AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean adults.METHODS:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examina...AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean adults.METHODS:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this study.Subjects diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were rejected.Anthropometry,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all subjects.Homeostasis model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin sensitivity.Each participant was categorized into a negative,recovery,or CVHB group.To compare variables between groups,a t-test and/or one-way analysis of variance were used.Partial correlation coefficients were computed to present the association between insulin resistance and other variables.Multiple logistic regression analysis was used to assess the independent association between CVHB and IR.RESULTS:The mean age of men and women were 48.9 and 48.6 years,respectively.Subjects in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P < 0.001 in women)],cystatin C [(0.96 ± 0.15 mg/dL vs 1.02 ± 0.22 mg/dL,P < 0.001 in men),(0.84 ± 0.15 mg/dL vs 0.90 ± 0.16 mg/dL,P < 0.001 in women)],fasting insulin [(5.47 ± 3.38 U/mL vs 6.12 ± 4.62 U/mL,P < 0.001 in men),(4.57 ± 2.82 U/mL vs 5.06 ± 3.10 U/mL,P < 0.001 in women)] and HOMA index [(1.24 ± 0.86 vs 1.43 ± 1.24,P < 0.001 in men),(1.02 ± 0.76 vs 1.13 ± 0.87,P = 0.033 in women)] compared to control group.The HOMA index revealed a positive correlation with body mass index(BMI)(r = 0.378,P < 0.001),waist circumference(r =0.356,P < 0.001),percent body fat(r = 0.296,P < 0.001),systolic blood pressure(r = 0.202,P < 0.001),total cholesterol(r = 0.134,P < 0.001),triglycerides(r = 0.292,P < 0.001),cystatin C(r = 0.069,P < 0.001) and uric acid(r = 0.142,P < 0.001).The QUICKI index revealed a negative correlation with BMI(r =-0.254,P < 0.001),waist circumference(r = 0-0.243,P < 0.001),percent body fat(r =-0.217,P < 0.001),systolic blood pressure(r =-0.132,P < 0.001),total cholesterol(r =-0.106,P < 0.001),triglycerides(r =-0.205,P < 0.001),cystatin C(r =-0.044,P < 0.001) and uric acid(r =-0.096,P < 0.001).For subjects identified with IR,the odds ratio of an accompanying diagnosis of chronic hepatitis B was 1.534(95% CI:1.158-2.031,HOMA index criteria) or 1.566(95% CI:1.124-2.182,QUICKI criteria) after adjustment for age,gender,BMI,and amount of alcohol consumption.CONCLUSION:Our study demonstrates that CVHB is associated with IR.CVHB may need to be monitored for occurrence of IR and diabetes mellitus.展开更多
The transverse permeability of unidirectional fiber tows is calculated using homogenization method.Each fiber tow consisting of 21 filaments is arranged in uniform square packing.Stokes governing equation is analogize...The transverse permeability of unidirectional fiber tows is calculated using homogenization method.Each fiber tow consisting of 21 filaments is arranged in uniform square packing.Stokes governing equation is analogized with Lame equation used in the linear elasticity problem and is solved by the finite element code ANSYS.The prediction for transverse permeability of unidirectional fiber obtained by the homogenization approach is compared with other analytical methods.The result shows a good agreement with Kozeny-Carman equation and Gebart square packing model.A model for nonuniform fiber distribution and measurement technology are proposed.It can be found that the experimental result is in excellent agreement with predicted permeability in the nonuniform distribution model.展开更多
Opsaridium microlepis migrates for spawning during the rainy season (November to May) to major affluent rivers. Linthipe River is one of the major rivers, into which this species migrates. Determination of reproduct...Opsaridium microlepis migrates for spawning during the rainy season (November to May) to major affluent rivers. Linthipe River is one of the major rivers, into which this species migrates. Determination of reproductive seasonality of O. microlepis is paramount in the improved management of this endangered species. Reproductive seasonality ofO. microlepis in the Linthipe River in Central Malawi was estimated using 546 specimens for 12 months. The GSI (Gonadosomatic Index) ranged between 5.6% and 13% for females and between 0.3% and 1.4% for males, respectively. GSI variation between the months was significantly different (one-way ANOVA (analysis of variance), P 〈 0.05). The peak breeding activity was observed between January to April. This was at the onset of rainy season while the condition factor of O. microlepis was found to be variable with lowest value in the month of August. The study revealed that for O. microlepis fishery to be sustainably exploited, proper management regimes should be instituted along the migratory rivers during the peak breeding periods. These sustainable methods need to be managed in a participatory manner together with the majority of people living along these rivers.展开更多
文摘AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean adults.METHODS:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this study.Subjects diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were rejected.Anthropometry,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all subjects.Homeostasis model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin sensitivity.Each participant was categorized into a negative,recovery,or CVHB group.To compare variables between groups,a t-test and/or one-way analysis of variance were used.Partial correlation coefficients were computed to present the association between insulin resistance and other variables.Multiple logistic regression analysis was used to assess the independent association between CVHB and IR.RESULTS:The mean age of men and women were 48.9 and 48.6 years,respectively.Subjects in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P < 0.001 in women)],cystatin C [(0.96 ± 0.15 mg/dL vs 1.02 ± 0.22 mg/dL,P < 0.001 in men),(0.84 ± 0.15 mg/dL vs 0.90 ± 0.16 mg/dL,P < 0.001 in women)],fasting insulin [(5.47 ± 3.38 U/mL vs 6.12 ± 4.62 U/mL,P < 0.001 in men),(4.57 ± 2.82 U/mL vs 5.06 ± 3.10 U/mL,P < 0.001 in women)] and HOMA index [(1.24 ± 0.86 vs 1.43 ± 1.24,P < 0.001 in men),(1.02 ± 0.76 vs 1.13 ± 0.87,P = 0.033 in women)] compared to control group.The HOMA index revealed a positive correlation with body mass index(BMI)(r = 0.378,P < 0.001),waist circumference(r =0.356,P < 0.001),percent body fat(r = 0.296,P < 0.001),systolic blood pressure(r = 0.202,P < 0.001),total cholesterol(r = 0.134,P < 0.001),triglycerides(r = 0.292,P < 0.001),cystatin C(r = 0.069,P < 0.001) and uric acid(r = 0.142,P < 0.001).The QUICKI index revealed a negative correlation with BMI(r =-0.254,P < 0.001),waist circumference(r = 0-0.243,P < 0.001),percent body fat(r =-0.217,P < 0.001),systolic blood pressure(r =-0.132,P < 0.001),total cholesterol(r =-0.106,P < 0.001),triglycerides(r =-0.205,P < 0.001),cystatin C(r =-0.044,P < 0.001) and uric acid(r =-0.096,P < 0.001).For subjects identified with IR,the odds ratio of an accompanying diagnosis of chronic hepatitis B was 1.534(95% CI:1.158-2.031,HOMA index criteria) or 1.566(95% CI:1.124-2.182,QUICKI criteria) after adjustment for age,gender,BMI,and amount of alcohol consumption.CONCLUSION:Our study demonstrates that CVHB is associated with IR.CVHB may need to be monitored for occurrence of IR and diabetes mellitus.
基金Tianjin Natural Science Foundation, China (No.06YFJ MJC03100,013604311)
文摘The transverse permeability of unidirectional fiber tows is calculated using homogenization method.Each fiber tow consisting of 21 filaments is arranged in uniform square packing.Stokes governing equation is analogized with Lame equation used in the linear elasticity problem and is solved by the finite element code ANSYS.The prediction for transverse permeability of unidirectional fiber obtained by the homogenization approach is compared with other analytical methods.The result shows a good agreement with Kozeny-Carman equation and Gebart square packing model.A model for nonuniform fiber distribution and measurement technology are proposed.It can be found that the experimental result is in excellent agreement with predicted permeability in the nonuniform distribution model.
文摘Opsaridium microlepis migrates for spawning during the rainy season (November to May) to major affluent rivers. Linthipe River is one of the major rivers, into which this species migrates. Determination of reproductive seasonality of O. microlepis is paramount in the improved management of this endangered species. Reproductive seasonality ofO. microlepis in the Linthipe River in Central Malawi was estimated using 546 specimens for 12 months. The GSI (Gonadosomatic Index) ranged between 5.6% and 13% for females and between 0.3% and 1.4% for males, respectively. GSI variation between the months was significantly different (one-way ANOVA (analysis of variance), P 〈 0.05). The peak breeding activity was observed between January to April. This was at the onset of rainy season while the condition factor of O. microlepis was found to be variable with lowest value in the month of August. The study revealed that for O. microlepis fishery to be sustainably exploited, proper management regimes should be instituted along the migratory rivers during the peak breeding periods. These sustainable methods need to be managed in a participatory manner together with the majority of people living along these rivers.