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自然边界元法在弹性圆形薄板弯曲问题中的应用 被引量:3
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作者 李顺才 董正筑 谢卫红 《徐州师范大学学报(自然科学版)》 CAS 2002年第4期12-15,22,共5页
利用圆内双调和方程的格林函数,通过自然边界归化,得到了圆形薄板弯曲挠度的泊松积分公式及其边界内力的自然积分方程,利用强奇异积分的数值计算方法,求得了圆形薄板的弯曲解,从实践上证实了这种方法的可行性.
关键词 弹性圆形薄板 弯曲 格林函数 自然边界元法 强奇异积分 挠度 单性力学
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Synthesis of Li^+ adsorbent(H_2TiO_3) and its adsorption properties 被引量:9
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作者 石西昌 张志兵 +3 位作者 周定方 张丽芬 陈白珍 余亮良 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第1期253-259,共7页
H2TiO3 was obtained from the acid-modified adsorbent precursor Li2TiO3,which was synthesized by a solid-phase reaction between TiO2 and Li2CO3.The extraction ratio of Li+ from Li2TiO3 was 98.86%,almost with no Ti4+ ... H2TiO3 was obtained from the acid-modified adsorbent precursor Li2TiO3,which was synthesized by a solid-phase reaction between TiO2 and Li2CO3.The extraction ratio of Li+ from Li2TiO3 was 98.86%,almost with no Ti4+ extracted.The effects of lithium titanium ratio,calcining temperature and time were investigated on the synthesis of Li2TiO3.Li2TiO3,H2TiO3 and the adsorbed Li+ adsorbent were characterized by XRD and SEM.The lithium adsorption properties were investigated by the adsorption kinetics and adsorption isotherm.The results indicate that H2TiO3 has an excellent adsorptive capacity for Li+.Two simplified kinetic models including the pseudo-first-order and pseudo-second-order equations were selected to follow the adsorption processes.The rate constants of adsorption for these kinetic models were calculated.The results show that the adsorption process can be described by the pseudo-second-order equation,and the process is proved to be a chemical adsorption.The adsorption process that H2TiO3 adsorbs Li+ in LiCl solution well fits the Langmuir equation with monolayer adsorption. 展开更多
关键词 Li+ adsorbent Li2TiO3 adsorption property kinetic models monolayer adsorption TIO2 Li2CO3
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INCLINED LAMINAL COMBINATION MODEL OF 3D BRAIDED COMPOSITES
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作者 周光明 王鑫伟 乔新 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1995年第1期8-14,共7页
As an advanced composite material, the 3D braided composite has received more and more attention in foreign countries. However, it has received less attention in China. The geometric unit cell which can describe the b... As an advanced composite material, the 3D braided composite has received more and more attention in foreign countries. However, it has received less attention in China. The geometric unit cell which can describe the basic structure and the relationship between the braiding angle and geometric parameters of the fabric and fiber volume ratio are given in this paper based on two 3D braiding processes, namely, the four-step and the twostep ones. Several existing mechanical models to predict groperties of the 3D braided comPOsites are discussed and their shortcomings are pointed out herein. Then a new model called the inclined laminal combination model is proposed, which is based on the classical laminated plate theory and can predict the basic mechanical behavior of the two 3D braided composites with four-step or two-step braid. In the model, each yarn in the unit cell is regarded as an inclined laminate and then a 3D analysis is performed. It is found that the predicted mechanical properties of the 3D braided composites by the proposed model are compared well with the experimental data. 展开更多
关键词 COMPOSITES mechanical properties unit cell mechanical model 3D braided
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Effects of Freeze–thaw Cycles on Soil Mechanical and Physical Properties in the Qinghai–Tibet Plateau 被引量:34
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作者 XIE Sheng-bo QU Jian-jun +2 位作者 LAI Yuan-ming ZHOU Zhi-wei XU Xiang-tian 《Journal of Mountain Science》 SCIE CSCD 2015年第4期999-1009,共11页
Extreme freeze-thaw action occurs on the Qinghai-Tibet Plateau due to its unique climate resulting from high elevation and cold temperature.This action causes damage to the surface soil structure, as soil erosion in t... Extreme freeze-thaw action occurs on the Qinghai-Tibet Plateau due to its unique climate resulting from high elevation and cold temperature.This action causes damage to the surface soil structure, as soil erosion in the Qinghai-Tibet Plateau is dominated by freeze-thaw erosion.In this research,freezing–thawing process of the soil samples collected from the Qinghai–Tibet Plateau was carried out by laboratory experiments to determinate the volume variation of soil as well as physical and mechanical properties, such as porosity, granularity and uniaxial compressive strength, after the soil experiences various freeze–thaw cycles.Results show that cohesion and uniaxial compressive strength decreased as the volume and porosity of the soil increased after experiencing various freeze–thaw cycles, especially in the first six freeze–thaw cycles.Consequently, the physical and mechanical properties of the soil were altered.However, granularity and internal friction angle did not vary significantly with an increase in the freeze–thaw cycle.The structural damage among soil particles due to frozen water expansion was the major cause of changes in soil mechanical behavior in the Qinghai–Tibet Plateau. 展开更多
关键词 Qinghai Tibet Plateau Soil erosion Freeze thaw action Mechanical behavior
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Effect of loading rates on the characteristics of thermal damage for mudstone under different temperatures 被引量:8
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作者 Mao Rongrong Mao Xianbiao +1 位作者 Zhang Lianying Liu Ruixue 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2015年第5期797-801,共5页
The uniaxial compression tests for mudstone specimens are carried out with four different loading rates from room temperature to 400℃ by using the Rock Mechanics Servo-controlled Testing System MTS810 and high temper... The uniaxial compression tests for mudstone specimens are carried out with four different loading rates from room temperature to 400℃ by using the Rock Mechanics Servo-controlled Testing System MTS810 and high temperature furnace MTS652.02.The mechanical properties of mudstone with various loading rates are studied under different temperature conditions.The results show that when temperature increases from room temperature to 400℃ and loading rate is less than 0.03 mm/s,the peak strength of mudstone specimen decreases as loading rate increases,while the various peak strengths show significant differences when loading rate exceeds 0.03 mm/s.At room temperature,the elastic modulus decreases at the first time and then increases with loading rate rising.When the temperature is between200 and 400℃,the elastic modulus presents a decreasing trend with increasing loading rate.With increasing the loading rate,the number of fragments in mudstone becomes larger and even the powder is observed in mudstone with higher loading rate.Under high loading rate,the failure mode of mudstone specimens under different temperatures is mainly conical damage. 展开更多
关键词 MUDSTONE High temperature Loading rate Characteristics of thermal damage
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Mechanical properties and microstructure evolution in incremental forming of AA5754 and AA6061 aluminum alloys 被引量:4
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作者 Ghulam HUSSAIN Muhammad ILYAS +1 位作者 B.B.LEMOPI ISIDORE Wasim A.KHAN 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2020年第1期51-64,共14页
This study performs single point incremental forming(SPIF)on two aluminum alloys(i.e.AA5754 and AA6061),and analyzes their post forming mechanical properties and microstructure evolution.The forming parameters namely ... This study performs single point incremental forming(SPIF)on two aluminum alloys(i.e.AA5754 and AA6061),and analyzes their post forming mechanical properties and microstructure evolution.The forming parameters namely wall angle(35°-55°),feed rate(1-4 m/min),spindle rotational speed(50-1000 r/min),and lubricant(grease and hydraulic oil)are varied to probe detailed processing effects.The pre-and post-SPIF mechanical properties and microstructures are characterized by conducting tensile tests and optical microscopy,respectively.It is shown that an increase in the wall angle,feed rate and rotational speed causes microscopic variations in the alloys such that the grains of AA5754 and the second phase particles of AA6061 elongate.As a result,the ultimate tensile strength of the formed parts is increased by 10%for AA5754 and by 8%for AA6061.And,the ductility of AA5754 is decreased from 22.9%to 12%and that of AA6061 is decreased from 16%to 10.7%.Regarding the lubricant effect,it is shown that the mechanical properties remain insensitive to the type of lubricant employed.These results indicate that SPIF processing modifies the microstructure of Al alloys in a way to enhance the strength at the cost of ductility. 展开更多
关键词 single point incremental forming mechanical properties microstructure evolution aluminum alloy wall angle forming parameter
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Experimental investigation on the relevance of mechanical properties and porosity of sandstone after hydrochemical erosion 被引量:9
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作者 CAI Yan-yan YU Jin +1 位作者 FU Guo-feng LI Hong 《Journal of Mountain Science》 SCIE CSCD 2016年第11期2053-2068,共16页
Under the effect of chemical etching,the macroscopic mechanical properties,mesoscopic structure,mineral content,and porosity of rocks undergo significant changes,which can lead to the geological disasters; thus,an und... Under the effect of chemical etching,the macroscopic mechanical properties,mesoscopic structure,mineral content,and porosity of rocks undergo significant changes,which can lead to the geological disasters; thus,an understanding of changes in the microscopic and macroscopic structure of rocks after chemical etching is crucial.In this study,uniaxial mechanical tests and nuclear magnetic resonance(NMR) spectroscopy were carried out on sandstone samples that had been previously subjected to chemical erosion under different p H values.The aim was to study changes in properties and mechanical characteristics,including deformation and strength characteristics,of the rock,and microscopic pore variation characteristics,and to perform preliminary studies of the chemical corrosion mechanism.Results show that different chemical solutions have a significant influence on the uniaxial compressive strength,the axial strain corresponding to the peak axial stress,elastic modulus,etc.With the passage of time,porosity increases gradually with exposure to different chemical solutions,and exposure to chemical solutions results in large changes in the NMR T2 curve and T2 spectrum area.Sandstone exposed to different chemical solutions exhibits different corrosion mechanisms; the root cause is the change of mineral. 展开更多
关键词 Chemical erosion HYDROCHEMISTRY Mechanical properties Nuclear magnetic resonance POROSITY SANDSTONE
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Effect of Freeze-Thaw Cycles on Mechanical Properties and Permeability of Red Sandstone under Triaxial Compression 被引量:16
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作者 YU Jin CHEN Xu +2 位作者 LI Hong ZHOU Jia-wen CAI Yan-yan 《Journal of Mountain Science》 SCIE CSCD 2015年第1期218-231,共14页
Geological disasters will happen in cold regions because of the effects of freeze-thaw cycles on rocks or soils, so studying the effects of these cycles on the mechanical characteristics and permeability properties of... Geological disasters will happen in cold regions because of the effects of freeze-thaw cycles on rocks or soils, so studying the effects of these cycles on the mechanical characteristics and permeability properties of rocks is very important. In this study, red sandstone samples were frozen and thawed with o, 4, 8 and 12 cycles, each cycle including 12 h of freezing and 12 h of thawing. The P-wave velocities of these samples were measured, and the mechanical properties and evolution of the steady-state permeabilities were investigated in a series of uniaxial and triaxial compression tests. Experimental results show that, with the increasing of cyclic freeze-thaw times, the P-wave velocity of the red sandstone decreases. The number of freeze-thaw cycles has a significant influence on the uniaxial compressive strength, elastic modulus, cohesion, and angle of internal friction. The evolution of permeability of the rock samples after cycles of freeze-thaw in a complete stress-strain process under triaxial compression is closely related to the variation of the microstructure in the rock. There is a highly corresponding relationship between volumetric strain and permeability with axial strain in all stages of the stress-strain behaviour. 展开更多
关键词 Freeze-thaw cycles Red sandstone Triaxial compression PERMEABILITY Mechanicalproperties
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Variation of vertical and horizontal drilling rates depending on some rock properties in the marble quarries 被引量:7
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作者 Servet Demirdag Nazmi Sengun +3 位作者 Ibrahim Ugur Tamer Efe Deniz Akbay Rasit Altindag 《International Journal of Mining Science and Technology》 SCIE EI 2014年第2期269-273,共5页
The main objective of this study is to determine the rates of vertically and horizontally oriented drilling processes in marble quarries and to observe the factors affecting the drilling rates in terms of physical and... The main objective of this study is to determine the rates of vertically and horizontally oriented drilling processes in marble quarries and to observe the factors affecting the drilling rates in terms of physical and mechanical properties of the rocks. In situ drilling tests were performed in different marble quarries with different marble types and drilling times and penetration rates for a series of successive depthincrements were trying to be determined under vertically and horizontally oriented conditions. In order to understand the relation between the parameters that are investigated within the scope of this research, uniaxial compressive strength, Brazilian tensile strength, impact strength, Bohme abrasion strength, P-wave velocity, porosity, unit volume weight, Schmidt hardness index and brittleness index values were correlated with the drilling rates. It was noticed that the porosity and unit volume weight could be taken as the key parameters among them for obtaining meaningful correlation with drilling performance. It was also observed that the physical and mechanical rock properties are more relevant in vertical drilling than horizontal drilling. 展开更多
关键词 Mechanical properties Drilling Drilling rate Marble quarry
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Drift Intermittent Synchronization and Controllability in a Simple Model
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作者 XIE Bai-Song YU Ming-Young 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第2X期297-302,共6页
A simple model of three coupled oscillators as an approximation of main modes behaviors in a spatial extended system is proposed. Multi-looping generalized synchronization and drift intermittent lag phase synchronizat... A simple model of three coupled oscillators as an approximation of main modes behaviors in a spatial extended system is proposed. Multi-looping generalized synchronization and drift intermittent lag phase synchronization phenomena are found in this simple model. For a certain of parameters in which chaotic-like intermittent behavior exhibit the amplitudes and phases of three modes are controlled to be synchronized states via coupling them with an external periodic mode. 展开更多
关键词 nolinear dynamics SYNCHRONIZATION
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Hydrodynamic Behavior of a Single Bubble Rising in Viscous Liquids 被引量:7
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作者 CAI Ziqi BAO Yuyun GAO Zhengming 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第6期923-930,共8页
The rising behavior of single bubbles has been investigated in six systems with different viscosity and Morton number(Mo) from 3.21×10-11 to 163. Bubbles with maximum equivalent diameter of up to 16 mm were inves... The rising behavior of single bubbles has been investigated in six systems with different viscosity and Morton number(Mo) from 3.21×10-11 to 163. Bubbles with maximum equivalent diameter of up to 16 mm were investigated. The bubble Reynolds number(Re) ranged from 0.02 to 1200 covering 3 regimes in which two func-tions are obtained relating the drag coefficient,CD,with Re and Mo. It has been found that in the high Reynolds number regime the drag coefficient increases until the Reynolds number of about 1200. The classic expression of Jamialahmadi(1994) is improved and extended to high viscosity liquids. A new relationship for the aspect ratio of deformed bubbles in terms of Re,the Etvs number and Mo,applicable to a wide range of system properties,espe-cially in high viscosity liquids,is also suggested. 展开更多
关键词 BUBBLE rising velocity viscous liquid drag coefficient DEFORMATION
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Analysis of the mechanical property of mudstone/shale in paralic coal measures and its influence factors 被引量:2
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作者 Zhao-ping MENG Xian-mingXIAN 《Journal of Coal Science & Engineering(China)》 2013年第1期1-7,共7页
The mechanical property of mudstone/shale in coal measures is a key factor of engineering mechanics that influences the development of shale gas. A rock mechanics test was performed in order to analyze the complete st... The mechanical property of mudstone/shale in coal measures is a key factor of engineering mechanics that influences the development of shale gas. A rock mechanics test was performed in order to analyze the complete stress-strain mechanic characteristics and influence factors of mudstone/shale in paralic coal measures, from the Carboniferous-Permian periods in a coal field of Northern China. The relationship between the mechanical properties of mudstone/shale in coal measures, and its chemical component, water content are established, and their models are constructed. Research results show that mud- stone/shale has low mechanical strength, low elastic modulus and a high Poisson's ratio. The complete stress-strain curve has apparent elastoplastic deformation characteristics, and after reaching peak strength, it exhibits obvious strain softening characteristics. The uniaxial compressive strength of mudstone/shale and its elastic modulus increases exponentially with the increase of SiO2 content, and as the ignition loss increases, the uniaxial compressive strength and elastic modulus of mudstone/shale will decrease according to the law of power function. The compressive strength of mudstone/shale and its elastic modulus will decrease with the increase of water content in mudstone/shale. 展开更多
关键词 coal measure mudstone/shale mechanical property influence factors
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Microscopic Theory of Nonlinear Spin Waves in Ferromagnets
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作者 张建军 袁建辉 +1 位作者 曾奇军 张俊佩 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第7期173-176,共4页
Considering the attractive interaction between ferromagnet, we propose the model of magnon-pairs, which two magnons with opposite wave vectors in a Heisenberg is suitable for low-temperature environment. A dressed mag... Considering the attractive interaction between ferromagnet, we propose the model of magnon-pairs, which two magnons with opposite wave vectors in a Heisenberg is suitable for low-temperature environment. A dressed magnon is an energy quantum of the magnon-pairs whose energy is a monotonically increasing function of absolute temperature. Based on the model, we re-investigate the excitation mechanism and thermodynamic properties of the Heisenberg ferromagnet. The correction factor e(O) plays an important role in studying the low-temperature properties of a ferromagnet. 展开更多
关键词 FERROMAGNETS MAGNONS spin waves MAGNETIZATION
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Synthesis, characterization of monodispersed MgO microspheres and thermal decomposition kinetics of its precusor
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作者 袁培 郭雅坤 +1 位作者 谷昆泓 肖奇 《Journal of Central South University》 SCIE EI CAS 2014年第9期3463-3469,共7页
Monodispersed MgO microspheres were successfully synthesized by a simple solvothermal method using PEG-400 as solvent. The samples were characterized by X-ray diffraction(XRD) and scanning electron microscopy(SEM). Th... Monodispersed MgO microspheres were successfully synthesized by a simple solvothermal method using PEG-400 as solvent. The samples were characterized by X-ray diffraction(XRD) and scanning electron microscopy(SEM). The results reveal that the precusor was monoclinic Mg5(CO3)4(OH)2·4H2O and composed of nanosheets with the thickness of about 250 nm. By calcining the precusor at 500 °C for 5 min, cubic MgO with similar morphology was obtained. According to the SEM images, it is found that the volume ratio of PEG-400 to deionized water is considered as a crucial factor in the evolution of the morphology. Based on the SEM images obtained under different experimental conditions, a possible growth mechanism which involves self-assembly process was proposed. The thermal decomposition process of MgO precusor was studied by thermogravimetry-differential thermogravimetry(TG-DTG) at different heating rates in air. Thermal analysis kinetics results show that the most probale mechanism models of MgO precusor are An and D3, respectively. In addition, isothermal prediction was studied to quantitatively characterize the thermal decomposition process. 展开更多
关键词 PEG-400 monodisphersed MgO thermal decomposition kinetics isothermal prediction
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Controller design based on viscoelasticity dynamics model and experiment for flexible drive unit 被引量:1
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作者 吴伟国 侯月阳 《Journal of Central South University》 SCIE EI CAS 2014年第12期4468-4477,共10页
In order to ensure that the system has the advantage of light weight and vibration absorption, the steel rope is used as a flexible transmission part. A flexible drive unit(FDU) is developed, whose features are guided... In order to ensure that the system has the advantage of light weight and vibration absorption, the steel rope is used as a flexible transmission part. A flexible drive unit(FDU) is developed, whose features are guided by steel rope, increasing force by the movable pulley group, modular, convenient and flexible. Dynamics model for controller is deduced based on the constitutive equation of viscoelasticity. Controller is designed for position control and is based on the viscoelasticity dynamics model compensation control strategy proposed. The control system is based on the TURBO PMAC multi-axis motion control card.Prototype loading experiments and velocity experiments results show that the FDU can reach 2 Hz with no load and the max speed of 30(°)/s. The FDU has the capability of the load torque 11.2 N·m and the speed of 24(°)/s simultaneously, and the frequency response is 1.3 Hz. The FDU can be used to be the pitch joint of hip for biped robot whose walking speed is 0.144 km/h theoretically. 展开更多
关键词 flexible drive unit steel rope drive viscoelasticity dynamic model speed-load characteristic
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Thermal-hydro-mechanical coupling damage model of brittle rock 被引量:1
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作者 李鹏 饶秋华 +2 位作者 李卓 马雯波 马彬 《Journal of Central South University》 SCIE EI CAS 2014年第3期1136-1141,共6页
Based on fluid mechanics, thermodynamics and damage mechanics, thermal-hydro-mechanical (THM) coupling damage model of brittle rock is established by analyzing THM coupling mechanism, where THM coupling damage varia... Based on fluid mechanics, thermodynamics and damage mechanics, thermal-hydro-mechanical (THM) coupling damage model of brittle rock is established by analyzing THM coupling mechanism, where THM coupling damage variable DTHM is dominated by TH coupling damage variable DTH, TM coupling damage variable DTM and HM coupling damage variable DHM, and DTH is firstly expressed in term of dimensionless total thermal conductivity of the water Nu. Permeability test, uni-axial compression test and THM coupling test are conducted to measure the permeability, elastic modulus and THM coupling stress-strain curves of brittle rock. The tested values of THM coupling elastic modulus E'HM are in good agreement with the predicted values of THM coupling elastic modulus ETHM, which can verify the newly established THM coupling damage model. 展开更多
关键词 damage model THM coupling mechanism permeability test THM coupling test brittle rock
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Depinning Dynamics of Fluid Monolayer on a Quenched Substrate
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作者 曹义刚 刘嘉 付根义 《Communications in Theoretical Physics》 SCIE CAS CSCD 2010年第11期893-896,共4页
Langevin simulations are preformed on the depinning dynamics of fluid monolayer on a quenched substrate. With increase in the strength of the substrate, we find for the first time a crossover from elastic crystal to s... Langevin simulations are preformed on the depinning dynamics of fluid monolayer on a quenched substrate. With increase in the strength of the substrate, we find for the first time a crossover from elastic crystal to smectic flows as well as a crossover from smectic to plastic flows above the depinning. A power-law scaling relationship can be derived between the drift velocity and the driving force for both the elastic crystal and smectic flows, but fails to be obtained for the plastic flow. The power-law exponents are found to be no larger than 1 for the elastic crystal flow and larger than 1 for the smeetic flow. The critical driving force and the averaged intensity of Bragg peaks remain invariant basically in the regime of smectic flow. A sudden increase in the critical driving force is observed within the crossover from the smeetic to plastic flows, and the averaged intensity of Bragg peaks shows sudden decreases within the crossovers both from the elastic crystal to smectic flows and from the smectic to plastic flows. The results are helpful for understanding the slip dynamics of fluids on a molecular level. 展开更多
关键词 FLUID elastic crystal flow smectic flow plastic flow
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One-Parameter Equation of State for Gases and Gas Mixtures
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作者 李鸿仪 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2000年第2期163-166,共4页
The simplest equation of state that can be applied to calculate the thermodynamic properties of gases is the virial equation with the second coefficient B. The probability of applying the one-coefficient equation Z = ... The simplest equation of state that can be applied to calculate the thermodynamic properties of gases is the virial equation with the second coefficient B. The probability of applying the one-coefficient equation Z = exp(A/V) for the calculation of compressibility factor at critical temperature of gases and gas mixtures is investigated. It was verified that the one-coefficient equation of state can be applied to calculated the thermodynamic properties for both normal and strongly polar gases and gas mixtures. 展开更多
关键词 equation of state virial equation GASES FUGACITY correlation MIXTURE POLAR NONPOLAR
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STUDY ON THE DAMAGE CONSTITUTIVE RELATION OF ROCK UNDER UNIAXIAL STRESS CONDITION
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作者 杨更社 《Journal of Coal Science & Engineering(China)》 1999年第2期25-28,共4页
The damage propagation constitutive relation of rock under uniaxial stress condition is studied by CT scanning in this paper. Damage variables of rock are calculated using CT scanning method and Lemaitre’s equivalent... The damage propagation constitutive relation of rock under uniaxial stress condition is studied by CT scanning in this paper. Damage variables of rock are calculated using CT scanning method and Lemaitre’s equivalent strain hypothesis respecively, the damage propagation constitutive relation of rock is discussed. 展开更多
关键词 rock damage constitutive relation CT scanning
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Simulation-based simplification of target-mediated drug disposition model of denosumab
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作者 Yu Fu Ye Yao +3 位作者 Peiming Ma Xuan Zhou Wei Lu Tianyan Zhou 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2018年第11期767-776,共10页
Target-mediated drug disposition (TMDD)model is one of the main modeling theories for studying nonlinear pharmacokinetics (PK)ofmonoclonal antibodies.However,there are too many parameters in full TMDD model to be esti... Target-mediated drug disposition (TMDD)model is one of the main modeling theories for studying nonlinear pharmacokinetics (PK)ofmonoclonal antibodies.However,there are too many parameters in full TMDD model to be estimated based on limited clinical data,leading to instability of the final model.In the present study,we analyzed the predictive ability and applicability of a simplified quasi-steady state (QSS)model with the assumption that the total target concentration was a constant parameter during treatment with monoelonal antibody in clinical data modeling.Based on the parameters of a published TMDD model of denosumab,simulations were performed at population and individual levels.Then,a simplified TMDD model,QSS model, was used to examine the effects of hypotheses,in which the total receptor concentration was constant or variable on model fit and stability of parameter estimation.Both simulations at the population level and model fit results of simulated individual data showed that at the therapeutic doses,the total receptor concentration had little influence on changes in drug concentration,and the model with constant total receptor concentration had the same predictive power.The validated hypothesis could be applied to clinical trial design and selection of the optimal PK model in the development of monoclonal antibodies. 展开更多
关键词 Target-mediated drug disposition model Monoclonal antibody Nonlinear pharmacokinetics DENOSUMAB SIMULATION
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