixed-points and vice versa.展开更多
Let R be a ring, * be an involutory function of the set of all finite matrices over R. In this paper, necessary and sufficient conditions are given for a matrix to have a (1,3)-inverse, (1,4)-inverse, or Moore-P enros...Let R be a ring, * be an involutory function of the set of all finite matrices over R. In this paper, necessary and sufficient conditions are given for a matrix to have a (1,3)-inverse, (1,4)-inverse, or Moore-P enrose inverse, relative to *. Some results about generalized inverses of matrices over division rings are generalized and improved.展开更多
Under the conditions of compatility or sub -c ompatility between a sigle-valued mapping and set-valued mapping, this paper d iscusses the existence of common fixed points for two set-valued mappings and a single-value...Under the conditions of compatility or sub -c ompatility between a sigle-valued mapping and set-valued mapping, this paper d iscusses the existence of common fixed points for two set-valued mappings and a single-valued mapping in complete, convex matric spaces. We extend and develop the main results.展开更多
Objective:The optimal treatment of patients with metastatic spinal cord compression(MSCC) is still being debated.This randomized trial was planned to compare the functional outcome and its related prognostic factors,t...Objective:The optimal treatment of patients with metastatic spinal cord compression(MSCC) is still being debated.This randomized trial was planned to compare the functional outcome and its related prognostic factors,toxicity and in-field recurrence of the three schedules of radiotherapy.Methods:Two hundred and eighty five patients enrolled in the study of which 95 received 1 × 8 Gy,100 received 10 x 3 Gy and 90 received the radiation treatment of 20 × 2 Gy.Irradiation was performed with 6-10 Mv linear accelerators or cobalt-60 units by single posterior field or parallel opposed fields according to depth of irradiation spines.Premedication with dexamethasone was started from the first day of clinico-radiologic diagnosis till 4-5 days after the end of radiotherapy(RT) then tapered off during 10 days.Potential prognostic factors were evaluated with respect to functional outcome.Results:All groups were balanced for patient's characteristics and potential prognostic factors.No statistically significant difference was observed between the 3 groups as regard functional outcome and toxicity while single fraction was associated with higher in-field recurrences(22.8%) with statistically significant difference between the 3 groups(P = 0.01).Functional outcome was significantly better with younger age(≤ 60 y),Eastern Cooperative Oncology Group performance status(ECOG-PS) of 1-2,involved vertebra of 1-2,favorable tumor type,absence of visceral or other bone metastasis,decreased time of developing motor deficit before radiotherapy,long interval between cancer diagnosis to metastatic spinal cord compression,and normal ambulatory status.Conclusion:The three schedules provided similar functional outcome.Single-radiation dose was associated with higher in-field recurrence.To minimize treatment time and costs,the dose of 1 × 8 Gy is recommended for patients with poor predicated survival and 10 × 3 Gy for other patients.展开更多
OBJECTIVE To explore the method of preparation of 99m↑Tc labeled AntiVEGF McAb 5-FU loaded polylactic acid nanoparticles (99m↑TC-5-FU-Ab-NPs), and investigate the biological distribution of the nanoparticles in hu...OBJECTIVE To explore the method of preparation of 99m↑Tc labeled AntiVEGF McAb 5-FU loaded polylactic acid nanoparticles (99m↑TC-5-FU-Ab-NPs), and investigate the biological distribution of the nanoparticles in human gastric carcinoma xenografts. METHODS Anti-VEGF monoclonal antibodyes (MCAB)in 5-FU-Ab-NPs were labeled with 99m↑Tc using a modified Schwarz method. After isolation of the 99m↑TC-5-FU-Ab-NPs using a Sephadex G-250 column, the labeling percentage and radiochemical purity were determined using paper chromatography. The immunocempetence of the 99m↑TC-5-FU-Ab-NPs as tumor markers was determined using ELISA and immunohistochemistry. 99m↑TC-5-FU-Ab-NPs (experimental group), 99m↑Tc-labelled murine multiclonal IgG loaded polylactic acid and nanoparticles (control group) were injected via the tail vein into SCID mice bearing human gastric carcinoma. A radio-immunity ECT image was developed at 2 and 6 h after the injection. Following the ECT imaging, the mice were sacrificed, their tissue and tumor radioactivity distribution determined, and percentage of the injected-dose per gram (%ID/g) and tumor/ nontumor (T/NT) ratio calculated. High performance liquid chromatography (HPLC) was used to determine the 5-FU concentration in the tumor tissue and blood in the mice of both groups. RESULTS The percentage of 99m↑TC-5-FU-Ab-NPs labeling was 90%-95%. There was no obvious decrease in the antibody activity before and after labeling. The radio-immuno-imaging (RII) showed that the tumor image had developed 2 h after injection of the 99m↑TC-5-FU-Ab-NPs, and with time it was clearer at the 6th hour following the injection. The %lD/g of the tumor tissue at both 2 h and 6 h after the injection was significantly higher compared to the control group. The tumor %lD/g and the tumor to blood activity ratio (TB) of the experimental group at 6 h following the injection increased compared to that at 2 h, and at the same time, 5-FU concentration in the tumor of the experimental group continuously increased over time, and showed a significant difference compared to the 5-FU concentration in the tumor of the control group. CONCLUSION The 99m↑TC-5-FU-Ab-NPs prepared in this study are adequate to meet the demands of the RII, and the immune targeting ability of the anti-VEGF MCAB is reliable. Six hours after injection, the 99m↑TC-5-FU-Ab-NPs showed a relatively high specific concentration shadow in the human gastric carcinoma xenografts.展开更多
Data on aerosol optical thickness(AOT) and single scattering albedo(SSA) derived from Moderate Resolution Imaging Spectrometer(MODIS) and Ozone Monitoring Instrument(OMI) measurements,respectively,are used jointly to ...Data on aerosol optical thickness(AOT) and single scattering albedo(SSA) derived from Moderate Resolution Imaging Spectrometer(MODIS) and Ozone Monitoring Instrument(OMI) measurements,respectively,are used jointly to examine the seasonal variations of aerosols over East Asia.The seasonal signals of the total AOT are well defined and nearly similar over the land and over the ocean.These findings indicate a natural cycle of aerosols that originate primarily from natural emissions. In contrast,the small-sized aerosols represented by the fine-mode AOT,which are primarily generated over the land by human activities,do not have evident seasonalscale fluctuations.A persistent maximum of aerosol loadings centered over the Sichuan basin is associated with considerable amounts of fine-mode aerosols throughout the year.Most regions exhibit a general spring maximum. During the summer,however,the aerosol loadings are the most marked over north central China.This occurrence may result from anthropogenic fine particles,such as sulfate and nitrate.Four typical regions were selected to perform a covariation analysis of the monthly gridded AOT and SSA.Over southwestern and southeastern China,if the aerosol loadings are small to moderate they are composed primarily of the highly absorptive aerosols. However,more substantial aerosol loadings probably represent less-absorptive aerosols.The opposite covariation pattern occurring over the coastal-adjacent oceans suggests that the polluted oceanic atmosphere is closely correlated with the windward terrestrial aerosols.North central China is strongly affected by dust aerosols that show moderate absorption.This finding may explain the lower variability in the SSA that accompanies increasing aerosol loadings in this region.展开更多
AIM: To explore a specific diagnostic method for local recurrent rectal cancer.METHODS: Immunoscintigraphy with 99mTc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a ...AIM: To explore a specific diagnostic method for local recurrent rectal cancer.METHODS: Immunoscintigraphy with 99mTc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology.RESULTS: A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with 99mTc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of 99mTc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%.CONCLUSION: Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).展开更多
Urban aerosols have a large effect on the deterioration of air quality and the degradation of atmospheric visibility.Characterization of the chemical composition of PM 2.5 and in situ measurements of the optical prope...Urban aerosols have a large effect on the deterioration of air quality and the degradation of atmospheric visibility.Characterization of the chemical composition of PM 2.5 and in situ measurements of the optical properties of aerosols were conducted in July 2008 at an urban site in Guangzhou,Southern China.The mean PM 2.5 concentration for the entire period was 53.7±23.2 μg m 3.The mean PM 2.5 concentration (82.7±25.4 μg m 3) on hazy days was roughly two times higher than that on clear days (38.8±8.7 μg m 3).The total water-soluble ion species and the total average carbon accounted for 47.9%±4.3% and 35.2%±4.5%,respectively,of the major components of PM 2.5.The increase of secondary and carbonaceous aerosols,in particular ammonium sulfate,played an important role in the formation of haze pollution.The mean absorption and scattering coefficients and the single scattering albedo over the whole period were 53±20 M m 1,226±111 M m 1,and 0.80±0.04,respectively.PM 2.5 had a high linear correlation with the aerosol extinction coefficient,elemental carbon (EC) was correlated with aerosol absorption,and organic carbon (OC) and SO 4 2 were tightly linked to aerosol scattering.展开更多
Enantiomers (R (+) and S(-)), RS-racemate mixture of enantiomers) of malic acid C4H605 have been (double compound) and (R + S) -conglomerate (mechanical investigated by means of X-ray diffractometry and ...Enantiomers (R (+) and S(-)), RS-racemate mixture of enantiomers) of malic acid C4H605 have been (double compound) and (R + S) -conglomerate (mechanical investigated by means of X-ray diffractometry and high tern- perature X-ray diffraction method. The RS-racemate was found to be able to form three polymorphic modifications, which we denominated as M1 (monoclinic, space group P21/c), M2 (monoclinic, space group Cc), and Tc (triclinic, space group P-l ), the latter modification having been unknown before. Modification Tc was also described, and its X- ray diffraction characteristics, including interplanar spacings d, hkl indices, unit cell parameters, were defined. In addi- tion, X-ray diffraction characteristics for both reported earlier M1 and M2 monoclinic polymorphic modifications were measured with higher accuracy. The ability of RS-racemate to form one of the above three modifications (MI, M2, and Tc) or their mixtures containing various proportions and combinations of the components (M1 + M2, M1 + Tc, or M2 + Tc) was found to depend on the type of crystallization medium (a melt, aqueous medium, ethanol or acetone solu- tion), crystallization rate (from 2--3 minutes to 4 months), and crystallization temperature. Heating S-enantiomer and M1 RS-racemate up to their respective melting points (100 ℃ and 124 ℃, correspondingly) only made them undergo thermal deformations, while heating (R + S) -conglomerate in the temperature range of 96--110 ℃ resulted in its homogenization to form M2 RS-racemate, which, near the melting point (118 ℃), namely, in the range of 112-116 ℃, was transformed into MI RS-racemate. Keywords: polvmorDhism; racemic, chiral展开更多
This paper deals with a new class of nonlinear set valued implicit variational inclusion problems involving (A, η)-monotone mappings in 2-uniformly smooth Banach spaces. Semi-inner product structure has been used t...This paper deals with a new class of nonlinear set valued implicit variational inclusion problems involving (A, η)-monotone mappings in 2-uniformly smooth Banach spaces. Semi-inner product structure has been used to study the (A, η)-monotonicity. Using the generalized resolvent operator technique and the semi-inner product structure, the approximation solvability of the proposed problem is investigated. An iterative algorithm is constructed to approximate the solution of the problem. Convergence analysis of the proposed algorithm is investigated. Similar results are also investigated for variational inclusion problems involving (H, η)-monotone mappings.展开更多
Elucidation of the relationships between genetic polymorphisms and environmental exposures can provide insights into the pathways and mechanisms underlying complex traits. A new approach was used to detect G×E (...Elucidation of the relationships between genetic polymorphisms and environmental exposures can provide insights into the pathways and mechanisms underlying complex traits. A new approach was used to detect G×E (gene-environment) interactions involved in human skin pigmentation variation to better understand the adaptive evolution of skin pigmentation. Specifically, we used genetic engineering, remote UVR (ultraviolet radiation) sensing and GIS (geographic information systems) to integrate the analysis of genetic and environmental factors into a coherent biological framework. Since we expected to generate large datasets for this multidimensional analysis, we used PCA (principal components analysis) as a spatial statistical analysis technique for analyzing the G×E interactions. The results suggest that skin pigmentation may be affected by mutations induced by UVR and support the hypothesis that global variation in skin pigmentation may be the result of localized adaptation to different UVR conditions via natural selection. Analyzing the relationships between heterozygous frequencies for SNP (single nucleotide polymorphism) loci and seasonal UVR levels as the environment changes will help elucidate the selective mechanisms involved in the UVR-induced evolution of skin pigmentation. Skin pigmentation fulfills the criteria for a successful evolutionary G×E interactions model.展开更多
A novel chain complex was synthesized and its crystal structure has been deter- mined by X-ray diffraction technique. It was found that the local coordination geometry around Cu(Ⅱ) is a distorted tetrahedron and C14H...A novel chain complex was synthesized and its crystal structure has been deter- mined by X-ray diffraction technique. It was found that the local coordination geometry around Cu(Ⅱ) is a distorted tetrahedron and C14H9CuNO3CH3OH is bridged by the carboxylate oxygen atom to form an infinite one-dimensional linear chain. The hydrogen bond exists between O(1) and solvate molecule O(4). The crystal belongs to monoclinic, space group P21 with a = 9.6650(19), b = 7.1280(14), c = 9.925(2) ? b = 98.39(3)? V = 676.4(2) 3, Z = 2, F(000) = 342 and m(MoK? = 1.629 mm-1 .展开更多
We study molybdenum disulfide (MoS2) structures generated by folding single-layer and bilayer MoS2 flakes. We find that this modified layer stacking leads to a decrease in the interlayer coupling and an enhancement ...We study molybdenum disulfide (MoS2) structures generated by folding single-layer and bilayer MoS2 flakes. We find that this modified layer stacking leads to a decrease in the interlayer coupling and an enhancement of the photoluminescence emission yield. We additionally find that folded single-layer MoS2 structures show a contribution to photoluminescence spectra of both neutral and charged excitons, which is a characteristic feature of single-layer MoS2 that has not been observed in multilayer MoS2. The results presented here open the door to fabrication of multilayered MoS2 samples with high optical absorption while maintaining the advantageous enhanced photoluminescence emission of single-layer MoS2 by controllably twisting the MoS2 layers.展开更多
文摘This paper,combined algebraical structure with analytical system,has studied the part of theory of C~*-modules over A by using the homolgical methods, where A is a commutative C~*-algebra over complex number field C. That is to say we have not only defined some relevant new concept,but also obtained some results about them.
基金Project supported by the National Basic Research Program (973) of China (No. 2004CB719802) and the Natural Science Foundation of Zhejiang Province (No. Y104539), China
文摘Based on the analytical solution of electromagnetic scattering by a uniaxial anisotropic sphere in the spectral domain, an analytical solution to the electromagnetic scattering by a uniaxial left-handed materials (LHMs) sphere is obtained in terms of spherical vector wave functions in a uniaxial anisotropic LHM medium. The expression of the analytical solution contains only some one-dimensional integral which can be calculated easily. Numerical results show that Mie series of plane wave scattering by an isotropic LHM sphere is a special case of the present method. Some numerical results of electromagnetic scattering of a uniaxial anisotropic sphere by a plane wave are given.
文摘Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed with conventional single-poly pMOS transistors, based on the bi-directional Fowler-Nordheim tunneling effect, and the typical program/erase time is 10ms for every 16bits. A new ,single-ended sense amplifier is proposed to reduce the power dissipation in the current sensing scheme. The average current consumption of the whole memory chip is 0.8μA for the power supply voltage of 1.2V at a reading rate of 640kHz.
基金supported by the National Natural Science Foundation of China(Nos.21506151,21576195 and 21776207)
文摘A thioester-functionalized triphenylamine hole-transporting molecule (TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface was characterized by aqueous contact angle, ellipsometer, atomic force microscopy, X-ray photoelectron spectroscopy, and ultraviolet pho- toelectron spectrometer to substantiate the formation of compact and pinhole-free monolayers. The modified organic light emitting diode device [indium-tin oxide/Au (5 nm)/self-assembled monolayers (SAM)/TPD (50 nm)/Alq3 (40 nm)/TPBI (15 nm)/LiF (1 nm)/A1 (100 nm)] showed a luminance of 7303.90 cd/m^2 and a current efficiency of 8.49 cd/A with 1.78 and 2.29-fold increase, respectively, compared to the control device without SAM. The improvements were attributed to the enhanced compatibility of the organic-inorganic interface, matched energy level by introduction of an energy mediating step and superior hole-injection property of SAM molecules.
文摘The scattering theory in periodic structures has many applications in modern microoptics and industry. Periodic structures are often referred to as diffraction gratings. In this paper we consider a planar dielectric-layer modulated grating problem. The diffraction problem may be modeled by a Helmholtz equation with periodic coefficients. Results on existence and uniqueness of the solution for the diffraction problem are obtained by variational method and integral equation method, respectively. At the end of the paper, we also discuss the Born approximation to the solution of an equivalent integral equation.
基金National Natural Science Foundation of China, No. 30770604
文摘For over one hundred years, viruses have been recognized as capable of killing tumor cells. At present, people are still researching and constructing more suitable oncolytic viruses for treating different malignant tumors. Although extensive studies have demonstrated that herpes simplex virus type 1 (HSV-1) is the most potential oncolytic virus, therapies based on herpes simplex virus type 1 vectors still arouse bio-safety and risk management issues. Researchers have therefore introduced the new idea of treating cancer with HSV-1 mutants labeled with radionuclides, combining radionuclide and oncolytic virus therapies. This overview briefly summarizes the status and mechanisms by which oncolytic viruses kill tumor cells, discusses the application of HSV-1 and HSV-1 derived vectors for tumor therapy, and demonstrates the feasibility and prospect of HSV-1 mutants labeled with radionuclides for treating tumors.
文摘It is known that certain one parameter families of unimodal maps of the interval have a topological universality with regard to their dynamic behavior [ 1, 2]. As a parameter is smoothly increased, a fascinating variety of dynamic behaviors are produced. For some families the behaviors are monotonic in the parameter, while in others they are not [3]. The question is what sort of conditions on a one parameter family will ensure this monotonicity of the behavior with the parameter? The answer is unknown and will not be given here. What we do instead is to investigate certain geometric-dynamic-combinatorial consequences of assuming that the family has this monotonicity. Specifically, using tools of symbolic dynamics, state space is "course grained" with a finite alphabet. We decompose a non-invertible map into nonlinear but invertible pieces. From these invertible pieces, we form inverse maps via composition along words. Equations of motion are developed for both forward and inverse orbits (in both the variables of state space and the parameter), and an equation relating forward and inverse motions at fix-points is exhibited. Finally, we deduce a list of conditions, each of which is equivalent to monotone behavior. One of these conditions states that simple parity characteristics of words correspond to definite dynamics near fixed-points and vice versa.
文摘Let R be a ring, * be an involutory function of the set of all finite matrices over R. In this paper, necessary and sufficient conditions are given for a matrix to have a (1,3)-inverse, (1,4)-inverse, or Moore-P enrose inverse, relative to *. Some results about generalized inverses of matrices over division rings are generalized and improved.
文摘Under the conditions of compatility or sub -c ompatility between a sigle-valued mapping and set-valued mapping, this paper d iscusses the existence of common fixed points for two set-valued mappings and a single-valued mapping in complete, convex matric spaces. We extend and develop the main results.
文摘Objective:The optimal treatment of patients with metastatic spinal cord compression(MSCC) is still being debated.This randomized trial was planned to compare the functional outcome and its related prognostic factors,toxicity and in-field recurrence of the three schedules of radiotherapy.Methods:Two hundred and eighty five patients enrolled in the study of which 95 received 1 × 8 Gy,100 received 10 x 3 Gy and 90 received the radiation treatment of 20 × 2 Gy.Irradiation was performed with 6-10 Mv linear accelerators or cobalt-60 units by single posterior field or parallel opposed fields according to depth of irradiation spines.Premedication with dexamethasone was started from the first day of clinico-radiologic diagnosis till 4-5 days after the end of radiotherapy(RT) then tapered off during 10 days.Potential prognostic factors were evaluated with respect to functional outcome.Results:All groups were balanced for patient's characteristics and potential prognostic factors.No statistically significant difference was observed between the 3 groups as regard functional outcome and toxicity while single fraction was associated with higher in-field recurrences(22.8%) with statistically significant difference between the 3 groups(P = 0.01).Functional outcome was significantly better with younger age(≤ 60 y),Eastern Cooperative Oncology Group performance status(ECOG-PS) of 1-2,involved vertebra of 1-2,favorable tumor type,absence of visceral or other bone metastasis,decreased time of developing motor deficit before radiotherapy,long interval between cancer diagnosis to metastatic spinal cord compression,and normal ambulatory status.Conclusion:The three schedules provided similar functional outcome.Single-radiation dose was associated with higher in-field recurrence.To minimize treatment time and costs,the dose of 1 × 8 Gy is recommended for patients with poor predicated survival and 10 × 3 Gy for other patients.
基金the grants as fol-lows:The Problems-Tackling Program in Sci-ence and Technology of Guangzhou City,Chi-na(No.2003 Z 3-E0381)National Foundationof Natural Science,China(No.30670951)+1 种基金Guangdong Foundation of Natural Science,Guangdong,China(No.06021322)TheProblems-Tackling Program in Science andTechnology of Guangdong Province,China(No.2005 B31211002).
文摘OBJECTIVE To explore the method of preparation of 99m↑Tc labeled AntiVEGF McAb 5-FU loaded polylactic acid nanoparticles (99m↑TC-5-FU-Ab-NPs), and investigate the biological distribution of the nanoparticles in human gastric carcinoma xenografts. METHODS Anti-VEGF monoclonal antibodyes (MCAB)in 5-FU-Ab-NPs were labeled with 99m↑Tc using a modified Schwarz method. After isolation of the 99m↑TC-5-FU-Ab-NPs using a Sephadex G-250 column, the labeling percentage and radiochemical purity were determined using paper chromatography. The immunocempetence of the 99m↑TC-5-FU-Ab-NPs as tumor markers was determined using ELISA and immunohistochemistry. 99m↑TC-5-FU-Ab-NPs (experimental group), 99m↑Tc-labelled murine multiclonal IgG loaded polylactic acid and nanoparticles (control group) were injected via the tail vein into SCID mice bearing human gastric carcinoma. A radio-immunity ECT image was developed at 2 and 6 h after the injection. Following the ECT imaging, the mice were sacrificed, their tissue and tumor radioactivity distribution determined, and percentage of the injected-dose per gram (%ID/g) and tumor/ nontumor (T/NT) ratio calculated. High performance liquid chromatography (HPLC) was used to determine the 5-FU concentration in the tumor tissue and blood in the mice of both groups. RESULTS The percentage of 99m↑TC-5-FU-Ab-NPs labeling was 90%-95%. There was no obvious decrease in the antibody activity before and after labeling. The radio-immuno-imaging (RII) showed that the tumor image had developed 2 h after injection of the 99m↑TC-5-FU-Ab-NPs, and with time it was clearer at the 6th hour following the injection. The %lD/g of the tumor tissue at both 2 h and 6 h after the injection was significantly higher compared to the control group. The tumor %lD/g and the tumor to blood activity ratio (TB) of the experimental group at 6 h following the injection increased compared to that at 2 h, and at the same time, 5-FU concentration in the tumor of the experimental group continuously increased over time, and showed a significant difference compared to the 5-FU concentration in the tumor of the control group. CONCLUSION The 99m↑TC-5-FU-Ab-NPs prepared in this study are adequate to meet the demands of the RII, and the immune targeting ability of the anti-VEGF MCAB is reliable. Six hours after injection, the 99m↑TC-5-FU-Ab-NPs showed a relatively high specific concentration shadow in the human gastric carcinoma xenografts.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(Grant No.KZCX2-YW-Q11-03)
文摘Data on aerosol optical thickness(AOT) and single scattering albedo(SSA) derived from Moderate Resolution Imaging Spectrometer(MODIS) and Ozone Monitoring Instrument(OMI) measurements,respectively,are used jointly to examine the seasonal variations of aerosols over East Asia.The seasonal signals of the total AOT are well defined and nearly similar over the land and over the ocean.These findings indicate a natural cycle of aerosols that originate primarily from natural emissions. In contrast,the small-sized aerosols represented by the fine-mode AOT,which are primarily generated over the land by human activities,do not have evident seasonalscale fluctuations.A persistent maximum of aerosol loadings centered over the Sichuan basin is associated with considerable amounts of fine-mode aerosols throughout the year.Most regions exhibit a general spring maximum. During the summer,however,the aerosol loadings are the most marked over north central China.This occurrence may result from anthropogenic fine particles,such as sulfate and nitrate.Four typical regions were selected to perform a covariation analysis of the monthly gridded AOT and SSA.Over southwestern and southeastern China,if the aerosol loadings are small to moderate they are composed primarily of the highly absorptive aerosols. However,more substantial aerosol loadings probably represent less-absorptive aerosols.The opposite covariation pattern occurring over the coastal-adjacent oceans suggests that the polluted oceanic atmosphere is closely correlated with the windward terrestrial aerosols.North central China is strongly affected by dust aerosols that show moderate absorption.This finding may explain the lower variability in the SSA that accompanies increasing aerosol loadings in this region.
基金Supported by National High-Tech R&D Program of China (863 Program), No. 2004AA215270
文摘AIM: To explore a specific diagnostic method for local recurrent rectal cancer.METHODS: Immunoscintigraphy with 99mTc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology.RESULTS: A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with 99mTc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of 99mTc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%.CONCLUSION: Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).
基金supported by the Special Scientific Research Funds for Environment Protection Commonweal Section(Grant Nos.200809143and201009001)the National Basic Research Program of China(Grant No.2010CB428503)+4 种基金the National Natural Science Foundation of China(Grant No.41075096)the Knowledge Innovation Program of the Chinese Academy of Sciences(Grant No.IAP09320)the Research and Development Special Fund for Public Welfare Industry(Meteorology) of the China Meteorological Administration(Grant No.GYHY201006047)the Ministry of Science and Technology of China(Grant No.2010DFA22770)the Innovation Method Fund of China(Grant No.2008IM020500)
文摘Urban aerosols have a large effect on the deterioration of air quality and the degradation of atmospheric visibility.Characterization of the chemical composition of PM 2.5 and in situ measurements of the optical properties of aerosols were conducted in July 2008 at an urban site in Guangzhou,Southern China.The mean PM 2.5 concentration for the entire period was 53.7±23.2 μg m 3.The mean PM 2.5 concentration (82.7±25.4 μg m 3) on hazy days was roughly two times higher than that on clear days (38.8±8.7 μg m 3).The total water-soluble ion species and the total average carbon accounted for 47.9%±4.3% and 35.2%±4.5%,respectively,of the major components of PM 2.5.The increase of secondary and carbonaceous aerosols,in particular ammonium sulfate,played an important role in the formation of haze pollution.The mean absorption and scattering coefficients and the single scattering albedo over the whole period were 53±20 M m 1,226±111 M m 1,and 0.80±0.04,respectively.PM 2.5 had a high linear correlation with the aerosol extinction coefficient,elemental carbon (EC) was correlated with aerosol absorption,and organic carbon (OC) and SO 4 2 were tightly linked to aerosol scattering.
基金Supported by the Russian Fund for Basic Research (RFBR) under Grant No. 10-05-00891 and 12-05-00876
文摘Enantiomers (R (+) and S(-)), RS-racemate mixture of enantiomers) of malic acid C4H605 have been (double compound) and (R + S) -conglomerate (mechanical investigated by means of X-ray diffractometry and high tern- perature X-ray diffraction method. The RS-racemate was found to be able to form three polymorphic modifications, which we denominated as M1 (monoclinic, space group P21/c), M2 (monoclinic, space group Cc), and Tc (triclinic, space group P-l ), the latter modification having been unknown before. Modification Tc was also described, and its X- ray diffraction characteristics, including interplanar spacings d, hkl indices, unit cell parameters, were defined. In addi- tion, X-ray diffraction characteristics for both reported earlier M1 and M2 monoclinic polymorphic modifications were measured with higher accuracy. The ability of RS-racemate to form one of the above three modifications (MI, M2, and Tc) or their mixtures containing various proportions and combinations of the components (M1 + M2, M1 + Tc, or M2 + Tc) was found to depend on the type of crystallization medium (a melt, aqueous medium, ethanol or acetone solu- tion), crystallization rate (from 2--3 minutes to 4 months), and crystallization temperature. Heating S-enantiomer and M1 RS-racemate up to their respective melting points (100 ℃ and 124 ℃, correspondingly) only made them undergo thermal deformations, while heating (R + S) -conglomerate in the temperature range of 96--110 ℃ resulted in its homogenization to form M2 RS-racemate, which, near the melting point (118 ℃), namely, in the range of 112-116 ℃, was transformed into MI RS-racemate. Keywords: polvmorDhism; racemic, chiral
文摘This paper deals with a new class of nonlinear set valued implicit variational inclusion problems involving (A, η)-monotone mappings in 2-uniformly smooth Banach spaces. Semi-inner product structure has been used to study the (A, η)-monotonicity. Using the generalized resolvent operator technique and the semi-inner product structure, the approximation solvability of the proposed problem is investigated. An iterative algorithm is constructed to approximate the solution of the problem. Convergence analysis of the proposed algorithm is investigated. Similar results are also investigated for variational inclusion problems involving (H, η)-monotone mappings.
文摘Elucidation of the relationships between genetic polymorphisms and environmental exposures can provide insights into the pathways and mechanisms underlying complex traits. A new approach was used to detect G×E (gene-environment) interactions involved in human skin pigmentation variation to better understand the adaptive evolution of skin pigmentation. Specifically, we used genetic engineering, remote UVR (ultraviolet radiation) sensing and GIS (geographic information systems) to integrate the analysis of genetic and environmental factors into a coherent biological framework. Since we expected to generate large datasets for this multidimensional analysis, we used PCA (principal components analysis) as a spatial statistical analysis technique for analyzing the G×E interactions. The results suggest that skin pigmentation may be affected by mutations induced by UVR and support the hypothesis that global variation in skin pigmentation may be the result of localized adaptation to different UVR conditions via natural selection. Analyzing the relationships between heterozygous frequencies for SNP (single nucleotide polymorphism) loci and seasonal UVR levels as the environment changes will help elucidate the selective mechanisms involved in the UVR-induced evolution of skin pigmentation. Skin pigmentation fulfills the criteria for a successful evolutionary G×E interactions model.
文摘A novel chain complex was synthesized and its crystal structure has been deter- mined by X-ray diffraction technique. It was found that the local coordination geometry around Cu(Ⅱ) is a distorted tetrahedron and C14H9CuNO3CH3OH is bridged by the carboxylate oxygen atom to form an infinite one-dimensional linear chain. The hydrogen bond exists between O(1) and solvate molecule O(4). The crystal belongs to monoclinic, space group P21 with a = 9.6650(19), b = 7.1280(14), c = 9.925(2) ? b = 98.39(3)? V = 676.4(2) 3, Z = 2, F(000) = 342 and m(MoK? = 1.629 mm-1 .
文摘We study molybdenum disulfide (MoS2) structures generated by folding single-layer and bilayer MoS2 flakes. We find that this modified layer stacking leads to a decrease in the interlayer coupling and an enhancement of the photoluminescence emission yield. We additionally find that folded single-layer MoS2 structures show a contribution to photoluminescence spectra of both neutral and charged excitons, which is a characteristic feature of single-layer MoS2 that has not been observed in multilayer MoS2. The results presented here open the door to fabrication of multilayered MoS2 samples with high optical absorption while maintaining the advantageous enhanced photoluminescence emission of single-layer MoS2 by controllably twisting the MoS2 layers.